Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Newamsterdam Pharma Company ORDINARY SHARES | 16,701,956 | 16,943,774 | +241,818 | $475.00M | $594.39M | 15.96% | +$119.38M |
| Mirum Pharmaceuticals, Inc.(MIRM) | 6,795,121 | 6,795,121 | 0 | $498.15M | $536.75M | 14.42% | +$38.60M |
| Arcutis Biotherapeutics, Inc.(ARQT) | 9,874,511 | 9,874,511 | 0 | $186.13M | $286.76M | 7.70% | +$100.62M |
| BridgeBio Pharma, Inc.(BBIO) | 3,845,457 | 3,545,557 | -299,900 | $199.73M | $271.20M | 7.28% | +$71.47M |
| MBX Biosciences, Inc.(MBX) | 6,652,013 | 6,652,013 | 0 | $116.41M | $209.80M | 5.64% | +$93.39M |
| Phathom Pharmaceuticals, Inc.(PHAT) | 12,466,489 | 12,466,489 | 0 | $146.73M | $206.82M | 5.55% | +$60.09M |
| Maze Therapeutics, Inc.(MAZE) | 4,567,274 | 4,567,274 | 0 | $118.43M | $189.22M | 5.08% | +$70.79M |
| Trevi Therapeutics, Inc.(TRVI) | 10,259,409 | 10,259,409 | 0 | $93.87M | $128.45M | 3.45% | +$34.57M |
| Krystal Biotech, Inc.(KRYS) | 688,460 | 488,460 | -200,000 | $121.53M | $120.42M | 3.23% | -$1.11M |
| Disc Medicine, Inc.(IRON) | 1,438,534 | 1,260,000 | -178,534 | $95.06M | $100.06M | 2.69% | +$5.00M |
| Erasca, Inc.(ERAS) | 22,729,436 | 22,729,436 | 0 | $49.55M | $84.55M | 2.27% | +$35.00M |
| Kalvista Pharmaceuticals Inc | 5,039,867 | 5,039,867 | 0 | $61.39M | $81.39M | 2.19% | +$20.01M |
| Palvella Therapeutics, Inc.(PVLA) | 722,400 | 722,400 | 0 | $45.29M | $75.61M | 2.03% | +$30.33M |
| Avidity Biosciences Inc | 625,000 | 983,125 | +358,125 | $27.23M | $70.91M | 1.90% | +$43.68M |
| Revolution Medicines, Inc.(RVMD) | 997,455 | 797,455 | -200,000 | $46.58M | $63.52M | 1.71% | +$16.94M |
| Dyne Therapeutics, Inc.(DYN) | 2,718,105 | 3,153,082 | +434,977 | $34.38M | $61.67M | 1.66% | +$27.29M |
| Tarsus Pharmaceuticals, Inc.(TARS) | 1,167,527 | 728,644 | -438,883 | $69.39M | $59.66M | 1.60% | -$9.72M |
| Savara Inc.(SVRA) | 11,462,301 | 9,862,301 | -1,600,000 | $40.92M | $59.47M | 1.60% | +$18.55M |
| Cytokinetics, Incorporated(CYTK) | 890,445 | 934,642 | +44,197 | $48.94M | $59.39M | 1.60% | +$10.45M |
| ABIVAX Société AnonymeADS(ABVX) | 378,300 | 378,300 | 0 | $32.12M | $51.02M | 1.37% | +$18.90M |
| Lexeo Therapeutics, Inc.(LXEO) | 4,424,725 | 4,424,725 | 0 | $29.38M | $43.94M | 1.18% | +$14.56M |
| Agios Pharmaceuticals, Inc.(AGIO) | 1,279,754 | 1,279,754 | 0 | $51.37M | $34.83M | 0.94% | -$16.53M |
| Acadia Pharmaceuticals Inc | 613,837 | 1,297,198 | +683,361 | $13.10M | $34.65M | 0.93% | +$21.55M |
| Zai Lab LimitedADR(ZLAB) | 1,627,320 | 1,902,320 | +275,000 | $55.15M | $33.56M | 0.90% | -$21.59M |
| Rapt Therapeutics Inc | 0 | 983,333 | +983,333 | $0 | $33.31M | 0.89% | +$33.31M |
| Vor Biopharma Inc.(VOR) | 0 | 2,543,939 | +2,543,939 | $0 | $33.27M | 0.89% | +$33.27M |
| Ascendis Pharma A/SADR(ASND) | 133,333 | 133,333 | 0 | $26.51M | $28.43M | 0.76% | +$1.92M |
| Aura Biosciences, Inc.(AURA) | 5,100,000 | 5,100,000 | 0 | $31.52M | $27.80M | 0.75% | -$3.72M |
| MannKind Corporation(MNKD) | 0 | 4,225,000 | +4,225,000 | $0 | $23.96M | 0.64% | +$23.96M |
| Valneva SEADS(VALN) | 2,291,666 | 2,291,666 | 0 | $27.96M | $20.21M | 0.54% | -$7.75M |
| Alkermes plcSHS(ALKS) | 700,647 | 700,647 | 0 | $21.02M | $19.60M | 0.53% | -$1.42M |
| Evolus, Inc.(EOLS) | 2,630,665 | 2,630,665 | 0 | $16.15M | $17.49M | 0.47% | +$1.34M |
| Immunocore Holdings plcADS(IMCR) | 384,782 | 384,782 | 0 | $13.98M | $13.36M | 0.36% | -$623.3K |
| Newamsterdam Pharma CompanyW EXP 99 99 999 *W EXP 99/99/999 | 500,333 | 500,333 | 0 | $8.56M | $11.51M | 0.31% | +$2.95M |
| Travere Therapeutics, Inc.(TVTX) | 392,092 | 241,592 | -150,500 | $9.37M | $9.23M | 0.25% | -$139.8K |
| Autolus Therapeutics plcADS(AUTL) | 4,623,324 | 4,623,324 | 0 | $7.54M | $9.20M | 0.25% | +$1.66M |
| Allogene Therapeutics Inc | 3,868,750 | 3,868,750 | 0 | $4.80M | $5.30M | 0.14% | +$502.9K |
| Design Therapeutics, Inc.(DSGN) | 1,953,547 | 521,000 | -1,432,547 | $14.71M | $4.89M | 0.13% | -$9.82M |
| Xilio Therapeutics, Inc.(XLO) | 0 | 5,915,091 | +5,915,091 | $0 | $3.79M | 0.10% | +$3.79M |
| iBio, Inc.(IBIO) | 0 | 1,953,467 | +1,953,467 | $0 | $3.77M | 0.10% | +$3.77M |
| Adverum Biotechnologies Inc | 2,077,431 | 0 | -2,077,431 | $9.41M | $0 | — | -$9.41M |
| Akero Therapeutics Inc | 366,784 | 0 | -366,784 | $17.41M | $0 | — | -$17.41M |
| Assembly Biosciences Inc | 456,249 | 0 | -456,249 | $11.68M | $0 | — | -$11.68M |
| Crescent Biopharma, Inc.(CBIO) | 272,951 | 0 | -272,951 | $3.25M | $0 | — | -$3.25M |
| Engene Holdings Inc COM | 1,157,380 | 0 | -1,157,380 | $7.90M | $0 | — | -$7.90M |
| Jade Biosciences Inc | 1,413,280 | 0 | -1,413,280 | $12.20M | $0 | — | -$12.20M |
| MacroGenics, Inc.(MGNX) | 3,175,665 | 0 | -3,175,665 | $5.34M | $0 | — | -$5.34M |
| Mereo BioPharma Group plcADS(MREO) | 9,440,112 | 0 | -9,440,112 | $19.45M | $0 | — | -$19.45M |
| Silence Therapeutics plcADS(SLN) | 970,130 | 0 | -970,130 | $5.03M | $0 | — | -$5.03M |
| Ultragenyx Pharmaceutical Inc.(RARE) | 983,715 | 0 | -983,715 | $29.59M | $0 | — | -$29.59M |
| Vaxcyte, Inc.(PCVX) | 474,405 | 0 | -474,405 | $17.09M | $0 | — | -$17.09M |
| Verona Pharma PlcADS | 3,383,950 | 0 | -3,383,950 | $361.10M | $0 | — | -$361.10M |