Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2024 ▲▼ | Q4 2024 ▲▼ | Change ▲▼ | Q3 2024 ▲▼ | Q4 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| BIONTECH SE(BNTX) | 0 | 300,000 | +300,000 | 0 | 34,185 | 4.00% | +34,185 |
| INSMED INC(INSM) | 0 | 450,000 | +450,000 | 0 | 31,068 | 3.64% | +31,068 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 0 | 200,000 | +200,000 | 0 | 27,300 | 3.19% | +27,300 |
| JAZZ PHARMACEUTICALS PLC(JAZZ) | 0 | 175,000 | +175,000 | 0 | 21,551 | 2.52% | +21,551 |
| JANUX THERAPEUTICS INC(JANX) | 1,000,000 | 1,250,000 | +250,000 | 45,430 | 66,925 | 7.83% | +21,495 |
| CYTOKINETICS INC(CYTK) | 400,000 | 900,000 | +500,000 | 21,120 | 42,336 | 4.95% | +21,216 |
| BLUEPRINT MEDICINES CORP | 0 | 200,000 | +200,000 | 0 | 17,444 | 2.04% | +17,444 |
| APELLIS PHARMACEUTICALS INC COM | 0 | 500,000 | +500,000 | 0 | 15,955 | 1.87% | +15,955 |
| SOLENO THERAPEUTICS INC | 0 | 350,000 | +350,000 | 0 | 15,733 | 1.84% | +15,733 |
| VERA THERAPEUTICS INC(VERA) | 500,000 | 875,000 | +375,000 | 22,100 | 37,004 | 4.33% | +14,904 |
| ALKERMES PLC(ALKS) | 0 | 500,000 | +500,000 | 0 | 14,380 | 1.68% | +14,380 |
| APOGEE THERAPEUTICS INC(APGE) | 0 | 300,000 | +300,000 | 0 | 13,590 | 1.59% | +13,590 |
| IDEAYA BIOSCIENCES INC(IDYA) | 2,100,000 | 3,000,000 | +900,000 | 66,528 | 77,100 | 9.02% | +10,572 |
| PLIANT THERAPEUTICS INC(PLRX) | 0 | 750,000 | +750,000 | 0 | 9,878 | 1.16% | +9,878 |
| REVOLUTION MEDICINES INC(RVMD) | 1,200,000 | 1,450,000 | +250,000 | 54,420 | 63,423 | 7.42% | +9,003 |
| BRIGHT MINDS BIOSCIENCES INC(DRUG) | 0 | 245,000 | +245,000 | 0 | 8,825 | 1.03% | +8,825 |
| GERON CORP(GERN) | 0 | 2,000,000 | +2,000,000 | 0 | 7,080 | 0.83% | +7,080 |
| SPYRE THERAPEUTICS INC(SYRE) | 200,000 | 500,000 | +300,000 | 5,882 | 11,640 | 1.36% | +5,758 |
| ACLARIS THERAPEUTICS INC(ACRS) | 0 | 2,222,222 | +2,222,222 | 0 | 5,511 | 0.64% | +5,511 |
| DYNE THERAPEUTICS INC(DYN) | 160,000 | 450,000 | +290,000 | 5,747 | 10,602 | 1.24% | +4,855 |
| AEROVATE THERAPEUTICS INC | 0 | 1,400,000 | +1,400,000 | 0 | 3,710 | 0.43% | +3,710 |
| ARVINAS INC(ARVN) | 400,000 | 700,000 | +300,000 | 9,852 | 13,419 | 1.57% | +3,567 |
| DESIGN THERAPEUTICS INC(DSGN) | 4,217,627 | 4,217,627 | 0 | 22,691 | 26,023 | 3.04% | +3,332 |
| SEPTERNA INC(SEPN) | 0 | 134,202 | +134,202 | 0 | 3,073 | 0.36% | +3,073 |
| MERUS N V | 575,000 | 750,000 | +175,000 | 28,727 | 31,538 | 3.69% | +2,811 |
| TRAVERE THERAPEUTICS INC(TVTX) | 1,100,000 | 1,000,000 | -100,000 | 15,389 | 17,420 | 2.04% | +2,031 |
| UNICYCIVE THERAPEUTICS INC | 5,078,927 | 5,078,927 | 0 | 2,072 | 4,034 | 0.47% | +1,962 |
| ERASCA INC(ERAS) | 10,900,000 | 12,500,000 | +1,600,000 | 29,757 | 31,375 | 3.67% | +1,618 |
| ALLAKOS INC | 2,900,000 | 2,900,000 | 0 | 1,894 | 3,509 | 0.41% | +1,615 |
| GLYCOMIMETICS INC | 0 | 5,400,000 | +5,400,000 | 0 | 1,345 | 0.16% | +1,345 |
| ATYR PHARMA INC | 2,000,000 | 1,000,000 | -1,000,000 | 3,520 | 3,620 | 0.42% | +100 |
| NUVATION BIO INC(NUVB) | 0 | 66,666 | +66,666 | 0 | 15 | 0.00% | +15 |
| BOUNDLESS BIO INC(BOLD) | 58,903 | 0 | -58,903 | 204 | 0 | — | -204 |
| RAPPORT THERAPEUTICS INC(RAPP) | 208,910 | 208,910 | 0 | 4,065 | 3,706 | 0.43% | -358 |
| SKYE BIOSCIENCE INC(SKYE) | 100,000 | 0 | -100,000 | 391 | 0 | — | -391 |
| IO BIOTECH INC(IOBTQ) | 493,827 | 0 | -493,827 | 519 | 0 | — | -519 |
| OCULAR THERAPEUTIX INC(OCUL) | 3,500,000 | 3,500,000 | 0 | 30,450 | 29,890 | 3.50% | -560 |
| ARTIVA BIOTHERAPEUTICS INC(ARTV) | 145,089 | 145,089 | 0 | 2,130 | 1,462 | 0.17% | -667 |
| AKERO THERAPEUTICS INC | 800,000 | 800,000 | 0 | 22,952 | 22,256 | 2.60% | -696 |
| ASTRIA THERAPEUTICS INC | 500,000 | 500,000 | 0 | 5,505 | 4,470 | 0.52% | -1,035 |
| NEUMORA THERAPEUTICS INC.(NMRA) | 100,000 | 0 | -100,000 | 1,321 | 0 | — | -1,321 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 450,000 | 400,000 | -50,000 | 12,011 | 10,680 | 1.25% | -1,330 |
| ANNEXON INC(ANNX) | 2,600,000 | 2,550,000 | -50,000 | 15,392 | 13,082 | 1.53% | -2,310 |
| Y-MABS THERAPEUTICS INC | 800,000 | 1,000,000 | +200,000 | 10,520 | 7,830 | 0.92% | -2,690 |
| ADVERUM BIOTECHNOLOGIES INC | 416,666 | 0 | -416,666 | 2,925 | 0 | — | -2,925 |
| NEXTCURE INC | 2,500,000 | 0 | -2,500,000 | 3,425 | 0 | — | -3,425 |
| SILENCE THERAPEUTICS PLC(SLN) | 200,000 | 0 | -200,000 | 3,636 | 0 | — | -3,636 |
| TREVI THERAPEUTICS INC(TRVI) | 2,750,000 | 1,250,000 | -1,500,000 | 9,185 | 5,150 | 0.60% | -4,035 |
| LINEAGE CELL THERAPEUTICS IN(LCTX) | 5,000,000 | 0 | -5,000,000 | 4,527 | 0 | — | -4,526 |
| AVALO THERAPEUTICS INC(AVTX) | 539,079 | 0 | -539,079 | 5,121 | 0 | — | -5,121 |
| ENGENE HOLDINGS INC COM | 800,000 | 0 | -800,000 | 5,280 | 0 | — | -5,280 |
| CYBIN INC(HELP) | 600,000 | 0 | -600,000 | 5,334 | 0 | — | -5,334 |
| ROCKET PHARMACEUTICALS INC(RCKT) | 325,000 | 0 | -325,000 | 6,003 | 0 | — | -6,003 |
| ORUKA THERAPEUTICS INC(ORKA) | 257,330 | 0 | -257,330 | 6,307 | 0 | — | -6,307 |
| COMPASS PATHWAYS PLC(CMPS) | 1,159,030 | 0 | -1,159,030 | 7,302 | 0 | — | -7,302 |
| NUVALENT INC | 75,000 | 0 | -75,000 | 7,673 | 0 | — | -7,672 |
| ENLIVEN THERAPEUTICS INC | 495,000 | 140,000 | -355,000 | 12,642 | 3,150 | 0.37% | -9,492 |
| VAXCYTE INC(PCVX) | 300,000 | 300,000 | 0 | 34,281 | 24,558 | 2.87% | -9,723 |
| BICYCLE THERAPEUTICS PLC | 500,000 | 0 | -500,000 | 11,315 | 0 | — | -11,315 |
| BEAM THERAPEUTICS INC(BEAM) | 500,000 | 0 | -500,000 | 12,250 | 0 | — | -12,250 |
| SAREPTA THERAPEUTICS INC(SRPT) | 150,000 | 0 | -150,000 | 18,734 | 0 | — | -18,733 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 3,208,875 | 3,208,875 | 0 | 38,314 | 18,708 | 2.19% | -19,606 |
| BICARA THERAPEUTICS INC | 800,000 | 0 | -800,000 | 20,376 | 0 | — | -20,376 |
| COGENT BIOSCIENCES INC(COGT) | 2,000,000 | 0 | -2,000,000 | 21,600 | 0 | — | -21,600 |
| GALAPAGOS NV(LKFT) | 800,000 | 0 | -800,000 | 23,032 | 0 | — | -23,032 |
| IMMUNOVANT INC(IMVT) | 1,100,000 | 300,000 | -800,000 | 31,361 | 7,431 | 0.87% | -23,930 |
| IONIS PHARMACEUTICALS INC(IONS) | 750,000 | 0 | -750,000 | 30,045 | 0 | — | -30,045 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 900,000 | 0 | -900,000 | 30,591 | 0 | — | -30,591 |
| DISC MEDICINE INC(IRON) | 935,000 | 200,000 | -735,000 | 45,946 | 12,680 | 1.48% | -33,266 |
| STRUCTURE THERAPEUTICS INC | 1,250,000 | 700,000 | -550,000 | 54,863 | 18,984 | 2.22% | -35,878 |