Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2023 ▲▼ | Q4 2023 ▲▼ | Change ▲▼ | Q3 2023 ▲▼ | Q4 2023 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| ARGENX SE(ARGX) | 0 | 70,000 | +70,000 | 0 | 26,538 | 7.26% | +26,538 |
| SPDR SER TR ST STR SP HOME | 0 | 200,000 | +200,000 | 0 | 19,132 | 5.23% | +19,132 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 0 | 877,500 | +877,500 | 0 | 12,917 | 3.53% | +12,917 |
| SAREPTA THERAPEUTICS INC(SRPT) | 0 | 132,640 | +132,640 | 0 | 12,790 | 3.50% | +12,790 |
| ANNEXON INC(ANNX) | 0 | 2,650,000 | +2,650,000 | 0 | 12,031 | 3.29% | +12,031 |
| ALPINE IMMUNE SCIENCES INC | 0 | 487,248 | +487,248 | 0 | 9,287 | 2.54% | +9,287 |
| EYEPOINT PHARMACEUTICALS INC(EYPT) | 0 | 368,130 | +368,130 | 0 | 8,507 | 2.33% | +8,507 |
| SOLENO THERAPEUTICS INC | 536,720 | 590,243 | +53,523 | 15,839 | 23,757 | 6.50% | +7,919 |
| PROTAGONIST THERAPEUTICS INC | 0 | 319,000 | +319,000 | 0 | 7,315 | 2.00% | +7,315 |
| ICOSAVAX INC | 0 | 440,000 | +440,000 | 0 | 6,934 | 1.90% | +6,934 |
| BRIDGEBIO PHARMA INC(BBIO) | 473,126 | 473,126 | 0 | 12,476 | 19,100 | 5.22% | +6,624 |
| NUVALENT INC | 278,034 | 258,142 | -19,892 | 12,781 | 18,997 | 5.20% | +6,215 |
| CABALETTA BIO INC(CABA) | 0 | 216,620 | +216,620 | 0 | 4,917 | 1.35% | +4,917 |
| FUSION PHARMACEUTICALS INC | 0 | 500,000 | +500,000 | 0 | 4,805 | 1.31% | +4,805 |
| DISC MEDICINE INC(IRON) | 142,766 | 194,982 | +52,216 | 6,707 | 11,262 | 3.08% | +4,555 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 0 | 200,000 | +200,000 | 0 | 4,456 | 1.22% | +4,456 |
| DYNE THERAPEUTICS INC(DYN) | 0 | 285,900 | +285,900 | 0 | 3,802 | 1.04% | +3,802 |
| LONGBOARD PHARMACEUTICALS IN | 514,101 | 979,462 | +465,361 | 2,858 | 5,906 | 1.62% | +3,048 |
| CRISPR THERAPEUTICS AG(CRSP) | 30,546 | 70,546 | +40,000 | 1,386 | 4,416 | 1.21% | +3,030 |
| ABEONA THERAPEUTICS INC(ABEO) | 0 | 600,000 | +600,000 | 0 | 3,006 | 0.82% | +3,006 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 0 | 270,000 | +270,000 | 0 | 2,954 | 0.81% | +2,954 |
| CATALYST PHARMACEUTICALS INC | 505,862 | 505,862 | 0 | 5,914 | 8,504 | 2.33% | +2,590 |
| CYTOKINETICS INC(CYTK) | 0 | 30,000 | +30,000 | 0 | 2,505 | 0.69% | +2,505 |
| MODERNA INC(MRNA) | 0 | 24,546 | +24,546 | 0 | 2,441 | 0.67% | +2,441 |
| MIND MEDICINE MINDMED INC | 0 | 600,000 | +600,000 | 0 | 2,196 | 0.60% | +2,196 |
| MARINUS PHARMACEUTICALS INC | 746,069 | 746,069 | 0 | 6,006 | 8,110 | 2.22% | +2,104 |
| APELLIS PHARMACEUTICALS INC COM | 0 | 34,361 | +34,361 | 0 | 2,057 | 0.56% | +2,057 |
| ROIVANT SCIENCES LTD(ROIV) | 1,821 | 151,821 | +150,000 | 21 | 1,705 | 0.47% | +1,684 |
| LYRA THERAPEUTICS INC | 1,254,384 | 1,254,384 | 0 | 4,905 | 6,573 | 1.80% | +1,668 |
| TARSUS PHARMACEUTICALS INC(TARS) | 518,519 | 518,519 | 0 | 9,214 | 10,500 | 2.87% | +1,286 |
| AUTOLUS THERAPEUTICS PLC(AUTL) | 262,694 | 262,694 | 0 | 612 | 1,692 | 0.46% | +1,080 |
| LANTHEUS HLDGS INC(LNTH) | 0 | 15,000 | +15,000 | 0 | 930 | 0.25% | +930 |
| KODIAK SCIENCES INC(KOD) | 312,881 | 412,881 | +100,000 | 563 | 1,255 | 0.34% | +692 |
| RENEO PHARMACEUTICALS INC | 0 | 421,300 | +421,300 | 0 | 674 | 0.18% | +674 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 792,920 | 680,370 | -112,550 | 23,581 | 24,208 | 6.62% | +626 |
| TEMPEST THERAPEUTICS INC(TPST) | 0 | 105,600 | +105,600 | 0 | 465 | 0.13% | +465 |
| AEON BIOPHARMA INC | 257,977 | 257,977 | 0 | 1,445 | 1,857 | 0.51% | +413 |
| PROQR THRAPEUTICS N V SHS EURO | 472,625 | 472,625 | 0 | 614 | 936 | 0.26% | +321 |
| TERNS PHARMACEUTICALS INC | 165,480 | 165,480 | 0 | 832 | 1,074 | 0.29% | +242 |
| VOYAGER THERAPEUTICS INC(VYGR) | 305,857 | 305,857 | 0 | 2,370 | 2,581 | 0.71% | +211 |
| NUVATION BIO INC(NUVB) | 1,222,852 | 1,222,852 | 0 | 1,639 | 1,847 | 0.51% | +208 |
| HOOKIPA PHARMA INC | 530,776 | 530,776 | 0 | 327 | 430 | 0.12% | +103 |
| ASTRIA THERAPEUTICS INC | 374,807 | 374,807 | 0 | 2,796 | 2,879 | 0.79% | +82 |
| RELMADA THERAPEUTICS INC(RLMD) | 40,369 | 40,369 | 0 | 121 | 167 | 0.05% | +46 |
| LARIMAR THERAPEUTICS INC(LRMR) | 682,868 | 602,868 | -80,000 | 2,697 | 2,743 | 0.75% | +46 |
| VERONA PHARMA PLC | 318,591 | 367,468 | +48,877 | 214 | 257 | 0.07% | +44 |
| PROTARA THERAPEUTICS INC(TARA) | 188,664 | 188,664 | 0 | 315 | 353 | 0.10% | +38 |
| SYNLOGIC INC(SYBX) | 20,448 | 20,448 | 0 | 57 | 79 | 0.02% | +21 |
| ACLARIS THERAPEUTICS INC(ACRS) | 0 | 19,482 | +19,482 | 0 | 20 | 0.01% | +20 |
| STOKE THERAPEUTICS INC(STOK) | 12,116 | 12,116 | 0 | 48 | 64 | 0.02% | +16 |
| VENTYX BIOSCIENCES INC | 0 | 5,914 | +5,914 | 0 | 15 | 0.00% | +15 |
| UNIQURE NV(QURE) | 157,365 | 157,365 | 0 | 1,056 | 1,065 | 0.29% | +9 |
| BRAINSTORM CELL THERAPEUTICS | 90,242 | 90,242 | 0 | 18 | 25 | 0.01% | +7 |
| TYRA BIOSCIENCES INC(TYRA) | 48,170 | 48,170 | 0 | 663 | 667 | 0.18% | +4 |
| ASLAN PHARMACEUTICALS LTD | 35,420 | 35,420 | 0 | 6 | 7 | 0.00% | 0 |
| ITEOS THERAPEUTICS INC | 346,471 | 346,471 | 0 | 3,794 | 3,794 | 1.04% | 0 |
| PHAXIAM THERAPEUTICS S A | 301 | 0 | -301 | 2 | 0 | — | -2 |
| FIBROGEN INC | 2,774 | 0 | -2,774 | 2 | 0 | — | -2 |
| TRACON PHARMACEUTICALS INC | 2,765,530 | 2,765,530 | 0 | 492 | 484 | 0.13% | -8 |
| FINCH THERAPEUTICS GROUP INC | 6,892 | 6,892 | 0 | 35 | 25 | 0.01% | -10 |
| BLACK DIAMOND THERAPEUTICS I | 555,572 | 555,572 | 0 | 1,594 | 1,561 | 0.43% | -33 |
| IMMATICS N.V(IMTX) | 49,031 | 49,031 | 0 | 568 | 516 | 0.14% | -51 |
| SYNDAX PHARMACEUTICALS INC(SNDX) | 4,000 | 0 | -4,000 | 58 | 0 | — | -58 |
| OCULAR THERAPEUTIX INC(OCUL) | 21,590 | 0 | -21,590 | 68 | 0 | — | -68 |
| FOGHORN THERAPEUTICS INC(FHTX) | 15,292 | 0 | -15,292 | 76 | 0 | — | -76 |
| CHEMOMAB THERAPEUTICS LTD | 213,392 | 213,392 | 0 | 191 | 109 | 0.03% | -82 |
| ACUMEN PHARMACEUTICALS INC(ABOS) | 315,265 | 315,265 | 0 | 1,308 | 1,211 | 0.33% | -98 |
| ANEBULO PHARMACEUTICALS INC | 157,862 | 157,862 | 0 | 504 | 382 | 0.10% | -122 |
| AVROBIO INC | 718,259 | 718,259 | 0 | 1,106 | 977 | 0.27% | -129 |
| SCPHARMACEUTICALS INC | 18,647 | 0 | -18,647 | 133 | 0 | — | -133 |
| CORBUS PHARMACEUTICALS HLDGS(CRBP) | 195,899 | 195,899 | 0 | 1,320 | 1,183 | 0.32% | -137 |
| ELEVATION ONCOLOGY INC | 1,171,939 | 1,171,939 | 0 | 777 | 629 | 0.17% | -147 |
| KARYOPHARM THERAPEUTICS INC(KPTI) | 400,000 | 400,000 | 0 | 536 | 346 | 0.09% | -190 |
| MEREO BIOPHARMA GROUP PLC(MREO) | 591,676 | 0 | -591,676 | 191 | 0 | — | -191 |
| KEZAR LIFE SCIENCES INC | 853,391 | 853,391 | 0 | 1,016 | 809 | 0.22% | -207 |
| PTC THERAPEUTICS INC(PTCT) | 10,862 | 0 | -10,862 | 243 | 0 | — | -243 |
| TG THERAPEUTICS INC(TGTX) | 32,547 | 0 | -32,547 | 272 | 0 | — | -272 |
| COGENT BIOSCIENCES INC(COGT) | 62,766 | 0 | -62,766 | 612 | 0 | — | -612 |
| ELI LILLY & CO(LLY) | 1,227 | 0 | -1,227 | 659 | 0 | — | -659 |
| IMMUNIC INC(IMUX) | 450,000 | 0 | -450,000 | 662 | 0 | — | -662 |
| MILESTONE PHARMACEUTICALS IN(MIST) | 462,828 | 462,828 | 0 | 1,435 | 773 | 0.21% | -662 |
| ESPERION THERAPEUTICS INC NE | 1,737,636 | 337,636 | -1,400,000 | 1,703 | 1,010 | 0.28% | -693 |
| JASPER THERAPEUTICS INC(JSPR) | 1,125,087 | 0 | -1,125,087 | 788 | 0 | — | -788 |
| INFLARX NV(IFRX) | 688,604 | 688,604 | 0 | 2,052 | 1,122 | 0.31% | -930 |
| ALLAKOS INC | 787,056 | 237,056 | -550,000 | 1,787 | 647 | 0.18% | -1,139 |
| VISTAGEN THERAPEUTICS INC(VTGN) | 229,100 | 0 | -229,100 | 1,200 | 0 | — | -1,200 |
| KALVISTA PHARMACEUTICALS INC | 142,692 | 0 | -142,692 | 1,374 | 0 | — | -1,374 |
| CYMABAY THERAPEUTICS INC | 104,300 | 0 | -104,300 | 1,555 | 0 | — | -1,555 |
| BIOVIE INC(BIVI) | 457,345 | 0 | -457,345 | 1,560 | 0 | — | -1,560 |
| IMMUNOVANT INC(IMVT) | 297,794 | 233,394 | -64,400 | 11,432 | 9,833 | 2.69% | -1,599 |
| MERSANA THERAPEUTICS INC | 1,579,770 | 0 | -1,579,770 | 2,006 | 0 | — | -2,006 |
| COHERUS BIOSCIENCES INC(CHRS) | 865,787 | 340,787 | -525,000 | 3,238 | 1,135 | 0.31% | -2,103 |
| BIOHAVEN LTD(BHVN) | 106,138 | 0 | -106,138 | 2,761 | 0 | — | -2,761 |
| IMMUNOGEN INC | 390,162 | 90,162 | -300,000 | 6,192 | 2,673 | 0.73% | -3,519 |
| PRAXIS PRECISION MEDICINES I | 2,250,000 | 0 | -2,250,000 | 3,848 | 0 | — | -3,848 |
| INSMED INC(INSM) | 154,900 | 0 | -154,900 | 3,911 | 0 | — | -3,911 |
| SPRINGWORKS THERAPEUTICS INC | 178,360 | 0 | -178,360 | 4,124 | 0 | — | -4,124 |
| ARCUS BIOSCIENCES INC(RCUS) | 254,876 | 0 | -254,876 | 4,575 | 0 | — | -4,575 |
| IDEAYA BIOSCIENCES INC(IDYA) | 216,949 | 0 | -216,949 | 5,853 | 0 | — | -5,853 |
| ROCKET PHARMACEUTICALS INC(RCKT) | 654,726 | 239,726 | -415,000 | 13,415 | 7,185 | 1.97% | -6,231 |