Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q2 2025 ▲▼ | Q3 2025 ▲▼ | Change ▲▼ | Q2 2025 ▲▼ | Q3 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Guardant Health, Inc.(GH) | 4,250,000 | 4,154,086 | -95,914 | $221.17M | $259.55M | 7.24% | +$38.38M |
| Ionis Pharmaceuticals, Inc.(IONS) | 4,891,544 | 3,808,144 | -1,083,400 | $193.26M | $249.13M | 6.95% | +$55.86M |
| Cytokinetics, Incorporated(CYTK) | 3,650,000 | 4,300,000 | +650,000 | $120.60M | $236.33M | 6.60% | +$115.73M |
| Akero Therapeutics Inc | 3,042,598 | 4,000,978 | +958,380 | $162.35M | $189.97M | 5.30% | +$27.61M |
| Apellis Pharmaceuticals Inc COM | 7,000,000 | 8,000,382 | +1,000,382 | $121.17M | $181.05M | 5.05% | +$59.88M |
| Tarsus Pharmaceuticals, Inc.(TARS) | 1,750,000 | 3,000,000 | +1,250,000 | $70.89M | $178.29M | 4.98% | +$107.40M |
| Immunovant, Inc.(IMVT) | 9,500,000 | 9,728,845 | +228,845 | $152.00M | $156.83M | 4.38% | +$4.83M |
| Dynavax Technologies Corp | 17,791,486 | 15,726,349 | -2,065,137 | $176.49M | $156.16M | 4.36% | -$20.33M |
| Ocular Therapeutix, Inc.(OCUL) | 14,294,420 | 11,932,137 | -2,362,283 | $132.65M | $139.49M | 3.89% | +$6.83M |
| 89bio Inc | 9,500,000 | 9,356,171 | -143,829 | $93.29M | $137.54M | 3.84% | +$44.25M |
| Structure Therapeutics IncADS | 5,133,917 | 4,215,811 | -918,106 | $106.48M | $118.04M | 3.29% | +$11.57M |
| Viridian Therapeutics, Inc.(VRDN) | 5,380,449 | 5,380,449 | 0 | $75.22M | $116.11M | 3.24% | +$40.89M |
| Protagonist Therapeutics Inc | 3,245,899 | 1,715,691 | -1,530,208 | $179.40M | $113.97M | 3.18% | -$65.43M |
| Axsome Therapeutics, Inc.(AXSM) | 801,371 | 900,000 | +98,629 | $83.66M | $109.31M | 3.05% | +$25.65M |
| Vaxcyte, Inc.(PCVX) | 2,150,000 | 3,000,000 | +850,000 | $69.90M | $108.06M | 3.02% | +$38.16M |
| Maze Therapeutics, Inc.(MAZE) | 3,948,910 | 3,948,910 | 0 | $48.45M | $102.40M | 2.86% | +$53.94M |
| Immunocore Holdings plcADS(IMCR) | 1,800,000 | 1,800,000 | 0 | $56.48M | $65.39M | 1.82% | +$8.91M |
| BridgeBio Pharma, Inc.(BBIO) | 900,000 | 1,200,000 | +300,000 | $38.86M | $62.33M | 1.74% | +$23.47M |
| Geron Corporation(GERN) | 43,000,000 | 41,096,522 | -1,903,478 | $60.63M | $56.30M | 1.57% | -$4.33M |
| Terns Pharmaceuticals Inc | 7,495,000 | 7,495,000 | 0 | $27.96M | $56.29M | 1.57% | +$28.33M |
| Nurix Therapeutics, Inc.(NRIX) | 6,064,910 | 6,057,024 | -7,886 | $69.08M | $55.97M | 1.56% | -$13.11M |
| MBX Biosciences, Inc.(MBX) | 2,188,592 | 3,150,000 | +961,408 | $24.97M | $55.13M | 1.54% | +$30.15M |
| Endeavour Silver Corp.(EXK) | 0 | 1,000,000 | +1,000,000 | $0 | $54.71M | 1.53% | +$54.71M |
| LB Pharmaceuticals Inc(LBRX) | 0 | 3,352,804 | +3,352,804 | $0 | $52.94M | 1.48% | +$52.94M |
| Celldex Therapeutics, Inc.(CLDX) | 2,000,000 | 2,000,000 | 0 | $40.70M | $51.74M | 1.44% | +$11.04M |
| Oruka Therapeutics, Inc.(ORKA) | 1,918,798 | 2,654,781 | +735,983 | $21.51M | $51.05M | 1.42% | +$29.54M |
| Xenon Pharmaceuticals Inc.(XENE) | 1,350,000 | 1,200,000 | -150,000 | $42.26M | $48.18M | 1.34% | +$5.92M |
| COMPASS Pathways plcADS(CMPS) | 8,831,007 | 7,859,648 | -971,359 | $24.73M | $45.04M | 1.26% | +$20.31M |
| ANI Pharmaceuticals, Inc.(ANIP) | 700,000 | 450,000 | -250,000 | $45.67M | $41.22M | 1.15% | -$4.46M |
| Bicara Therapeutics Inc | 2,426,657 | 2,426,657 | 0 | $22.54M | $38.32M | 1.07% | +$15.77M |
| Olema Pharmaceuticals, Inc.(OLMA) | 3,442,833 | 3,470,172 | +27,339 | $14.67M | $33.97M | 0.95% | +$19.31M |
| Cidara Therapeutics Inc | 250,000 | 300,000 | +50,000 | $12.18M | $28.73M | 0.80% | +$16.55M |
| uniQure N.V.SHS(QURE) | 0 | 483,092 | +483,092 | $0 | $28.20M | 0.79% | +$28.20M |
| Dyne Therapeutics, Inc.(DYN) | 0 | 2,000,000 | +2,000,000 | $0 | $25.30M | 0.71% | +$25.30M |
| Jade Biosciences Inc | 2,509,301 | 2,279,892 | -229,409 | $25.07M | $19.68M | 0.55% | -$5.39M |
| Rapt Therapeutics Inc | 751,422 | 751,422 | 0 | $6.01M | $19.38M | 0.54% | +$13.37M |
| GH Research PLC(GHRS) | 2,000,000 | 1,250,000 | -750,000 | $24.38M | $17.88M | 0.50% | -$6.50M |
| Mind Medicine Mindmed Inc | 2,500,000 | 1,500,000 | -1,000,000 | $16.23M | $17.68M | 0.49% | +$1.46M |
| Engene Holdings Inc COM | 4,557,575 | 2,239,353 | -2,318,222 | $16.59M | $15.29M | 0.43% | -$1.29M |
| Genmab A/SADS(GMAB) | 0 | 481,267 | +481,267 | $0 | $14.76M | 0.41% | +$14.76M |
| Tango Therapeutics, Inc.(TNGX) | 0 | 1,454,562 | +1,454,562 | $0 | $12.22M | 0.34% | +$12.22M |
| Context Therapeutics Inc.(CNTX) | 7,419,355 | 7,419,355 | 0 | $4.86M | $7.19M | 0.20% | +$2.33M |
| ImageneBio, Inc.(IMA) | 0 | 878,516 | +878,516 | $0 | $7.16M | 0.20% | +$7.16M |
| Xencor, Inc.(XNCR) | 549,439 | 549,439 | 0 | $4.32M | $6.44M | 0.18% | +$2.13M |
| Cybin D/B/A Helus Pharma(HELP) | 1,529,987 | 1,000,000 | -529,987 | $12.84M | $5.89M | 0.16% | -$6.95M |
| CorMedix Inc.(CRMD) | 0 | 500,000 | +500,000 | $0 | $5.82M | 0.16% | +$5.82M |
| PepGen Inc.(PEPG) | 0 | 1,200,000 | +1,200,000 | $0 | $5.54M | 0.15% | +$5.54M |
| Crescent Biopharma, Inc.(CBIO) | 453,686 | 453,686 | 0 | $7.32M | $5.39M | 0.15% | -$1.93M |
| Aligos Therapeutics, Inc.(ALGS) | 444,110 | 444,110 | 0 | $3.20M | $4.35M | 0.12% | +$1.15M |
| Autolus Therapeutics plcADS(AUTL) | 16,852,147 | 2,568,613 | -14,283,534 | $38.42M | $4.19M | 0.12% | -$34.24M |
| X4 Pharmaceuticals, Inc.(XFOR) | 0 | 1,122,484 | +1,122,484 | $0 | $3.84M | 0.11% | +$3.84M |
| Acadia Pharmaceuticals Inc | 0 | 105,085 | +105,085 | $0 | $2.24M | 0.06% | +$2.24M |
| Avalo Therapeutics, Inc.(AVTX) | 567,103 | 144,600 | -422,503 | $2.83M | $1.84M | 0.05% | -$992.0K |
| BioMarin Pharmaceutical Inc.(BMRN) | 0 | 24,856 | +24,856 | $0 | $1.35M | 0.04% | +$1.35M |
| Zura Bio LimitedCL A(ZURA) | 1,727,562 | 259,014 | -1,468,548 | $1.81M | $1.12M | 0.03% | -$692.4K |
| Climb Bio, Inc.(CLYM) | 1,040,115 | 509,789 | -530,326 | $1.29M | $1.02M | 0.03% | -$265.1K |
| ABIVAX Société AnonymeADS(ABVX) | 3,480,144 | 0 | -3,480,144 | $26.62M | $0 | — | -$26.62M |
| Bicycle Therapeutics PlcADS | 1,203,244 | 0 | -1,203,244 | $8.36M | $0 | — | -$8.36M |
| Centessa Pharmaceuticals PlcADS | 500,000 | 0 | -500,000 | $6.57M | $0 | — | -$6.57M |
| Dianthus Therapeutics, Inc.(DNTH) | 2,233,148 | 0 | -2,233,148 | $41.60M | $0 | — | -$41.60M |
| Ikena Oncology Inc | 2,515,513 | 0 | -2,515,513 | $3.37M | $0 | — | -$3.37M |
| Inovio Pharmaceuticals, Inc.(INO) | 1,981,370 | 0 | -1,981,370 | $4.03M | $0 | — | -$4.03M |
| Insmed Incorporated(INSM) | 1,750,000 | 0 | -1,750,000 | $176.12M | $0 | — | -$176.12M |
| Invivyd, Inc.(IVVD) | 8,585,980 | 0 | -8,585,980 | $6.14M | $0 | — | -$6.14M |
| Korro Bio, Inc.(KRRO) | 277,966 | 0 | -277,966 | $3.47M | $0 | — | -$3.47M |
| Merus N V | 275,000 | 0 | -275,000 | $14.46M | $0 | — | -$14.46M |
| Metsera Inc | 1,094,408 | 0 | -1,094,408 | $31.14M | $0 | — | -$31.14M |
| Novavax, Inc.(NVAX) | 998,542 | 0 | -998,542 | $6.29M | $0 | — | -$6.29M |
| OnKure Therapeutics, Inc.CL A(OKUR) | 180,510 | 0 | -180,510 | $431.4K | $0 | — | -$431.4K |
| Pliant Therapeutics, Inc.(PLRX) | 3,947,807 | 0 | -3,947,807 | $4.58M | $0 | — | -$4.58M |
| Rapport Therapeutics, Inc.(RAPP) | 98,237 | 0 | -98,237 | $1.12M | $0 | — | -$1.12M |
| Sarepta Therapeutics, Inc.(SRPT) | 259,800 | 0 | -259,800 | $4.44M | $0 | — | -$4.44M |
| Septerna, Inc.(SEPN) | 121,716 | 0 | -121,716 | $1.29M | $0 | — | -$1.29M |
| Spyre Therapeutics, Inc.(SYRE) | 219,015 | 0 | -219,015 | $3.28M | $0 | — | -$3.28M |
| Tectonic Therapeutic, Inc.(TECX) | 1,401,938 | 0 | -1,401,938 | $27.86M | $0 | — | -$27.86M |
| Ultragenyx Pharmaceutical Inc.(RARE) | 1,350,000 | 0 | -1,350,000 | $49.09M | $0 | — | -$49.09M |
| Upstream Bio, Inc.(UPB) | 1,442,767 | 0 | -1,442,767 | $15.84M | $0 | — | -$15.84M |