Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q2 2025 ▲▼ | Q3 2025 ▲▼ | Change ▲▼ | Q2 2025 ▲▼ | Q3 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| ABIVAX SA(ABVX) | 0 | 539,704 | +539,704 | 0 | 45,821 | 6.63% | +45,821 |
| AVIDITY BIOSCIENCES INC | 410,000 | 844,633 | +434,633 | 11,644 | 36,801 | 5.33% | +25,157 |
| DIANTHUS THERAPEUTICS INC(DNTH) | 95,806 | 674,966 | +579,160 | 1,785 | 26,560 | 3.85% | +24,775 |
| UNIQURE NV(QURE) | 202,565 | 455,000 | +252,435 | 2,824 | 26,558 | 3.84% | +23,735 |
| FRACTYL HEALTH INC(GUTS) | 202,590 | 10,600,000 | +10,397,410 | 328 | 16,854 | 2.44% | +16,526 |
| CIDARA THERAPEUTICS INC | 103,943 | 220,902 | +116,959 | 5,063 | 21,154 | 3.06% | +16,091 |
| KODIAK SCIENCES INC(KOD) | 401,540 | 1,000,000 | +598,460 | 1,498 | 16,370 | 2.37% | +14,872 |
| NUVALENT INC | 235,583 | 372,300 | +136,717 | 17,975 | 32,197 | 4.66% | +14,222 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 400,772 | 369,996 | -30,776 | 25,325 | 37,366 | 5.41% | +12,041 |
| COGENT BIOSCIENCES INC(COGT) | 0 | 815,075 | +815,075 | 0 | 11,704 | 1.69% | +11,704 |
| CG ONCOLOGY INC(CGON) | 541,034 | 638,346 | +97,312 | 14,067 | 25,713 | 3.72% | +11,646 |
| CYTOKINETICS INC(CYTK) | 0 | 211,000 | +211,000 | 0 | 11,597 | 1.68% | +11,597 |
| BIOGEN INC(BIIB) | 0 | 80,419 | +80,419 | 0 | 11,265 | 1.63% | +11,265 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 0 | 700,000 | +700,000 | 0 | 9,513 | 1.38% | +9,513 |
| VERASTEM INC(VSTM) | 0 | 1,042,757 | +1,042,757 | 0 | 9,208 | 1.33% | +9,208 |
| AVALO THERAPEUTICS INC(AVTX) | 0 | 720,922 | +720,922 | 0 | 9,163 | 1.33% | +9,163 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 0 | 933,541 | +933,541 | 0 | 9,139 | 1.32% | +9,139 |
| COMPASS THERAPEUTICS INC(CMPX) | 1,249,781 | 2,833,988 | +1,584,207 | 3,249 | 9,919 | 1.44% | +6,670 |
| GOSSAMER BIO INC(GOSS) | 5,146,782 | 4,779,082 | -367,700 | 6,331 | 12,569 | 1.82% | +6,238 |
| RAPPORT THERAPEUTICS INC(RAPP) | 0 | 203,946 | +203,946 | 0 | 6,057 | 0.88% | +6,057 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 0 | 259,509 | +259,509 | 0 | 5,600 | 0.81% | +5,600 |
| ALKERMES PLC(ALKS) | 0 | 180,513 | +180,513 | 0 | 5,415 | 0.78% | +5,415 |
| BRIDGEBIO ONCOLOGY THERAPEUT(BBOT) | 0 | 457,414 | +457,414 | 0 | 5,297 | 0.77% | +5,297 |
| LEXEO THERAPEUTICS INC(LXEO) | 0 | 778,611 | +778,611 | 0 | 5,170 | 0.75% | +5,170 |
| MONTE ROSA THERAPEUTICS INC(GLUE) | 0 | 694,942 | +694,942 | 0 | 5,150 | 0.75% | +5,150 |
| ORIC PHARMACEUTICALS INC(ORIC) | 1,800,829 | 1,948,808 | +147,979 | 18,278 | 23,386 | 3.39% | +5,107 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 198,441 | 348,922 | +150,481 | 4,038 | 9,027 | 1.31% | +4,988 |
| INSMED INC(INSM) | 249,060 | 206,648 | -42,412 | 25,065 | 29,759 | 4.31% | +4,694 |
| PHARVARIS N V COM | 0 | 183,903 | +183,903 | 0 | 4,588 | 0.66% | +4,588 |
| CELCUITY INC(CELC) | 0 | 88,686 | +88,686 | 0 | 4,381 | 0.63% | +4,381 |
| C4 THERAPEUTICS INC(CCCC) | 0 | 1,897,383 | +1,897,383 | 0 | 4,212 | 0.61% | +4,212 |
| BICARA THERAPEUTICS INC | 0 | 250,606 | +250,606 | 0 | 3,957 | 0.57% | +3,957 |
| UROGEN PHARMA LTD(URGN) | 2,022,482 | 1,577,283 | -445,199 | 27,708 | 31,467 | 4.56% | +3,759 |
| SYNDAX PHARMACEUTICALS INC(SNDX) | 402,964 | 463,708 | +60,744 | 3,774 | 7,134 | 1.03% | +3,360 |
| CENTESSA PHARMACEUTICALS PLC | 5,000 | 141,238 | +136,238 | 66 | 3,425 | 0.50% | +3,359 |
| EYEPOINT PHARMACEUTICALS INC(EYPT) | 0 | 230,837 | +230,837 | 0 | 3,287 | 0.48% | +3,287 |
| ZURA BIO LTD(ZURA) | 0 | 720,452 | +720,452 | 0 | 3,120 | 0.45% | +3,120 |
| TREVI THERAPEUTICS INC(TRVI) | 539,587 | 588,789 | +49,202 | 2,952 | 5,387 | 0.78% | +2,436 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 10,000 | 51,210 | +41,210 | 421 | 2,714 | 0.39% | +2,294 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 0 | 50,000 | +50,000 | 0 | 2,083 | 0.30% | +2,083 |
| VAXCYTE INC(PCVX) | 287,796 | 314,339 | +26,543 | 9,356 | 11,322 | 1.64% | +1,966 |
| CAMP4 THERAPEUTICS CORP(CAMP) | 0 | 653,594 | +653,594 | 0 | 1,961 | 0.28% | +1,961 |
| CONTINEUM THERAPEUTICS INC(CTNM) | 0 | 166,161 | +166,161 | 0 | 1,952 | 0.28% | +1,952 |
| MINERALYS THERAPEUTICS INC(MLYS) | 115,282 | 80,000 | -35,282 | 1,560 | 3,034 | 0.44% | +1,474 |
| KINIKSA PHARMACEUTICALS INTL(KNSA) | 75,959 | 88,910 | +12,951 | 2,102 | 3,452 | 0.50% | +1,351 |
| DYNE THERAPEUTICS INC(DYN) | 0 | 100,000 | +100,000 | 0 | 1,265 | 0.18% | +1,265 |
| LB PHARMACEUTICALS INC(LBRX) | 0 | 70,000 | +70,000 | 0 | 1,105 | 0.16% | +1,105 |
| MERSANA THERAPEUTICS INC | 0 | 133,636 | +133,636 | 0 | 1,037 | 0.15% | +1,037 |
| BENITEC BIOPHARMA INC(BNTC) | 253,234 | 276,267 | +23,033 | 2,963 | 3,876 | 0.56% | +913 |
| CERUS CORP(CERS) | 2,488,291 | 2,715,786 | +227,495 | 3,508 | 4,318 | 0.63% | +810 |
| IMMUNOVANT INC(IMVT) | 0 | 50,000 | +50,000 | 0 | 806 | 0.12% | +806 |
| DELCATH SYS INC(DCTH) | 103,026 | 203,386 | +100,360 | 1,401 | 2,186 | 0.32% | +785 |
| BIODESIX INC(BDSX) | 0 | 49,607 | +49,607 | 0 | 375 | 0.05% | +375 |
| MBX BIOSCIENCES INC(MBX) | 0 | 15,000 | +15,000 | 0 | 263 | 0.04% | +263 |
| AARDVARK THERAPEUTICS INC | 286,807 | 306,912 | +20,105 | 3,878 | 4,079 | 0.59% | +201 |
| RADIOPHARM THERANOSTICS LTD(RADX) | 187,406 | 187,406 | 0 | 870 | 1,034 | 0.15% | +165 |
| ARCTURUS THERAPEUTICS HLDGS(ARCT) | 0 | 3,445 | +3,445 | 0 | 63 | 0.01% | +63 |
| ABEONA THERAPEUTICS INC(ABEO) | 917,898 | 994,754 | +76,856 | 5,214 | 5,252 | 0.76% | +39 |
| ENLIVEN THERAPEUTICS INC | 10,000 | 10,675 | +675 | 201 | 219 | 0.03% | +18 |
| NEKTAR THERAPEUTICS(NKTR) | 346 | 365 | +19 | 9 | 21 | 0.00% | +12 |
| ROCKET PHARMACEUTICALS INC(RCKT) | 104,828 | 104,828 | 0 | 3 | 4 | 0.00% | +1 |
| SIONNA THERAPEUTICS INC(SION) | 186,015 | 108,801 | -77,214 | 3,227 | 3,200 | 0.46% | -28 |
| MODULAR MED INC | 710,363 | 639,531 | -70,832 | 529 | 448 | 0.06% | -82 |
| ERASCA INC(ERAS) | 2,569,591 | 1,368,075 | -1,201,516 | 3,263 | 2,982 | 0.43% | -281 |
| SAGIMET BIOSCIENCES INC(SGMT) | 37,539 | 0 | -37,539 | 286 | 0 | — | -286 |
| BIODESIX INC(BDSX) | 1,070,367 | 0 | -1,070,367 | 302 | 0 | — | -302 |
| COMPUGEN LTD(CGEN) | 3,033,879 | 3,311,165 | +277,286 | 5,400 | 4,867 | 0.70% | -533 |
| MERSANA THERAPEUTICS INC | 3,128,421 | 0 | -3,128,421 | 926 | 0 | — | -926 |
| TELA BIO INC(TELA) | 2,779,795 | 2,782,923 | +3,128 | 5,393 | 4,147 | 0.60% | -1,246 |
| TOURMALINE BIO INC | 109,257 | 0 | -109,257 | 1,747 | 0 | — | -1,747 |
| ORUKA THERAPEUTICS INC(ORKA) | 165,389 | 0 | -165,389 | 1,854 | 0 | — | -1,854 |
| ELUTIA INC(ELUT) | 2,761,684 | 2,850,987 | +89,303 | 5,468 | 2,538 | 0.37% | -2,930 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 341,010 | 233,920 | -107,090 | 12,079 | 8,711 | 1.26% | -3,367 |
| STRUCTURE THERAPEUTICS INC | 175,636 | 0 | -175,636 | 3,643 | 0 | — | -3,643 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX) | 82,023 | 30,000 | -52,023 | 3,871 | 215 | 0.03% | -3,656 |
| VERACYTE INC(VCYT) | 448,495 | 235,791 | -212,704 | 12,123 | 8,095 | 1.17% | -4,028 |
| KALVISTA PHARMACEUTICALS INC | 1,832,171 | 1,363,378 | -468,793 | 20,713 | 16,606 | 2.40% | -4,107 |
| ASCENDIS PHARMA A/S(ASND) | 86,552 | 53,554 | -32,998 | 14,939 | 10,647 | 1.54% | -4,292 |
| METSERA INC | 207,581 | 0 | -207,581 | 5,906 | 0 | — | -5,906 |
| HELIX ACQUISITION CORP II | 613,393 | 0 | -613,393 | 6,514 | 0 | — | -6,514 |
| AKERO THERAPEUTICS INC | 713,811 | 643,636 | -70,175 | 38,089 | 30,560 | 4.42% | -7,529 |
| PFIZER INC(PFE) | 344,338 | 0 | -344,338 | 8,347 | 0 | — | -8,347 |
| SOLENO THERAPEUTICS INC | 204,591 | 0 | -204,591 | 17,141 | 0 | — | -17,141 |
| 89BIO INC | 2,037,087 | 0 | -2,037,087 | 20,004 | 0 | — | -20,004 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 162,969 | 0 | -162,969 | 20,484 | 0 | — | -20,484 |
| VERONA PHARMA PLC | 358,297 | 0 | -358,297 | 33,888 | 0 | — | -33,888 |
| MERUS N V | 741,972 | 0 | -741,972 | 39,028 | 0 | — | -39,028 |