Fund HoldingsParadigm Biocapital Advisors LP

Total Portfolio Value
$4.89B
Total Bought
$1.89B
Total Sold
$960.33M
Net Transaction
+$933.54M
Filing Period:
Securities
SharesValue ($K)
Q4 2025
Q1 2026
Change
Q4 2025
Q1 2026
Weight (%)
Change
ARCELLX INC
COMMON STOCK
5,724,0165,774,016+50,000373,206662,97313.55%+289,767
INSMED INC(INSM)01,254,488+1,254,4880205,1344.19%+205,134
BELITE BIO INC(BLTE)01,114,784+1,114,7840177,7413.63%+177,741
CENTESSA PHARMACEUTICALS PLC03,574,048+3,574,0480141,9612.90%+141,961
REVOLUTION MEDICINES INC(RVMD)6,644,4036,655,703+11,300529,227647,26713.23%+118,040
ERASCA INC(ERAS)14,159,09510,392,702-3,766,39352,672168,1543.44%+115,482
CYTOKINETICS INC(CYTK)01,480,857+1,480,857097,6031.99%+97,603
VAXCYTE INC(PCVX)4,068,0204,793,020+725,000187,698278,5225.69%+90,824
TERNS PHARMACEUTICALS INC810,2862,216,499+1,406,21332,736116,8542.39%+84,118
TANGO THERAPEUTICS INC(TNGX)04,009,679+4,009,679083,8821.71%+83,882
MAZE THERAPEUTICS INC(MAZE)02,744,399+2,744,399081,9201.67%+81,920
TYRA BIOSCIENCES INC(TYRA)02,054,991+2,054,991078,7061.61%+78,706
EDGEWISE THERAPEUTICS INC(EWTX)6,541,2107,365,038+823,828162,320231,9994.74%+69,679
ORUKA THERAPEUTICS INC(ORKA)1,710,3162,320,316+610,00051,840113,8122.33%+61,972
MIRUM PHARMACEUTICALS INC(MIRM)0625,000+625,000057,7381.18%+57,738
SPYRE THERAPEUTICS INC(SYRE)1,467,2661,957,266+490,00048,06898,7242.02%+50,657
VERADERMICS INC(MANE)0525,000+525,000033,1540.68%+33,154
APOGEE THERAPEUTICS INC(APGE)1,123,2431,348,243+225,00084,782113,4822.32%+28,699
STRUCTURE THERAPEUTICS INC0545,287+545,287026,2830.54%+26,283
VIRIDIAN THERAPEUTICS INC(VRDN)1,443,1023,148,893+1,705,79144,90961,5921.26%+16,683
NUVALENT INC(NUVL)5,269,4335,324,433+55,000530,052545,48811.15%+15,436
VOR BIOPHARMA INC(VOR)1,750,0001,750,000022,89031,2200.64%+8,330
INVENTIVA SA(IVA)4,000,0004,000,000018,60022,2000.45%+3,600
ORIC PHARMACEUTICALS INC(ORIC)2,401,2171,701,217-700,00019,64221,5540.44%+1,912
KALARIS THERAPEUTICS INC700,000700,00005,9084,0390.08%-1,869
GENMAB A/S(GMAB)7,039,8347,967,836+928,002216,827213,7774.37%-3,050
ASSEMBLY BIOSCIENCES INC665,251665,251022,62518,4610.38%-4,164
LEXEO THERAPEUTICS INC4,763,1986,184,134+1,420,93647,29935,4970.73%-11,802
BRIDGEBIO ONCOLOGY THERAPEUT2,261,749868,213-1,393,53628,3177,7710.16%-20,547
EYEPOINT INC(EYPT)3,691,4753,142,437-549,03867,44340,5060.83%-26,937
TARSUS PHARMACEUTICALS INC(TARS)2,562,1542,562,1540209,789179,7353.67%-30,054
OCULAR THERAPEUTIX INC(OCUL)2,935,2840-2,935,28435,6340-35,634
BRIDGEBIO PHARMA INC(BBIO)684,2770-684,27752,3400-52,340
OLEMA PHARMACEUTICALS INC(OLMA)7,544,1728,020,576+476,404188,604119,5872.44%-69,018
UROGEN PHARMA LTD(URGN)4,473,6481,703,949-2,769,699104,77330,6370.63%-74,136
SCHOLAR ROCK HLDG CORP(SRRK)3,062,1571,226,080-1,836,077134,88860,2741.23%-74,614
CRINETICS PHARMACEUTICALS IN(CRNX)2,210,7740-2,210,774102,9120-102,912
ABIVAX SA(ABVX)1,417,473772,473-645,000191,15386,0151.76%-105,138
CIDARA THERAPEUTICS INC759,5650-759,565167,7800-167,780
SPDR SERIES TRUST(Put)
ST STR SP BIOT
1,500,0000-1,500,000182,8950-182,895
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