Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2024 ▲▼ | Q4 2024 ▲▼ | Change ▲▼ | Q3 2024 ▲▼ | Q4 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES | 12,855,194 | 15,916,418 | +3,061,224 | 213,396 | 409,052 | 16.98% | +195,656 |
| VERONA PHARMA PLC | 3,383,950 | 3,383,950 | 0 | 97,356 | 157,151 | 6.52% | +59,794 |
| ARCUTIS BIOTHERAPEUTICS INC(ARQT) | 8,785,284 | 8,785,284 | 0 | 81,703 | 122,379 | 5.08% | +40,676 |
| TARSUS PHARMACEUTICALS INC(TARS) | 1,587,527 | 1,587,527 | 0 | 52,214 | 87,901 | 3.65% | +35,688 |
| DISC MEDICINE INC(IRON) | 1,754,834 | 1,754,834 | 0 | 86,233 | 111,256 | 4.62% | +25,024 |
| TREVI THERAPEUTICS INC(TRVI) | 7,381,090 | 10,664,774 | +3,283,684 | 24,653 | 43,939 | 1.82% | +19,286 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 6,570,392 | 6,570,392 | 0 | 256,245 | 271,686 | 11.28% | +15,440 |
| PLIANT THERAPEUTICS INC(PLRX) | 0 | 1,120,803 | +1,120,803 | 0 | 14,761 | 0.61% | +14,761 |
| BRIDGEBIO PHARMA INC(BBIO) | 3,760,457 | 3,800,457 | +40,000 | 95,741 | 104,285 | 4.33% | +8,543 |
| PALVELLA THERAPEUTICS INC NE(PVLA) | 0 | 653,892 | +653,892 | 0 | 7,847 | 0.33% | +7,847 |
| ELEDON PHARMACEUTICALS INC(ELDN) | 0 | 1,176,735 | +1,176,735 | 0 | 4,848 | 0.20% | +4,848 |
| NEWAMSTERDAM PHARMA COMPANY *W EXP 99/99/999 | 500,333 | 500,333 | 0 | 3,502 | 7,130 | 0.30% | +3,627 |
| HILLEVAX INC | 10,617,062 | 10,617,062 | 0 | 18,686 | 21,977 | 0.91% | +3,291 |
| DESIGN THERAPEUTICS INC(DSGN) | 1,892,547 | 1,953,547 | +61,000 | 10,182 | 12,053 | 0.50% | +1,871 |
| ACADIA PHARMACEUTICALS INC | 470,338 | 470,338 | 0 | 7,234 | 8,631 | 0.36% | +1,397 |
| ALKERMES PLC(ALKS) | 576,129 | 601,129 | +25,000 | 16,126 | 17,288 | 0.72% | +1,163 |
| 89BIO INC | 1,000,000 | 1,000,000 | 0 | 7,400 | 7,820 | 0.32% | +420 |
| MACROGENICS INC(MGNX) | 3,010,727 | 3,175,665 | +164,938 | 9,905 | 10,321 | 0.43% | +416 |
| IMMUNOCORE HLDGS PLC(IMCR) | 108,762 | 108,762 | 0 | 3,386 | 3,208 | 0.13% | -177 |
| IMMATICS N.V(IMTX) | 1,354,711 | 2,147,911 | +793,200 | 15,457 | 15,272 | 0.63% | -186 |
| ELEVATION ONCOLOGY INC | 5,993,579 | 5,993,579 | 0 | 3,596 | 3,372 | 0.14% | -224 |
| PIERIS PHARMACEUTICALS INC | 15,942 | 0 | -15,942 | 267 | 0 | — | -267 |
| ACLARIS THERAPEUTICS INC(ACRS) | 264,377 | 0 | -264,377 | 304 | 0 | — | -304 |
| ORUKA THERAPEUTICS INC(ORKA) | 477,327 | 583,327 | +106,000 | 11,699 | 11,311 | 0.47% | -389 |
| DAY ONE BIOPHARMACEUTICALS I COM | 689,655 | 689,655 | 0 | 9,607 | 8,738 | 0.36% | -869 |
| KALVISTA PHARMACEUTICALS INC | 3,687,867 | 4,887,867 | +1,200,000 | 42,706 | 41,400 | 1.72% | -1,305 |
| ASCENDIS PHARMA A/S(ASND) | 133,333 | 133,333 | 0 | 19,908 | 18,356 | 0.76% | -1,552 |
| ARVINAS INC(ARVN) | 285,331 | 285,331 | 0 | 7,028 | 5,470 | 0.23% | -1,558 |
| REVOLUTION MEDICINES INC(RVMD) | 997,455 | 997,455 | 0 | 45,235 | 43,629 | 1.81% | -1,606 |
| ALLOGENE THERAPEUTICS INC | 2,867,750 | 2,867,750 | 0 | 8,030 | 6,108 | 0.25% | -1,921 |
| ADVERUM BIOTECHNOLOGIES INC | 1,069,244 | 1,069,244 | 0 | 7,506 | 4,993 | 0.21% | -2,513 |
| NUVATION BIO INC(NUVB) | 1,218,236 | 0 | -1,218,236 | 2,790 | 0 | — | -2,790 |
| COGENT BIOSCIENCES INC(COGT) | 936,576 | 936,576 | 0 | 10,115 | 7,305 | 0.30% | -2,810 |
| MERUS N V | 373,100 | 373,100 | 0 | 18,640 | 15,689 | 0.65% | -2,951 |
| MEREO BIOPHARMA GROUP PLC(MREO) | 5,097,779 | 5,097,779 | 0 | 20,952 | 17,842 | 0.74% | -3,110 |
| ERASCA INC(ERAS) | 19,391,687 | 19,391,687 | 0 | 52,939 | 48,673 | 2.02% | -4,266 |
| LEXEO THERAPEUTICS INC(LXEO) | 1,250,786 | 955,515 | -295,271 | 11,307 | 6,287 | 0.26% | -5,020 |
| AUTOLUS THERAPEUTICS PLC(AUTL) | 4,623,324 | 4,623,324 | 0 | 16,783 | 10,865 | 0.45% | -5,918 |
| PEPGEN INC(PEPG) | 702,694 | 0 | -702,694 | 6,008 | 0 | — | -6,008 |
| CG ONCOLOGY INC(CGON) | 770,000 | 770,000 | 0 | 29,052 | 22,084 | 0.92% | -6,968 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 633,715 | 658,715 | +25,000 | 35,203 | 27,712 | 1.15% | -7,491 |
| PUMA BIOTECHNOLOGY INC(PBYI) | 3,062,558 | 0 | -3,062,558 | 7,810 | 0 | — | -7,810 |
| SAVARA INC(SVRA) | 8,157,385 | 8,660,379 | +502,994 | 34,587 | 26,587 | 1.10% | -8,000 |
| ROCKET PHARMACEUTICALS INC(RCKT) | 1,485,630 | 1,479,025 | -6,605 | 27,440 | 18,591 | 0.77% | -8,848 |
| ORIC PHARMACEUTICALS INC(ORIC) | 4,142,855 | 3,888,238 | -254,617 | 42,464 | 31,378 | 1.30% | -11,086 |
| AGIOS PHARMACEUTICALS INC(AGIO) | 1,044,154 | 1,069,754 | +25,600 | 46,392 | 35,152 | 1.46% | -11,240 |
| SOLENO THERAPEUTICS INC | 875,667 | 699,159 | -176,508 | 44,212 | 31,427 | 1.30% | -12,785 |
| SILENCE THERAPEUTICS PLC(SLN) | 1,148,591 | 1,148,591 | 0 | 20,881 | 7,902 | 0.33% | -12,979 |
| TYRA BIOSCIENCES INC(TYRA) | 731,020 | 0 | -731,020 | 17,186 | 0 | — | -17,186 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 2,416,952 | 1,869,808 | -547,144 | 126,624 | 104,672 | 4.34% | -21,952 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 2,832,867 | 1,271,245 | -1,561,622 | 75,609 | 33,942 | 1.41% | -41,667 |
| MBX BIOSCIENCES INC(MBX) | 5,985,347 | 5,985,347 | 0 | 155,499 | 110,310 | 4.58% | -45,189 |
| ANAPTYSBIO INC | 2,209,189 | 1,573,719 | -635,470 | 74,008 | 20,836 | 0.86% | -53,172 |
| VAXCYTE INC(PCVX) | 879,405 | 539,405 | -340,000 | 100,490 | 44,156 | 1.83% | -56,334 |
| KRYSTAL BIOTECH INC(KRYS) | 988,460 | 788,460 | -200,000 | 179,929 | 123,520 | 5.13% | -56,409 |
| PHATHOM PHARMACEUTICALS INC(PHAT) | 10,109,279 | 10,109,279 | 0 | 182,776 | 82,087 | 3.41% | -100,688 |