Fund HoldingsParadigm Biocapital Advisors LP

Total Portfolio Value
$3.73B
Total Bought
$1.14B
Total Sold
$1.25B
Net Transaction
-$115.60M
Filing Period:
Securities
SharesValue ($K)
Q3 2025
Q4 2025
Change
Q3 2025
Q4 2025
Weight (%)
Change
REVOLUTION MEDICINES INC(RVMD)6,223,2916,644,403+421,112290,628529,22714.17%+238,599
SPDR SERIES TRUST(Put)
ST STR SP BIOT
01,500,000+1,500,0000182,895+182,895
OLEMA PHARMACEUTICALS INC(OLMA)6,794,1727,544,172+750,00066,515188,6045.05%+122,089
GENMAB A/S(GMAB)3,816,8517,039,834+3,222,983117,063216,8275.81%+99,764
CIDARA THERAPEUTICS INC961,164759,565-201,59992,041167,7804.49%+75,739
NUVALENT INC(NUVL)5,269,4335,269,4330455,701530,05214.19%+74,352
EDGEWISE THERAPEUTICS INC(EWTX)6,170,1316,541,210+371,079100,080162,3204.35%+62,241
SCHOLAR ROCK HLDG CORP(SRRK)2,009,7453,062,157+1,052,41274,843134,8883.61%+60,045
ABIVAX SA(ABVX)1,564,1961,417,473-146,723132,800191,1535.12%+58,353
ORUKA THERAPEUTICS INC(ORKA)01,710,316+1,710,316051,8401.39%+51,840
VAXCYTE INC(PCVX)3,784,7554,068,020+283,265136,327187,6985.03%+51,372
TARSUS PHARMACEUTICALS INC(TARS)2,665,6982,562,154-103,544158,422209,7895.62%+51,367
LEXEO THERAPEUTICS INC04,763,198+4,763,198047,2991.27%+47,299
EYEPOINT INC(EYPT)2,005,3653,691,475+1,686,11028,55667,4431.81%+38,887
TERNS PHARMACEUTICALS INC0810,286+810,286032,7360.88%+32,736
APOGEE THERAPEUTICS INC(APGE)1,521,7571,123,243-398,51460,45984,7822.27%+24,323
SPYRE THERAPEUTICS INC(SYRE)1,467,2661,467,266024,59148,0681.29%+23,476
ERASCA INC(ERAS)13,560,01714,159,095+599,07829,56152,6721.41%+23,111
VOR BIOPHARMA INC(VOR)01,750,000+1,750,000022,8900.61%+22,890
ASSEMBLY BIOSCIENCES INC0665,251+665,251022,6250.61%+22,625
UROGEN PHARMA LTD(URGN)4,216,0844,473,648+257,56484,111104,7732.81%+20,662
ORIC PHARMACEUTICALS INC(ORIC)02,401,217+2,401,217019,6420.53%+19,642
INVENTIVA SA(IVA)04,000,000+4,000,000018,6000.50%+18,600
BRIDGEBIO PHARMA INC(BBIO)684,277684,277035,54152,3401.40%+16,799
BRIDGEBIO ONCOLOGY THERAPEUT1,866,1412,261,749+395,60821,61028,3170.76%+6,707
KALARIS THERAPEUTICS INC0700,000+700,00005,9080.16%+5,908
CRINETICS PHARMACEUTICALS IN(CRNX)2,550,7742,210,774-340,000106,240102,9122.76%-3,328
OCULAR THERAPEUTIX INC(OCUL)3,497,3072,935,284-562,02340,88435,6340.95%-5,249
AGIOS PHARMACEUTICALS INC(AGIO)(Call)200,0000-200,0008,0280-8,028
ARCELLX INC
COMMON STOCK
4,649,0165,724,016+1,075,000381,684373,2069.99%-8,478
STRUCTURE THERAPEUTICS INC372,8690-372,86910,4400-10,440
VIRIDIAN THERAPEUTICS INC(VRDN)2,609,3531,443,102-1,166,25156,31044,9091.20%-11,401
DISC MEDICINE INC(IRON)247,7160-247,71616,3690-16,369
DYNE THERAPEUTICS INC(DYN)1,898,9500-1,898,95024,0220-24,022
AMYLYX PHARMACEUTICALS INC(AMLX)1,900,0000-1,900,00025,8210-25,821
TANGO THERAPEUTICS INC(TNGX)3,086,1840-3,086,18425,9240-25,924
MERUS N V(Call)300,0000-300,00028,2450-28,245
COGENT BIOSCIENCES INC(COGT)3,156,3980-3,156,39845,3260-45,326
PHARVARIS N V
COM
1,835,4940-1,835,49445,7960-45,796
LENZ THERAPEUTICS INC1,073,4610-1,073,46150,0020-50,002
ALKERMES PLC(ALKS)1,719,3340-1,719,33451,5800-51,580
JANUX THERAPEUTICS INC(JANX)2,920,2580-2,920,25871,3710-71,371
SPDR SERIES TRUST(Put)
ST STR SP BIOT
1,000,0000-1,000,000100,2000-100,200
AGIOS PHARMACEUTICALS INC(AGIO)2,673,5550-2,673,555107,3160-107,316
MERUS N V4,373,7700-4,373,770411,7900-411,790
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