Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q1 2025 ▲▼ | Q2 2025 ▲▼ | Change ▲▼ | Q1 2025 ▲▼ | Q2 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| CG ONCOLOGY INC(CGON) | 0 | 541,034 | +541,034 | 0 | 14,067 | 2.88% | +14,067 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 72,583 | 162,969 | +90,386 | 8,028 | 20,484 | 4.19% | +12,456 |
| UROGEN PHARMA LTD(URGN) | 1,381,158 | 2,022,482 | +641,324 | 15,276 | 27,708 | 5.67% | +12,432 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 0 | 341,010 | +341,010 | 0 | 12,079 | 2.47% | +12,079 |
| VAXCYTE INC(PCVX) | 0 | 287,796 | +287,796 | 0 | 9,356 | 1.91% | +9,356 |
| 89BIO INC | 1,510,498 | 2,037,087 | +526,589 | 10,981 | 20,004 | 4.09% | +9,023 |
| AKERO THERAPEUTICS INC | 719,992 | 713,811 | -6,181 | 29,145 | 38,089 | 7.80% | +8,944 |
| PFIZER INC(PFE) | 0 | 344,338 | +344,338 | 0 | 8,347 | 1.71% | +8,347 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 337,605 | 400,772 | +63,167 | 17,883 | 25,325 | 5.18% | +7,442 |
| ORIC PHARMACEUTICALS INC(ORIC) | 2,060,240 | 1,800,829 | -259,411 | 11,496 | 18,278 | 3.74% | +6,782 |
| SOLENO THERAPEUTICS INC | 166,417 | 204,591 | +38,174 | 11,890 | 17,141 | 3.51% | +5,250 |
| ABEONA THERAPEUTICS INC(ABEO) | 0 | 917,898 | +917,898 | 0 | 5,214 | 1.07% | +5,214 |
| CIDARA THERAPEUTICS INC | 0 | 103,943 | +103,943 | 0 | 5,063 | 1.04% | +5,063 |
| MERUS N V | 811,021 | 741,972 | -69,049 | 34,136 | 39,028 | 7.99% | +4,892 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX) | 0 | 82,023 | +82,023 | 0 | 3,871 | 0.79% | +3,871 |
| ASCENDIS PHARMA A/S(ASND) | 75,751 | 86,552 | +10,801 | 11,807 | 14,939 | 3.06% | +3,132 |
| AARDVARK THERAPEUTICS INC | 119,496 | 286,807 | +167,311 | 897 | 3,878 | 0.79% | +2,980 |
| METSERA INC | 112,759 | 207,581 | +94,822 | 3,069 | 5,906 | 1.21% | +2,836 |
| SIONNA THERAPEUTICS INC(SION) | 114,138 | 186,015 | +71,877 | 1,194 | 3,227 | 0.66% | +2,033 |
| TELA BIO INC(TELA) | 2,771,288 | 2,779,795 | +8,507 | 3,381 | 5,393 | 1.10% | +2,012 |
| ORUKA THERAPEUTICS INC(ORKA) | 0 | 165,389 | +165,389 | 0 | 1,854 | 0.38% | +1,854 |
| TOURMALINE BIO INC | 0 | 109,257 | +109,257 | 0 | 1,747 | 0.36% | +1,747 |
| COMPASS THERAPEUTICS INC(CMPX) | 874,869 | 1,249,781 | +374,912 | 1,662 | 3,249 | 0.67% | +1,587 |
| COMPUGEN LTD(CGEN) | 2,895,430 | 3,033,879 | +138,449 | 4,227 | 5,400 | 1.11% | +1,173 |
| KALVISTA PHARMACEUTICALS INC | 1,698,984 | 1,832,171 | +133,187 | 19,606 | 20,713 | 4.24% | +1,106 |
| UNIQURE NV(QURE) | 203,400 | 202,565 | -835 | 2,156 | 2,824 | 0.58% | +668 |
| INSMED INC(INSM) | 321,366 | 249,060 | -72,306 | 24,517 | 25,065 | 5.13% | +548 |
| STRUCTURE THERAPEUTICS INC | 188,069 | 175,636 | -12,433 | 3,255 | 3,643 | 0.75% | +387 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 205,962 | 198,441 | -7,521 | 3,738 | 4,038 | 0.83% | +300 |
| SAGIMET BIOSCIENCES INC(SGMT) | 0 | 37,539 | +37,539 | 0 | 286 | 0.06% | +286 |
| KODIAK SCIENCES INC(KOD) | 441,807 | 401,540 | -40,267 | 1,239 | 1,498 | 0.31% | +258 |
| ENLIVEN THERAPEUTICS INC | 0 | 10,000 | +10,000 | 0 | 201 | 0.04% | +201 |
| KINIKSA PHARMACEUTICALS INTL(KNSA) | 88,215 | 75,959 | -12,256 | 1,959 | 2,102 | 0.43% | +143 |
| CERUS CORP(CERS) | 2,456,537 | 2,488,291 | +31,754 | 3,415 | 3,508 | 0.72% | +94 |
| FRACTYL HEALTH INC(GUTS) | 237,448 | 202,590 | -34,858 | 283 | 328 | 0.07% | +46 |
| NEKTAR THERAPEUTICS(NKTR) | 0 | 346 | +346 | 0 | 9 | 0.00% | +9 |
| ROCKET PHARMACEUTICALS INC(RCKT) | 104,828 | 104,828 | 0 | 5 | 3 | 0.00% | -2 |
| RADIOPHARM THERANOSTICS LTD(RADX) | 187,406 | 187,406 | 0 | 901 | 870 | 0.18% | -32 |
| MERSANA THERAPEUTICS INC | 3,088,505 | 3,128,421 | +39,916 | 1,063 | 926 | 0.19% | -137 |
| VAXART INC(VXRT) | 683,825 | 0 | -683,825 | 278 | 0 | — | -278 |
| BENITEC BIOPHARMA INC(BNTC) | 250,000 | 253,234 | +3,234 | 3,253 | 2,963 | 0.61% | -290 |
| AVADEL PHARMACEUTICALS PLC | 39,366 | 0 | -39,366 | 308 | 0 | — | -308 |
| XENON PHARMACEUTICALS INC(XENE) | 10,121 | 0 | -10,121 | 340 | 0 | — | -340 |
| TREVI THERAPEUTICS INC(TRVI) | 530,000 | 539,587 | +9,587 | 3,334 | 2,952 | 0.60% | -382 |
| HELIX ACQUISITION CORP II | 613,393 | 613,393 | 0 | 6,931 | 6,514 | 1.33% | -417 |
| AVIDITY BIOSCIENCES INC | 411,312 | 410,000 | -1,312 | 12,142 | 11,644 | 2.38% | -498 |
| MODULAR MED INC | 958,881 | 710,363 | -248,518 | 1,045 | 529 | 0.11% | -516 |
| GOSSAMER BIO INC(GOSS) | 6,320,684 | 5,146,782 | -1,173,902 | 6,953 | 6,331 | 1.30% | -622 |
| VERONA PHARMA PLC | 545,872 | 358,297 | -187,575 | 34,657 | 33,888 | 6.94% | -770 |
| DELCATH SYS INC(DCTH) | 191,470 | 103,026 | -88,444 | 2,437 | 1,401 | 0.29% | -1,036 |
| INFLARX NV(IFRX) | 1,161,567 | 0 | -1,161,567 | 1,185 | 0 | — | -1,185 |
| ELUTIA INC(ELUT) | 2,670,056 | 2,761,684 | +91,628 | 6,755 | 5,468 | 1.12% | -1,287 |
| ABIVAX SA(ABVX) | 210,901 | 0 | -210,901 | 1,318 | 0 | — | -1,318 |
| UNICYCIVE THERAPEUTICS INC | 2,413,489 | 0 | -2,413,489 | 1,388 | 0 | — | -1,388 |
| KALA BIO INC(KALA) | 246,079 | 0 | -246,079 | 1,410 | 0 | — | -1,410 |
| C4 THERAPEUTICS INC(CCCC) | 882,300 | 0 | -882,300 | 1,412 | 0 | — | -1,412 |
| DIANTHUS THERAPEUTICS INC(DNTH) | 190,334 | 95,806 | -94,528 | 3,453 | 1,785 | 0.37% | -1,668 |
| SOLID BIOSCIENCES INC | 452,239 | 0 | -452,239 | 1,673 | 0 | — | -1,673 |
| BIODESIX INC(BDSX) | 4,098,406 | 1,070,367 | -3,028,039 | 2,562 | 302 | 0.06% | -2,260 |
| PTC THERAPEUTICS INC(PTCT) | 60,389 | 0 | -60,389 | 3,077 | 0 | — | -3,077 |
| LIQUIDIA CORPORATION(LQDA) | 214,057 | 0 | -214,057 | 3,157 | 0 | — | -3,157 |
| CENTESSA PHARMACEUTICALS PLC | 232,758 | 5,000 | -227,758 | 3,347 | 66 | 0.01% | -3,281 |
| BLUEPRINT MEDICINES CORP | 37,345 | 0 | -37,345 | 3,305 | 0 | — | -3,305 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 10,344 | 0 | -10,344 | 3,426 | 0 | — | -3,426 |
| MINERALYS THERAPEUTICS INC(MLYS) | 338,354 | 115,282 | -223,072 | 5,373 | 1,560 | 0.32% | -3,813 |
| KURA ONCOLOGY INC(KURA) | 581,369 | 0 | -581,369 | 3,837 | 0 | — | -3,837 |
| BRIDGEBIO PHARMA INC(BBIO) | 111,000 | 0 | -111,000 | 3,837 | 0 | — | -3,837 |
| OCULAR THERAPEUTIX INC(OCUL) | 551,570 | 0 | -551,570 | 4,043 | 0 | — | -4,043 |
| ALKERMES PLC(ALKS) | 124,871 | 0 | -124,871 | 4,123 | 0 | — | -4,123 |
| TARSUS PHARMACEUTICALS INC(TARS) | 81,331 | 0 | -81,331 | 4,178 | 0 | — | -4,178 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 166,074 | 10,000 | -156,074 | 6,289 | 421 | 0.09% | -5,869 |
| VERACYTE INC(VCYT) | 633,832 | 448,495 | -185,337 | 18,793 | 12,123 | 2.48% | -6,670 |
| ERASCA INC(ERAS) | 7,367,996 | 2,569,591 | -4,798,405 | 10,094 | 3,263 | 0.67% | -6,831 |
| GILEAD SCIENCES INC(GILD) | 62,029 | 0 | -62,029 | 6,950 | 0 | — | -6,950 |
| TRAVERE THERAPEUTICS INC(TVTX) | 408,849 | 0 | -408,849 | 7,327 | 0 | — | -7,327 |
| WAVE LIFE SCIENCES LTD(WVE) | 1,050,374 | 0 | -1,050,374 | 8,487 | 0 | — | -8,487 |
| DISC MEDICINE INC(IRON) | 236,471 | 0 | -236,471 | 11,738 | 0 | — | -11,738 |
| SYNDAX PHARMACEUTICALS INC(SNDX) | 1,309,224 | 402,964 | -906,260 | 16,084 | 3,774 | 0.77% | -12,310 |
| NUVALENT INC | 439,018 | 235,583 | -203,435 | 31,135 | 17,975 | 3.68% | -13,160 |