Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2023 ▲▼ | Q4 2023 ▲▼ | Change ▲▼ | Q3 2023 ▲▼ | Q4 2023 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| CYTOKINETICS INC(CYTK)(Call) | 2,035 | 603,500 | +601,465 | 5,995 | 50,386 | — | +44,391 |
| KRYSTAL BIOTECH INC(KRYS)(Put) | 845 | 412,000 | +411,155 | 9,802 | 51,113 | — | +41,311 |
| ELI LILLY & CO(LLY)(Put) | 0 | 70,000 | +70,000 | 0 | 40,804 | — | +40,804 |
| ALNYLAM PHARMACEUTICALS INC(ALNY)(Call) | 0 | 169,700 | +169,700 | 0 | 32,482 | — | +32,482 |
| CRISPR THERAPEUTICS AG(CRSP)(Put) | 0 | 649,400 | +649,400 | 0 | 40,652 | — | +40,652 |
| ARGENX SE(ARGX)(Call) | 0 | 78,100 | +78,100 | 0 | 29,712 | — | +29,712 |
| ARGENX SE(ARGX)(Put) | 0 | 78,100 | +78,100 | 0 | 29,712 | — | +29,712 |
| ARGENX SE(ARGX) | 0 | 70,000 | +70,000 | 0 | 26,538 | 7.26% | +26,538 |
| PROTHENA CORP PLC(Call) SHS | 0 | 600,000 | +600,000 | 0 | 21,804 | — | +21,804 |
| SPDR SER TR ST STR SP HOME | 0 | 200,000 | +200,000 | 0 | 19,132 | 5.23% | +19,132 |
| ALNYLAM PHARMACEUTICALS INC(ALNY)(Put) | 0 | 98,600 | +98,600 | 0 | 18,873 | — | +18,873 |
| KARUNA THERAPEUTICS INC(Call) | 0 | 58,600 | +58,600 | 0 | 18,547 | — | +18,547 |
| LANTHEUS HLDGS INC(LNTH)(Call) | 0 | 270,000 | +270,000 | 0 | 16,740 | — | +16,740 |
| AMYLYX PHARMACEUTICALS INC(AMLX)(Call) | 2,065 | 1,298,400 | +1,296,335 | 3,781 | 19,112 | — | +15,331 |
| PROTHENA CORP PLC(Put) SHS | 0 | 418,400 | +418,400 | 0 | 15,205 | — | +15,205 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 0 | 877,500 | +877,500 | 0 | 12,917 | 3.53% | +12,917 |
| SAREPTA THERAPEUTICS INC(SRPT) | 0 | 132,640 | +132,640 | 0 | 12,790 | 3.50% | +12,790 |
| SPDR SER TR(Put) ST STR SP BIOT | 5,000 | 550,000 | +545,000 | 36,510 | 49,110 | — | +12,600 |
| KRYSTAL BIOTECH INC(KRYS)(Call) | 0 | 100,000 | +100,000 | 0 | 12,406 | — | +12,406 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX)(Put) | 0 | 200,600 | +200,600 | 0 | 12,114 | — | +12,114 |
| ANNEXON INC(ANNX) | 0 | 2,650,000 | +2,650,000 | 0 | 12,031 | 3.29% | +12,031 |
| BIOMEA FUSION INC(Call) | 0 | 777,600 | +777,600 | 0 | 11,291 | — | +11,291 |
| AMGEN INC(AMGN)(Call) | 0 | 35,000 | +35,000 | 0 | 10,081 | — | +10,081 |
| ALEXANDRIA REAL ESTATE EQ IN(Put) | 0 | 73,300 | +73,300 | 0 | 9,292 | — | +9,292 |
| ALPINE IMMUNE SCIENCES INC | 0 | 487,248 | +487,248 | 0 | 9,287 | 2.54% | +9,287 |
| EYEPOINT PHARMACEUTICALS INC(EYPT)(Call) | 0 | 391,000 | +391,000 | 0 | 9,036 | — | +9,036 |
| CORCEPT THERAPEUTICS INC(CORT)(Call) | 0 | 271,300 | +271,300 | 0 | 8,812 | — | +8,812 |
| CORCEPT THERAPEUTICS INC(CORT)(Put) | 0 | 271,300 | +271,300 | 0 | 8,812 | — | +8,812 |
| EYEPOINT PHARMACEUTICALS INC(EYPT) | 0 | 368,130 | +368,130 | 0 | 8,507 | 2.33% | +8,507 |
| SOLENO THERAPEUTICS INC | 536,720 | 590,243 | +53,523 | 15,839 | 23,757 | 6.50% | +7,919 |
| IMMUNOGEN INC(Call) | 0 | 456,800 | +456,800 | 0 | 13,544 | — | +13,544 |
| PROTAGONIST THERAPEUTICS INC | 0 | 319,000 | +319,000 | 0 | 7,315 | 2.00% | +7,315 |
| BIOMEA FUSION INC(Put) | 0 | 500,000 | +500,000 | 0 | 7,260 | — | +7,260 |
| XENON PHARMACEUTICALS INC(XENE)(Put) | 11 | 154,089 | +154,078 | 38 | 7,097 | — | +7,060 |
| ICOSAVAX INC | 0 | 440,000 | +440,000 | 0 | 6,934 | 1.90% | +6,934 |
| BRIDGEBIO PHARMA INC(BBIO) | 473,126 | 473,126 | 0 | 12,476 | 19,100 | 5.22% | +6,624 |
| NUVALENT INC(NUVL) | 278,034 | 258,142 | -19,892 | 12,781 | 18,997 | 5.20% | +6,215 |
| DYNE THERAPEUTICS INC(DYN)(Call) | 2,726 | 607,600 | +604,874 | 2,442 | 8,081 | — | +5,639 |
| CABALETTA BIO INC | 0 | 216,620 | +216,620 | 0 | 4,917 | 1.35% | +4,917 |
| FUSION PHARMACEUTICALS INC | 0 | 500,000 | +500,000 | 0 | 4,805 | 1.31% | +4,805 |
| DISC MEDICINE INC(IRON) | 0 | 194,982 | +194,982 | 0 | 11,262 | 3.08% | +11,262 |
| CABALETTA BIO INC(Put) | 0 | 200,000 | +200,000 | 0 | 4,540 | — | +4,540 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 0 | 200,000 | +200,000 | 0 | 4,456 | 1.22% | +4,456 |
| MORPHOSYS AG(Call) | 0 | 400,000 | +400,000 | 0 | 3,960 | — | +3,960 |
| DYNE THERAPEUTICS INC(DYN) | 0 | 285,900 | +285,900 | 0 | 3,802 | 1.04% | +3,802 |
| DYNE THERAPEUTICS INC(DYN)(Put) | 0 | 250,000 | +250,000 | 0 | 3,325 | — | +3,325 |
| LONGBOARD PHARMACEUTICALS IN | 0 | 979,462 | +979,462 | 0 | 5,906 | 1.62% | +5,906 |
| CRISPR THERAPEUTICS AG(CRSP) | 30,546 | 70,546 | +40,000 | 1,386 | 4,416 | 1.21% | +3,030 |
| ABEONA THERAPEUTICS INC | 0 | 600,000 | +600,000 | 0 | 3,006 | 0.82% | +3,006 |
| EYEPOINT PHARMACEUTICALS INC(EYPT)(Put) | 4,487 | 283,200 | +278,713 | 3,585 | 6,545 | — | +2,960 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 0 | 270,000 | +270,000 | 0 | 2,954 | 0.81% | +2,954 |
| CATALYST PHARMACEUTICALS INC(CPRX) | 505,862 | 505,862 | 0 | 5,914 | 8,504 | 2.33% | +2,590 |
| CYTOKINETICS INC(CYTK) | 0 | 30,000 | +30,000 | 0 | 2,505 | 0.69% | +2,505 |
| MODERNA INC(MRNA) | 0 | 24,546 | +24,546 | 0 | 2,441 | 0.67% | +2,441 |
| MIND MEDICINE MINDMED INC | 0 | 600,000 | +600,000 | 0 | 2,196 | 0.60% | +2,196 |
| MARINUS PHARMACEUTICALS INC | 0 | 746,069 | +746,069 | 0 | 8,110 | 2.22% | +8,110 |
| APELLIS PHARMACEUTICALS INC COM | 0 | 34,361 | +34,361 | 0 | 2,057 | 0.56% | +2,057 |
| TARSUS PHARMACEUTICALS INC(TARS)(Call) | 0 | 100,000 | +100,000 | 0 | 2,025 | — | +2,025 |
| RENEO PHARMACEUTICALS INC(Call) | 0 | 1,082,600 | +1,082,600 | 0 | 1,732 | — | +1,732 |
| ROIVANT SCIENCES LTD(ROIV) | 0 | 151,821 | +151,821 | 0 | 1,705 | 0.47% | +1,705 |
| LYRA THERAPEUTICS INC | 1,254,384 | 1,254,384 | 0 | 4,905 | 6,573 | 1.80% | +1,668 |
| RAPT THERAPEUTICS INC(Put) | 0 | 58,800 | +58,800 | 0 | 1,461 | — | +1,461 |
| ROCKET PHARMACEUTICALS INC(Call) | 1,500 | 150,000 | +148,500 | 3,074 | 4,496 | — | +1,422 |
| TARSUS PHARMACEUTICALS INC(TARS) | 518,519 | 518,519 | 0 | 9,214 | 10,500 | 2.87% | +1,286 |
| NUVALENT INC(NUVL)(Put) | 523 | 48,400 | +47,877 | 2,404 | 3,562 | — | +1,158 |
| ACELYRIN INC(Call) | 0 | 336,900 | +336,900 | 0 | 2,513 | — | +2,513 |
| AUTOLUS THERAPEUTICS PLC | 262,694 | 262,694 | 0 | 612 | 1,692 | 0.46% | +1,080 |
| LANTHEUS HLDGS INC(LNTH) | 0 | 15,000 | +15,000 | 0 | 930 | 0.25% | +930 |
| SOLENO THERAPEUTICS INC(Call) | 0 | 21,200 | +21,200 | 0 | 853 | — | +853 |
| ABBVIE INC(ABBV)(Call) | 1,325 | 132,500 | +131,175 | 19,750 | 20,534 | — | +783 |
| RENEO PHARMACEUTICALS INC(Put) | 0 | 432,600 | +432,600 | 0 | 692 | — | +692 |
| KODIAK SCIENCES INC(KOD) | 312,881 | 412,881 | +100,000 | 563 | 1,255 | 0.34% | +692 |
| IMMUNIC INC(Call) | 0 | 450,000 | +450,000 | 0 | 675 | — | +675 |
| RENEO PHARMACEUTICALS INC | 0 | 421,300 | +421,300 | 0 | 674 | 0.18% | +674 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 792,920 | 680,370 | -112,550 | 23,581 | 24,208 | 6.62% | +626 |
| TEMPEST THERAPEUTICS INC | 0 | 105,600 | +105,600 | 0 | 465 | 0.13% | +465 |
| ARCUS BIOSCIENCES INC(RCUS)(Call) | 4,000 | 400,000 | +396,000 | 7,180 | 7,640 | — | +460 |
| AEON BIOPHARMA INC | 257,977 | 257,977 | 0 | 1,445 | 1,857 | 0.51% | +413 |
| PROQR THRAPEUTICS N V SHS EURO | 472,625 | 472,625 | 0 | 614 | 936 | 0.26% | +321 |
| TERNS PHARMACEUTICALS INC | 0 | 165,480 | +165,480 | 0 | 1,074 | 0.29% | +1,074 |
| VOYAGER THERAPEUTICS INC | 0 | 305,857 | +305,857 | 0 | 2,581 | 0.71% | +2,581 |
| NUVATION BIO INC(NUVB) | 1,222,852 | 1,222,852 | 0 | 1,639 | 1,847 | 0.51% | +208 |
| HOOKIPA PHARMA INC | 0 | 530,776 | +530,776 | 0 | 430 | 0.12% | +430 |
| ASTRIA THERAPEUTICS INC | 0 | 374,807 | +374,807 | 0 | 2,879 | 0.79% | +2,879 |
| CRISPR THERAPEUTICS AG(CRSP)(Call) | 0 | 3,900 | +3,900 | 0 | 244 | — | +244 |
| ANNOVIS BIO INC(Put) | 0 | 3,400 | +3,400 | 0 | 64 | — | +64 |
| RELMADA THERAPEUTICS INC | 40,369 | 40,369 | 0 | 121 | 167 | 0.05% | +46 |
| LARIMAR THERAPEUTICS INC | 682,868 | 602,868 | -80,000 | 2,697 | 2,743 | 0.75% | +46 |
| VERONA PHARMA PLC | 318,591 | 367,468 | +48,877 | 214 | 257 | 0.07% | +44 |
| PROTARA THERAPEUTICS INC | 188,664 | 188,664 | 0 | 315 | 353 | 0.10% | +38 |
| SYNLOGIC INC | 20,448 | 20,448 | 0 | 57 | 79 | 0.02% | +21 |
| ACLARIS THERAPEUTICS INC | 0 | 19,482 | +19,482 | 0 | 20 | 0.01% | +20 |
| STOKE THERAPEUTICS INC(STOK) | 0 | 12,116 | +12,116 | 0 | 64 | 0.02% | +64 |
| VENTYX BIOSCIENCES INC | 0 | 5,914 | +5,914 | 0 | 15 | 0.00% | +15 |
| UNIQURE NV(QURE) | 157,365 | 157,365 | 0 | 1,056 | 1,065 | 0.29% | +9 |
| BRAINSTORM CELL THERAPEUTICS | 0 | 90,242 | +90,242 | 0 | 25 | 0.01% | +25 |
| TYRA BIOSCIENCES INC(TYRA) | 0 | 48,170 | +48,170 | 0 | 667 | 0.18% | +667 |
| INSMED INC(INSM)(Call) | 0 | 200 | +200 | 0 | 6 | — | +6 |
| ASLAN PHARMACEUTICALS LTD | 35,420 | 35,420 | 0 | 6 | 7 | 0.00% | 0 |
| ITEOS THERAPEUTICS INC | 346,471 | 346,471 | 0 | 3,794 | 3,794 | 1.04% | 0 |