Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2023 ▲▼ | Q4 2023 ▲▼ | Change ▲▼ | Q3 2023 ▲▼ | Q4 2023 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Nuvalent Inc | 0 | 193,000 | +193,000 | 0 | 14,203 | 4.38% | +14,203 |
| Rocket Pharmaceuticals Inc(RCKT) | 0 | 382,672 | +382,672 | 0 | 11,469 | 3.54% | +11,469 |
| Medtronic PLC(MDT) | 0 | 135,000 | +135,000 | 0 | 11,121 | 3.43% | +11,121 |
| Sanofi SA(SNY) | 0 | 220,000 | +220,000 | 0 | 10,941 | 3.37% | +10,941 |
| Celldex Therapeutics Inc(CLDX) | 0 | 247,215 | +247,215 | 0 | 9,805 | 3.02% | +9,805 |
| Mersana Therapeutics Inc | 5,000,000 | 6,420,136 | +1,420,136 | 6,350 | 14,895 | 4.59% | +8,545 |
| Praxis Precision Medicines Inc(PRAX) | 0 | 283,841 | +283,841 | 0 | 6,324 | 1.95% | +6,324 |
| MacroGenics Inc(MGNX) | 1,264,158 | 1,258,641 | -5,517 | 5,891 | 12,108 | 3.73% | +6,217 |
| Merus NV | 500,000 | 645,581 | +145,581 | 11,790 | 17,753 | 5.48% | +5,963 |
| Alpine Immune Sciences Inc | 0 | 297,789 | +297,789 | 0 | 5,676 | 1.75% | +5,676 |
| Xenon Pharmaceuticals Inc(XENE) | 53,996 | 163,168 | +109,172 | 1,845 | 7,516 | 2.32% | +5,671 |
| Intuitive Surgical Inc | 0 | 15,808 | +15,808 | 0 | 5,333 | 1.64% | +5,333 |
| Penumbra Inc(PEN) | 0 | 20,000 | +20,000 | 0 | 5,031 | 1.55% | +5,031 |
| Scholar Rock Holding Corp(SRRK) | 9,711 | 270,000 | +260,289 | 69 | 5,076 | 1.57% | +5,007 |
| Akero Therapeutics Inc | 31,336 | 249,254 | +217,918 | 1,585 | 5,820 | 1.79% | +4,235 |
| Oric Pharmaceuticals Inc(ORIC) | 1,123,345 | 1,170,000 | +46,655 | 6,796 | 10,764 | 3.32% | +3,968 |
| Poseida Therapeutics Inc | 3,567,985 | 3,705,779 | +137,794 | 8,492 | 12,451 | 3.84% | +3,960 |
| DexCom Inc(DXCM) | 0 | 31,000 | +31,000 | 0 | 3,847 | 1.19% | +3,847 |
| Solid Biosciences Inc | 0 | 594,855 | +594,855 | 0 | 3,652 | 1.13% | +3,652 |
| Sarepta Therapeutics Inc(SRPT) | 9,197 | 46,884 | +37,687 | 1,115 | 4,521 | 1.39% | +3,406 |
| MoonLake Immunotherapeutics(MLTX) | 0 | 50,000 | +50,000 | 0 | 3,020 | 0.93% | +3,020 |
| Olema Pharmaceuticals Inc(OLMA) | 407,801 | 573,830 | +166,029 | 5,036 | 8,051 | 2.48% | +3,014 |
| Biohaven Ltd(BHVN) | 10,000 | 70,695 | +60,695 | 260 | 3,026 | 0.93% | +2,766 |
| Rhythm Pharmaceuticals Inc(RYTM) | 260,537 | 174,248 | -86,289 | 5,973 | 8,010 | 2.47% | +2,037 |
| argenx SE(ARGX) | 0 | 4,826 | +4,826 | 0 | 1,836 | 0.57% | +1,836 |
| Pmv Pharmaceuticals Inc(PMVP) | 0 | 550,000 | +550,000 | 0 | 1,705 | 0.53% | +1,705 |
| Altimmune Inc(ALT) | 0 | 150,000 | +150,000 | 0 | 1,688 | 0.52% | +1,688 |
| Compugen Ltd(CGEN) | 350,188 | 940,000 | +589,812 | 326 | 1,861 | 0.57% | +1,536 |
| Veracyte Inc(VCYT) | 239,571 | 247,723 | +8,152 | 5,350 | 6,815 | 2.10% | +1,465 |
| Pliant Therapeutics Inc(PLRX) | 250,409 | 318,524 | +68,115 | 4,342 | 5,768 | 1.78% | +1,426 |
| Tela Bio Inc(TELA) | 490,471 | 795,080 | +304,609 | 3,924 | 5,263 | 1.62% | +1,340 |
| Cerus Corp(CERS) | 1,203,890 | 1,499,851 | +295,961 | 1,950 | 3,240 | 1.00% | +1,289 |
| Kodiak Sciences Inc(KOD) | 1,114,461 | 1,000,000 | -114,461 | 2,006 | 3,040 | 0.94% | +1,034 |
| Insmed Inc(INSM) | 150,387 | 155,504 | +5,117 | 3,797 | 4,819 | 1.49% | +1,022 |
| Annexon Inc(ANNX) | 399,716 | 417,429 | +17,713 | 943 | 1,895 | 0.58% | +952 |
| Morphic Holding Inc | 590,829 | 500,042 | -90,787 | 13,536 | 14,441 | 4.45% | +905 |
| Caribou Biosciences Inc(CRBU) | 892,786 | 900,818 | +8,032 | 4,268 | 5,162 | 1.59% | +894 |
| 89bio Inc | 60,247 | 158,719 | +98,472 | 930 | 1,773 | 0.55% | +843 |
| Immunovant Inc(IMVT) | 0 | 20,000 | +20,000 | 0 | 843 | 0.26% | +843 |
| Terns Pharmaceuticals Inc | 500,000 | 516,999 | +16,999 | 2,515 | 3,355 | 1.03% | +840 |
| Evogene Ltd | 3,100,000 | 3,100,000 | 0 | 1,818 | 2,604 | 0.80% | +786 |
| Urogen Pharma Ltd(URGN) | 508,883 | 525,404 | +16,521 | 7,129 | 7,881 | 2.43% | +752 |
| Apellis Pharmaceuticals Inc COM | 0 | 10,000 | +10,000 | 0 | 599 | 0.18% | +599 |
| Gossamer Bio Inc(GOSS) | 6,130,268 | 6,130,268 | 0 | 5,105 | 5,594 | 1.73% | +489 |
| Viridian Therapeutics Inc(VRDN) | 47,438 | 50,438 | +3,000 | 728 | 1,099 | 0.34% | +371 |
| Schrodinger Inc(SDGR) | 30,311 | 31,117 | +806 | 857 | 1,114 | 0.34% | +257 |
| Relmada Therapeutics Inc(RLMD) | 100,000 | 100,000 | 0 | 300 | 414 | 0.13% | +114 |
| Rocket Pharmaceuticals Inc Wts(RCKT) | 104,828 | 104,828 | 0 | 18 | 51 | 0.02% | +34 |
| Intellia Therapeutics Inc(NTLA) | 53,018 | 54,822 | +1,804 | 1,676 | 1,672 | 0.52% | -5 |
| Aligos Therapeutics Inc | 631,887 | 668,512 | +36,625 | 472 | 444 | 0.14% | -28 |
| Clene Inc(CLNN) | 500,000 | 0 | -500,000 | 248 | 0 | — | -248 |
| Eloxx Pharmaceuticals Inc | 54,075 | 0 | -54,075 | 260 | 0 | — | -260 |
| Karyopharm Therapeutics Inc(KPTI) | 561,955 | 561,955 | 0 | 753 | 486 | 0.15% | -267 |
| Syndax Pharmaceuticals Inc(SNDX) | 20,000 | 0 | -20,000 | 290 | 0 | — | -290 |
| Eliem Therapeutics Inc(CLYM) | 121,110 | 0 | -121,110 | 319 | 0 | — | -319 |
| Rezolute Inc(RZLT) | 433,240 | 157,085 | -276,155 | 572 | 156 | 0.05% | -416 |
| Zura Bio Ltd(ZURA) | 404,040 | 462,997 | +58,957 | 2,667 | 2,162 | 0.67% | -504 |
| Point Biopharma Global Inc | 93,700 | 0 | -93,700 | 625 | 0 | — | -625 |
| Cogent Biosciences Inc(COGT) | 651,372 | 966,748 | +315,376 | 6,351 | 5,684 | 1.75% | -666 |
| Voyager Therapeutics Inc(VYGR) | 103,966 | 0 | -103,966 | 806 | 0 | — | -806 |
| KalVista Pharmaceuticals Inc | 228,934 | 111,734 | -117,200 | 2,205 | 1,369 | 0.42% | -836 |
| Trevi Therapeutics Inc(TRVI) | 927,415 | 863,883 | -63,532 | 2,022 | 1,158 | 0.36% | -864 |
| Sagimet Biosciences Inc(SGMT) | 100,000 | 0 | -100,000 | 880 | 0 | — | -880 |
| BioMarin Pharmaceutical Inc(BMRN) | 10,000 | 0 | -10,000 | 885 | 0 | — | -885 |
| Molecular Templates Inc | 354,608 | 354,608 | 0 | 2,241 | 1,323 | 0.41% | -918 |
| Mirum Pharmaceuticals Inc(MIRM) | 110,114 | 80,811 | -29,303 | 3,480 | 2,386 | 0.74% | -1,094 |
| Alkermes Plc(ALKS) | 41,455 | 0 | -41,455 | 1,161 | 0 | — | -1,161 |
| Roivant Sciences Ltd(ROIV) | 100,000 | 0 | -100,000 | 1,168 | 0 | — | -1,168 |
| Prothena Corporation PLC SHS | 26,629 | 0 | -26,629 | 1,285 | 0 | — | -1,285 |
| Aerovate Therapeutics Inc | 100,000 | 0 | -100,000 | 1,357 | 0 | — | -1,357 |
| Biogen Idec Inc(BIIB) | 28,069 | 20,000 | -8,069 | 7,214 | 5,175 | 1.60% | -2,039 |
| United Therapeutics Corp(UTHR) | 31,424 | 16,360 | -15,064 | 7,098 | 3,597 | 1.11% | -3,500 |
| CymaBay Therapeutics Inc | 590,000 | 218,975 | -371,025 | 8,797 | 5,172 | 1.60% | -3,625 |
| BioCryst Pharmaceuticals Inc(BCRX) | 791,671 | 248,728 | -542,943 | 5,605 | 1,490 | 0.46% | -4,115 |
| Gilead Sciences Inc(GILD) | 62,789 | 0 | -62,789 | 4,705 | 0 | — | -4,705 |
| Vertex Pharmaceuticals Inc(VRTX) | 13,765 | 0 | -13,765 | 4,787 | 0 | — | -4,787 |
| Humana Inc(HUM) | 10,000 | 0 | -10,000 | 4,865 | 0 | — | -4,865 |
| Intra-Cellular Therapies Inc | 208,730 | 80,000 | -128,730 | 10,873 | 5,730 | 1.77% | -5,143 |
| Novo Nordisk A/S(NVO) | 60,000 | 0 | -60,000 | 5,456 | 0 | — | -5,456 |
| Crinetics Pharmaceuticals Inc(CRNX) | 220,000 | 0 | -220,000 | 6,543 | 0 | — | -6,543 |
| Praxis Precision Medicines Inc | 4,117,920 | 0 | -4,117,920 | 7,042 | 0 | — | -7,042 |
| Soleno Therapeutics Inc | 370,000 | 73,665 | -296,335 | 10,919 | 2,965 | 0.91% | -7,954 |
| Krystal Biotech Inc(KRYS) | 71,531 | 0 | -71,531 | 8,298 | 0 | — | -8,298 |
| Mirati Therapeutics Inc | 200,000 | 0 | -200,000 | 8,712 | 0 | — | -8,712 |
| ImmunoGen Inc | 1,307,435 | 0 | -1,307,435 | 20,749 | 0 | — | -20,749 |