Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| PRAXIS PRECISION MEDICINES I(PRAX) | 125,000 | 375,000 | +250,000 | 6,625 | 110,528 | 7.37% | +103,903 |
| REVOLUTION MEDICINES INC(RVMD) | 1,750,000 | 2,000,000 | +250,000 | 81,725 | 159,300 | 10.62% | +77,575 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 3,208,875 | 3,208,875 | 0 | 31,415 | 80,222 | 5.35% | +48,807 |
| IDEAYA BIOSCIENCES INC(IDYA) | 2,250,000 | 3,125,000 | +875,000 | 61,223 | 108,031 | 7.20% | +46,809 |
| REVOLUTION MEDICINES INC(RVMD)(Call) | 1,000,000 | 1,000,000 | 0 | 46,700 | 79,650 | — | +32,950 |
| CIDARA THERAPEUTICS INC | 375,000 | 310,000 | -65,000 | 35,910 | 68,476 | 4.56% | +32,566 |
| IMMUNOVANT INC(IMVT) | 275,000 | 1,375,000 | +1,100,000 | 4,433 | 34,953 | 2.33% | +30,520 |
| TERNS PHARMACEUTICALS INC | 0 | 750,000 | +750,000 | 0 | 30,300 | 2.02% | +30,300 |
| TANGO THERAPEUTICS INC(TNGX) | 950,000 | 4,200,000 | +3,250,000 | 7,980 | 37,212 | 2.48% | +29,232 |
| ARCUS BIOSCIENCES INC(RCUS)(Call) | 0 | 1,050,000 | +1,050,000 | 0 | 25,022 | — | +25,022 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX) | 0 | 1,750,000 | +1,750,000 | 0 | 23,065 | 1.54% | +23,065 |
| ACADIA PHARMACEUTICALS INC | 0 | 850,000 | +850,000 | 0 | 22,704 | 1.51% | +22,704 |
| BIOGEN INC(BIIB) | 100,000 | 200,000 | +100,000 | 14,008 | 35,198 | 2.35% | +21,190 |
| CYTOKINETICS INC(CYTK) | 0 | 300,000 | +300,000 | 0 | 19,062 | 1.27% | +19,062 |
| ABIVAX SA(ABVX) | 415,000 | 400,000 | -15,000 | 35,234 | 53,942 | 3.59% | +18,709 |
| STRUCTURE THERAPEUTICS INC | 850,000 | 600,000 | -250,000 | 23,800 | 41,730 | 2.78% | +17,930 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 0 | 225,000 | +225,000 | 0 | 17,773 | 1.18% | +17,773 |
| NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES | 0 | 450,000 | +450,000 | 0 | 15,786 | 1.05% | +15,786 |
| ERASCA INC(ERAS) | 15,150,000 | 13,000,000 | -2,150,000 | 33,027 | 48,360 | 3.22% | +15,333 |
| KINIKSA PHARMACEUTICALS INTL(KNSA) | 0 | 350,000 | +350,000 | 0 | 14,438 | 0.96% | +14,438 |
| SOLENO THERAPEUTICS INC | 0 | 300,000 | +300,000 | 0 | 13,890 | 0.93% | +13,890 |
| MINERVA NEUROSCIENCES INC | 0 | 3,311,000 | +3,311,000 | 0 | 13,310 | 0.89% | +13,310 |
| DISC MEDICINE INC(IRON) | 450,000 | 510,000 | +60,000 | 29,736 | 40,499 | 2.70% | +10,763 |
| AVIDITY BIOSCIENCES INC | 600,000 | 500,000 | -100,000 | 26,142 | 36,065 | 2.40% | +9,923 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 0 | 350,000 | +350,000 | 0 | 9,506 | 0.63% | +9,506 |
| NURIX THERAPEUTICS INC(NRIX) | 0 | 500,000 | +500,000 | 0 | 9,485 | 0.63% | +9,485 |
| IMMATICS N.V(IMTX)(Call) | 0 | 850,000 | +850,000 | 0 | 8,925 | — | +8,925 |
| LB PHARMACEUTICALS INC(LBRX) | 1,130,000 | 1,200,000 | +70,000 | 17,843 | 26,712 | 1.78% | +8,869 |
| CG ONCOLOGY INC(CGON) | 0 | 200,000 | +200,000 | 0 | 8,304 | 0.55% | +8,304 |
| JAZZ PHARMACEUTICALS PLC(JAZZ) | 200,000 | 200,000 | 0 | 26,360 | 34,000 | 2.27% | +7,640 |
| MAZE THERAPEUTICS INC(MAZE) | 1,227,300 | 950,000 | -277,300 | 31,824 | 39,359 | 2.62% | +7,535 |
| VAXCYTE INC(PCVX) | 625,000 | 650,000 | +25,000 | 22,513 | 29,991 | 2.00% | +7,479 |
| TYRA BIOSCIENCES INC(TYRA) | 0 | 210,000 | +210,000 | 0 | 5,521 | 0.37% | +5,521 |
| IMMIX BIOPHARMA INC | 0 | 1,000,000 | +1,000,000 | 0 | 5,230 | 0.35% | +5,230 |
| DIANTHUS THERAPEUTICS INC(DNTH) | 200,000 | 315,000 | +115,000 | 7,870 | 12,981 | 0.87% | +5,111 |
| OCULAR THERAPEUTIX INC(OCUL) | 3,250,000 | 3,500,000 | +250,000 | 37,993 | 42,490 | 2.83% | +4,498 |
| NEUROGENE INC | 0 | 195,000 | +195,000 | 0 | 4,017 | 0.27% | +4,017 |
| IBIO INC | 0 | 2,000,000 | +2,000,000 | 0 | 3,860 | 0.26% | +3,860 |
| CORVUS PHARMACEUTICALS INC(CRVS) | 0 | 500,000 | +500,000 | 0 | 3,850 | 0.26% | +3,850 |
| ORIC PHARMACEUTICALS INC(ORIC) | 0 | 450,000 | +450,000 | 0 | 3,681 | 0.25% | +3,681 |
| IDEAYA BIOSCIENCES INC(IDYA)(Call) | 450,000 | 450,000 | 0 | 12,245 | 15,557 | — | +3,312 |
| DAY ONE BIOPHARMACEUTICALS I COM | 0 | 300,000 | +300,000 | 0 | 2,796 | 0.19% | +2,796 |
| APELLIS PHARMACEUTICALS INC(Call) COM | 1,000,000 | 1,000,000 | 0 | 22,630 | 25,120 | — | +2,490 |
| PALATIN TECHNOLOGIES INC | 0 | 140,000 | +140,000 | 0 | 2,153 | 0.14% | +2,153 |
| FRACTYL HEALTH INC | 500,000 | 1,100,000 | +600,000 | 795 | 2,420 | 0.16% | +1,625 |
| VOR BIOPHARMA INC(VOR) | 0 | 100,000 | +100,000 | 0 | 1,308 | 0.09% | +1,308 |
| JADE BIOSCIENCES INC | 625,000 | 395,000 | -230,000 | 5,394 | 6,095 | 0.41% | +701 |
| UNICYCIVE THERAPEUTICS INC | 473,563 | 473,563 | 0 | 2,065 | 2,732 | 0.18% | +668 |
| DBV TECHNOLOGIES S A | 0 | 25,000 | +25,000 | 0 | 479 | 0.03% | +479 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 200,000 | 190,000 | -10,000 | 20,198 | 20,338 | 1.36% | +140 |
| NUVATION BIO INC(NUVB) | 66,666 | 66,666 | 0 | 13 | 22 | 0.00% | +9 |
| CRESCENT BIOPHARMA INC. | 600,000 | 600,000 | 0 | 7,134 | 7,116 | 0.47% | -18 |
| MEREO BIOPHARMA GROUP PLC | 500,000 | 1,850,000 | +1,350,000 | 1,030 | 771 | 0.05% | -259 |
| TREVI THERAPEUTICS INC(TRVI) | 2,200,000 | 1,550,000 | -650,000 | 20,130 | 19,406 | 1.29% | -724 |
| SEPTERNA INC(SEPN) | 83,548 | 23,548 | -60,000 | 1,572 | 657 | 0.04% | -915 |
| PHARVARIS N V COM | 150,000 | 100,000 | -50,000 | 3,743 | 2,775 | 0.18% | -967 |
| COMPASS THERAPEUTICS INC | 2,050,000 | 1,150,000 | -900,000 | 7,175 | 6,176 | 0.41% | -999 |
| ACLARIS THERAPEUTICS INC | 1,500,000 | 600,000 | -900,000 | 2,850 | 1,806 | 0.12% | -1,044 |
| UNIQURE NV(QURE) | 300,000 | 675,000 | +375,000 | 17,511 | 16,153 | 1.08% | -1,358 |
| IMMUNOCORE HLDGS PLC(IMCR) | 850,000 | 850,000 | 0 | 30,881 | 29,504 | 1.97% | -1,377 |
| ALECTOR INC(Call) | 500,000 | 0 | -500,000 | 1,480 | 0 | — | -1,480 |
| ENLIVEN THERAPEUTICS INC | 340,000 | 340,000 | 0 | 6,960 | 5,236 | 0.35% | -1,724 |
| ESPERION THERAPEUTICS INC NE(ESPR) | 750,000 | 0 | -750,000 | 1,988 | 0 | — | -1,987 |
| PEPGEN INC | 750,000 | 0 | -750,000 | 3,465 | 0 | — | -3,465 |
| ASTRIA THERAPEUTICS INC | 500,000 | 0 | -500,000 | 3,640 | 0 | — | -3,640 |
| KYMERA THERAPEUTICS INC(KYMR) | 250,000 | 130,000 | -120,000 | 14,150 | 10,115 | 0.67% | -4,035 |
| DESIGN THERAPEUTICS INC | 3,655,000 | 2,500,000 | -1,155,000 | 27,522 | 23,450 | 1.56% | -4,072 |
| EUPRAXIA PHARMACEUTICALS INC | 900,000 | 0 | -900,000 | 5,310 | 0 | — | -5,310 |
| DYNE THERAPEUTICS INC(DYN) | 2,400,000 | 1,250,000 | -1,150,000 | 30,360 | 24,450 | 1.63% | -5,910 |
| ARCELLX INC COMMON STOCK | 165,000 | 115,000 | -50,000 | 13,547 | 7,498 | 0.50% | -6,048 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 175,000 | 0 | -175,000 | 6,517 | 0 | — | -6,517 |
| IMMUNEERING CORP | 950,000 | 0 | -950,000 | 6,650 | 0 | — | -6,650 |
| COGENT BIOSCIENCES INC(COGT) | 500,000 | 0 | -500,000 | 7,180 | 0 | — | -7,180 |
| CENTESSA PHARMACEUTICALS PLC | 525,000 | 200,000 | -325,000 | 12,731 | 5,002 | 0.33% | -7,729 |
| LARIMAR THERAPEUTICS INC(Call) | 2,500,000 | 0 | -2,500,000 | 8,075 | 0 | — | -8,075 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 1,450,000 | 950,000 | -500,000 | 19,706 | 11,476 | 0.76% | -8,229 |
| JANUX THERAPEUTICS INC(JANX) | 935,000 | 1,000,000 | +65,000 | 22,851 | 13,800 | 0.92% | -9,051 |
| JANUX THERAPEUTICS INC(JANX)(Call) | 500,000 | 0 | -500,000 | 12,220 | 0 | — | -12,220 |
| KEROS THERAPEUTICS INC | 850,000 | 0 | -850,000 | 13,447 | 0 | — | -13,447 |
| PROTAGONIST THERAPEUTICS INC | 300,000 | 0 | -300,000 | 19,929 | 0 | — | -19,929 |
| VERASTEM INC | 4,050,000 | 1,700,000 | -2,350,000 | 35,762 | 13,124 | 0.87% | -22,637 |
| ARVINAS INC | 5,575,000 | 0 | -5,575,000 | 47,499 | 0 | — | -47,499 |
| AKERO THERAPEUTICS INC | 1,200,000 | 0 | -1,200,000 | 56,976 | 0 | — | -56,976 |