Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2024 ▲▼ | Q1 2025 ▲▼ | Change ▲▼ | Q4 2024 ▲▼ | Q1 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| PROTAGONIST THERAPEUTICS INC | 1,000,000 | 3,000,000 | +2,000,000 | 38,600 | 145,080 | 4.70% | +106,480 |
| INTRA-CELLULAR THERAPIES INC | 2,000,000 | 2,000,000 | 0 | 167,040 | 263,840 | 8.54% | +96,800 |
| AKERO THERAPEUTICS INC | 1,490,000 | 3,210,270 | +1,720,270 | 41,452 | 129,952 | 4.21% | +88,500 |
| TARSUS PHARMACEUTICALS INC(TARS) | 0 | 1,484,266 | +1,484,266 | 0 | 76,247 | 2.47% | +76,247 |
| BRIDGEBIO PHARMA INC(BBIO) | 819,162 | 2,800,000 | +1,980,838 | 22,478 | 96,796 | 3.13% | +74,318 |
| IONIS PHARMACEUTICALS INC(IONS) | 1,933,928 | 4,564,207 | +2,630,279 | 67,610 | 137,702 | 4.46% | +70,092 |
| SAREPTA THERAPEUTICS INC(SRPT) | 0 | 899,731 | +899,731 | 0 | 57,421 | 1.86% | +57,421 |
| GERON CORP(GERN) | 4,011,287 | 38,176,251 | +34,164,964 | 14,200 | 60,700 | 1.97% | +46,500 |
| DIANTHUS THERAPEUTICS INC(DNTH) | 0 | 2,357,702 | +2,357,702 | 0 | 42,769 | 1.38% | +42,769 |
| MAZE THERAPEUTICS INC(MAZE) | 0 | 3,269,126 | +3,269,126 | 0 | 35,993 | 1.17% | +35,993 |
| GUARDANT HEALTH INC(GH) | 6,419,566 | 5,443,721 | -975,845 | 196,118 | 231,903 | 7.51% | +35,785 |
| AMGEN INC(AMGN) | 0 | 113,035 | +113,035 | 0 | 35,216 | 1.14% | +35,216 |
| METSERA INC | 0 | 1,094,408 | +1,094,408 | 0 | 29,790 | 0.96% | +29,790 |
| VAXCYTE INC(PCVX) | 0 | 750,000 | +750,000 | 0 | 28,320 | 0.92% | +28,320 |
| XENON PHARMACEUTICALS INC(XENE) | 169,132 | 1,000,000 | +830,868 | 6,630 | 33,550 | 1.09% | +26,920 |
| IMMUNOCORE HLDGS PLC(IMCR) | 519,376 | 1,411,402 | +892,026 | 15,322 | 41,876 | 1.36% | +26,555 |
| COMPASS PATHWAYS PLC(CMPS) | 0 | 8,859,648 | +8,859,648 | 0 | 25,339 | 0.82% | +25,339 |
| TECTONIC THERAPEUTIC INC | 0 | 1,401,938 | +1,401,938 | 0 | 24,828 | 0.80% | +24,828 |
| GH RESEARCH PLC(GHRS) | 0 | 2,000,000 | +2,000,000 | 0 | 22,060 | 0.71% | +22,060 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 653,513 | 1,350,000 | +696,487 | 27,493 | 48,884 | 1.58% | +21,390 |
| INSMED INC(INSM) | 0 | 254,751 | +254,751 | 0 | 19,435 | 0.63% | +19,435 |
| 89BIO INC | 6,478,249 | 9,316,333 | +2,838,084 | 50,660 | 67,730 | 2.19% | +17,070 |
| SAGE THERAPEUTICS INC | 0 | 2,038,845 | +2,038,845 | 0 | 16,209 | 0.52% | +16,209 |
| IMMUNOVANT INC(IMVT) | 6,000,000 | 9,500,000 | +3,500,000 | 148,620 | 162,355 | 5.26% | +13,735 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 710,421 | 1,400,000 | +689,579 | 18,968 | 30,800 | 1.00% | +11,832 |
| ANI PHARMACEUTICALS INC(ANIP) | 649,042 | 700,000 | +50,958 | 35,879 | 46,865 | 1.52% | +10,986 |
| NURIX THERAPEUTICS INC(NRIX) | 3,000,000 | 5,500,000 | +2,500,000 | 56,520 | 65,340 | 2.12% | +8,820 |
| BEAM THERAPEUTICS INC(BEAM) | 0 | 315,765 | +315,765 | 0 | 6,167 | 0.20% | +6,167 |
| CYTOKINETICS INC(CYTK) | 2,500,000 | 3,073,853 | +573,853 | 117,600 | 123,538 | 4.00% | +5,938 |
| RAPPORT THERAPEUTICS INC(RAPP) | 0 | 457,556 | +457,556 | 0 | 4,589 | 0.15% | +4,589 |
| DYNAVAX TECHNOLOGIES CORP | 17,791,486 | 17,791,486 | 0 | 227,197 | 230,756 | 7.47% | +3,558 |
| IKENA ONCOLOGY INC | 0 | 2,515,513 | +2,515,513 | 0 | 3,220 | 0.10% | +3,220 |
| NEUROGENE INC | 0 | 116,660 | +116,660 | 0 | 1,366 | 0.04% | +1,366 |
| INVIVYD INC | 10,689,603 | 9,722,254 | -967,349 | 4,737 | 5,885 | 0.19% | +1,148 |
| REGULUS THERAPEUTICS INC | 3,262,564 | 3,262,564 | 0 | 5,155 | 5,709 | 0.18% | +555 |
| AVALO THERAPEUTICS INC(AVTX) | 867,000 | 859,876 | -7,124 | 6,442 | 6,888 | 0.22% | +446 |
| ORUKA THERAPEUTICS INC(ORKA) | 750,000 | 1,444,709 | +694,709 | 14,543 | 14,823 | 0.48% | +280 |
| CLIMB BIO INC | 1,040,115 | 1,040,115 | 0 | 1,872 | 1,269 | 0.04% | -603 |
| INOVIO PHARMACEUTICALS INC | 3,119,162 | 3,119,162 | 0 | 5,708 | 5,084 | 0.16% | -624 |
| CASSAVA SCIENCES INC(Put) | 500,000 | 0 | -500,000 | 1,180 | 0 | — | -1,180 |
| SPYRE THERAPEUTICS INC(SYRE) | 219,015 | 219,015 | 0 | 5,099 | 3,534 | 0.11% | -1,565 |
| NEKTAR THERAPEUTICS(NKTR) | 1,975,998 | 0 | -1,975,998 | 1,838 | 0 | — | -1,838 |
| RAPT THERAPEUTICS INC | 6,011,380 | 6,011,380 | 0 | 9,498 | 7,334 | 0.24% | -2,164 |
| ONKURE THERAPEUTICS INC | 523,989 | 523,989 | 0 | 4,506 | 2,253 | 0.07% | -2,253 |
| UPSTREAM BIO INC | 1,000,000 | 2,299,567 | +1,299,567 | 16,440 | 14,073 | 0.46% | -2,367 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 1,540,132 | 2,000,000 | +459,868 | 38,919 | 36,300 | 1.18% | -2,619 |
| GALAPAGOS NV(LKFT) | 780,778 | 741,068 | -39,710 | 21,471 | 18,616 | 0.60% | -2,856 |
| CONTEXT THERAPEUTICS INC | 7,419,355 | 7,419,355 | 0 | 7,790 | 4,541 | 0.15% | -3,250 |
| 4D MOLECULAR THERAPEUTICS IN | 609,900 | 0 | -609,900 | 3,397 | 0 | — | -3,397 |
| CYBIN INC | 1,529,987 | 1,529,987 | 0 | 13,494 | 9,700 | 0.31% | -3,794 |
| ABIVAX SA(ABVX) | 3,579,209 | 3,579,209 | 0 | 26,200 | 22,370 | 0.72% | -3,830 |
| ZURA BIO LTD | 3,283,783 | 3,283,783 | 0 | 8,209 | 4,236 | 0.14% | -3,973 |
| OCULAR THERAPEUTIX INC(OCUL) | 12,836,282 | 14,294,420 | +1,458,138 | 109,622 | 104,778 | 3.39% | -4,844 |
| STRUCTURE THERAPEUTICS INC | 2,800,000 | 4,100,000 | +1,300,000 | 75,936 | 70,971 | 2.30% | -4,965 |
| MIND MEDICINE MINDMED INC | 2,816,594 | 2,500,000 | -316,594 | 19,603 | 14,625 | 0.47% | -4,978 |
| ALLAKOS INC | 5,704,282 | 7,232,701 | +1,528,419 | 6,902 | 1,646 | 0.05% | -5,256 |
| XENCOR INC(XNCR) | 500,000 | 549,439 | +49,439 | 11,490 | 5,846 | 0.19% | -5,644 |
| AUTOLUS THERAPEUTICS PLC | 14,218,903 | 17,849,482 | +3,630,579 | 33,414 | 27,667 | 0.90% | -5,748 |
| ALIGOS THERAPEUTICS INC | 244,110 | 444,110 | +200,000 | 9,725 | 3,664 | 0.12% | -6,061 |
| NOVAVAX INC(NVAX) | 2,000,000 | 1,518,182 | -481,818 | 16,080 | 9,732 | 0.32% | -6,348 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 3,442,833 | 3,442,833 | 0 | 20,072 | 12,945 | 0.42% | -7,127 |
| BICARA THERAPEUTICS INC | 2,000,000 | 2,000,000 | 0 | 34,840 | 26,060 | 0.84% | -8,780 |
| ENGENE HOLDINGS INC COM | 4,557,575 | 4,557,575 | 0 | 30,308 | 20,418 | 0.66% | -9,890 |
| BICYCLE THERAPEUTICS PLC | 1,276,081 | 767,016 | -509,065 | 17,865 | 6,512 | 0.21% | -11,353 |
| NEUMORA THERAPEUTICS INC.(Call) | 1,189,800 | 0 | -1,189,800 | 12,612 | 0 | — | -12,612 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 4,522,741 | 5,380,449 | +857,708 | 86,701 | 72,528 | 2.35% | -14,172 |
| TERNS PHARMACEUTICALS INC | 5,576,558 | 5,576,558 | 0 | 30,894 | 15,391 | 0.50% | -15,503 |
| KORRO BIO INC | 874,614 | 874,614 | 0 | 33,297 | 15,227 | 0.49% | -18,070 |
| CENTESSA PHARMACEUTICALS PLC | 1,350,000 | 0 | -1,350,000 | 22,613 | 0 | — | -22,612 |
| DYNE THERAPEUTICS INC(DYN) | 2,000,000 | 2,000,000 | 0 | 47,120 | 20,920 | 0.68% | -26,200 |
| APELLIS PHARMACEUTICALS INC COM | 4,274,921 | 5,000,000 | +725,079 | 136,413 | 109,350 | 3.54% | -27,063 |
| SEPTERNA INC(SEPN) | 1,912,929 | 1,912,929 | 0 | 43,806 | 11,076 | 0.36% | -32,730 |
| MBX BIOSCIENCES INC(MBX) | 3,018,935 | 3,018,935 | 0 | 55,639 | 22,280 | 0.72% | -33,359 |
| VERONA PHARMA PLC | 850,000 | 0 | -850,000 | 39,474 | 0 | — | -39,474 |
| GENMAB A/S(GMAB) | 2,000,000 | 0 | -2,000,000 | 41,740 | 0 | — | -41,740 |
| NEUMORA THERAPEUTICS INC. | 4,000,000 | 0 | -4,000,000 | 42,400 | 0 | — | -42,400 |
| HARMONY BIOSCIENCES HLDGS IN(HRMY) | 1,450,000 | 0 | -1,450,000 | 49,895 | 0 | — | -49,894 |
| PLIANT THERAPEUTICS INC | 5,972,257 | 5,399,681 | -572,576 | 78,655 | 7,290 | 0.24% | -71,365 |
| SPRINGWORKS THERAPEUTICS INC | 3,460,756 | 0 | -3,460,756 | 125,037 | 0 | — | -125,037 |