Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2024 ▲▼ | Q1 2025 ▲▼ | Change ▲▼ | Q4 2024 ▲▼ | Q1 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| VERONA PHARMA PLC | 3,383,950 | 3,457,850 | +73,900 | 157,151 | 219,539 | 10.03% | +62,388 |
| MAZE THERAPEUTICS INC(MAZE) | 0 | 4,129,001 | +4,129,001 | 0 | 45,460 | 2.08% | +45,460 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 6,570,392 | 6,795,121 | +224,729 | 271,686 | 306,120 | 13.99% | +34,434 |
| BRIDGEBIO PHARMA INC(BBIO) | 3,800,457 | 3,800,457 | 0 | 104,285 | 131,382 | 6.00% | +27,097 |
| TREVI THERAPEUTICS INC(TRVI) | 10,664,774 | 10,259,409 | -405,365 | 43,939 | 64,532 | 2.95% | +20,593 |
| AVIDITY BIOSCIENCES INC | 0 | 525,000 | +525,000 | 0 | 15,498 | 0.71% | +15,498 |
| DYNE THERAPEUTICS INC(DYN) | 0 | 1,443,341 | +1,443,341 | 0 | 15,097 | 0.69% | +15,097 |
| ARCUTIS BIOTHERAPEUTICS INC(ARQT) | 8,785,284 | 8,785,284 | 0 | 122,379 | 137,402 | 6.28% | +15,023 |
| KALVISTA PHARMACEUTICALS INC | 4,887,867 | 4,887,867 | 0 | 41,400 | 56,406 | 2.58% | +15,006 |
| ZAI LAB LTD(ZLAB) | 0 | 350,000 | +350,000 | 0 | 12,649 | 0.58% | +12,649 |
| PALVELLA THERAPEUTICS INC NE(PVLA) | 653,892 | 690,012 | +36,120 | 7,847 | 19,313 | 0.88% | +11,467 |
| IMMUNOCORE HLDGS PLC(IMCR) | 108,762 | 301,170 | +192,408 | 3,208 | 8,936 | 0.41% | +5,727 |
| SAVARA INC(SVRA) | 8,660,379 | 11,462,301 | +2,801,922 | 26,587 | 31,751 | 1.45% | +5,163 |
| SOLENO THERAPEUTICS INC | 699,159 | 499,159 | -200,000 | 31,427 | 35,665 | 1.63% | +4,238 |
| ALKERMES PLC(ALKS) | 601,129 | 601,129 | 0 | 17,288 | 19,849 | 0.91% | +2,561 |
| ASCENDIS PHARMA A/S(ASND) | 133,333 | 133,333 | 0 | 18,356 | 20,781 | 0.95% | +2,425 |
| KRYSTAL BIOTECH INC(KRYS) | 788,460 | 688,460 | -100,000 | 123,520 | 124,129 | 5.67% | +609 |
| MERUS N V | 373,100 | 373,100 | 0 | 15,689 | 15,704 | 0.72% | +15 |
| MEREO BIOPHARMA GROUP PLC | 5,097,779 | 7,819,863 | +2,722,084 | 17,842 | 17,595 | 0.80% | -248 |
| ADVERUM BIOTECHNOLOGIES INC | 1,069,244 | 1,069,244 | 0 | 4,993 | 4,673 | 0.21% | -321 |
| ALLOGENE THERAPEUTICS INC | 2,867,750 | 3,868,750 | +1,001,000 | 6,108 | 5,648 | 0.26% | -460 |
| ACADIA PHARMACEUTICALS INC | 470,338 | 470,338 | 0 | 8,631 | 7,812 | 0.36% | -818 |
| COGENT BIOSCIENCES INC(COGT) | 936,576 | 936,576 | 0 | 7,305 | 5,610 | 0.26% | -1,695 |
| ELEVATION ONCOLOGY INC | 5,993,579 | 5,993,579 | 0 | 3,372 | 1,553 | 0.07% | -1,819 |
| NEWAMSTERDAM PHARMA COMPANY *W EXP 99/99/999 | 500,333 | 500,333 | 0 | 7,130 | 4,498 | 0.21% | -2,632 |
| LEXEO THERAPEUTICS INC | 955,515 | 955,515 | 0 | 6,287 | 3,316 | 0.15% | -2,972 |
| CG ONCOLOGY INC(CGON) | 770,000 | 770,000 | 0 | 22,084 | 18,857 | 0.86% | -3,226 |
| AUTOLUS THERAPEUTICS PLC | 4,623,324 | 4,623,324 | 0 | 10,865 | 7,166 | 0.33% | -3,699 |
| AGIOS PHARMACEUTICALS INC(AGIO) | 1,069,754 | 1,069,854 | +100 | 35,152 | 31,347 | 1.43% | -3,805 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 658,715 | 658,715 | 0 | 27,712 | 23,852 | 1.09% | -3,860 |
| DESIGN THERAPEUTICS INC | 1,953,547 | 1,953,547 | 0 | 12,053 | 7,541 | 0.34% | -4,513 |
| SILENCE THERAPEUTICS PLC | 1,148,591 | 1,148,591 | 0 | 7,902 | 3,239 | 0.15% | -4,663 |
| ELEDON PHARMACEUTICALS INC | 1,176,735 | 0 | -1,176,735 | 4,848 | 0 | — | -4,848 |
| ORUKA THERAPEUTICS INC(ORKA) | 583,327 | 583,327 | 0 | 11,311 | 5,985 | 0.27% | -5,326 |
| ARVINAS INC | 285,331 | 0 | -285,331 | 5,470 | 0 | — | -5,470 |
| MACROGENICS INC | 3,175,665 | 3,175,665 | 0 | 10,321 | 4,033 | 0.18% | -6,288 |
| HILLEVAX INC | 10,617,062 | 10,617,062 | 0 | 21,977 | 15,395 | 0.70% | -6,583 |
| 89BIO INC | 1,000,000 | 0 | -1,000,000 | 7,820 | 0 | — | -7,820 |
| REVOLUTION MEDICINES INC(RVMD) | 997,455 | 997,455 | 0 | 43,629 | 35,270 | 1.61% | -8,359 |
| DAY ONE BIOPHARMACEUTICALS I COM | 689,655 | 0 | -689,655 | 8,738 | 0 | — | -8,738 |
| IMMATICS N.V(IMTX) | 2,147,911 | 1,247,911 | -900,000 | 15,272 | 5,628 | 0.26% | -9,644 |
| ROCKET PHARMACEUTICALS INC | 1,479,025 | 1,079,025 | -400,000 | 18,591 | 7,197 | 0.33% | -11,394 |
| PLIANT THERAPEUTICS INC | 1,120,803 | 0 | -1,120,803 | 14,761 | 0 | — | -14,761 |
| TARSUS PHARMACEUTICALS INC(TARS) | 1,587,527 | 1,397,527 | -190,000 | 87,901 | 71,791 | 3.28% | -16,110 |
| ERASCA INC(ERAS) | 19,391,687 | 22,575,851 | +3,184,164 | 48,673 | 30,929 | 1.41% | -17,744 |
| PHATHOM PHARMACEUTICALS INC(PHAT) | 10,109,279 | 10,109,279 | 0 | 82,087 | 63,385 | 2.90% | -18,702 |
| ANAPTYSBIO INC | 1,573,719 | 0 | -1,573,719 | 20,836 | 0 | — | -20,836 |
| ORIC PHARMACEUTICALS INC(ORIC) | 3,888,238 | 1,410,193 | -2,478,045 | 31,378 | 7,869 | 0.36% | -23,509 |
| VAXCYTE INC(PCVX) | 539,405 | 539,405 | 0 | 44,156 | 20,368 | 0.93% | -23,788 |
| DISC MEDICINE INC(IRON) | 1,754,834 | 1,754,834 | 0 | 111,256 | 87,110 | 3.98% | -24,147 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 1,271,245 | 0 | -1,271,245 | 33,942 | 0 | — | -33,942 |
| MBX BIOSCIENCES INC(MBX) | 5,985,347 | 5,985,347 | 0 | 110,310 | 44,172 | 2.02% | -66,138 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 1,869,808 | 678,760 | -1,191,048 | 104,672 | 35,954 | 1.64% | -68,718 |
| NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES | 15,916,418 | 16,116,418 | +200,000 | 409,052 | 329,903 | 15.08% | -79,149 |