Paradigm Biocapital Advisors LP
Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | Q4 2025 ▲▼ | Q1 2026 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| ARCELLX INC COMMON STOCK | 5,724,016 | 5,774,016 | +50,000 | 373,205,843 | 662,972,517 | 13.55% | +289,766,674 |
| INSMED INC(INSM) | 0 | 1,254,488 | +1,254,488 | 0 | 205,133,878 | 4.19% | +205,133,878 |
| BELITE BIO INC(BLTE) | 0 | 1,114,784 | +1,114,784 | 0 | 177,741,161 | 3.63% | +177,741,161 |
| CENTESSA PHARMACEUTICALS PLC | 0 | 3,574,048 | +3,574,048 | 0 | 141,961,187 | 2.90% | +141,961,187 |
| REVOLUTION MEDICINES INC(RVMD) | 6,644,403 | 6,655,703 | +11,300 | 529,226,699 | 647,267,117 | 13.23% | +118,040,418 |
| ERASCA INC(ERAS) | 14,159,095 | 10,392,702 | -3,766,393 | 52,671,833 | 168,153,918 | 3.44% | +115,482,085 |
| CYTOKINETICS INC(CYTK) | 0 | 1,480,857 | +1,480,857 | 0 | 97,603,285 | 1.99% | +97,603,285 |
| VAXCYTE INC(PCVX) | 4,068,020 | 4,793,020 | +725,000 | 187,698,443 | 278,522,392 | 5.69% | +90,823,949 |
| TERNS PHARMACEUTICALS INC | 810,286 | 2,216,499 | +1,406,213 | 32,735,554 | 116,853,827 | 2.39% | +84,118,273 |
| TANGO THERAPEUTICS INC(TNGX) | 0 | 4,009,679 | +4,009,679 | 0 | 83,882,485 | 1.71% | +83,882,485 |
| MAZE THERAPEUTICS INC(MAZE) | 0 | 2,744,399 | +2,744,399 | 0 | 81,920,310 | 1.67% | +81,920,310 |
| TYRA BIOSCIENCES INC(TYRA) | 0 | 2,054,991 | +2,054,991 | 0 | 78,706,155 | 1.61% | +78,706,155 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 6,541,210 | 7,365,038 | +823,828 | 162,320,126 | 231,998,697 | 4.74% | +69,678,571 |
| ORUKA THERAPEUTICS INC(ORKA) | 1,710,316 | 2,320,316 | +610,000 | 51,839,678 | 113,811,500 | 2.33% | +61,971,822 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 0 | 625,000 | +625,000 | 0 | 57,737,500 | 1.18% | +57,737,500 |
| SPYRE THERAPEUTICS INC(SYRE) | 1,467,266 | 1,957,266 | +490,000 | 48,067,634 | 98,724,497 | 2.02% | +50,656,863 |
| VERADERMICS INC(MANE) | 0 | 525,000 | +525,000 | 0 | 33,153,750 | 0.68% | +33,153,750 |
| APOGEE THERAPEUTICS INC(APGE) | 1,123,243 | 1,348,243 | +225,000 | 84,782,382 | 113,481,613 | 2.32% | +28,699,231 |
| STRUCTURE THERAPEUTICS INC | 0 | 545,287 | +545,287 | 0 | 26,282,833 | 0.54% | +26,282,833 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 1,443,102 | 3,148,893 | +1,705,791 | 44,909,334 | 61,592,347 | 1.26% | +16,683,013 |
| NUVALENT INC(NUVL) | 5,269,433 | 5,324,433 | +55,000 | 530,052,265 | 545,488,161 | 11.15% | +15,435,896 |
| VOR BIOPHARMA INC(VOR) | 1,750,000 | 1,750,000 | 0 | 22,890,000 | 31,220,000 | 0.64% | +8,330,000 |
| INVENTIVA SA(IVA) | 4,000,000 | 4,000,000 | 0 | 18,600,000 | 22,200,000 | 0.45% | +3,600,000 |
| ORIC PHARMACEUTICALS INC(ORIC) | 2,401,217 | 1,701,217 | -700,000 | 19,641,955 | 21,554,419 | 0.44% | +1,912,464 |
| KALARIS THERAPEUTICS INC | 700,000 | 700,000 | 0 | 5,908,000 | 4,039,000 | 0.08% | -1,869,000 |
| GENMAB A/S(GMAB) | 7,039,834 | 7,967,836 | +928,002 | 216,826,887 | 213,777,040 | 4.37% | -3,049,847 |
| ASSEMBLY BIOSCIENCES INC | 665,251 | 665,251 | 0 | 22,625,187 | 18,460,715 | 0.38% | -4,164,472 |
| LEXEO THERAPEUTICS INC | 4,763,198 | 6,184,134 | +1,420,936 | 47,298,556 | 35,496,929 | 0.73% | -11,801,627 |
| BRIDGEBIO ONCOLOGY THERAPEUT | 2,261,749 | 868,213 | -1,393,536 | 28,317,097 | 7,770,506 | 0.16% | -20,546,591 |
| EYEPOINT INC(EYPT) | 3,691,475 | 3,142,437 | -549,038 | 67,443,248 | 40,506,013 | 0.83% | -26,937,235 |
| TARSUS PHARMACEUTICALS INC(TARS) | 2,562,154 | 2,562,154 | 0 | 209,789,170 | 179,735,103 | 3.67% | -30,054,067 |
| OCULAR THERAPEUTIX INC(OCUL) | 2,935,284 | 0 | -2,935,284 | 35,634,348 | 0 | — | -35,634,348 |
| BRIDGEBIO PHARMA INC(BBIO) | 684,277 | 0 | -684,277 | 52,340,348 | 0 | — | -52,340,348 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 7,544,172 | 8,020,576 | +476,404 | 188,604,300 | 119,586,788 | 2.44% | -69,017,512 |
| UROGEN PHARMA LTD(URGN) | 4,473,648 | 1,703,949 | -2,769,699 | 104,772,836 | 30,637,003 | 0.63% | -74,135,833 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 3,062,157 | 1,226,080 | -1,836,077 | 134,888,016 | 60,274,093 | 1.23% | -74,613,923 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 2,210,774 | 0 | -2,210,774 | 102,911,530 | 0 | — | -102,911,530 |
| ABIVAX SA(ABVX) | 1,417,473 | 772,473 | -645,000 | 191,153,321 | 86,014,869 | 1.76% | -105,138,452 |
| CIDARA THERAPEUTICS INC | 759,565 | 0 | -759,565 | 167,780,313 | 0 | — | -167,780,313 |
| SPDR SERIES TRUST(Put) ST STR SP BIOT | 1,500,000 | 0 | -1,500,000 | 182,895,000 | 0 | — | -182,895,000 |