Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2023 ▲▼ | Q4 2023 ▲▼ | Change ▲▼ | Q3 2023 ▲▼ | Q4 2023 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| CYTOKINETICS INC(CYTK) | 1,250,000 | 1,625,000 | +375,000 | 36,825 | 135,671 | 15.09% | +98,846 |
| ARGENX SE(ARGX) | 0 | 145,000 | +145,000 | 0 | 55,162 | 6.13% | +55,162 |
| RAYZEBIO INC | 0 | 568,173 | +568,173 | 0 | 35,323 | 3.93% | +35,323 |
| AMBRX BIOPHARMA INC | 0 | 2,100,000 | +2,100,000 | 0 | 29,904 | 3.33% | +29,904 |
| APELLIS PHARMACEUTICALS INC COM | 750,000 | 950,000 | +200,000 | 28,530 | 56,867 | 6.32% | +28,337 |
| STRUCTURE THERAPEUTICS INC | 500,000 | 1,070,058 | +570,058 | 25,210 | 43,616 | 4.85% | +18,406 |
| OCULAR THERAPEUTIX INC(OCUL) | 0 | 4,000,000 | +4,000,000 | 0 | 17,840 | 1.98% | +17,840 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 0 | 950,000 | +950,000 | 0 | 10,393 | 1.16% | +10,393 |
| ANNEXON INC(ANNX) | 5,300,000 | 4,950,000 | -350,000 | 12,508 | 22,473 | 2.50% | +9,965 |
| ACELYRIN INC | 0 | 1,250,000 | +1,250,000 | 0 | 9,325 | 1.04% | +9,325 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX) | 0 | 150,000 | +150,000 | 0 | 9,059 | 1.01% | +9,059 |
| KARUNA THERAPEUTICS INC | 115,000 | 90,000 | -25,000 | 19,445 | 28,486 | 3.17% | +9,041 |
| ATYR PHARMA INC | 0 | 5,850,000 | +5,850,000 | 0 | 8,249 | 0.92% | +8,249 |
| MORPHOSYS AG | 950,000 | 1,475,000 | +525,000 | 6,384 | 14,603 | 1.62% | +8,219 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 3,743,875 | 4,383,875 | +640,000 | 46,237 | 54,377 | 6.05% | +8,140 |
| FULCRUM THERAPEUTICS INC(FULC) | 0 | 1,200,000 | +1,200,000 | 0 | 8,100 | 0.90% | +8,100 |
| TOURMALINE BIO INC | 0 | 284,372 | +284,372 | 0 | 7,445 | 0.83% | +7,445 |
| AVIDITY BIOSCIENCES INC | 0 | 775,000 | +775,000 | 0 | 7,014 | 0.78% | +7,014 |
| SILENCE THERAPEUTICS PLC(SLN) | 0 | 400,000 | +400,000 | 0 | 6,948 | 0.77% | +6,948 |
| NEUMORA THERAPEUTICS INC.(NMRA) | 0 | 382,345 | +382,345 | 0 | 6,519 | 0.72% | +6,519 |
| ARCUS BIOSCIENCES INC(RCUS) | 0 | 325,000 | +325,000 | 0 | 6,208 | 0.69% | +6,208 |
| MORPHIC HLDG INC | 0 | 200,000 | +200,000 | 0 | 5,776 | 0.64% | +5,776 |
| APPLIED THERAPEUTICS INC | 0 | 1,660,000 | +1,660,000 | 0 | 5,561 | 0.62% | +5,561 |
| DYNE THERAPEUTICS INC(DYN) | 2,180,000 | 1,880,000 | -300,000 | 19,533 | 25,004 | 2.78% | +5,471 |
| IMMUNOCORE HLDGS PLC(IMCR) | 450,000 | 400,000 | -50,000 | 23,355 | 27,328 | 3.04% | +3,973 |
| INHIBRX INC | 0 | 100,000 | +100,000 | 0 | 3,800 | 0.42% | +3,800 |
| IDEAYA BIOSCIENCES INC(IDYA) | 2,250,000 | 1,800,000 | -450,000 | 60,705 | 64,044 | 7.12% | +3,339 |
| REVOLUTION MEDICINES INC(RVMD) | 250,000 | 350,000 | +100,000 | 6,920 | 10,038 | 1.12% | +3,118 |
| KINIKSA PHARMACEUTICALS LTD | 0 | 150,000 | +150,000 | 0 | 2,631 | 0.29% | +2,631 |
| DESIGN THERAPEUTICS INC(DSGN) | 5,032,501 | 5,032,501 | 0 | 11,877 | 13,336 | 1.48% | +1,459 |
| REPARE THERAPEUTICS INC | 300,000 | 600,000 | +300,000 | 3,624 | 4,380 | 0.49% | +756 |
| SPYRE THERAPEUTICS INC(SYRE) | 210,000 | 150,000 | -60,000 | 2,573 | 3,228 | 0.36% | +656 |
| IO BIOTECH INC(IOBTQ) | 493,827 | 493,827 | 0 | 696 | 928 | 0.10% | +232 |
| ASTRIA THERAPEUTICS INC | 544,960 | 544,960 | 0 | 4,065 | 4,185 | 0.47% | +120 |
| ENLIVEN THERAPEUTICS INC | 307,076 | 307,076 | 0 | 4,195 | 4,250 | 0.47% | +55 |
| IMMUNIC INC(IMUX) | 421,184 | 421,184 | 0 | 619 | 632 | 0.07% | +13 |
| NUVATION BIO INC(NUVB) | 66,666 | 66,666 | 0 | 7 | 4 | 0.00% | -3 |
| LIANBIO(LIANY) | 280,000 | 0 | -280,000 | 417 | 0 | — | -417 |
| TYRA BIOSCIENCES INC(TYRA) | 31,872 | 0 | -31,872 | 439 | 0 | — | -439 |
| LEAP THERAPEUTICS INC(CYPH) | 354,266 | 0 | -354,266 | 489 | 0 | — | -489 |
| VIGIL NEUROSCIENCE INC | 188,390 | 0 | -188,390 | 1,015 | 0 | — | -1,015 |
| AMBRX BIOPHARMA INC | 115,000 | 0 | -115,000 | 1,323 | 0 | — | -1,322 |
| ROCKET PHARMACEUTICALS INC(RCKT) | 1,975,000 | 1,275,000 | -700,000 | 40,468 | 38,212 | 4.25% | -2,256 |
| ALLAKOS INC | 4,650,000 | 2,900,000 | -1,750,000 | 10,556 | 7,917 | 0.88% | -2,638 |
| COMPASS PATHWAYS PLC(CMPS) | 950,000 | 500,000 | -450,000 | 7,030 | 4,375 | 0.49% | -2,655 |
| ZURA BIO LTD(ZURA) | 424,000 | 0 | -424,000 | 2,798 | 0 | — | -2,798 |
| VERVE THERAPEUTICS INC | 215,000 | 0 | -215,000 | 2,851 | 0 | — | -2,851 |
| VENTYX BIOSCIENCES INC | 225,000 | 2,000,000 | +1,775,000 | 7,814 | 4,940 | 0.55% | -2,874 |
| DELCATH SYS INC(DCTH) | 1,044,444 | 300,000 | -744,444 | 4,230 | 1,248 | 0.14% | -2,982 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 1,050,000 | 600,000 | -450,000 | 16,107 | 13,068 | 1.45% | -3,039 |
| SOLENO THERAPEUTICS INC | 125,000 | 0 | -125,000 | 3,689 | 0 | — | -3,689 |
| 89BIO INC | 310,000 | 0 | -310,000 | 4,786 | 0 | — | -4,786 |
| ALX ONCOLOGY HLDGS INC(ALXO) | 1,000,000 | 0 | -1,000,000 | 4,800 | 0 | — | -4,800 |
| MERUS N V | 245,000 | 0 | -245,000 | 5,777 | 0 | — | -5,777 |
| GERON CORP(GERN) | 2,750,000 | 0 | -2,750,000 | 5,830 | 0 | — | -5,830 |
| GRACELL BIOTECHNOLOGIES INC | 2,525,000 | 0 | -2,525,000 | 7,272 | 0 | — | -7,272 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 250,000 | 0 | -250,000 | 7,435 | 0 | — | -7,435 |
| XENON PHARMACEUTICALS INC(XENE) | 450,000 | 150,000 | -300,000 | 15,372 | 6,909 | 0.77% | -8,463 |
| KALVISTA PHARMACEUTICALS INC | 900,000 | 0 | -900,000 | 8,667 | 0 | — | -8,667 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 400,000 | 0 | -400,000 | 9,170 | 0 | — | -9,170 |
| BRIDGEBIO PHARMA INC(BBIO) | 400,000 | 0 | -400,000 | 10,548 | 0 | — | -10,548 |
| IMMUNOVANT INC(IMVT) | 1,600,000 | 1,200,000 | -400,000 | 61,424 | 50,556 | 5.62% | -10,868 |
| AKERO THERAPEUTICS INC | 600,000 | 800,000 | +200,000 | 30,348 | 18,680 | 2.08% | -11,668 |
| IMMATICS N.V(IMTX) | 1,050,000 | 0 | -1,050,000 | 12,159 | 0 | — | -12,159 |
| MIRATI THERAPEUTICS INC | 300,000 | 0 | -300,000 | 13,068 | 0 | — | -13,068 |
| ROIVANT SCIENCES LTD(ROIV) | 1,200,000 | 0 | -1,200,000 | 14,016 | 0 | — | -14,016 |
| CEREVEL THERAPEUTICS HLDNG I | 700,000 | 0 | -700,000 | 15,281 | 0 | — | -15,281 |
| ICOSAVAX INC | 2,765,741 | 300,000 | -2,465,741 | 21,434 | 4,728 | 0.53% | -16,706 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 150,000 | 0 | -150,000 | 16,875 | 0 | — | -16,875 |
| SAREPTA THERAPEUTICS INC(SRPT) | 200,000 | 0 | -200,000 | 24,244 | 0 | — | -24,244 |