Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2024 ▲▼ | Q4 2024 ▲▼ | Change ▲▼ | Q3 2024 ▲▼ | Q4 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| DYNAVAX TECHNOLOGIES CORP | 12,526,486 | 17,791,486 | +5,265,000 | 139,545 | 227,197 | 8.52% | +87,652 |
| CYTOKINETICS INC(CYTK) | 629,906 | 2,500,000 | +1,870,094 | 33,259 | 117,600 | 4.41% | +84,341 |
| GUARDANT HEALTH INC(GH) | 6,000,560 | 6,419,566 | +419,006 | 137,653 | 196,118 | 7.35% | +58,465 |
| INTRA-CELLULAR THERAPIES INC | 1,600,693 | 2,000,000 | +399,307 | 117,123 | 167,040 | 6.26% | +49,917 |
| HARMONY BIOSCIENCES HLDGS IN(HRMY) | 0 | 1,450,000 | +1,450,000 | 0 | 49,895 | 1.87% | +49,895 |
| SEPTERNA INC(SEPN) | 0 | 1,912,929 | +1,912,929 | 0 | 43,806 | 1.64% | +43,806 |
| GENMAB A/S(GMAB) | 0 | 2,000,000 | +2,000,000 | 0 | 41,740 | 1.56% | +41,740 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 0 | 1,540,132 | +1,540,132 | 0 | 38,919 | 1.46% | +38,919 |
| PROTAGONIST THERAPEUTICS INC | 0 | 1,000,000 | +1,000,000 | 0 | 38,600 | 1.45% | +38,600 |
| NEUMORA THERAPEUTICS INC. | 567,428 | 4,000,000 | +3,432,572 | 7,496 | 42,400 | 1.59% | +34,904 |
| 89BIO INC | 2,766,512 | 6,478,249 | +3,711,737 | 20,472 | 50,660 | 1.90% | +30,188 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 0 | 653,513 | +653,513 | 0 | 27,493 | 1.03% | +27,493 |
| IMMUNOVANT INC(IMVT) | 4,347,464 | 6,000,000 | +1,652,536 | 123,946 | 148,620 | 5.57% | +24,674 |
| BRIDGEBIO PHARMA INC(BBIO) | 0 | 819,162 | +819,162 | 0 | 22,478 | 0.84% | +22,478 |
| STRUCTURE THERAPEUTICS INC | 1,220,508 | 2,800,000 | +1,579,492 | 53,568 | 75,936 | 2.85% | +22,368 |
| AKERO THERAPEUTICS INC | 689,784 | 1,490,000 | +800,216 | 19,790 | 41,452 | 1.55% | +21,662 |
| GALAPAGOS NV(LKFT) | 0 | 780,778 | +780,778 | 0 | 21,471 | 0.81% | +21,471 |
| UPSTREAM BIO INC | 0 | 1,000,000 | +1,000,000 | 0 | 16,440 | 0.62% | +16,440 |
| NOVAVAX INC(NVAX) | 0 | 2,000,000 | +2,000,000 | 0 | 16,080 | 0.60% | +16,080 |
| IMMUNOCORE HLDGS PLC(IMCR) | 0 | 519,376 | +519,376 | 0 | 15,322 | 0.57% | +15,322 |
| BICARA THERAPEUTICS INC | 796,852 | 2,000,000 | +1,203,148 | 20,296 | 34,840 | 1.31% | +14,544 |
| ENGENE HOLDINGS INC COM | 2,607,633 | 4,557,575 | +1,949,942 | 17,210 | 30,308 | 1.14% | +13,097 |
| PLIANT THERAPEUTICS INC | 5,972,257 | 5,972,257 | 0 | 66,949 | 78,655 | 2.95% | +11,706 |
| NEUMORA THERAPEUTICS INC.(Call) | 180,500 | 1,189,800 | +1,009,300 | 2,384 | 12,612 | — | +10,227 |
| RAPT THERAPEUTICS INC | 0 | 6,011,380 | +6,011,380 | 0 | 9,498 | 0.36% | +9,498 |
| APELLIS PHARMACEUTICALS INC COM | 4,400,654 | 4,274,921 | -125,733 | 126,915 | 136,413 | 5.11% | +9,498 |
| ALIGOS THERAPEUTICS INC | 244,110 | 244,110 | 0 | 2,114 | 9,725 | 0.36% | +7,611 |
| XENON PHARMACEUTICALS INC(XENE) | 0 | 169,132 | +169,132 | 0 | 6,630 | 0.25% | +6,630 |
| ANI PHARMACEUTICALS INC(ANIP) | 504,828 | 649,042 | +144,214 | 30,118 | 35,879 | 1.35% | +5,761 |
| KORRO BIO INC | 850,000 | 874,614 | +24,614 | 28,407 | 33,297 | 1.25% | +4,890 |
| ONKURE THERAPEUTICS INC | 0 | 523,989 | +523,989 | 0 | 4,506 | 0.17% | +4,506 |
| ALLAKOS INC | 5,000,000 | 5,704,282 | +704,282 | 3,266 | 6,902 | 0.26% | +3,636 |
| SPRINGWORKS THERAPEUTICS INC | 3,843,900 | 3,460,756 | -383,144 | 123,159 | 125,037 | 4.69% | +1,879 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 3,750,945 | 4,522,741 | +771,796 | 85,334 | 86,701 | 3.25% | +1,367 |
| CASSAVA SCIENCES INC(Put) | 0 | 500,000 | +500,000 | 0 | 1,180 | — | +1,180 |
| CENTESSA PHARMACEUTICALS PLC | 1,350,000 | 1,350,000 | 0 | 21,587 | 22,613 | 0.85% | +1,026 |
| REGULUS THERAPEUTICS INC | 3,262,564 | 3,262,564 | 0 | 5,122 | 5,155 | 0.19% | +33 |
| CYBIN INC | 1,529,987 | 1,529,987 | 0 | 13,602 | 13,494 | 0.51% | -107 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 48,100 | 0 | -48,100 | 385 | 0 | — | -385 |
| METAGENOMI INC | 307,500 | 0 | -307,500 | 667 | 0 | — | -667 |
| OCULAR THERAPEUTIX INC(OCUL) | 12,721,460 | 12,836,282 | +114,822 | 110,677 | 109,622 | 4.11% | -1,055 |
| SYROS PHARMACEUTICALS INC | 828,485 | 0 | -828,485 | 1,781 | 0 | — | -1,781 |
| RELMADA THERAPEUTICS INC | 674,833 | 0 | -674,833 | 2,186 | 0 | — | -2,186 |
| PROTHENA CORP PLC SHS | 140,000 | 0 | -140,000 | 2,342 | 0 | — | -2,342 |
| ALTO NEUROSCIENCE INC(ANRO) | 219,648 | 0 | -219,648 | 2,513 | 0 | — | -2,513 |
| AVALO THERAPEUTICS INC(AVTX) | 967,000 | 867,000 | -100,000 | 9,187 | 6,442 | 0.24% | -2,745 |
| XENCOR INC(XNCR) | 800,000 | 500,000 | -300,000 | 16,088 | 11,490 | 0.43% | -4,598 |
| INOVIO PHARMACEUTICALS INC | 1,804,366 | 3,119,162 | +1,314,796 | 10,429 | 5,708 | 0.21% | -4,721 |
| ZURA BIO LTD | 3,283,783 | 3,283,783 | 0 | 13,332 | 8,209 | 0.31% | -5,123 |
| VIGIL NEUROSCIENCE INC | 1,553,996 | 0 | -1,553,996 | 5,284 | 0 | — | -5,284 |
| INVIVYD INC | 10,953,937 | 10,689,603 | -264,334 | 11,173 | 4,737 | 0.18% | -6,436 |
| CONTEXT THERAPEUTICS INC | 7,419,355 | 7,419,355 | 0 | 14,542 | 7,790 | 0.29% | -6,752 |
| TRAVERE THERAPEUTICS INC(TVTX) | 531,857 | 0 | -531,857 | 7,441 | 0 | — | -7,441 |
| CLIMB BIO INC | 2,169,143 | 1,040,115 | -1,129,028 | 11,041 | 1,872 | 0.07% | -9,169 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 1,100,536 | 710,421 | -390,115 | 29,373 | 18,968 | 0.71% | -10,405 |
| ABIVAX SA(ABVX) | 3,579,209 | 3,579,209 | 0 | 41,232 | 26,200 | 0.98% | -15,033 |
| PYXIS ONCOLOGY INC | 4,184,100 | 0 | -4,184,100 | 15,356 | 0 | — | -15,356 |
| TERNS PHARMACEUTICALS INC | 5,576,558 | 5,576,558 | 0 | 46,508 | 30,894 | 1.16% | -15,614 |
| ORUKA THERAPEUTICS INC(ORKA) | 1,235,187 | 750,000 | -485,187 | 30,274 | 14,543 | 0.55% | -15,732 |
| EDITAS MEDICINE INC | 4,900,334 | 0 | -4,900,334 | 16,710 | 0 | — | -16,710 |
| AXSOME THERAPEUTICS INC(AXSM)(Call) | 200,000 | 0 | -200,000 | 17,974 | 0 | — | -17,974 |
| SILENCE THERAPEUTICS PLC | 1,000,000 | 0 | -1,000,000 | 18,180 | 0 | — | -18,180 |
| NEKTAR THERAPEUTICS(NKTR) | 15,922,655 | 1,975,998 | -13,946,657 | 20,699 | 1,838 | 0.07% | -18,862 |
| FATE THERAPEUTICS INC | 5,572,607 | 0 | -5,572,607 | 19,504 | 0 | — | -19,504 |
| GERON CORP(GERN) | 7,575,049 | 4,011,287 | -3,563,762 | 34,391 | 14,200 | 0.53% | -20,191 |
| IONIS PHARMACEUTICALS INC(IONS) | 2,200,000 | 1,933,928 | -266,072 | 88,132 | 67,610 | 2.53% | -20,522 |
| MIND MEDICINE MINDMED INC | 7,065,099 | 2,816,594 | -4,248,505 | 40,200 | 19,603 | 0.73% | -20,597 |
| ALECTOR INC | 4,631,998 | 0 | -4,631,998 | 21,585 | 0 | — | -21,585 |
| AVIDITY BIOSCIENCES INC | 475,000 | 0 | -475,000 | 21,817 | 0 | — | -21,817 |
| AUTOLUS THERAPEUTICS PLC | 15,272,172 | 14,218,903 | -1,053,269 | 55,438 | 33,414 | 1.25% | -22,024 |
| MBX BIOSCIENCES INC(MBX) | 3,018,935 | 3,018,935 | 0 | 78,432 | 55,639 | 2.09% | -22,793 |
| SPYRE THERAPEUTICS INC(SYRE) | 1,000,000 | 219,015 | -780,985 | 29,410 | 5,099 | 0.19% | -24,311 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 4,000,000 | 3,442,833 | -557,167 | 47,760 | 20,072 | 0.75% | -27,688 |
| KYMERA THERAPEUTICS INC(KYMR) | 600,326 | 0 | -600,326 | 28,413 | 0 | — | -28,413 |
| NURIX THERAPEUTICS INC(NRIX) | 3,868,104 | 3,000,000 | -868,104 | 86,916 | 56,520 | 2.12% | -30,396 |
| KURA ONCOLOGY INC(KURA) | 1,963,505 | 0 | -1,963,505 | 38,367 | 0 | — | -38,367 |
| TG THERAPEUTICS INC(TGTX) | 1,725,000 | 0 | -1,725,000 | 40,348 | 0 | — | -40,348 |
| 4D MOLECULAR THERAPEUTICS IN | 4,096,452 | 609,900 | -3,486,552 | 44,283 | 3,397 | 0.13% | -40,886 |
| VERONA PHARMA PLC | 3,180,025 | 850,000 | -2,330,025 | 91,489 | 39,474 | 1.48% | -52,015 |
| APOGEE THERAPEUTICS INC(APGE) | 1,000,000 | 0 | -1,000,000 | 58,740 | 0 | — | -58,740 |
| BICYCLE THERAPEUTICS PLC | 3,548,001 | 1,276,081 | -2,271,920 | 80,291 | 17,865 | 0.67% | -62,426 |
| DYNE THERAPEUTICS INC(DYN) | 3,282,000 | 2,000,000 | -1,282,000 | 117,889 | 47,120 | 1.77% | -70,769 |
| AXSOME THERAPEUTICS INC(AXSM) | 857,219 | 0 | -857,219 | 77,038 | 0 | — | -77,038 |
| ALKERMES PLC(ALKS) | 3,500,000 | 0 | -3,500,000 | 97,965 | 0 | — | -97,965 |
| INTELLIA THERAPEUTICS INC(NTLA) | 4,950,000 | 0 | -4,950,000 | 101,723 | 0 | — | -101,722 |
| ARGENX SE(ARGX) | 365,000 | 0 | -365,000 | 197,859 | 0 | — | -197,859 |