Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| SPDR SERIES TRUST(Put) ST STR SP BIOT | 0 | 2,900,000 | +2,900,000 | 0 | 353,597 | — | +353,597 |
| CELCUITY INC(CELC) | 1,178,860 | 1,808,258 | +629,398 | 58,236 | 180,356 | 7.65% | +122,120 |
| DEXCOM INC(DXCM) | 0 | 1,297,094 | +1,297,094 | 0 | 86,088 | 3.65% | +86,088 |
| GLOBUS MED INC(GMED) | 176,000 | 887,000 | +711,000 | 10,080 | 77,444 | 3.29% | +67,364 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 859,166 | 362,966 | -496,200 | 45,536 | 106,981 | 4.54% | +61,445 |
| KRYSTAL BIOTECH INC(KRYS) | 1,018,831 | 941,059 | -77,772 | 179,854 | 232,009 | 9.84% | +52,154 |
| INSULET CORP(PODD) | 0 | 150,000 | +150,000 | 0 | 42,636 | 1.81% | +42,636 |
| AMICUS THERAPEUTICS INC COM | 4,690,000 | 5,207,284 | +517,284 | 36,957 | 74,152 | 3.15% | +37,195 |
| ALKERMES PLC(ALKS) | 0 | 1,322,364 | +1,322,364 | 0 | 37,000 | 1.57% | +37,000 |
| LIVANOVA PLC(LIVN) | 0 | 567,500 | +567,500 | 0 | 34,918 | 1.48% | +34,918 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 148,696 | 573,614 | +424,918 | 10,901 | 45,310 | 1.92% | +34,409 |
| BIOMARIN PHARMACEUTICAL INC(BMRN) | 890,304 | 1,320,000 | +429,696 | 48,219 | 78,448 | 3.33% | +30,229 |
| IMMUNOVANT INC(IMVT) | 0 | 1,110,000 | +1,110,000 | 0 | 28,216 | 1.20% | +28,216 |
| VAXCYTE INC(PCVX) | 0 | 608,958 | +608,958 | 0 | 28,097 | 1.19% | +28,097 |
| TELEFLEX INCORPORATED(TFX) | 0 | 190,000 | +190,000 | 0 | 23,188 | 0.98% | +23,188 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 0 | 910,000 | +910,000 | 0 | 22,582 | 0.96% | +22,582 |
| GSK PLC(GSK) | 220,000 | 639,000 | +419,000 | 9,495 | 31,337 | 1.33% | +21,841 |
| ALNYLAM PHARMACEUTICALS INC(ALNY) | 0 | 70,000 | +70,000 | 0 | 27,836 | 1.18% | +27,836 |
| INVIVYD INC | 0 | 7,708,727 | +7,708,727 | 0 | 19,041 | 0.81% | +19,041 |
| CAPRICOR THERAPEUTICS INC(CAPR) | 0 | 646,390 | +646,390 | 0 | 18,655 | 0.79% | +18,655 |
| KINIKSA PHARMACEUTICALS INTL(KNSA) | 150,000 | 587,000 | +437,000 | 5,825 | 24,214 | 1.03% | +18,389 |
| TENET HEALTHCARE CORP(THC) | 0 | 92,500 | +92,500 | 0 | 18,382 | 0.78% | +18,382 |
| ARCUS BIOSCIENCES INC(RCUS) | 0 | 711,983 | +711,983 | 0 | 16,967 | 0.72% | +16,967 |
| SYNDAX PHARMACEUTICALS INC(SNDX) | 2,012,110 | 2,247,110 | +235,000 | 30,956 | 47,212 | 2.00% | +16,255 |
| ENLIVEN THERAPEUTICS INC | 0 | 1,025,000 | +1,025,000 | 0 | 15,785 | 0.67% | +15,785 |
| INHIBIKASE THERAPEUTICS INC | 6,325,000 | 10,875,000 | +4,550,000 | 10,247 | 22,294 | 0.95% | +12,047 |
| RAPT THERAPEUTICS INC | 537,903 | 764,000 | +226,097 | 13,873 | 25,877 | 1.10% | +12,004 |
| VERICEL CORP(VCEL) | 497,953 | 764,000 | +266,047 | 15,671 | 27,512 | 1.17% | +11,841 |
| NEUROPACE INC | 2,957,957 | 2,703,208 | -254,749 | 30,497 | 41,738 | 1.77% | +11,241 |
| TREVI THERAPEUTICS INC(TRVI) | 25,000 | 900,000 | +875,000 | 229 | 11,268 | 0.48% | +11,039 |
| SEPTERNA INC(SEPN) | 18,260 | 383,368 | +365,108 | 343 | 10,688 | 0.45% | +10,345 |
| AXOGEN INC(AXGN) | 1,726,553 | 1,206,855 | -519,698 | 30,802 | 39,500 | 1.68% | +8,699 |
| CERUS CORP | 0 | 4,000,000 | +4,000,000 | 0 | 8,240 | 0.35% | +8,240 |
| MBX BIOSCIENCES INC(MBX) | 275,000 | 408,900 | +133,900 | 4,813 | 12,897 | 0.55% | +8,084 |
| INSMED INC(INSM) | 0 | 48,500 | +48,500 | 0 | 8,441 | 0.36% | +8,441 |
| AVALO THERAPEUTICS INC(AVTX) | 0 | 441,978 | +441,978 | 0 | 8,026 | 0.34% | +8,026 |
| EDAP TMS S A | 7,309,254 | 7,309,254 | 0 | 16,738 | 24,047 | 1.02% | +7,309 |
| ANI PHARMACEUTICALS INC(ANIP) | 340,243 | 486,243 | +146,000 | 31,166 | 38,384 | 1.63% | +7,218 |
| GERON CORP(GERN) | 17,290,000 | 23,290,000 | +6,000,000 | 23,687 | 30,743 | 1.30% | +7,056 |
| ORTHOPEDIATRICS CORP | 128,000 | 525,447 | +397,447 | 2,372 | 9,332 | 0.40% | +6,960 |
| TWIST BIOSCIENCE CORP(TWST) | 1,866,234 | 1,861,802 | -4,432 | 52,516 | 59,056 | 2.51% | +6,541 |
| STRUCTURE THERAPEUTICS INC | 0 | 90,000 | +90,000 | 0 | 6,260 | 0.27% | +6,260 |
| ABIVAX SA(ABVX) | 0 | 45,000 | +45,000 | 0 | 6,068 | 0.26% | +6,068 |
| ORUKA THERAPEUTICS INC(ORKA) | 0 | 190,000 | +190,000 | 0 | 5,759 | 0.24% | +5,759 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 138,000 | 175,982 | +37,982 | 19,372 | 24,960 | 1.06% | +5,587 |
| JADE BIOSCIENCES INC | 796,744 | 796,744 | 0 | 6,876 | 12,294 | 0.52% | +5,418 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX) | 0 | 400,000 | +400,000 | 0 | 5,272 | 0.22% | +5,272 |
| NEOGENOMICS INC(NEO) | 0 | 427,504 | +427,504 | 0 | 5,027 | 0.21% | +5,027 |
| NATERA INC(NTRA) | 0 | 20,000 | +20,000 | 0 | 4,582 | 0.19% | +4,582 |
| PULMONX CORP | 0 | 2,038,323 | +2,038,323 | 0 | 4,505 | 0.19% | +4,505 |
| COGENT BIOSCIENCES INC(COGT) | 0 | 120,000 | +120,000 | 0 | 4,262 | 0.18% | +4,262 |
| RIGEL PHARMACEUTICALS INC | 330,010 | 300,034 | -29,976 | 9,349 | 12,850 | 0.55% | +3,501 |
| PHARVARIS N V COM | 647,052 | 702,052 | +55,000 | 16,144 | 19,482 | 0.83% | +3,338 |
| ERASCA INC(ERAS) | 2,162,162 | 2,162,162 | 0 | 4,714 | 8,043 | 0.34% | +3,330 |
| TYRA BIOSCIENCES INC(TYRA) | 0 | 125,000 | +125,000 | 0 | 3,286 | 0.14% | +3,286 |
| KARYOPHARM THERAPEUTICS INC | 0 | 440,000 | +440,000 | 0 | 3,238 | 0.14% | +3,238 |
| ZYMEWORKS INC(ZYME) | 0 | 100,000 | +100,000 | 0 | 2,633 | 0.11% | +2,633 |
| VIKING THERAPEUTICS INC(VKTX) | 0 | 70,000 | +70,000 | 0 | 2,463 | 0.10% | +2,463 |
| CALCIMEDICA INC | 683,904 | 683,904 | 0 | 2,104 | 4,507 | 0.19% | +2,403 |
| INHIBRX BIOSCIENCES INC(INBX) | 0 | 25,000 | +25,000 | 0 | 1,975 | 0.08% | +1,975 |
| BICARA THERAPEUTICS INC | 0 | 100,000 | +100,000 | 0 | 1,683 | 0.07% | +1,683 |
| KODIAK SCIENCES INC(KOD) | 19,644 | 60,000 | +40,356 | 322 | 1,678 | 0.07% | +1,356 |
| GRAIL INC(GRAL) | 0 | 11,000 | +11,000 | 0 | 941 | 0.04% | +941 |
| NURIX THERAPEUTICS INC(NRIX) | 0 | 1,219,394 | +1,219,394 | 0 | 23,132 | 0.98% | +23,132 |
| ORGANOGENESIS HLDGS INC | 12,131,699 | 9,985,951 | -2,145,748 | 51,196 | 51,727 | 2.19% | +531 |
| QUOIN PHARMACEUTICALS LTD | 0 | 25,000 | +25,000 | 0 | 361 | 0.02% | +361 |
| BETA BIONICS INC | 3,870,158 | 2,534,565 | -1,335,593 | 76,900 | 77,228 | 3.28% | +328 |
| DYNE THERAPEUTICS INC(DYN) | 0 | 10,000 | +10,000 | 0 | 196 | 0.01% | +196 |
| DELCATH SYS INC | 10,000 | 10,000 | 0 | 108 | 101 | 0.00% | -6 |
| TECTONIC THERAPEUTIC INC | 25,000 | 0 | -25,000 | 392 | 0 | — | -392 |
| MEREO BIOPHARMA GROUP PLC | 299,711 | 0 | -299,711 | 617 | 0 | — | -617 |
| MYOMO INC | 704,275 | 0 | -704,275 | 628 | 0 | — | -628 |
| ESSA PHARMA INC | 4,362,026 | 0 | -4,362,026 | 833 | 0 | — | -833 |
| SIONNA THERAPEUTICS INC(SION) | 413,500 | 268,500 | -145,000 | 12,161 | 11,046 | 0.47% | -1,115 |
| LIQUIDIA CORPORATION(LQDA) | 50,000 | 0 | -50,000 | 1,137 | 0 | — | -1,137 |
| ADVERUM BIOTECHNOLOGIES INC | 287,246 | 0 | -287,246 | 1,301 | 0 | — | -1,301 |
| IMMUNIC INC | 1,580,007 | 0 | -1,580,007 | 1,393 | 0 | — | -1,393 |
| INSPIREMD INC | 1,470,934 | 1,150,000 | -320,934 | 3,545 | 2,047 | 0.09% | -1,498 |
| MANNKIND CORP(MNKD) | 300,000 | 0 | -300,000 | 1,611 | 0 | — | -1,611 |
| EVOLUS INC | 0 | 1,070,000 | +1,070,000 | 0 | 7,116 | 0.30% | +7,116 |
| VISTAGEN THERAPEUTICS INC | 550,000 | 0 | -550,000 | 1,953 | 0 | — | -1,952 |
| IOVANCE BIOTHERAPEUTICS INC(IOVA) | 976,707 | 0 | -976,707 | 2,119 | 0 | — | -2,119 |
| RAPPORT THERAPEUTICS INC(RAPP) | 80,000 | 0 | -80,000 | 2,376 | 0 | — | -2,376 |
| CRESCENT BIOPHARMA INC. | 200,000 | 0 | -200,000 | 2,378 | 0 | — | -2,378 |
| TANGO THERAPEUTICS INC(TNGX) | 300,000 | 10,000 | -290,000 | 2,520 | 89 | 0.00% | -2,431 |
| IDEAYA BIOSCIENCES INC(IDYA) | 100,000 | 0 | -100,000 | 2,721 | 0 | — | -2,721 |
| FRACTYL HEALTH INC | 2,500,000 | 400,000 | -2,100,000 | 3,975 | 880 | 0.04% | -3,095 |
| JASPER THERAPEUTICS INC | 1,494,420 | 200,000 | -1,294,420 | 3,557 | 366 | 0.02% | -3,191 |
| AKERO THERAPEUTICS INC | 71,000 | 0 | -71,000 | 3,371 | 0 | — | -3,371 |
| HARROW INC(HROW) | 85,498 | 0 | -85,498 | 4,119 | 0 | — | -4,119 |
| CERIBELL INC | 360,000 | 0 | -360,000 | 4,136 | 0 | — | -4,136 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 619,874 | 69,874 | -550,000 | 6,069 | 1,747 | 0.07% | -4,322 |
| ETON PHARMACEUTICALS INC(ETON) | 200,000 | 0 | -200,000 | 4,346 | 0 | — | -4,346 |
| CG ONCOLOGY INC(CGON) | 290,000 | 170,000 | -120,000 | 11,681 | 7,058 | 0.30% | -4,623 |
| ESTABLISHMENT LABS HLDGS INC(ESTA) | 139,512 | 0 | -139,512 | 5,719 | 0 | — | -5,719 |
| LB PHARMACEUTICALS INC(LBRX) | 400,000 | 10,000 | -390,000 | 6,316 | 223 | 0.01% | -6,093 |
| ARCELLX INC COMMON STOCK | 100,000 | 30,000 | -70,000 | 8,210 | 1,956 | 0.08% | -6,254 |
| NUVALENT INC(NUVL) | 88,000 | 0 | -88,000 | 7,610 | 0 | — | -7,610 |
| VERASTEM INC | 935,909 | 0 | -935,909 | 8,264 | 0 | — | -8,264 |
| C4 THERAPEUTICS INC | 7,053,942 | 3,803,942 | -3,250,000 | 15,660 | 7,266 | 0.31% | -8,394 |