Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q2 2025 ▲▼ | Q3 2025 ▲▼ | Change ▲▼ | Q2 2025 ▲▼ | Q3 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| CYTOKINETICS INC(CYTK) | 3,650,000 | 4,300,000 | +650,000 | 120,596 | 236,328 | 6.60% | +115,732 |
| TARSUS PHARMACEUTICALS INC(TARS) | 1,750,000 | 3,000,000 | +1,250,000 | 70,893 | 178,290 | 4.98% | +107,398 |
| APELLIS PHARMACEUTICALS INC COM | 7,000,000 | 8,000,382 | +1,000,382 | 121,170 | 181,049 | 5.05% | +59,879 |
| IONIS PHARMACEUTICALS INC(IONS) | 4,891,544 | 3,808,144 | -1,083,400 | 193,265 | 249,129 | 6.95% | +55,864 |
| EXACT SCIENCES CORP(EXK) | 0 | 1,000,000 | +1,000,000 | 0 | 54,710 | 1.53% | +54,710 |
| MAZE THERAPEUTICS INC(MAZE) | 3,948,910 | 3,948,910 | 0 | 48,453 | 102,395 | 2.86% | +53,942 |
| LB PHARMACEUTICALS INC(LBRX) | 0 | 3,352,804 | +3,352,804 | 0 | 52,941 | 1.48% | +52,941 |
| 89BIO INC | 9,500,000 | 9,356,171 | -143,829 | 93,290 | 137,536 | 3.84% | +44,246 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 5,380,449 | 5,380,449 | 0 | 75,219 | 116,110 | 3.24% | +40,891 |
| GUARDANT HEALTH INC(GH) | 4,250,000 | 4,154,086 | -95,914 | 221,170 | 259,547 | 7.24% | +38,377 |
| VAXCYTE INC(PCVX) | 2,150,000 | 3,000,000 | +850,000 | 69,897 | 108,060 | 3.02% | +38,164 |
| MBX BIOSCIENCES INC(MBX) | 2,188,592 | 3,150,000 | +961,408 | 24,972 | 55,125 | 1.54% | +30,153 |
| ORUKA THERAPEUTICS INC(ORKA) | 1,918,798 | 2,654,781 | +735,983 | 21,510 | 51,051 | 1.42% | +29,542 |
| TERNS PHARMACEUTICALS INC | 7,495,000 | 7,495,000 | 0 | 27,956 | 56,287 | 1.57% | +28,331 |
| UNIQURE NV(QURE) | 0 | 483,092 | +483,092 | 0 | 28,198 | 0.79% | +28,198 |
| AKERO THERAPEUTICS INC | 3,042,598 | 4,000,978 | +958,380 | 162,353 | 189,966 | 5.30% | +27,613 |
| AXSOME THERAPEUTICS INC(AXSM) | 801,371 | 900,000 | +98,629 | 83,655 | 109,305 | 3.05% | +25,650 |
| DYNE THERAPEUTICS INC(DYN) | 0 | 2,000,000 | +2,000,000 | 0 | 25,300 | 0.71% | +25,300 |
| BRIDGEBIO PHARMA INC(BBIO) | 900,000 | 1,200,000 | +300,000 | 38,862 | 62,328 | 1.74% | +23,466 |
| COMPASS PATHWAYS PLC(CMPS) | 8,831,007 | 7,859,648 | -971,359 | 24,727 | 45,036 | 1.26% | +20,309 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 3,442,833 | 3,470,172 | +27,339 | 14,666 | 33,973 | 0.95% | +19,307 |
| CIDARA THERAPEUTICS INC | 250,000 | 300,000 | +50,000 | 12,178 | 28,728 | 0.80% | +16,551 |
| BICARA THERAPEUTICS INC | 2,426,657 | 2,426,657 | 0 | 22,544 | 38,317 | 1.07% | +15,773 |
| GENMAB A/S(GMAB) | 0 | 481,267 | +481,267 | 0 | 14,760 | 0.41% | +14,760 |
| RAPT THERAPEUTICS INC | 751,422 | 751,422 | 0 | 6,011 | 19,379 | 0.54% | +13,368 |
| TANGO THERAPEUTICS INC(TNGX) | 0 | 1,454,562 | +1,454,562 | 0 | 12,218 | 0.34% | +12,218 |
| STRUCTURE THERAPEUTICS INC | 5,133,917 | 4,215,811 | -918,106 | 106,477 | 118,043 | 3.29% | +11,565 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 2,000,000 | 2,000,000 | 0 | 40,700 | 51,740 | 1.44% | +11,040 |
| IMMUNOCORE HLDGS PLC(IMCR) | 1,800,000 | 1,800,000 | 0 | 56,484 | 65,394 | 1.82% | +8,910 |
| IMAGENEBIO INC(IMA) | 0 | 878,516 | +878,516 | 0 | 7,160 | 0.20% | +7,160 |
| OCULAR THERAPEUTIX INC(OCUL) | 14,294,420 | 11,932,137 | -2,362,283 | 132,652 | 139,487 | 3.89% | +6,834 |
| XENON PHARMACEUTICALS INC(XENE) | 1,350,000 | 1,200,000 | -150,000 | 42,255 | 48,180 | 1.34% | +5,925 |
| CORMEDIX INC(CRMD) | 0 | 500,000 | +500,000 | 0 | 5,815 | 0.16% | +5,815 |
| PEPGEN INC(PEPG) | 0 | 1,200,000 | +1,200,000 | 0 | 5,544 | 0.15% | +5,544 |
| IMMUNOVANT INC(IMVT) | 9,500,000 | 9,728,845 | +228,845 | 152,000 | 156,829 | 4.38% | +4,829 |
| X4 PHARMACEUTICALS INC(XFOR) | 0 | 1,122,484 | +1,122,484 | 0 | 3,839 | 0.11% | +3,839 |
| CONTEXT THERAPEUTICS INC(CNTX) | 7,419,355 | 7,419,355 | 0 | 4,861 | 7,188 | 0.20% | +2,327 |
| ACADIA PHARMACEUTICALS INC | 0 | 105,085 | +105,085 | 0 | 2,243 | 0.06% | +2,243 |
| XENCOR INC(XNCR) | 549,439 | 549,439 | 0 | 4,319 | 6,445 | 0.18% | +2,126 |
| MIND MEDICINE MINDMED INC | 2,500,000 | 1,500,000 | -1,000,000 | 16,225 | 17,685 | 0.49% | +1,460 |
| BIOMARIN PHARMACEUTICAL INC(BMRN) | 0 | 24,856 | +24,856 | 0 | 1,346 | 0.04% | +1,346 |
| ALIGOS THERAPEUTICS INC(ALGS) | 444,110 | 444,110 | 0 | 3,202 | 4,352 | 0.12% | +1,150 |
| CLIMB BIO INC(CLYM) | 1,040,115 | 509,789 | -530,326 | 1,290 | 1,025 | 0.03% | -265 |
| ONKURE THERAPEUTICS INC(OKUR) | 180,510 | 0 | -180,510 | 431 | 0 | — | -431 |
| ZURA BIO LTD(ZURA) | 1,727,562 | 259,014 | -1,468,548 | 1,814 | 1,122 | 0.03% | -692 |
| AVALO THERAPEUTICS INC(AVTX) | 567,103 | 144,600 | -422,503 | 2,830 | 1,838 | 0.05% | -992 |
| RAPPORT THERAPEUTICS INC(RAPP) | 98,237 | 0 | -98,237 | 1,117 | 0 | — | -1,117 |
| SEPTERNA INC(SEPN) | 121,716 | 0 | -121,716 | 1,287 | 0 | — | -1,287 |
| ENGENE HOLDINGS INC COM | 4,557,575 | 2,239,353 | -2,318,222 | 16,590 | 15,295 | 0.43% | -1,295 |
| CRESCENT BIOPHARMA INC.(CBIO) | 453,686 | 453,686 | 0 | 7,322 | 5,394 | 0.15% | -1,928 |
| SPYRE THERAPEUTICS INC(SYRE) | 219,015 | 0 | -219,015 | 3,279 | 0 | — | -3,279 |
| IKENA ONCOLOGY INC | 2,515,513 | 0 | -2,515,513 | 3,371 | 0 | — | -3,371 |
| KORRO BIO INC(KRRO) | 277,966 | 0 | -277,966 | 3,472 | 0 | — | -3,472 |
| INOVIO PHARMACEUTICALS INC(INO) | 1,981,370 | 0 | -1,981,370 | 4,032 | 0 | — | -4,032 |
| GERON CORP(GERN) | 43,000,000 | 41,096,522 | -1,903,478 | 60,630 | 56,302 | 1.57% | -4,328 |
| SAREPTA THERAPEUTICS INC(SRPT) | 259,800 | 0 | -259,800 | 4,443 | 0 | — | -4,443 |
| ANI PHARMACEUTICALS INC(ANIP) | 700,000 | 450,000 | -250,000 | 45,675 | 41,220 | 1.15% | -4,455 |
| PLIANT THERAPEUTICS INC(PLRX) | 3,947,807 | 0 | -3,947,807 | 4,579 | 0 | — | -4,579 |
| JADE BIOSCIENCES INC | 2,509,301 | 2,279,892 | -229,409 | 25,068 | 19,675 | 0.55% | -5,392 |
| INVIVYD INC(IVVD) | 8,585,980 | 0 | -8,585,980 | 6,139 | 0 | — | -6,139 |
| NOVAVAX INC(NVAX) | 998,542 | 0 | -998,542 | 6,291 | 0 | — | -6,291 |
| GH RESEARCH PLC(GHRS) | 2,000,000 | 1,250,000 | -750,000 | 24,380 | 17,875 | 0.50% | -6,505 |
| CENTESSA PHARMACEUTICALS PLC | 500,000 | 0 | -500,000 | 6,570 | 0 | — | -6,570 |
| CYBIN INC(HELP) | 1,529,987 | 1,000,000 | -529,987 | 12,837 | 5,890 | 0.16% | -6,947 |
| BICYCLE THERAPEUTICS PLC | 1,203,244 | 0 | -1,203,244 | 8,363 | 0 | — | -8,363 |
| NURIX THERAPEUTICS INC(NRIX) | 6,064,910 | 6,057,024 | -7,886 | 69,079 | 55,967 | 1.56% | -13,112 |
| MERUS N V | 275,000 | 0 | -275,000 | 14,465 | 0 | — | -14,465 |
| UPSTREAM BIO INC(UPB) | 1,442,767 | 0 | -1,442,767 | 15,842 | 0 | — | -15,842 |
| DYNAVAX TECHNOLOGIES CORP | 17,791,486 | 15,726,349 | -2,065,137 | 176,492 | 156,163 | 4.36% | -20,329 |
| ABIVAX SA(ABVX) | 3,480,144 | 0 | -3,480,144 | 26,623 | 0 | — | -26,623 |
| TECTONIC THERAPEUTIC INC(TECX) | 1,401,938 | 0 | -1,401,938 | 27,857 | 0 | — | -27,857 |
| METSERA INC | 1,094,408 | 0 | -1,094,408 | 31,136 | 0 | — | -31,136 |
| AUTOLUS THERAPEUTICS PLC(AUTL) | 16,852,147 | 2,568,613 | -14,283,534 | 38,423 | 4,187 | 0.12% | -34,236 |
| DIANTHUS THERAPEUTICS INC(DNTH) | 2,233,148 | 0 | -2,233,148 | 41,604 | 0 | — | -41,604 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 1,350,000 | 0 | -1,350,000 | 49,086 | 0 | — | -49,086 |
| PROTAGONIST THERAPEUTICS INC | 3,245,899 | 1,715,691 | -1,530,208 | 179,401 | 113,973 | 3.18% | -65,427 |
| INSMED INC(INSM) | 1,750,000 | 0 | -1,750,000 | 176,120 | 0 | — | -176,120 |