Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Krystal Biotech, Inc.(KRYS) | 1,018,831 | 941,059 | -77,772 | $179.85M | $232.01M | 9.84% | +$52.15M |
| Celcuity Inc.(CELC) | 1,178,860 | 1,808,258 | +629,398 | $58.24M | $180.36M | 7.65% | +$122.12M |
| NovoCure Limited(NVCR) | 9,644,872 | 8,530,665 | -1,114,207 | $124.61M | $110.30M | 4.68% | -$14.31M |
| Praxis Precision Medicines, Inc.(PRAX) | 859,166 | 362,966 | -496,200 | $45.54M | $106.98M | 4.54% | +$61.44M |
| TG Therapeutics, Inc.(TGTX) | 3,844,731 | 3,139,312 | -705,419 | $138.89M | $93.58M | 3.97% | -$45.31M |
| DexCom, Inc.(DXCM) | 0 | 1,297,094 | +1,297,094 | $0 | $86.09M | 3.65% | +$86.09M |
| BioMarin Pharmaceutical Inc.(BMRN) | 890,304 | 1,320,000 | +429,696 | $48.22M | $78.45M | 3.33% | +$30.23M |
| Globus Medical, Inc.CL A(GMED) | 176,000 | 887,000 | +711,000 | $10.08M | $77.44M | 3.29% | +$67.36M |
| Beta Bionics, Inc.(BBNX) | 3,870,158 | 2,534,565 | -1,335,593 | $76.90M | $77.23M | 3.28% | +$328.2K |
| Amicus Therapeutics Inc COM | 4,690,000 | 5,207,284 | +517,284 | $36.96M | $74.15M | 3.15% | +$37.19M |
| Twist Bioscience Corporation(TWST) | 1,866,234 | 1,861,802 | -4,432 | $52.52M | $59.06M | 2.51% | +$6.54M |
| Organogenesis Holdings Inc.(ORGO) | 12,131,699 | 9,985,951 | -2,145,748 | $51.20M | $51.73M | 2.19% | +$531.5K |
| Syndax Pharmaceuticals, Inc.(SNDX) | 2,012,110 | 2,247,110 | +235,000 | $30.96M | $47.21M | 2.00% | +$16.26M |
| Mirum Pharmaceuticals, Inc.(MIRM) | 148,696 | 573,614 | +424,918 | $10.90M | $45.31M | 1.92% | +$34.41M |
| Insulet Corporation(PODD) | 0 | 150,000 | +150,000 | $0 | $42.64M | 1.81% | +$42.64M |
| NeuroPace, Inc.(NPCE) | 2,957,957 | 2,703,208 | -254,749 | $30.50M | $41.74M | 1.77% | +$11.24M |
| Axogen, Inc.(AXGN) | 1,726,553 | 1,206,855 | -519,698 | $30.80M | $39.50M | 1.68% | +$8.70M |
| ANI Pharmaceuticals, Inc.(ANIP) | 340,243 | 486,243 | +146,000 | $31.17M | $38.38M | 1.63% | +$7.22M |
| Alkermes plcSHS(ALKS) | 0 | 1,322,364 | +1,322,364 | $0 | $37.00M | 1.57% | +$37.00M |
| LivaNova PLCSHS(LIVN) | 0 | 567,500 | +567,500 | $0 | $34.92M | 1.48% | +$34.92M |
| GSK plcADR(GSK) | 220,000 | 639,000 | +419,000 | $9.50M | $31.34M | 1.33% | +$21.84M |
| Geron Corporation(GERN) | 17,290,000 | 23,290,000 | +6,000,000 | $23.69M | $30.74M | 1.30% | +$7.06M |
| United Therapeutics Corporation(UTHR) | 150,000 | 60,000 | -90,000 | $62.88M | $29.23M | 1.24% | -$33.65M |
| Immunovant, Inc.(IMVT) | 0 | 1,110,000 | +1,110,000 | $0 | $28.22M | 1.20% | +$28.22M |
| Vaxcyte, Inc.(PCVX) | 0 | 608,958 | +608,958 | $0 | $28.10M | 1.19% | +$28.10M |
| Alnylam Pharmaceuticals, Inc.(ALNY) | 15,250 | 70,000 | +54,750 | $6.95M | $27.84M | 1.18% | +$20.88M |
| Inspire Medical Systems, Inc.(INSP) | 728,188 | 299,399 | -428,789 | $54.03M | $27.61M | 1.17% | -$26.42M |
| Vericel Corporation(VCEL) | 497,953 | 764,000 | +266,047 | $15.67M | $27.51M | 1.17% | +$11.84M |
| argenx SEADR(ARGX) | 69,426 | 31,726 | -37,700 | $51.21M | $26.68M | 1.13% | -$24.53M |
| Rapt Therapeutics Inc | 537,903 | 764,000 | +226,097 | $13.87M | $25.88M | 1.10% | +$12.00M |
| Neurocrine Biosciences, Inc.(NBIX) | 138,000 | 175,982 | +37,982 | $19.37M | $24.96M | 1.06% | +$5.59M |
| Kiniksa Pharmaceuticals International, plcCL A(KNSA) | 150,000 | 587,000 | +437,000 | $5.82M | $24.21M | 1.03% | +$18.39M |
| EDAP TMS S.A.ADR(FOCL) | 7,309,254 | 7,309,254 | 0 | $16.74M | $24.05M | 1.02% | +$7.31M |
| Teleflex Incorporated(TFX) | 0 | 190,000 | +190,000 | $0 | $23.19M | 0.98% | +$23.19M |
| Nurix Therapeutics, Inc.(NRIX) | 2,422,833 | 1,219,394 | -1,203,439 | $22.39M | $23.13M | 0.98% | +$744.9K |
| Edgewise Therapeutics, Inc.(EWTX) | 0 | 910,000 | +910,000 | $0 | $22.58M | 0.96% | +$22.58M |
| Inhibikase Therapeutics, Inc.(IKT) | 6,325,000 | 10,875,000 | +4,550,000 | $10.25M | $22.29M | 0.95% | +$12.05M |
| Pharvaris N V COM | 647,052 | 702,052 | +55,000 | $16.14M | $19.48M | 0.83% | +$3.34M |
| Invivyd, Inc.(IVVD) | 0 | 7,708,727 | +7,708,727 | $0 | $19.04M | 0.81% | +$19.04M |
| Capricor Therapeutics, Inc.(CAPR) | 0 | 646,390 | +646,390 | $0 | $18.65M | 0.79% | +$18.65M |
| Tenet Healthcare Corporation(THC) | 0 | 92,500 | +92,500 | $0 | $18.38M | 0.78% | +$18.38M |
| Arcus Biosciences, Inc.(RCUS) | 0 | 711,983 | +711,983 | $0 | $16.97M | 0.72% | +$16.97M |
| Enliven Therapeutics Inc | 0 | 1,025,000 | +1,025,000 | $0 | $15.79M | 0.67% | +$15.79M |
| MBX Biosciences, Inc.(MBX) | 275,000 | 408,900 | +133,900 | $4.81M | $12.90M | 0.55% | +$8.08M |
| Rigel Pharmaceuticals, Inc.(RIGL) | 330,010 | 300,034 | -29,976 | $9.35M | $12.85M | 0.55% | +$3.50M |
| Jade Biosciences Inc | 796,744 | 796,744 | 0 | $6.88M | $12.29M | 0.52% | +$5.42M |
| Trevi Therapeutics, Inc.(TRVI) | 25,000 | 900,000 | +875,000 | $228.8K | $11.27M | 0.48% | +$11.04M |
| Sionna Therapeutics, Inc.(SION) | 413,500 | 268,500 | -145,000 | $12.16M | $11.05M | 0.47% | -$1.11M |
| Septerna, Inc.(SEPN) | 18,260 | 383,368 | +365,108 | $343.5K | $10.69M | 0.45% | +$10.34M |
| OrthoPediatrics Corp.(KIDS) | 128,000 | 525,447 | +397,447 | $2.37M | $9.33M | 0.40% | +$6.96M |
| Terns Pharmaceuticals Inc | 8,127,100 | 212,710 | -7,914,390 | $61.03M | $8.59M | 0.36% | -$52.44M |
| Cidara Therapeutics Inc | 493,811 | 38,811 | -455,000 | $47.29M | $8.57M | 0.36% | -$38.71M |
| Insmed Incorporated(INSM) | 2,550 | 48,500 | +45,950 | $367.2K | $8.44M | 0.36% | +$8.07M |
| Cerus Corporation(CERS) | 0 | 4,000,000 | +4,000,000 | $0 | $8.24M | 0.35% | +$8.24M |
| Erasca, Inc.(ERAS) | 2,162,162 | 2,162,162 | 0 | $4.71M | $8.04M | 0.34% | +$3.33M |
| Avalo Therapeutics, Inc.(AVTX) | 0 | 441,978 | +441,978 | $0 | $8.03M | 0.34% | +$8.03M |
| C4 Therapeutics, Inc.(CCCC) | 7,053,942 | 3,803,942 | -3,250,000 | $15.66M | $7.27M | 0.31% | -$8.39M |
| Evolus, Inc.(EOLS) | 1,450,000 | 1,070,000 | -380,000 | $8.90M | $7.12M | 0.30% | -$1.79M |
| CG Oncology, Inc.(CGON) | 290,000 | 170,000 | -120,000 | $11.68M | $7.06M | 0.30% | -$4.62M |
| Anaptysbio Inc | 626,040 | 135,000 | -491,040 | $19.17M | $6.54M | 0.28% | -$12.62M |
| Belite Bio, IncADS(BLTE) | 210,000 | 40,354 | -169,646 | $15.54M | $6.46M | 0.27% | -$9.08M |
| Structure Therapeutics IncADS | 0 | 90,000 | +90,000 | $0 | $6.26M | 0.27% | +$6.26M |
| ABIVAX Société AnonymeADS(ABVX) | 0 | 45,000 | +45,000 | $0 | $6.07M | 0.26% | +$6.07M |
| Oruka Therapeutics, Inc.(ORKA) | 0 | 190,000 | +190,000 | $0 | $5.76M | 0.24% | +$5.76M |
| MoonLake ImmunotherapeuticsCL A(MLTX) | 0 | 400,000 | +400,000 | $0 | $5.27M | 0.22% | +$5.27M |
| NeoGenomics, Inc.(NEO) | 0 | 427,504 | +427,504 | $0 | $5.03M | 0.21% | +$5.03M |
| Natera, Inc.(NTRA) | 0 | 20,000 | +20,000 | $0 | $4.58M | 0.19% | +$4.58M |
| CalciMedica, Inc.(CALC) | 683,904 | 683,904 | 0 | $2.10M | $4.51M | 0.19% | +$2.40M |
| Pulmonx Corporation(LUNG) | 0 | 2,038,323 | +2,038,323 | $0 | $4.50M | 0.19% | +$4.50M |
| Cogent Biosciences, Inc.(COGT) | 0 | 120,000 | +120,000 | $0 | $4.26M | 0.18% | +$4.26M |
| Indivior Plc | 1,466,000 | 100,000 | -1,366,000 | $35.35M | $3.59M | 0.15% | -$31.76M |
| UroGen Pharma Ltd.(URGN) | 679,000 | 150,000 | -529,000 | $13.55M | $3.51M | 0.15% | -$10.03M |
| Tyra Biosciences, Inc.(TYRA) | 0 | 125,000 | +125,000 | $0 | $3.29M | 0.14% | +$3.29M |
| Karyopharm Therapeutics Inc.(KPTI) | 0 | 440,000 | +440,000 | $0 | $3.24M | 0.14% | +$3.24M |
| Zymeworks Inc.(ZYME) | 0 | 100,000 | +100,000 | $0 | $2.63M | 0.11% | +$2.63M |
| Viking Therapeutics, Inc.(VKTX) | 0 | 70,000 | +70,000 | $0 | $2.46M | 0.10% | +$2.46M |
| QuidelOrtho Corporation(QDEL) | 375,000 | 75,000 | -300,000 | $11.04M | $2.14M | 0.09% | -$8.90M |
| InspireMD, Inc.(NSPR) | 1,470,934 | 1,150,000 | -320,934 | $3.54M | $2.05M | 0.09% | -$1.50M |
| Inhibrx Biosciences, Inc.(INBX) | 0 | 25,000 | +25,000 | $0 | $1.98M | 0.08% | +$1.98M |
| Arcellx Inc COMMON STOCK | 100,000 | 30,000 | -70,000 | $8.21M | $1.96M | 0.08% | -$6.25M |
| Olema Pharmaceuticals, Inc.(OLMA) | 619,874 | 69,874 | -550,000 | $6.07M | $1.75M | 0.07% | -$4.32M |
| Bicara Therapeutics Inc | 0 | 100,000 | +100,000 | $0 | $1.68M | 0.07% | +$1.68M |
| Kodiak Sciences Inc.(KOD) | 19,644 | 60,000 | +40,356 | $321.6K | $1.68M | 0.07% | +$1.36M |
| GRAIL, Inc.(GRAL) | 0 | 11,000 | +11,000 | $0 | $941.5K | 0.04% | +$941.5K |
| Fractyl Health, Inc.(GUTS) | 2,500,000 | 400,000 | -2,100,000 | $3.98M | $880.0K | 0.04% | -$3.10M |
| STAAR Surgical Company(STAA) | 500,000 | 25,000 | -475,000 | $13.44M | $577.3K | 0.02% | -$12.86M |
| Veracyte, Inc.(VCYT) | 422,055 | 10,000 | -412,055 | $14.49M | $421.0K | 0.02% | -$14.07M |
| Jasper Therapeutics, Inc.(JSPR) | 1,494,420 | 200,000 | -1,294,420 | $3.56M | $366.0K | 0.02% | -$3.19M |
| Quoin Pharmaceuticals, Ltd.ADS(QNRX) | 0 | 25,000 | +25,000 | $0 | $360.8K | 0.02% | +$360.8K |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 68,336 | 500 | -67,836 | $31.34M | $291.2K | 0.01% | -$31.05M |
| LB Pharmaceuticals Inc(LBRX) | 400,000 | 10,000 | -390,000 | $6.32M | $222.6K | 0.01% | -$6.09M |
| Dyne Therapeutics, Inc.(DYN) | 0 | 10,000 | +10,000 | $0 | $195.6K | 0.01% | +$195.6K |
| Delcath Systems, Inc.(DCTH) | 10,000 | 10,000 | 0 | $107.5K | $101.0K | 0.00% | -$6.5K |
| Tango Therapeutics, Inc.(TNGX) | 300,000 | 10,000 | -290,000 | $2.52M | $88.6K | 0.00% | -$2.43M |
| Adma Biologics Inc | 738,000 | 0 | -738,000 | $10.82M | $0 | — | -$10.82M |
| Adverum Biotechnologies Inc | 287,246 | 0 | -287,246 | $1.30M | $0 | — | -$1.30M |
| Akero Therapeutics Inc | 71,000 | 0 | -71,000 | $3.37M | $0 | — | -$3.37M |
| CeriBell, Inc.(CBLL) | 360,000 | 0 | -360,000 | $4.14M | $0 | — | -$4.14M |
| Crescent Biopharma, Inc.(CBIO) | 200,000 | 0 | -200,000 | $2.38M | $0 | — | -$2.38M |
| Elevance Health, Inc.(ELV) | 259,650 | 0 | -259,650 | $83.90M | $0 | — | -$83.90M |