Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q1 2025 ▲▼ | Q2 2025 ▲▼ | Change ▲▼ | Q1 2025 ▲▼ | Q2 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Guardant Health, Inc.(GH) | 5,443,721 | 4,250,000 | -1,193,721 | $231.90M | $221.17M | 7.11% | -$10.73M |
| Ionis Pharmaceuticals, Inc.(IONS) | 4,564,207 | 4,891,544 | +327,337 | $137.70M | $193.26M | 6.21% | +$55.56M |
| Protagonist Therapeutics Inc | 3,000,000 | 3,245,899 | +245,899 | $145.08M | $179.40M | 5.77% | +$34.32M |
| Dynavax Technologies Corp | 17,791,486 | 17,791,486 | 0 | $230.76M | $176.49M | 5.67% | -$54.26M |
| Insmed Incorporated(INSM) | 254,751 | 1,750,000 | +1,495,249 | $19.43M | $176.12M | 5.66% | +$156.69M |
| Akero Therapeutics Inc | 3,210,270 | 3,042,598 | -167,672 | $129.95M | $162.35M | 5.22% | +$32.40M |
| Immunovant, Inc.(IMVT) | 9,500,000 | 9,500,000 | 0 | $162.35M | $152.00M | 4.89% | -$10.36M |
| Ocular Therapeutix, Inc.(OCUL) | 14,294,420 | 14,294,420 | 0 | $104.78M | $132.65M | 4.26% | +$27.87M |
| Apellis Pharmaceuticals Inc COM | 5,000,000 | 7,000,000 | +2,000,000 | $109.35M | $121.17M | 3.90% | +$11.82M |
| Cytokinetics, Incorporated(CYTK) | 3,073,853 | 3,650,000 | +576,147 | $123.54M | $120.60M | 3.88% | -$2.94M |
| Structure Therapeutics IncADS | 4,100,000 | 5,133,917 | +1,033,917 | $70.97M | $106.48M | 3.42% | +$35.51M |
| 89bio Inc | 9,316,333 | 9,500,000 | +183,667 | $67.73M | $93.29M | 3.00% | +$25.56M |
| Axsome Therapeutics, Inc.(AXSM) | 0 | 801,371 | +801,371 | $0 | $83.66M | 2.69% | +$83.66M |
| Viridian Therapeutics, Inc.(VRDN) | 5,380,449 | 5,380,449 | 0 | $72.53M | $75.22M | 2.42% | +$2.69M |
| Tarsus Pharmaceuticals, Inc.(TARS) | 1,484,266 | 1,750,000 | +265,734 | $76.25M | $70.89M | 2.28% | -$5.35M |
| Vaxcyte, Inc.(PCVX) | 750,000 | 2,150,000 | +1,400,000 | $28.32M | $69.90M | 2.25% | +$41.58M |
| Nurix Therapeutics, Inc.(NRIX) | 5,500,000 | 6,064,910 | +564,910 | $65.34M | $69.08M | 2.22% | +$3.74M |
| Geron Corporation(GERN) | 38,176,251 | 43,000,000 | +4,823,749 | $60.70M | $60.63M | 1.95% | -$70.2K |
| Immunocore Holdings plcADS(IMCR) | 1,411,402 | 1,800,000 | +388,598 | $41.88M | $56.48M | 1.82% | +$14.61M |
| Ultragenyx Pharmaceutical Inc.(RARE) | 1,350,000 | 1,350,000 | 0 | $48.88M | $49.09M | 1.58% | +$202.5K |
| Maze Therapeutics, Inc.(MAZE) | 3,269,126 | 3,948,910 | +679,784 | $35.99M | $48.45M | 1.56% | +$12.46M |
| ANI Pharmaceuticals, Inc.(ANIP) | 700,000 | 700,000 | 0 | $46.87M | $45.67M | 1.47% | -$1.19M |
| Xenon Pharmaceuticals Inc.(XENE) | 1,000,000 | 1,350,000 | +350,000 | $33.55M | $42.26M | 1.36% | +$8.71M |
| Dianthus Therapeutics, Inc.(DNTH) | 2,357,702 | 2,233,148 | -124,554 | $42.77M | $41.60M | 1.34% | -$1.17M |
| Celldex Therapeutics, Inc.(CLDX) | 2,000,000 | 2,000,000 | 0 | $36.30M | $40.70M | 1.31% | +$4.40M |
| BridgeBio Pharma, Inc.(BBIO) | 2,800,000 | 900,000 | -1,900,000 | $96.80M | $38.86M | 1.25% | -$57.93M |
| Autolus Therapeutics plcADS(AUTL) | 17,849,482 | 16,852,147 | -997,335 | $27.67M | $38.42M | 1.24% | +$10.76M |
| Metsera Inc | 1,094,408 | 1,094,408 | 0 | $29.79M | $31.14M | 1.00% | +$1.35M |
| Terns Pharmaceuticals Inc | 5,576,558 | 7,495,000 | +1,918,442 | $15.39M | $27.96M | 0.90% | +$12.57M |
| Tectonic Therapeutic, Inc.(TECX) | 1,401,938 | 1,401,938 | 0 | $24.83M | $27.86M | 0.90% | +$3.03M |
| ABIVAX Société AnonymeADS(ABVX) | 3,579,209 | 3,480,144 | -99,065 | $22.37M | $26.62M | 0.86% | +$4.25M |
| Jade Biosciences Inc | 0 | 2,509,301 | +2,509,301 | $0 | $25.07M | 0.81% | +$25.07M |
| MBX Biosciences, Inc.(MBX) | 3,018,935 | 2,188,592 | -830,343 | $22.28M | $24.97M | 0.80% | +$2.69M |
| COMPASS Pathways plcADS(CMPS) | 8,859,648 | 8,831,007 | -28,641 | $25.34M | $24.73M | 0.79% | -$611.8K |
| GH Research PLC(GHRS) | 2,000,000 | 2,000,000 | 0 | $22.06M | $24.38M | 0.78% | +$2.32M |
| Bicara Therapeutics Inc | 2,000,000 | 2,426,657 | +426,657 | $26.06M | $22.54M | 0.72% | -$3.52M |
| Oruka Therapeutics, Inc.(ORKA) | 1,444,709 | 1,918,798 | +474,089 | $14.82M | $21.51M | 0.69% | +$6.69M |
| Engene Holdings Inc COM | 4,557,575 | 4,557,575 | 0 | $20.42M | $16.59M | 0.53% | -$3.83M |
| Mind Medicine Mindmed Inc | 2,500,000 | 2,500,000 | 0 | $14.63M | $16.23M | 0.52% | +$1.60M |
| Upstream Bio, Inc.(UPB) | 2,299,567 | 1,442,767 | -856,800 | $14.07M | $15.84M | 0.51% | +$1.77M |
| Olema Pharmaceuticals, Inc.(OLMA) | 3,442,833 | 3,442,833 | 0 | $12.95M | $14.67M | 0.47% | +$1.72M |
| Merus N V | 0 | 275,000 | +275,000 | $0 | $14.46M | 0.47% | +$14.46M |
| Cybin D/B/A Helus Pharma(HELP) | 1,529,987 | 1,529,987 | 0 | $9.70M | $12.84M | 0.41% | +$3.14M |
| Cidara Therapeutics Inc | 0 | 250,000 | +250,000 | $0 | $12.18M | 0.39% | +$12.18M |
| Bicycle Therapeutics PlcADS | 767,016 | 1,203,244 | +436,228 | $6.51M | $8.36M | 0.27% | +$1.85M |
| Crescent Biopharma, Inc.(CBIO) | 0 | 453,686 | +453,686 | $0 | $7.32M | 0.24% | +$7.32M |
| Centessa Pharmaceuticals PlcADS | 0 | 500,000 | +500,000 | $0 | $6.57M | 0.21% | +$6.57M |
| Novavax, Inc.(NVAX) | 1,518,182 | 998,542 | -519,640 | $9.73M | $6.29M | 0.20% | -$3.44M |
| Invivyd, Inc.(IVVD) | 9,722,254 | 8,585,980 | -1,136,274 | $5.88M | $6.14M | 0.20% | +$254.1K |
| Rapt Therapeutics Inc | 0 | 751,422 | +751,422 | $0 | $6.01M | 0.19% | +$6.01M |
| Context Therapeutics Inc.(CNTX) | 7,419,355 | 7,419,355 | 0 | $4.54M | $4.86M | 0.16% | +$320.5K |
| Pliant Therapeutics, Inc.(PLRX) | 5,399,681 | 3,947,807 | -1,451,874 | $7.29M | $4.58M | 0.15% | -$2.71M |
| Sarepta Therapeutics, Inc.(SRPT) | 899,731 | 259,800 | -639,931 | $57.42M | $4.44M | 0.14% | -$52.98M |
| Xencor, Inc.(XNCR) | 549,439 | 549,439 | 0 | $5.85M | $4.32M | 0.14% | -$1.53M |
| Inovio Pharmaceuticals, Inc.(INO) | 3,119,162 | 1,981,370 | -1,137,792 | $5.08M | $4.03M | 0.13% | -$1.05M |
| Korro Bio, Inc.(KRRO) | 874,614 | 277,966 | -596,648 | $15.23M | $3.47M | 0.11% | -$11.76M |
| Ikena Oncology Inc | 2,515,513 | 2,515,513 | 0 | $3.22M | $3.37M | 0.11% | +$150.9K |
| Spyre Therapeutics, Inc.(SYRE) | 219,015 | 219,015 | 0 | $3.53M | $3.28M | 0.11% | -$255.2K |
| Aligos Therapeutics, Inc.(ALGS) | 444,110 | 444,110 | 0 | $3.66M | $3.20M | 0.10% | -$461.9K |
| Avalo Therapeutics, Inc.(AVTX) | 859,876 | 567,103 | -292,773 | $6.89M | $2.83M | 0.09% | -$4.06M |
| Zura Bio LimitedCL A(ZURA) | 3,283,783 | 1,727,562 | -1,556,221 | $4.24M | $1.81M | 0.06% | -$2.42M |
| Climb Bio, Inc.(CLYM) | 1,040,115 | 1,040,115 | 0 | $1.27M | $1.29M | 0.04% | +$20.8K |
| Septerna, Inc.(SEPN) | 1,912,929 | 121,716 | -1,791,213 | $11.08M | $1.29M | 0.04% | -$9.79M |
| Rapport Therapeutics, Inc.(RAPP) | 457,556 | 98,237 | -359,319 | $4.59M | $1.12M | 0.04% | -$3.47M |
| OnKure Therapeutics, Inc.CL A(OKUR) | 523,989 | 180,510 | -343,479 | $2.25M | $431.4K | 0.01% | -$1.82M |
| Allakos Inc | 7,232,701 | 0 | -7,232,701 | $1.65M | $0 | — | -$1.65M |
| Amgen Inc.(AMGN) | 113,035 | 0 | -113,035 | $35.22M | $0 | — | -$35.22M |
| Beam Therapeutics Inc.(BEAM) | 315,765 | 0 | -315,765 | $6.17M | $0 | — | -$6.17M |
| Dyne Therapeutics, Inc.(DYN) | 2,000,000 | 0 | -2,000,000 | $20.92M | $0 | — | -$20.92M |
| Edgewise Therapeutics, Inc.(EWTX) | 1,400,000 | 0 | -1,400,000 | $30.80M | $0 | — | -$30.80M |
| Lakefront Biotherapeutics NVADR(LKFT) | 741,068 | 0 | -741,068 | $18.62M | $0 | — | -$18.62M |
| Intra-Cellular Therapies Inc | 2,000,000 | 0 | -2,000,000 | $263.84M | $0 | — | -$263.84M |
| Neurogene Inc.(NGNE) | 116,660 | 0 | -116,660 | $1.37M | $0 | — | -$1.37M |
| Rapt Therapeutics Inc | 6,011,380 | 0 | -6,011,380 | $7.33M | $0 | — | -$7.33M |
| Regulus Therapeutics Inc | 3,262,564 | 0 | -3,262,564 | $5.71M | $0 | — | -$5.71M |
| Sage Therapeutics Inc | 2,038,845 | 0 | -2,038,845 | $16.21M | $0 | — | -$16.21M |