Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q2 2025 ▲▼ | Q3 2025 ▲▼ | Change ▲▼ | Q2 2025 ▲▼ | Q3 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Mirum Pharmaceuticals, Inc.(MIRM) | 6,795,121 | 6,795,121 | 0 | $345.80M | $498.15M | 14.93% | +$152.35M |
| Newamsterdam Pharma Company ORDINARY SHARES | 16,607,074 | 16,701,956 | +94,882 | $300.75M | $475.00M | 14.23% | +$174.25M |
| Verona Pharma PlcADS | 3,383,950 | 3,383,950 | 0 | $320.05M | $361.10M | 10.82% | +$41.05M |
| BridgeBio Pharma, Inc.(BBIO) | 3,800,457 | 3,845,457 | +45,000 | $164.10M | $199.73M | 5.98% | +$35.63M |
| Arcutis Biotherapeutics, Inc.(ARQT) | 9,874,511 | 9,874,511 | 0 | $138.44M | $186.13M | 5.58% | +$47.69M |
| Phathom Pharmaceuticals, Inc.(PHAT) | 12,466,489 | 12,466,489 | 0 | $119.55M | $146.73M | 4.40% | +$27.18M |
| Krystal Biotech, Inc.(KRYS) | 688,460 | 688,460 | 0 | $94.64M | $121.53M | 3.64% | +$26.90M |
| Maze Therapeutics, Inc.(MAZE) | 4,567,275 | 4,567,274 | -1 | $56.04M | $118.43M | 3.55% | +$62.39M |
| MBX Biosciences, Inc.(MBX) | 5,985,347 | 6,652,013 | +666,666 | $68.29M | $116.41M | 3.49% | +$48.12M |
| Disc Medicine, Inc.(IRON) | 1,654,834 | 1,438,534 | -216,300 | $87.64M | $95.06M | 2.85% | +$7.42M |
| Trevi Therapeutics, Inc.(TRVI) | 10,259,409 | 10,259,409 | 0 | $56.12M | $93.87M | 2.81% | +$37.75M |
| Tarsus Pharmaceuticals, Inc.(TARS) | 1,397,527 | 1,167,527 | -230,000 | $56.61M | $69.39M | 2.08% | +$12.77M |
| Kalvista Pharmaceuticals Inc | 4,887,867 | 5,039,867 | +152,000 | $55.26M | $61.39M | 1.84% | +$6.13M |
| Zai Lab LimitedADR(ZLAB) | 1,308,138 | 1,627,320 | +319,182 | $45.75M | $55.15M | 1.65% | +$9.40M |
| Agios Pharmaceuticals, Inc.(AGIO) | 1,279,754 | 1,279,754 | 0 | $42.56M | $51.37M | 1.54% | +$8.80M |
| Erasca, Inc.(ERAS) | 22,729,436 | 22,729,436 | 0 | $28.87M | $49.55M | 1.48% | +$20.68M |
| Cytokinetics, Incorporated(CYTK) | 554,731 | 890,445 | +335,714 | $18.33M | $48.94M | 1.47% | +$30.61M |
| Revolution Medicines, Inc.(RVMD) | 997,455 | 997,455 | 0 | $36.70M | $46.58M | 1.40% | +$9.88M |
| Palvella Therapeutics, Inc.(PVLA) | 722,400 | 722,400 | 0 | $16.28M | $45.29M | 1.36% | +$29.00M |
| Savara Inc.(SVRA) | 11,462,301 | 11,462,301 | 0 | $26.13M | $40.92M | 1.23% | +$14.79M |
| Dyne Therapeutics, Inc.(DYN) | 1,505,984 | 2,718,105 | +1,212,121 | $14.34M | $34.38M | 1.03% | +$20.05M |
| ABIVAX Société AnonymeADS(ABVX) | 0 | 378,300 | +378,300 | $0 | $32.12M | 0.96% | +$32.12M |
| Aura Biosciences, Inc.(AURA) | 5,100,000 | 5,100,000 | 0 | $31.93M | $31.52M | 0.94% | -$408.0K |
| Ultragenyx Pharmaceutical Inc.(RARE) | 983,715 | 983,715 | 0 | $35.77M | $29.59M | 0.89% | -$6.18M |
| Lexeo Therapeutics, Inc.(LXEO) | 4,424,725 | 4,424,725 | 0 | $17.79M | $29.38M | 0.88% | +$11.59M |
| Valneva SEADS(VALN) | 1,458,333 | 2,291,666 | +833,333 | $8.24M | $27.96M | 0.84% | +$19.72M |
| Avidity Biosciences Inc | 625,000 | 625,000 | 0 | $17.75M | $27.23M | 0.82% | +$9.48M |
| Ascendis Pharma A/SADR(ASND) | 133,333 | 133,333 | 0 | $23.01M | $26.51M | 0.79% | +$3.49M |
| Alkermes plcSHS(ALKS) | 1,000,647 | 700,647 | -300,000 | $28.63M | $21.02M | 0.63% | -$7.61M |
| Mereo BioPharma Group plcADS(MREO) | 9,440,112 | 9,440,112 | 0 | $25.58M | $19.45M | 0.58% | -$6.14M |
| Akero Therapeutics Inc | 366,784 | 366,784 | 0 | $19.57M | $17.41M | 0.52% | -$2.16M |
| Vaxcyte, Inc.(PCVX) | 474,405 | 474,405 | 0 | $15.42M | $17.09M | 0.51% | +$1.67M |
| Evolus, Inc.(EOLS) | 2,435,550 | 2,630,665 | +195,115 | $22.43M | $16.15M | 0.48% | -$6.28M |
| Design Therapeutics, Inc.(DSGN) | 1,953,547 | 1,953,547 | 0 | $6.58M | $14.71M | 0.44% | +$8.13M |
| Immunocore Holdings plcADS(IMCR) | 384,782 | 384,782 | 0 | $12.07M | $13.98M | 0.42% | +$1.90M |
| Acadia Pharmaceuticals Inc | 0 | 613,837 | +613,837 | $0 | $13.10M | 0.39% | +$13.10M |
| Jade Biosciences Inc | 1,772,116 | 1,413,280 | -358,836 | $17.70M | $12.20M | 0.37% | -$5.51M |
| Assembly Biosciences Inc | 0 | 456,249 | +456,249 | $0 | $11.68M | 0.35% | +$11.68M |
| Adverum Biotechnologies Inc | 1,069,244 | 2,077,431 | +1,008,187 | $2.30M | $9.41M | 0.28% | +$7.11M |
| Travere Therapeutics, Inc.(TVTX) | 1,002,092 | 392,092 | -610,000 | $14.83M | $9.37M | 0.28% | -$5.46M |
| Newamsterdam Pharma CompanyW EXP 99 99 999 *W EXP 99/99/999 | 500,333 | 500,333 | 0 | $4.00M | $8.56M | 0.26% | +$4.56M |
| Engene Holdings Inc COM | 0 | 1,157,380 | +1,157,380 | $0 | $7.90M | 0.24% | +$7.90M |
| Autolus Therapeutics plcADS(AUTL) | 4,623,324 | 4,623,324 | 0 | $10.54M | $7.54M | 0.23% | -$3.01M |
| MacroGenics, Inc.(MGNX) | 3,175,665 | 3,175,665 | 0 | $3.84M | $5.34M | 0.16% | +$1.49M |
| Silence Therapeutics plcADS(SLN) | 970,130 | 970,130 | 0 | $5.63M | $5.03M | 0.15% | -$591.8K |
| Allogene Therapeutics Inc | 3,868,750 | 3,868,750 | 0 | $4.37M | $4.80M | 0.14% | +$425.6K |
| Crescent Biopharma, Inc.(CBIO) | 453,685 | 272,951 | -180,734 | $7.32M | $3.25M | 0.10% | -$4.08M |
| CG Oncology, Inc.(CGON) | 770,000 | 0 | -770,000 | $20.02M | $0 | — | -$20.02M |
| Cogent Biosciences, Inc.(COGT) | 1,734,601 | 0 | -1,734,601 | $12.45M | $0 | — | -$12.45M |
| Elevation Oncology Inc | 5,993,579 | 0 | -5,993,579 | $2.20M | $0 | — | -$2.20M |
| Hillevax Inc | 10,617,062 | 0 | -10,617,062 | $21.13M | $0 | — | -$21.13M |
| ORIC Pharmaceuticals, Inc.(ORIC) | 1,065,334 | 0 | -1,065,334 | $10.81M | $0 | — | -$10.81M |
| Oruka Therapeutics, Inc.(ORKA) | 583,327 | 0 | -583,327 | $6.54M | $0 | — | -$6.54M |