Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| CELCUITY INC(CELC) | 88,686 | 375,132 | +286,446 | 4,381 | 37,416 | 5.41% | +33,035 |
| COGENT BIOSCIENCES INC(COGT) | 815,075 | 1,245,254 | +430,179 | 11,704 | 44,231 | 6.40% | +32,527 |
| IMMUNOME INC(IMNM) | 0 | 1,126,210 | +1,126,210 | 0 | 24,191 | 3.50% | +24,191 |
| KALVISTA PHARMACEUTICALS INC | 1,363,378 | 2,427,118 | +1,063,740 | 16,606 | 39,198 | 5.67% | +22,592 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 51,210 | 82,465 | +31,255 | 2,714 | 24,306 | 3.52% | +21,592 |
| KODIAK SCIENCES INC(KOD) | 1,000,000 | 1,023,122 | +23,122 | 16,370 | 28,606 | 4.14% | +12,236 |
| ABIVAX SA(ABVX) | 539,704 | 422,193 | -117,511 | 45,821 | 56,935 | 8.24% | +11,114 |
| MONTE ROSA THERAPEUTICS INC(GLUE) | 694,942 | 1,029,066 | +334,124 | 5,150 | 16,136 | 2.33% | +10,986 |
| PFIZER INC(PFE) | 0 | 419,134 | +419,134 | 0 | 10,436 | 1.51% | +10,436 |
| GUARDANT HEALTH INC(GH) | 0 | 91,914 | +91,914 | 0 | 9,388 | 1.36% | +9,388 |
| UROGEN PHARMA LTD(URGN) | 1,577,283 | 1,738,821 | +161,538 | 31,467 | 40,723 | 5.89% | +9,256 |
| CENTESSA PHARMACEUTICALS PLC | 141,238 | 458,203 | +316,965 | 3,425 | 11,460 | 1.66% | +8,035 |
| VERACYTE INC(VCYT) | 235,791 | 357,558 | +121,767 | 8,095 | 15,053 | 2.18% | +6,958 |
| SYNDAX PHARMACEUTICALS INC(SNDX) | 463,708 | 642,899 | +179,191 | 7,134 | 13,507 | 1.95% | +6,373 |
| SPYRE THERAPEUTICS INC(SYRE) | 0 | 187,737 | +187,737 | 0 | 6,150 | 0.89% | +6,150 |
| BENITEC BIOPHARMA INC(BNTC) | 276,267 | 731,717 | +455,450 | 3,876 | 9,856 | 1.43% | +5,980 |
| SOLENO THERAPEUTICS INC | 0 | 117,485 | +117,485 | 0 | 5,440 | 0.79% | +5,440 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 259,509 | 348,569 | +89,060 | 5,600 | 10,847 | 1.57% | +5,247 |
| FRACTYL HEALTH INC(GUTS) | 10,600,000 | 9,840,041 | -759,959 | 16,854 | 21,648 | 3.13% | +4,794 |
| FULCRUM THERAPEUTICS INC(FULC) | 0 | 394,650 | +394,650 | 0 | 4,463 | 0.65% | +4,463 |
| DIANTHUS THERAPEUTICS INC(DNTH) | 674,966 | 750,136 | +75,170 | 26,560 | 30,913 | 4.47% | +4,353 |
| SURROZEN INC(SRZN) | 0 | 157,323 | +157,323 | 0 | 3,556 | 0.51% | +3,556 |
| RELAY THERAPEUTICS INC(RLAY) | 0 | 398,167 | +398,167 | 0 | 3,368 | 0.49% | +3,368 |
| TARSUS PHARMACEUTICALS INC(TARS) | 0 | 36,124 | +36,124 | 0 | 2,958 | 0.43% | +2,958 |
| KYMERA THERAPEUTICS INC(KYMR) | 0 | 34,589 | +34,589 | 0 | 2,691 | 0.39% | +2,691 |
| NEXTCURE INC | 0 | 176,057 | +176,057 | 0 | 2,498 | 0.36% | +2,498 |
| BIOGEN INC(BIIB) | 80,419 | 75,412 | -5,007 | 11,265 | 13,272 | 1.92% | +2,007 |
| ERASCA INC(ERAS) | 1,368,075 | 1,317,584 | -50,491 | 2,982 | 4,901 | 0.71% | +1,919 |
| CYTOMX THERAPEUTICS INC(CTMX) | 0 | 385,974 | +385,974 | 0 | 1,644 | 0.24% | +1,644 |
| CONTINEUM THERAPEUTICS INC(CTNM) | 166,161 | 307,540 | +141,379 | 1,952 | 3,515 | 0.51% | +1,563 |
| CERUS CORP(CERS) | 2,715,786 | 2,814,383 | +98,597 | 4,318 | 5,798 | 0.84% | +1,480 |
| X4 PHARMACEUTICALS INC(XFOR) | 0 | 357,387 | +357,387 | 0 | 1,430 | 0.21% | +1,430 |
| TREVI THERAPEUTICS INC(TRVI) | 588,789 | 541,240 | -47,549 | 5,387 | 6,776 | 0.98% | +1,389 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 0 | 42,052 | +42,052 | 0 | 1,044 | 0.15% | +1,044 |
| LEXEO THERAPEUTICS INC(LXEO) | 778,611 | 617,608 | -161,003 | 5,170 | 6,133 | 0.89% | +963 |
| 4D MOLECULAR THERAPEUTICS IN | 0 | 100,000 | +100,000 | 0 | 750 | 0.11% | +750 |
| ADAGIO MED HLDGS INC(ADGM) | 0 | 515,384 | +515,384 | 0 | 536 | 0.08% | +536 |
| COMPUGEN LTD(CGEN) | 3,311,165 | 3,479,805 | +168,640 | 4,867 | 5,324 | 0.77% | +457 |
| MINERALYS THERAPEUTICS INC(MLYS) | 80,000 | 94,983 | +14,983 | 3,034 | 3,447 | 0.50% | +413 |
| AVALO THERAPEUTICS INC(AVTX) | 720,922 | 524,436 | -196,486 | 9,163 | 9,524 | 1.38% | +361 |
| PALISADE BIO INC(PALI) | 0 | 102,108 | +102,108 | 0 | 240 | 0.03% | +240 |
| IBIO INC(IBIO) | 0 | 106,000 | +106,000 | 0 | 205 | 0.03% | +205 |
| ROCKET PHARMACEUTICALS INC(RCKT) | 104,828 | 104,828 | 0 | 4 | 3 | 0.00% | -2 |
| NEKTAR THERAPEUTICS(NKTR) | 365 | 0 | -365 | 21 | 0 | — | -21 |
| RADIOPHARM THERANOSTICS LTD(RADX) | 187,406 | 187,406 | 0 | 1,034 | 978 | 0.14% | -56 |
| ARCTURUS THERAPEUTICS HLDGS(ARCT) | 3,445 | 0 | -3,445 | 63 | 0 | — | -63 |
| AARDVARK THERAPEUTICS INC | 306,912 | 303,939 | -2,973 | 4,079 | 3,989 | 0.58% | -90 |
| ASCENDIS PHARMA A/S(ASND) | 53,554 | 49,228 | -4,326 | 10,647 | 10,497 | 1.52% | -150 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX) | 30,000 | 0 | -30,000 | 215 | 0 | — | -215 |
| ENLIVEN THERAPEUTICS INC | 10,675 | 0 | -10,675 | 219 | 0 | — | -219 |
| MBX BIOSCIENCES INC(MBX) | 15,000 | 0 | -15,000 | 263 | 0 | — | -262 |
| BIODESIX INC(BDSX) | 49,607 | 0 | -49,607 | 375 | 0 | — | -375 |
| C4 THERAPEUTICS INC(CCCC) | 1,897,383 | 1,994,224 | +96,841 | 4,212 | 3,809 | 0.55% | -403 |
| MODULAR MED INC | 639,531 | 0 | -639,531 | 448 | 0 | — | -448 |
| ELUTIA INC(ELUT) | 2,850,987 | 2,751,314 | -99,673 | 2,538 | 1,906 | 0.28% | -632 |
| IMMUNOVANT INC(IMVT) | 50,000 | 0 | -50,000 | 806 | 0 | — | -806 |
| NUVALENT INC | 372,300 | 311,430 | -60,870 | 32,197 | 31,327 | 4.53% | -870 |
| TELA BIO INC(TELA) | 2,782,923 | 2,647,512 | -135,411 | 4,147 | 3,124 | 0.45% | -1,022 |
| MERSANA THERAPEUTICS INC | 133,636 | 0 | -133,636 | 1,037 | 0 | — | -1,037 |
| LB PHARMACEUTICALS INC(LBRX) | 70,000 | 0 | -70,000 | 1,105 | 0 | — | -1,105 |
| DYNE THERAPEUTICS INC(DYN) | 100,000 | 0 | -100,000 | 1,265 | 0 | — | -1,265 |
| SIONNA THERAPEUTICS INC(SION) | 108,801 | 41,460 | -67,341 | 3,200 | 1,706 | 0.25% | -1,494 |
| ABEONA THERAPEUTICS INC(ABEO) | 994,754 | 627,738 | -367,016 | 5,252 | 3,308 | 0.48% | -1,944 |
| CAMP4 THERAPEUTICS CORP(CAMP) | 653,594 | 0 | -653,594 | 1,961 | 0 | — | -1,961 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 50,000 | 0 | -50,000 | 2,083 | 0 | — | -2,082 |
| DELCATH SYS INC(DCTH) | 203,386 | 0 | -203,386 | 2,186 | 0 | — | -2,186 |
| ZURA BIO LTD(ZURA) | 720,452 | 0 | -720,452 | 3,120 | 0 | — | -3,120 |
| EYEPOINT PHARMACEUTICALS INC(EYPT) | 230,837 | 0 | -230,837 | 3,287 | 0 | — | -3,287 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 700,000 | 506,242 | -193,758 | 9,513 | 6,115 | 0.88% | -3,398 |
| KINIKSA PHARMACEUTICALS INTL(KNSA) | 88,910 | 0 | -88,910 | 3,452 | 0 | — | -3,452 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 348,922 | 191,074 | -157,848 | 9,027 | 5,190 | 0.75% | -3,837 |
| BICARA THERAPEUTICS INC | 250,606 | 0 | -250,606 | 3,957 | 0 | — | -3,957 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 933,541 | 206,280 | -727,261 | 9,139 | 5,157 | 0.75% | -3,982 |
| COMPASS THERAPEUTICS INC(CMPX) | 2,833,988 | 1,051,343 | -1,782,645 | 9,919 | 5,646 | 0.82% | -4,273 |
| VAXCYTE INC(PCVX) | 314,339 | 148,787 | -165,552 | 11,322 | 6,865 | 0.99% | -4,457 |
| PHARVARIS N V COM | 183,903 | 0 | -183,903 | 4,588 | 0 | — | -4,588 |
| BRIDGEBIO ONCOLOGY THERAPEUT(BBOT) | 457,414 | 0 | -457,414 | 5,297 | 0 | — | -5,297 |
| ALKERMES PLC(ALKS) | 180,513 | 0 | -180,513 | 5,415 | 0 | — | -5,415 |
| RAPPORT THERAPEUTICS INC(RAPP) | 203,946 | 9,659 | -194,287 | 6,057 | 293 | 0.04% | -5,764 |
| GOSSAMER BIO INC(GOSS) | 4,779,082 | 2,135,722 | -2,643,360 | 12,569 | 6,621 | 0.96% | -5,948 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 233,920 | 0 | -233,920 | 8,711 | 0 | — | -8,711 |
| VERASTEM INC(VSTM) | 1,042,757 | 0 | -1,042,757 | 9,208 | 0 | — | -9,208 |
| CG ONCOLOGY INC(CGON) | 638,346 | 361,158 | -277,188 | 25,713 | 14,995 | 2.17% | -10,717 |
| CYTOKINETICS INC(CYTK) | 211,000 | 0 | -211,000 | 11,597 | 0 | — | -11,597 |
| ORIC PHARMACEUTICALS INC(ORIC) | 1,948,808 | 1,116,604 | -832,204 | 23,386 | 9,134 | 1.32% | -14,252 |
| INSMED INC(INSM) | 206,648 | 71,256 | -135,392 | 29,759 | 12,401 | 1.79% | -17,358 |
| CIDARA THERAPEUTICS INC | 220,902 | 0 | -220,902 | 21,154 | 0 | — | -21,154 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 369,996 | 135,950 | -234,046 | 37,366 | 14,552 | 2.11% | -22,814 |
| UNIQURE NV(QURE) | 455,000 | 126,047 | -328,953 | 26,558 | 3,016 | 0.44% | -23,542 |
| AKERO THERAPEUTICS INC | 643,636 | 0 | -643,636 | 30,560 | 0 | — | -30,560 |
| AVIDITY BIOSCIENCES INC | 844,633 | 0 | -844,633 | 36,801 | 0 | — | -36,801 |