Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Immunovant, Inc.(IMVT) | 9,728,845 | 11,526,971 | +1,798,126 | $156.83M | $293.02M | 6.68% | +$136.19M |
| Guardant Health, Inc.(GH) | 4,154,086 | 2,800,000 | -1,354,086 | $259.55M | $285.99M | 6.52% | +$26.44M |
| Structure Therapeutics IncADS | 4,215,811 | 4,111,782 | -104,029 | $118.04M | $285.97M | 6.52% | +$167.93M |
| Tarsus Pharmaceuticals, Inc.(TARS) | 3,000,000 | 3,004,034 | +4,034 | $178.29M | $245.97M | 5.61% | +$67.68M |
| Dynavax Technologies Corp | 15,726,349 | 15,726,349 | 0 | $156.16M | $241.87M | 5.52% | +$85.71M |
| Cytokinetics, Incorporated(CYTK) | 4,300,000 | 3,336,998 | -963,002 | $236.33M | $212.03M | 4.84% | -$24.30M |
| Axsome Therapeutics, Inc.(AXSM) | 900,000 | 1,150,000 | +250,000 | $109.31M | $210.04M | 4.79% | +$100.73M |
| Apellis Pharmaceuticals Inc COM | 8,000,382 | 7,750,000 | -250,382 | $181.05M | $194.68M | 4.44% | +$13.63M |
| Vaxcyte, Inc.(PCVX) | 3,000,000 | 4,000,000 | +1,000,000 | $108.06M | $184.56M | 4.21% | +$76.50M |
| Maze Therapeutics, Inc.(MAZE) | 3,948,910 | 4,246,440 | +297,530 | $102.40M | $175.93M | 4.01% | +$73.53M |
| Vera Therapeutics, Inc.CL A(VERA) | 0 | 2,821,135 | +2,821,135 | $0 | $142.86M | 3.26% | +$142.86M |
| BioMarin Pharmaceutical Inc.(BMRN) | 24,856 | 2,300,000 | +2,275,144 | $1.35M | $136.69M | 3.12% | +$135.34M |
| Ionis Pharmaceuticals, Inc.(IONS) | 3,808,144 | 1,700,000 | -2,108,144 | $249.13M | $134.49M | 3.07% | -$114.64M |
| Nurix Therapeutics, Inc.(NRIX) | 6,057,024 | 7,036,455 | +979,431 | $55.97M | $133.48M | 3.04% | +$77.51M |
| MBX Biosciences, Inc.(MBX) | 3,150,000 | 3,249,790 | +99,790 | $55.13M | $102.50M | 2.34% | +$47.37M |
| Ocular Therapeutix, Inc.(OCUL) | 11,932,137 | 8,070,414 | -3,861,723 | $139.49M | $97.97M | 2.23% | -$41.51M |
| GRAIL, Inc.(GRAL) | 0 | 1,022,797 | +1,022,797 | $0 | $87.54M | 2.00% | +$87.54M |
| Viridian Therapeutics, Inc.(VRDN) | 5,380,449 | 2,524,833 | -2,855,616 | $116.11M | $78.57M | 1.79% | -$37.54M |
| LB Pharmaceuticals Inc(LBRX) | 3,352,804 | 3,352,804 | 0 | $52.94M | $74.63M | 1.70% | +$21.69M |
| Immunocore Holdings plcADS(IMCR) | 1,800,000 | 2,003,978 | +203,978 | $65.39M | $69.56M | 1.59% | +$4.16M |
| Oruka Therapeutics, Inc.(ORKA) | 2,654,781 | 2,161,510 | -493,271 | $51.05M | $65.52M | 1.49% | +$14.46M |
| BridgeBio Pharma, Inc.(BBIO) | 1,200,000 | 810,142 | -389,858 | $62.33M | $61.97M | 1.41% | -$360.2K |
| CorMedix Inc.(CRMD) | 500,000 | 5,274,076 | +4,774,076 | $5.82M | $61.34M | 1.40% | +$55.52M |
| MoonLake ImmunotherapeuticsCL A(MLTX) | 0 | 4,610,071 | +4,610,071 | $0 | $60.76M | 1.39% | +$60.76M |
| Alkermes plcSHS(ALKS) | 0 | 2,000,000 | +2,000,000 | $0 | $55.96M | 1.28% | +$55.96M |
| Dyne Therapeutics, Inc.(DYN) | 2,000,000 | 2,650,000 | +650,000 | $25.30M | $51.83M | 1.18% | +$26.53M |
| Celldex Therapeutics, Inc.(CLDX) | 2,000,000 | 1,900,738 | -99,262 | $51.74M | $51.62M | 1.18% | -$116.0K |
| COMPASS Pathways plcADS(CMPS) | 7,859,648 | 7,334,323 | -525,325 | $45.04M | $50.61M | 1.15% | +$5.57M |
| Centessa Pharmaceuticals PlcADS | 0 | 2,000,000 | +2,000,000 | $0 | $50.02M | 1.14% | +$50.02M |
| Soleno Therapeutics Inc | 0 | 1,000,000 | +1,000,000 | $0 | $46.30M | 1.06% | +$46.30M |
| Verastem, Inc.(VSTM) | 0 | 5,740,850 | +5,740,850 | $0 | $44.32M | 1.01% | +$44.32M |
| Bicara Therapeutics Inc | 2,426,657 | 2,614,004 | +187,347 | $38.32M | $43.99M | 1.00% | +$5.68M |
| Geron Corporation(GERN) | 41,096,522 | 32,511,271 | -8,585,251 | $56.30M | $42.91M | 0.98% | -$13.39M |
| Engene Holdings Inc COM | 2,239,353 | 4,377,572 | +2,138,219 | $15.29M | $39.53M | 0.90% | +$24.23M |
| ANI Pharmaceuticals, Inc.(ANIP) | 450,000 | 477,684 | +27,684 | $41.22M | $37.71M | 0.86% | -$3.51M |
| Terns Pharmaceuticals Inc | 7,495,000 | 769,048 | -6,725,952 | $56.29M | $31.07M | 0.71% | -$25.22M |
| Enanta Pharmaceuticals, Inc.(ENTA) | 0 | 1,956,867 | +1,956,867 | $0 | $30.86M | 0.70% | +$30.86M |
| Mind Medicine Mindmed Inc | 1,500,000 | 1,676,540 | +176,540 | $17.68M | $22.45M | 0.51% | +$4.76M |
| Tango Therapeutics, Inc.(TNGX) | 1,454,562 | 2,454,562 | +1,000,000 | $12.22M | $21.75M | 0.50% | +$9.53M |
| X4 Pharmaceuticals, Inc.(XFOR) | 1,122,484 | 5,013,661 | +3,891,177 | $3.84M | $20.05M | 0.46% | +$16.22M |
| Atai Beckley NvSHS | 0 | 4,677,289 | +4,677,289 | $0 | $19.13M | 0.44% | +$19.13M |
| Xenon Pharmaceuticals Inc.(XENE) | 1,200,000 | 366,435 | -833,565 | $48.18M | $16.42M | 0.37% | -$31.76M |
| Cogent Biosciences, Inc.(COGT) | 0 | 453,102 | +453,102 | $0 | $16.09M | 0.37% | +$16.09M |
| Cybin D/B/A Helus Pharma(HELP) | 1,000,000 | 1,854,255 | +854,255 | $5.89M | $15.17M | 0.35% | +$9.28M |
| Context Therapeutics Inc.(CNTX) | 7,419,355 | 7,419,355 | 0 | $7.19M | $10.91M | 0.25% | +$3.72M |
| Monopar Therapeutics Inc.(MNPR) | 0 | 95,408 | +95,408 | $0 | $6.23M | 0.14% | +$6.23M |
| Crescent Biopharma, Inc.(CBIO) | 453,686 | 453,686 | 0 | $5.39M | $5.38M | 0.12% | -$13.6K |
| Aligos Therapeutics, Inc.(ALGS) | 444,110 | 444,110 | 0 | $4.35M | $4.14M | 0.09% | -$213.2K |
| Billiontoone IncCL A | 0 | 50,000 | +50,000 | $0 | $4.09M | 0.09% | +$4.09M |
| Rapt Therapeutics Inc | 751,422 | 110,448 | -640,974 | $19.38M | $3.74M | 0.09% | -$15.64M |
| Inventiva S.A.ADS(IVA) | 0 | 490,000 | +490,000 | $0 | $2.28M | 0.05% | +$2.28M |
| Janux Therapeutics, Inc.(JANX) | 0 | 89,589 | +89,589 | $0 | $1.24M | 0.03% | +$1.24M |
| Adlai Nortye Group Ltd.ADS(ANL) | 0 | 34,852 | +34,852 | $0 | $49.5K | 0.00% | +$49.5K |
| 89bio Inc | 9,356,171 | 0 | -9,356,171 | $137.54M | $0 | — | -$137.54M |
| Acadia Pharmaceuticals Inc | 105,085 | 0 | -105,085 | $2.24M | $0 | — | -$2.24M |
| Akero Therapeutics Inc | 4,000,978 | 0 | -4,000,978 | $189.97M | $0 | — | -$189.97M |
| Autolus Therapeutics plcADS(AUTL) | 2,568,613 | 0 | -2,568,613 | $4.19M | $0 | — | -$4.19M |
| Avalo Therapeutics, Inc.(AVTX) | 144,600 | 0 | -144,600 | $1.84M | $0 | — | -$1.84M |
| Cidara Therapeutics Inc | 300,000 | 0 | -300,000 | $28.73M | $0 | — | -$28.73M |
| Climb Bio, Inc.(CLYM) | 509,789 | 0 | -509,789 | $1.02M | $0 | — | -$1.02M |
| Endeavour Silver Corp.(EXK) | 1,000,000 | 0 | -1,000,000 | $54.71M | $0 | — | -$54.71M |
| Genmab A/SADS(GMAB) | 481,267 | 0 | -481,267 | $14.76M | $0 | — | -$14.76M |
| GH Research PLC(GHRS) | 1,250,000 | 0 | -1,250,000 | $17.88M | $0 | — | -$17.88M |
| ImageneBio, Inc.(IMA) | 878,516 | 0 | -878,516 | $7.16M | $0 | — | -$7.16M |
| Jade Biosciences Inc | 2,279,892 | 0 | -2,279,892 | $19.68M | $0 | — | -$19.68M |
| Olema Pharmaceuticals, Inc.(OLMA) | 3,470,172 | 0 | -3,470,172 | $33.97M | $0 | — | -$33.97M |
| PepGen Inc.(PEPG) | 1,200,000 | 0 | -1,200,000 | $5.54M | $0 | — | -$5.54M |
| Protagonist Therapeutics Inc | 1,715,691 | 0 | -1,715,691 | $113.97M | $0 | — | -$113.97M |
| uniQure N.V.SHS(QURE) | 483,092 | 0 | -483,092 | $28.20M | $0 | — | -$28.20M |
| Xencor, Inc.(XNCR) | 549,439 | 0 | -549,439 | $6.44M | $0 | — | -$6.44M |
| Zura Bio LimitedCL A(ZURA) | 259,014 | 0 | -259,014 | $1.12M | $0 | — | -$1.12M |