Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| STRUCTURE THERAPEUTICS INC | 4,215,811 | 4,111,782 | -104,029 | 118,043 | 285,974 | 6.52% | +167,932 |
| VERA THERAPEUTICS INC(VERA) | 0 | 2,821,135 | +2,821,135 | 0 | 142,862 | 3.26% | +142,862 |
| IMMUNOVANT INC(IMVT) | 9,728,845 | 11,526,971 | +1,798,126 | 156,829 | 293,016 | 6.68% | +136,187 |
| BIOMARIN PHARMACEUTICAL INC(BMRN) | 24,856 | 2,300,000 | +2,275,144 | 1,346 | 136,689 | 3.12% | +135,343 |
| AXSOME THERAPEUTICS INC(AXSM) | 900,000 | 1,150,000 | +250,000 | 109,305 | 210,036 | 4.79% | +100,731 |
| GRAIL INC(GRAL) | 0 | 1,022,797 | +1,022,797 | 0 | 87,541 | 2.00% | +87,541 |
| DYNAVAX TECHNOLOGIES CORP | 15,726,349 | 15,726,349 | 0 | 156,163 | 241,871 | 5.52% | +85,709 |
| NURIX THERAPEUTICS INC(NRIX) | 6,057,024 | 7,036,455 | +979,431 | 55,967 | 133,482 | 3.04% | +77,515 |
| VAXCYTE INC(PCVX) | 3,000,000 | 4,000,000 | +1,000,000 | 108,060 | 184,560 | 4.21% | +76,500 |
| MAZE THERAPEUTICS INC(MAZE) | 3,948,910 | 4,246,440 | +297,530 | 102,395 | 175,930 | 4.01% | +73,535 |
| TARSUS PHARMACEUTICALS INC(TARS) | 3,000,000 | 3,004,034 | +4,034 | 178,290 | 245,970 | 5.61% | +67,680 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX) | 0 | 4,610,071 | +4,610,071 | 0 | 60,761 | 1.39% | +60,761 |
| ALKERMES PLC(ALKS) | 0 | 2,000,000 | +2,000,000 | 0 | 55,960 | 1.28% | +55,960 |
| CORMEDIX INC(CRMD) | 500,000 | 5,274,076 | +4,774,076 | 5,815 | 61,338 | 1.40% | +55,523 |
| CENTESSA PHARMACEUTICALS PLC | 0 | 2,000,000 | +2,000,000 | 0 | 50,020 | 1.14% | +50,020 |
| MBX BIOSCIENCES INC(MBX) | 3,150,000 | 3,249,790 | +99,790 | 55,125 | 102,498 | 2.34% | +47,373 |
| SOLENO THERAPEUTICS INC | 0 | 1,000,000 | +1,000,000 | 0 | 46,300 | 1.06% | +46,300 |
| VERASTEM INC(VSTM) | 0 | 5,740,850 | +5,740,850 | 0 | 44,319 | 1.01% | +44,319 |
| ENANTA PHARMACEUTICALS INC(ENTA) | 0 | 1,956,867 | +1,956,867 | 0 | 30,860 | 0.70% | +30,860 |
| DYNE THERAPEUTICS INC(DYN) | 2,000,000 | 2,650,000 | +650,000 | 25,300 | 51,834 | 1.18% | +26,534 |
| GUARDANT HEALTH INC(GH) | 4,154,086 | 2,800,000 | -1,354,086 | 259,547 | 285,992 | 6.52% | +26,445 |
| ENGENE HOLDINGS INC COM | 2,239,353 | 4,377,572 | +2,138,219 | 15,295 | 39,529 | 0.90% | +24,235 |
| LB PHARMACEUTICALS INC(LBRX) | 3,352,804 | 3,352,804 | 0 | 52,941 | 74,633 | 1.70% | +21,693 |
| ATAI BECKLEY NV | 0 | 4,677,289 | +4,677,289 | 0 | 19,130 | 0.44% | +19,130 |
| X4 PHARMACEUTICALS INC(XFOR) | 1,122,484 | 5,013,661 | +3,891,177 | 3,839 | 20,055 | 0.46% | +16,216 |
| COGENT BIOSCIENCES INC(COGT) | 0 | 453,102 | +453,102 | 0 | 16,094 | 0.37% | +16,094 |
| ORUKA THERAPEUTICS INC(ORKA) | 2,654,781 | 2,161,510 | -493,271 | 51,051 | 65,515 | 1.49% | +14,464 |
| APELLIS PHARMACEUTICALS INC COM | 8,000,382 | 7,750,000 | -250,382 | 181,049 | 194,680 | 4.44% | +13,631 |
| TANGO THERAPEUTICS INC(TNGX) | 1,454,562 | 2,454,562 | +1,000,000 | 12,218 | 21,747 | 0.50% | +9,529 |
| CYBIN INC(HELP) | 1,000,000 | 1,854,255 | +854,255 | 5,890 | 15,168 | 0.35% | +9,278 |
| MONOPAR THERAPEUTICS INC(MNPR) | 0 | 95,408 | +95,408 | 0 | 6,230 | 0.14% | +6,230 |
| BICARA THERAPEUTICS INC | 2,426,657 | 2,614,004 | +187,347 | 38,317 | 43,994 | 1.00% | +5,677 |
| COMPASS PATHWAYS PLC(CMPS) | 7,859,648 | 7,334,323 | -525,325 | 45,036 | 50,607 | 1.15% | +5,571 |
| MIND MEDICINE MINDMED INC | 1,500,000 | 1,676,540 | +176,540 | 17,685 | 22,449 | 0.51% | +4,764 |
| IMMUNOCORE HLDGS PLC(IMCR) | 1,800,000 | 2,003,978 | +203,978 | 65,394 | 69,558 | 1.59% | +4,164 |
| BILLIONTOONE INC | 0 | 50,000 | +50,000 | 0 | 4,092 | 0.09% | +4,092 |
| CONTEXT THERAPEUTICS INC(CNTX) | 7,419,355 | 7,419,355 | 0 | 7,188 | 10,906 | 0.25% | +3,719 |
| INVENTIVA SA(IVA) | 0 | 490,000 | +490,000 | 0 | 2,279 | 0.05% | +2,279 |
| JANUX THERAPEUTICS INC(JANX) | 0 | 89,589 | +89,589 | 0 | 1,236 | 0.03% | +1,236 |
| ADLAI NORTYE LTD(ANL) | 0 | 34,852 | +34,852 | 0 | 49 | 0.00% | +49 |
| CRESCENT BIOPHARMA INC.(CBIO) | 453,686 | 453,686 | 0 | 5,394 | 5,381 | 0.12% | -14 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 2,000,000 | 1,900,738 | -99,262 | 51,740 | 51,624 | 1.18% | -116 |
| ALIGOS THERAPEUTICS INC(ALGS) | 444,110 | 444,110 | 0 | 4,352 | 4,139 | 0.09% | -213 |
| BRIDGEBIO PHARMA INC(BBIO) | 1,200,000 | 810,142 | -389,858 | 62,328 | 61,968 | 1.41% | -360 |
| CLIMB BIO INC(CLYM) | 509,789 | 0 | -509,789 | 1,025 | 0 | — | -1,025 |
| ZURA BIO LTD(ZURA) | 259,014 | 0 | -259,014 | 1,122 | 0 | — | -1,122 |
| AVALO THERAPEUTICS INC(AVTX) | 144,600 | 0 | -144,600 | 1,838 | 0 | — | -1,838 |
| ACADIA PHARMACEUTICALS INC | 105,085 | 0 | -105,085 | 2,243 | 0 | — | -2,243 |
| ANI PHARMACEUTICALS INC(ANIP) | 450,000 | 477,684 | +27,684 | 41,220 | 37,708 | 0.86% | -3,512 |
| AUTOLUS THERAPEUTICS PLC(AUTL) | 2,568,613 | 0 | -2,568,613 | 4,187 | 0 | — | -4,187 |
| PEPGEN INC(PEPG) | 1,200,000 | 0 | -1,200,000 | 5,544 | 0 | — | -5,544 |
| XENCOR INC(XNCR) | 549,439 | 0 | -549,439 | 6,445 | 0 | — | -6,445 |
| IMAGENEBIO INC(IMA) | 878,516 | 0 | -878,516 | 7,160 | 0 | — | -7,160 |
| GERON CORP(GERN) | 41,096,522 | 32,511,271 | -8,585,251 | 56,302 | 42,915 | 0.98% | -13,387 |
| GENMAB A/S(GMAB) | 481,267 | 0 | -481,267 | 14,760 | 0 | — | -14,760 |
| RAPT THERAPEUTICS INC | 751,422 | 110,448 | -640,974 | 19,379 | 3,741 | 0.09% | -15,638 |
| GH RESEARCH PLC(GHRS) | 1,250,000 | 0 | -1,250,000 | 17,875 | 0 | — | -17,875 |
| JADE BIOSCIENCES INC | 2,279,892 | 0 | -2,279,892 | 19,675 | 0 | — | -19,675 |
| CYTOKINETICS INC(CYTK) | 4,300,000 | 3,336,998 | -963,002 | 236,328 | 212,033 | 4.84% | -24,295 |
| TERNS PHARMACEUTICALS INC | 7,495,000 | 769,048 | -6,725,952 | 56,287 | 31,070 | 0.71% | -25,218 |
| UNIQURE NV(QURE) | 483,092 | 0 | -483,092 | 28,198 | 0 | — | -28,198 |
| CIDARA THERAPEUTICS INC | 300,000 | 0 | -300,000 | 28,728 | 0 | — | -28,728 |
| XENON PHARMACEUTICALS INC(XENE) | 1,200,000 | 366,435 | -833,565 | 48,180 | 16,424 | 0.37% | -31,756 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 3,470,172 | 0 | -3,470,172 | 33,973 | 0 | — | -33,973 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 5,380,449 | 2,524,833 | -2,855,616 | 116,110 | 78,573 | 1.79% | -37,537 |
| OCULAR THERAPEUTIX INC(OCUL) | 11,932,137 | 8,070,414 | -3,861,723 | 139,487 | 97,975 | 2.23% | -41,512 |
| EXACT SCIENCES CORP(EXK) | 1,000,000 | 0 | -1,000,000 | 54,710 | 0 | — | -54,710 |
| PROTAGONIST THERAPEUTICS INC | 1,715,691 | 0 | -1,715,691 | 113,973 | 0 | — | -113,973 |
| IONIS PHARMACEUTICALS INC(IONS) | 3,808,144 | 1,700,000 | -2,108,144 | 249,129 | 134,487 | 3.07% | -114,642 |
| 89BIO INC | 9,356,171 | 0 | -9,356,171 | 137,536 | 0 | — | -137,536 |
| AKERO THERAPEUTICS INC | 4,000,978 | 0 | -4,000,978 | 189,966 | 0 | — | -189,966 |