Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2024 ▲▼ | Q1 2025 ▲▼ | Change ▲▼ | Q4 2024 ▲▼ | Q1 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| KALVISTA PHARMACEUTICALS INC | 612,173 | 1,698,984 | +1,086,811 | 5,185 | 19,606 | 4.10% | +14,421 |
| SOLENO THERAPEUTICS INC | 0 | 166,417 | +166,417 | 0 | 11,890 | 2.48% | +11,890 |
| VERONA PHARMA PLC | 516,014 | 545,872 | +29,858 | 23,964 | 34,657 | 7.24% | +10,694 |
| 89BIO INC | 96,511 | 1,510,498 | +1,413,987 | 755 | 10,981 | 2.29% | +10,227 |
| AKERO THERAPEUTICS INC | 739,563 | 719,992 | -19,571 | 20,575 | 29,145 | 6.09% | +8,571 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 0 | 72,583 | +72,583 | 0 | 8,028 | 1.68% | +8,028 |
| GILEAD SCIENCES INC(GILD) | 10,000 | 62,029 | +52,029 | 924 | 6,950 | 1.45% | +6,027 |
| MERUS N V | 680,845 | 811,021 | +130,176 | 28,630 | 34,136 | 7.13% | +5,506 |
| MINERALYS THERAPEUTICS INC(MLYS) | 0 | 338,354 | +338,354 | 0 | 5,373 | 1.12% | +5,373 |
| DISC MEDICINE INC(IRON) | 110,381 | 236,471 | +126,090 | 6,998 | 11,738 | 2.45% | +4,740 |
| ASCENDIS PHARMA A/S(ASND) | 51,491 | 75,751 | +24,260 | 7,089 | 11,807 | 2.47% | +4,718 |
| ALKERMES PLC(ALKS) | 0 | 124,871 | +124,871 | 0 | 4,123 | 0.86% | +4,123 |
| OCULAR THERAPEUTIX INC(OCUL) | 0 | 551,570 | +551,570 | 0 | 4,043 | 0.84% | +4,043 |
| BRIDGEBIO PHARMA INC(BBIO) | 0 | 111,000 | +111,000 | 0 | 3,837 | 0.80% | +3,837 |
| KURA ONCOLOGY INC(KURA) | 0 | 581,369 | +581,369 | 0 | 3,837 | 0.80% | +3,837 |
| DIANTHUS THERAPEUTICS INC(DNTH) | 0 | 190,334 | +190,334 | 0 | 3,453 | 0.72% | +3,453 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 0 | 10,344 | +10,344 | 0 | 3,426 | 0.72% | +3,426 |
| UROGEN PHARMA LTD(URGN) | 1,120,473 | 1,381,158 | +260,685 | 11,933 | 15,276 | 3.19% | +3,343 |
| BLUEPRINT MEDICINES CORP | 0 | 37,345 | +37,345 | 0 | 3,305 | 0.69% | +3,305 |
| BENITEC BIOPHARMA INC | 0 | 250,000 | +250,000 | 0 | 3,253 | 0.68% | +3,253 |
| LIQUIDIA CORPORATION(LQDA) | 0 | 214,057 | +214,057 | 0 | 3,157 | 0.66% | +3,157 |
| PTC THERAPEUTICS INC(PTCT) | 0 | 60,389 | +60,389 | 0 | 3,077 | 0.64% | +3,077 |
| METSERA INC | 0 | 112,759 | +112,759 | 0 | 3,069 | 0.64% | +3,069 |
| SOLENO THERAPEUTICS INC(Put) | 0 | 42,500 | +42,500 | 0 | 3,037 | — | +3,037 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 273,896 | 337,605 | +63,709 | 15,333 | 17,883 | 3.74% | +2,550 |
| TRAVERE THERAPEUTICS INC(TVTX) | 277,365 | 408,849 | +131,484 | 4,832 | 7,327 | 1.53% | +2,495 |
| ORIC PHARMACEUTICALS INC(ORIC) | 1,178,300 | 2,060,240 | +881,940 | 9,509 | 11,496 | 2.40% | +1,987 |
| KINIKSA PHARMACEUTICALS INTL(KNSA) | 0 | 88,215 | +88,215 | 0 | 1,959 | 0.41% | +1,959 |
| COMPUGEN LTD | 1,624,377 | 2,895,430 | +1,271,053 | 2,485 | 4,227 | 0.88% | +1,742 |
| SOLID BIOSCIENCES INC | 0 | 452,239 | +452,239 | 0 | 1,673 | 0.35% | +1,673 |
| COMPASS THERAPEUTICS INC | 0 | 874,869 | +874,869 | 0 | 1,662 | 0.35% | +1,662 |
| HELIX ACQUISITION CORP II | 513,369 | 613,393 | +100,024 | 5,390 | 6,931 | 1.45% | +1,541 |
| GOSSAMER BIO INC | 6,171,847 | 6,320,684 | +148,837 | 5,583 | 6,953 | 1.45% | +1,370 |
| SIONNA THERAPEUTICS INC(SION) | 0 | 114,138 | +114,138 | 0 | 1,194 | 0.25% | +1,194 |
| AKERO THERAPEUTICS INC(Call) | 220,000 | 180,600 | -39,400 | 6,120 | 7,311 | — | +1,190 |
| INFLARX NV | 0 | 1,161,567 | +1,161,567 | 0 | 1,185 | 0.25% | +1,185 |
| MERSANA THERAPEUTICS INC | 0 | 3,088,505 | +3,088,505 | 0 | 1,063 | 0.22% | +1,063 |
| CERUS CORP | 1,587,228 | 2,456,537 | +869,309 | 2,444 | 3,415 | 0.71% | +970 |
| WAVE LIFE SCIENCES LTD(WVE) | 608,897 | 1,050,374 | +441,477 | 7,532 | 8,487 | 1.77% | +955 |
| AARDVARK THERAPEUTICS INC | 0 | 119,496 | +119,496 | 0 | 897 | 0.19% | +897 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 72,516 | 166,074 | +93,558 | 5,581 | 6,289 | 1.31% | +708 |
| DELCATH SYS INC | 155,325 | 191,470 | +36,145 | 1,870 | 2,437 | 0.51% | +567 |
| TARSUS PHARMACEUTICALS INC(TARS) | 65,955 | 81,331 | +15,376 | 3,652 | 4,178 | 0.87% | +526 |
| UNIQURE NV(QURE) | 100,000 | 203,400 | +103,400 | 1,766 | 2,156 | 0.45% | +390 |
| XENON PHARMACEUTICALS INC(XENE) | 0 | 10,121 | +10,121 | 0 | 340 | 0.07% | +340 |
| TREVI THERAPEUTICS INC(TRVI) | 734,234 | 530,000 | -204,234 | 3,025 | 3,334 | 0.70% | +309 |
| AVADEL PHARMACEUTICALS PLC | 0 | 39,366 | +39,366 | 0 | 308 | 0.06% | +308 |
| ELUTIA INC | 1,782,271 | 2,670,056 | +887,785 | 6,666 | 6,755 | 1.41% | +90 |
| RADIOPHARM THERANOSTICS LTD | 187,406 | 187,406 | 0 | 841 | 901 | 0.19% | +60 |
| ROCKET PHARMACEUTICALS INC | 104,828 | 104,828 | 0 | 4 | 5 | 0.00% | +1 |
| FRACTYL HEALTH INC | 176,922 | 237,448 | +60,526 | 364 | 283 | 0.06% | -82 |
| NUVALENT INC(NUVL) | 400,014 | 439,018 | +39,004 | 31,313 | 31,135 | 6.50% | -178 |
| SYNDAX PHARMACEUTICALS INC(SNDX) | 1,230,400 | 1,309,224 | +78,824 | 16,266 | 16,084 | 3.36% | -182 |
| KALA BIO INC | 231,070 | 246,079 | +15,009 | 1,604 | 1,410 | 0.29% | -194 |
| BIOAGE LABS INC(BIOA) | 39,974 | 0 | -39,974 | 231 | 0 | — | -231 |
| KARYOPHARM THERAPEUTICS INC | 595,990 | 0 | -595,990 | 403 | 0 | — | -403 |
| VAXART INC | 1,077,782 | 683,825 | -393,957 | 714 | 278 | 0.06% | -435 |
| UNICYCIVE THERAPEUTICS INC | 2,486,709 | 2,413,489 | -73,220 | 1,975 | 1,388 | 0.29% | -587 |
| MODULAR MED INC | 1,272,015 | 958,881 | -313,134 | 1,743 | 1,045 | 0.22% | -697 |
| ABIVAX SA(ABVX) | 285,120 | 210,901 | -74,219 | 2,087 | 1,318 | 0.28% | -769 |
| STRUCTURE THERAPEUTICS INC | 152,395 | 188,069 | +35,674 | 4,133 | 3,255 | 0.68% | -877 |
| EYEPOINT PHARMACEUTICALS INC(EYPT) | 121,274 | 0 | -121,274 | 903 | 0 | — | -903 |
| VERACYTE INC(VCYT) | 503,281 | 633,832 | +130,551 | 19,930 | 18,793 | 3.93% | -1,137 |
| INSMED INC(INSM) | 372,230 | 321,366 | -50,864 | 25,699 | 24,517 | 5.12% | -1,182 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 233,281 | 0 | -233,281 | 1,360 | 0 | — | -1,360 |
| NEUMORA THERAPEUTICS INC.(Call) | 147,200 | 0 | -147,200 | 1,560 | 0 | — | -1,560 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 100,000 | 0 | -100,000 | 1,917 | 0 | — | -1,917 |
| SYNDAX PHARMACEUTICALS INC(SNDX)(Call) | 172,400 | 0 | -172,400 | 2,279 | 0 | — | -2,279 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 264,560 | 205,962 | -58,598 | 6,685 | 3,738 | 0.78% | -2,947 |
| C4 THERAPEUTICS INC | 1,221,131 | 882,300 | -338,831 | 4,396 | 1,412 | 0.29% | -2,984 |
| GERON CORP(GERN) | 920,022 | 0 | -920,022 | 3,257 | 0 | — | -3,257 |
| VAXCYTE INC(PCVX) | 40,788 | 0 | -40,788 | 3,339 | 0 | — | -3,339 |
| INCYTE CORP(INCY) | 49,000 | 0 | -49,000 | 3,384 | 0 | — | -3,384 |
| AVIDITY BIOSCIENCES INC | 543,651 | 411,312 | -132,339 | 15,809 | 12,142 | 2.54% | -3,667 |
| BIODESIX INC | 4,332,281 | 4,098,406 | -233,875 | 6,628 | 2,562 | 0.54% | -4,066 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 124,388 | 0 | -124,388 | 5,233 | 0 | — | -5,233 |
| TELA BIO INC | 3,065,649 | 2,771,288 | -294,361 | 9,258 | 3,381 | 0.71% | -5,877 |
| CENTESSA PHARMACEUTICALS PLC | 598,952 | 232,758 | -366,194 | 10,032 | 3,347 | 0.70% | -6,685 |
| COGENT BIOSCIENCES INC(COGT) | 921,137 | 0 | -921,137 | 7,185 | 0 | — | -7,185 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 183,243 | 0 | -183,243 | 7,920 | 0 | — | -7,920 |
| KODIAK SCIENCES INC(KOD) | 1,000,000 | 441,807 | -558,193 | 9,950 | 1,239 | 0.26% | -8,711 |
| ERASCA INC(ERAS) | 7,543,901 | 7,367,996 | -175,905 | 18,935 | 10,094 | 2.11% | -8,841 |
| POSEIDA THERAPEUTICS INC | 1,012,307 | 0 | -1,012,307 | 9,718 | 0 | — | -9,718 |
| INTRA-CELLULAR THERAPIES INC | 179,085 | 0 | -179,085 | 14,957 | 0 | — | -14,957 |
| PLIANT THERAPEUTICS INC | 1,315,601 | 0 | -1,315,601 | 17,326 | 0 | — | -17,326 |