Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | Q4 2025 ▲▼ | Q1 2026 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| SPDR SERIES TRUST(Put) PUT | 0 | 825,000 | +825,000 | 0 | 105,377 | — | +105,377 |
| ERASCA INC(ERAS) | 1,317,584 | 1,851,812 | +534,228 | 4,901 | 29,962 | 3.53% | +25,061 |
| DIANTHUS THERAPEUTICS INC(DNTH) | 750,136 | 654,746 | -95,390 | 30,913 | 54,946 | 6.47% | +24,033 |
| ZENAS BIOPHARMA INC(ZBIO) | 0 | 1,135,935 | +1,135,935 | 0 | 22,208 | 2.62% | +22,208 |
| KALVISTA PHARMACEUTICALS INC | 2,427,118 | 2,876,407 | +449,289 | 39,198 | 57,902 | 6.82% | +18,704 |
| ASCENDIS PHARMA A/S(ASND) | 49,228 | 124,658 | +75,430 | 10,497 | 28,513 | 3.36% | +18,016 |
| MONTE ROSA THERAPEUTICS INC(GLUE) | 1,029,066 | 2,002,040 | +972,974 | 16,136 | 32,934 | 3.88% | +16,798 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 0 | 339,613 | +339,613 | 0 | 16,695 | 1.97% | +16,695 |
| ALKERMES PLC(ALKS) | 0 | 460,314 | +460,314 | 0 | 16,277 | 1.92% | +16,277 |
| IMMUNOME INC(IMNM) | 1,126,210 | 1,850,278 | +724,068 | 24,191 | 40,466 | 4.77% | +16,275 |
| DISC MEDICINE INC(IRON) | 0 | 196,028 | +196,028 | 0 | 12,534 | 1.48% | +12,534 |
| HELIX ACQUISITION CORP III | 0 | 1,208,986 | +1,208,986 | 0 | 12,283 | 1.45% | +12,283 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 135,950 | 306,000 | +170,050 | 14,552 | 26,613 | 3.14% | +12,061 |
| XENON PHARMACEUTICALS INC(XENE) | 0 | 197,759 | +197,759 | 0 | 11,500 | 1.36% | +11,500 |
| IMMUNOVANT INC(IMVT) | 0 | 414,236 | +414,236 | 0 | 10,290 | 1.21% | +10,290 |
| KODIAK SCIENCES INC(KOD) | 1,023,122 | 991,930 | -31,192 | 28,606 | 37,812 | 4.46% | +9,206 |
| SAVARA INC(SVRA) | 0 | 1,430,982 | +1,430,982 | 0 | 7,813 | 0.92% | +7,813 |
| SYNDAX PHARMACEUTICALS INC(SNDX)(Call) | 0 | 320,000 | +320,000 | 0 | 7,475 | — | +7,475 |
| ORUKA THERAPEUTICS INC(ORKA) | 0 | 150,908 | +150,908 | 0 | 7,402 | 0.87% | +7,402 |
| SYNDAX PHARMACEUTICALS INC(SNDX) | 642,899 | 888,987 | +246,088 | 13,507 | 20,767 | 2.45% | +7,259 |
| CENTESSA PHARMACEUTICALS PLC | 458,203 | 466,345 | +8,142 | 11,460 | 18,523 | 2.18% | +7,064 |
| COGENT BIOSCIENCES INC(COGT) | 1,245,254 | 1,314,189 | +68,935 | 44,231 | 50,583 | 5.96% | +6,352 |
| CELCUITY INC(CELC)(Call) | 0 | 54,500 | +54,500 | 0 | 6,221 | — | +6,221 |
| NUVALENT INC(NUVL) | 311,430 | 354,914 | +43,484 | 31,327 | 36,361 | 4.28% | +5,034 |
| ORIC PHARMACEUTICALS INC(ORIC) | 1,116,604 | 1,100,010 | -16,594 | 9,134 | 13,937 | 1.64% | +4,803 |
| CYTOKINETICS INC(CYTK) | 0 | 71,203 | +71,203 | 0 | 4,693 | 0.55% | +4,693 |
| CLIMB BIO INC | 0 | 684,908 | +684,908 | 0 | 4,692 | 0.55% | +4,692 |
| CELCUITY INC(CELC) | 375,132 | 357,903 | -17,229 | 37,416 | 40,851 | 4.81% | +3,435 |
| ZURA BIO LTD | 0 | 560,651 | +560,651 | 0 | 3,336 | 0.39% | +3,336 |
| SPYRE THERAPEUTICS INC(SYRE) | 187,737 | 186,618 | -1,119 | 6,150 | 9,413 | 1.11% | +3,263 |
| CAMP4 THERAPEUTICS CORP | 0 | 653,594 | +653,594 | 0 | 2,882 | 0.34% | +2,882 |
| ANNEXON INC(ANNX) | 0 | 496,461 | +496,461 | 0 | 2,750 | 0.32% | +2,750 |
| CRESCENT BIOPHARMA INC. | 0 | 130,500 | +130,500 | 0 | 2,397 | 0.28% | +2,397 |
| MONOPAR THERAPEUTICS INC | 0 | 43,488 | +43,488 | 0 | 2,383 | 0.28% | +2,383 |
| OVID THERAPEUTICS INC | 0 | 1,000,000 | +1,000,000 | 0 | 2,220 | 0.26% | +2,220 |
| COMPUGEN LTD | 3,479,805 | 3,315,845 | -163,960 | 5,324 | 7,063 | 0.83% | +1,739 |
| COMPASS PATHWAYS PLC(CMPS) | 0 | 300,000 | +300,000 | 0 | 1,659 | 0.20% | +1,659 |
| NEUMORA THERAPEUTICS INC. | 0 | 818,156 | +818,156 | 0 | 1,595 | 0.19% | +1,595 |
| VAXCYTE INC(PCVX) | 148,787 | 144,981 | -3,806 | 6,865 | 8,425 | 0.99% | +1,560 |
| REPLIMUNE GROUP INC(REPL) | 0 | 171,936 | +171,936 | 0 | 1,315 | 0.15% | +1,315 |
| GENERATE BIOMEDICINES INC(GENB) | 0 | 100,000 | +100,000 | 0 | 1,250 | 0.15% | +1,250 |
| C4 THERAPEUTICS INC | 1,994,224 | 1,911,785 | -82,439 | 3,809 | 5,028 | 0.59% | +1,219 |
| COMPASS THERAPEUTICS INC(Call) | 0 | 172,400 | +172,400 | 0 | 912 | — | +912 |
| ELUTIA INC | 2,751,314 | 2,498,020 | -253,294 | 1,906 | 2,623 | 0.31% | +717 |
| SURROZEN INC | 157,323 | 144,255 | -13,068 | 3,556 | 4,202 | 0.50% | +647 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 191,074 | 178,378 | -12,696 | 5,190 | 5,658 | 0.67% | +469 |
| CONTINEUM THERAPEUTICS INC | 307,540 | 301,729 | -5,811 | 3,515 | 3,941 | 0.46% | +425 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 42,052 | 42,615 | +563 | 1,044 | 1,342 | 0.16% | +299 |
| IBIO INC | 106,000 | 226,000 | +120,000 | 205 | 429 | 0.05% | +225 |
| ROCKET PHARMACEUTICALS INC | 104,828 | 104,828 | 0 | 3 | 2 | 0.00% | -0 |
| CERUS CORP | 2,814,383 | 3,176,547 | +362,164 | 5,798 | 5,781 | 0.68% | -16 |
| SIONNA THERAPEUTICS INC(SION) | 41,460 | 39,417 | -2,043 | 1,706 | 1,580 | 0.19% | -125 |
| RADIOPHARM THERANOSTICS LTD | 187,406 | 187,406 | 0 | 978 | 806 | 0.09% | -172 |
| PALISADE BIO INC | 102,108 | 0 | -102,108 | 240 | 0 | — | -240 |
| ADAGIO MED HLDGS INC | 515,384 | 251,972 | -263,412 | 536 | 290 | 0.03% | -246 |
| GUARDANT HEALTH INC(GH) | 91,914 | 98,514 | +6,600 | 9,388 | 9,100 | 1.07% | -288 |
| RAPPORT THERAPEUTICS INC(RAPP) | 9,659 | 0 | -9,659 | 293 | 0 | — | -293 |
| ABEONA THERAPEUTICS INC | 627,738 | 648,942 | +21,204 | 3,308 | 2,907 | 0.34% | -401 |
| NEXTCURE INC | 176,057 | 176,057 | 0 | 2,498 | 1,880 | 0.22% | -618 |
| TREVI THERAPEUTICS INC(TRVI) | 541,240 | 511,127 | -30,113 | 6,776 | 6,098 | 0.72% | -679 |
| 4D MOLECULAR THERAPEUTICS IN | 100,000 | 0 | -100,000 | 750 | 0 | — | -750 |
| COMPASS THERAPEUTICS INC | 1,051,343 | 859,049 | -192,294 | 5,646 | 4,544 | 0.54% | -1,101 |
| FULCRUM THERAPEUTICS INC | 394,650 | 419,949 | +25,299 | 4,463 | 3,221 | 0.38% | -1,242 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 82,465 | 71,552 | -10,913 | 24,306 | 23,053 | 2.72% | -1,252 |
| FULCRUM THERAPEUTICS INC(Call) | 391,900 | 391,900 | 0 | 4,432 | 3,006 | — | -1,427 |
| X4 PHARMACEUTICALS INC | 357,387 | 0 | -357,387 | 1,430 | 0 | — | -1,430 |
| CYTOMX THERAPEUTICS INC | 385,974 | 0 | -385,974 | 1,644 | 0 | — | -1,644 |
| TELA BIO INC | 2,647,512 | 2,259,312 | -388,200 | 3,124 | 1,401 | 0.17% | -1,723 |
| BENITEC BIOPHARMA INC | 731,717 | 717,725 | -13,992 | 9,856 | 7,644 | 0.90% | -2,212 |
| ULTRAGENYX PHARMACEUTICAL IN(Call) CALL | 110,000 | 0 | -110,000 | 2,530 | 0 | — | -2,530 |
| KYMERA THERAPEUTICS INC(KYMR) | 34,589 | 0 | -34,589 | 2,691 | 0 | — | -2,691 |
| TARSUS PHARMACEUTICALS INC(TARS) | 36,124 | 0 | -36,124 | 2,958 | 0 | — | -2,958 |
| UNIQURE NV(QURE) | 126,047 | 0 | -126,047 | 3,016 | 0 | — | -3,016 |
| RELAY THERAPEUTICS INC(RLAY) | 398,167 | 0 | -398,167 | 3,368 | 0 | — | -3,368 |
| MINERALYS THERAPEUTICS INC(MLYS) | 94,983 | 0 | -94,983 | 3,447 | 0 | — | -3,447 |
| CG ONCOLOGY INC(CGON) | 361,158 | 166,349 | -194,809 | 14,995 | 11,259 | 1.33% | -3,737 |
| AARDVARK THERAPEUTICS INC | 303,939 | 33,684 | -270,255 | 3,989 | 127 | 0.01% | -3,862 |
| BIOGEN INC(BIIB) | 75,412 | 50,967 | -24,445 | 13,272 | 9,344 | 1.10% | -3,928 |
| KALVISTA PHARMACEUTICALS INC(Call) | 290,600 | 0 | -290,600 | 4,693 | 0 | — | -4,693 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 206,280 | 0 | -206,280 | 5,157 | 0 | — | -5,157 |
| SOLENO THERAPEUTICS INC | 117,485 | 0 | -117,485 | 5,440 | 0 | — | -5,440 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 506,242 | 0 | -506,242 | 6,115 | 0 | — | -6,115 |
| LEXEO THERAPEUTICS INC | 617,608 | 0 | -617,608 | 6,133 | 0 | — | -6,133 |
| INSMED INC(INSM) | 71,256 | 35,850 | -35,406 | 12,401 | 5,862 | 0.69% | -6,539 |
| GOSSAMER BIO INC | 2,135,722 | 0 | -2,135,722 | 6,621 | 0 | — | -6,621 |
| UNIQURE NV(QURE)(Call) | 720,800 | 500,000 | -220,800 | 17,249 | 8,175 | — | -9,074 |
| VERACYTE INC(VCYT) | 357,558 | 179,700 | -177,858 | 15,053 | 5,788 | 0.68% | -9,265 |
| AVALO THERAPEUTICS INC(AVTX) | 524,436 | 0 | -524,436 | 9,524 | 0 | — | -9,524 |
| PFIZER INC(PFE) | 419,134 | 0 | -419,134 | 10,436 | 0 | — | -10,436 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 348,569 | 0 | -348,569 | 10,847 | 0 | — | -10,847 |
| UROGEN PHARMA LTD(URGN) | 1,738,821 | 1,503,045 | -235,776 | 40,723 | 27,025 | 3.18% | -13,698 |
| FRACTYL HEALTH INC | 9,840,041 | 1,701,625 | -8,138,416 | 21,648 | 779 | 0.09% | -20,869 |
| ABIVAX SA(ABVX) | 422,193 | 302,530 | -119,663 | 56,935 | 33,687 | 3.97% | -23,248 |