Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| REVOLUTION MEDICINES INC(RVMD) | 6,223,291 | 6,644,403 | +421,112 | 290,628 | 529,227 | 14.17% | +238,599 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 6,794,172 | 7,544,172 | +750,000 | 66,515 | 188,604 | 5.05% | +122,089 |
| GENMAB A/S(GMAB) | 3,816,851 | 7,039,834 | +3,222,983 | 117,063 | 216,827 | 5.81% | +99,764 |
| CIDARA THERAPEUTICS INC | 961,164 | 759,565 | -201,599 | 92,041 | 167,780 | 4.49% | +75,739 |
| NUVALENT INC | 5,269,433 | 5,269,433 | 0 | 455,701 | 530,052 | 14.19% | +74,352 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 6,170,131 | 6,541,210 | +371,079 | 100,080 | 162,320 | 4.35% | +62,241 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 2,009,745 | 3,062,157 | +1,052,412 | 74,843 | 134,888 | 3.61% | +60,045 |
| ABIVAX SA(ABVX) | 1,564,196 | 1,417,473 | -146,723 | 132,800 | 191,153 | 5.12% | +58,353 |
| ORUKA THERAPEUTICS INC(ORKA) | 0 | 1,710,316 | +1,710,316 | 0 | 51,840 | 1.39% | +51,840 |
| VAXCYTE INC(PCVX) | 3,784,755 | 4,068,020 | +283,265 | 136,327 | 187,698 | 5.03% | +51,372 |
| TARSUS PHARMACEUTICALS INC(TARS) | 2,665,698 | 2,562,154 | -103,544 | 158,422 | 209,789 | 5.62% | +51,367 |
| LEXEO THERAPEUTICS INC(LXEO) | 0 | 4,763,198 | +4,763,198 | 0 | 47,299 | 1.27% | +47,299 |
| EYEPOINT INC(EYPT) | 2,005,365 | 3,691,475 | +1,686,110 | 28,556 | 67,443 | 1.81% | +38,887 |
| TERNS PHARMACEUTICALS INC | 0 | 810,286 | +810,286 | 0 | 32,736 | 0.88% | +32,736 |
| APOGEE THERAPEUTICS INC(APGE) | 1,521,757 | 1,123,243 | -398,514 | 60,459 | 84,782 | 2.27% | +24,323 |
| SPYRE THERAPEUTICS INC(SYRE) | 1,467,266 | 1,467,266 | 0 | 24,591 | 48,068 | 1.29% | +23,476 |
| ERASCA INC(ERAS) | 13,560,017 | 14,159,095 | +599,078 | 29,561 | 52,672 | 1.41% | +23,111 |
| VOR BIOPHARMA INC(VOR) | 0 | 1,750,000 | +1,750,000 | 0 | 22,890 | 0.61% | +22,890 |
| ASSEMBLY BIOSCIENCES INC | 0 | 665,251 | +665,251 | 0 | 22,625 | 0.61% | +22,625 |
| UROGEN PHARMA LTD(URGN) | 4,216,084 | 4,473,648 | +257,564 | 84,111 | 104,773 | 2.81% | +20,662 |
| ORIC PHARMACEUTICALS INC(ORIC) | 0 | 2,401,217 | +2,401,217 | 0 | 19,642 | 0.53% | +19,642 |
| INVENTIVA SA(IVA) | 0 | 4,000,000 | +4,000,000 | 0 | 18,600 | 0.50% | +18,600 |
| BRIDGEBIO PHARMA INC(BBIO) | 684,277 | 684,277 | 0 | 35,541 | 52,340 | 1.40% | +16,799 |
| BRIDGEBIO ONCOLOGY THERAPEUT(BBOT) | 1,866,141 | 2,261,749 | +395,608 | 21,610 | 28,317 | 0.76% | +6,707 |
| KALARIS THERAPEUTICS INC(KLRS) | 0 | 700,000 | +700,000 | 0 | 5,908 | 0.16% | +5,908 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 2,550,774 | 2,210,774 | -340,000 | 106,240 | 102,912 | 2.76% | -3,328 |
| OCULAR THERAPEUTIX INC(OCUL) | 3,497,307 | 2,935,284 | -562,023 | 40,884 | 35,634 | 0.95% | -5,249 |
| ARCELLX INC COMMON STOCK | 4,649,016 | 5,724,016 | +1,075,000 | 381,684 | 373,206 | 9.99% | -8,478 |
| STRUCTURE THERAPEUTICS INC | 372,869 | 0 | -372,869 | 10,440 | 0 | — | -10,440 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 2,609,353 | 1,443,102 | -1,166,251 | 56,310 | 44,909 | 1.20% | -11,401 |
| DISC MEDICINE INC(IRON) | 247,716 | 0 | -247,716 | 16,369 | 0 | — | -16,369 |
| DYNE THERAPEUTICS INC(DYN) | 1,898,950 | 0 | -1,898,950 | 24,022 | 0 | — | -24,022 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 1,900,000 | 0 | -1,900,000 | 25,821 | 0 | — | -25,821 |
| TANGO THERAPEUTICS INC(TNGX) | 3,086,184 | 0 | -3,086,184 | 25,924 | 0 | — | -25,924 |
| COGENT BIOSCIENCES INC(COGT) | 3,156,398 | 0 | -3,156,398 | 45,326 | 0 | — | -45,326 |
| PHARVARIS N V COM | 1,835,494 | 0 | -1,835,494 | 45,796 | 0 | — | -45,796 |
| LENZ THERAPEUTICS INC(LENZ) | 1,073,461 | 0 | -1,073,461 | 50,002 | 0 | — | -50,002 |
| ALKERMES PLC(ALKS) | 1,719,334 | 0 | -1,719,334 | 51,580 | 0 | — | -51,580 |
| JANUX THERAPEUTICS INC(JANX) | 2,920,258 | 0 | -2,920,258 | 71,371 | 0 | — | -71,371 |
| AGIOS PHARMACEUTICALS INC(AGIO) | 2,673,555 | 0 | -2,673,555 | 107,316 | 0 | — | -107,316 |
| MERUS N V | 4,373,770 | 0 | -4,373,770 | 411,790 | 0 | — | -411,790 |