Fund HoldingsFrazier Life Sciences Management, L.P.

Total Portfolio Value
$3.72B
Total Bought
$342.04M
Total Sold
$632.20M
Net Transaction
-$290.16M
Filing Period:
Securities
SharesValue ($K)
Q3 2025
Q4 2025
Change
Q3 2025
Q4 2025
Weight (%)
Change
NEWAMSTERDAM PHARMA COMPANY
ORDINARY SHARES
16,701,95616,943,774+241,818475,004594,38815.96%+119,384
ARCUTIS BIOTHERAPEUTICS INC(ARQT)9,874,5119,874,5110186,135286,7567.70%+100,621
MBX BIOSCIENCES INC(MBX)6,652,0136,652,0130116,410209,8045.64%+93,394
BRIDGEBIO PHARMA INC(BBIO)3,845,4573,545,557-299,900199,733271,2007.28%+71,467
MAZE THERAPEUTICS INC(MAZE)4,567,2744,567,2740118,429189,2225.08%+70,793
PHATHOM PHARMACEUTICALS INC(PHAT)12,466,48912,466,4890146,731206,8195.55%+60,088
AVIDITY BIOSCIENCES INC625,000983,125+358,12527,23170,9131.90%+43,682
MIRUM PHARMACEUTICALS INC(MIRM)6,795,1216,795,1210498,150536,74714.42%+38,596
ERASCA INC(ERAS)22,729,43622,729,436049,55084,5542.27%+35,003
TREVI THERAPEUTICS INC(TRVI)10,259,40910,259,409093,874128,4483.45%+34,574
RAPT THERAPEUTICS INC0983,333+983,333033,3050.89%+33,305
VOR BIOPHARMA INC(VOR)02,543,939+2,543,939033,2750.89%+33,275
PALVELLA THERAPEUTICS INC NE(PVLA)722,400722,400045,28775,6142.03%+30,326
DYNE THERAPEUTICS INC(DYN)2,718,1053,153,082+434,97734,38461,6741.66%+27,290
MANNKIND CORP(MNKD)04,225,000+4,225,000023,9560.64%+23,956
ACADIA PHARMACEUTICALS INC613,8371,297,198+683,36113,09934,6480.93%+21,549
KALVISTA PHARMACEUTICALS INC5,039,8675,039,867061,38681,3942.19%+20,008
ABIVAX SA(ABVX)378,300378,300032,11851,0161.37%+18,898
SAVARA INC(SVRA)11,462,3019,862,301-1,600,00040,92059,4701.60%+18,549
REVOLUTION MEDICINES INC(RVMD)997,455797,455-200,00046,58163,5171.71%+16,936
LEXEO THERAPEUTICS INC4,424,7254,424,725029,38043,9381.18%+14,557
CYTOKINETICS INC(CYTK)890,445934,642+44,19748,93959,3871.60%+10,448
DISC MEDICINE INC(IRON)1,438,5341,260,000-178,53495,058100,0572.69%+4,998
XILIO THERAPEUTICS INC05,915,091+5,915,09103,7870.10%+3,787
IBIO INC01,953,467+1,953,46703,7700.10%+3,770
NEWAMSTERDAM PHARMA COMPANY
*W EXP 99/99/999
500,333500,33308,56111,5080.31%+2,947
ASCENDIS PHARMA A/S(ASND)133,333133,333026,50828,4320.76%+1,924
AUTOLUS THERAPEUTICS PLC4,623,3244,623,32407,5369,2000.25%+1,664
EVOLUS INC2,630,6652,630,665016,15217,4940.47%+1,342
ALLOGENE THERAPEUTICS INC3,868,7503,868,75004,7975,3000.14%+503
TRAVERE THERAPEUTICS INC(TVTX)392,092241,592-150,5009,3719,2310.25%-140
IMMUNOCORE HLDGS PLC(IMCR)384,782384,782013,97913,3560.36%-623
KRYSTAL BIOTECH INC(KRYS)688,460488,460-200,000121,534120,4253.23%-1,109
ALKERMES PLC(ALKS)700,647700,647021,01919,6040.53%-1,415
CRESCENT BIOPHARMA INC.272,9510-272,9513,2450-3,245
AURA BIOSCIENCES INC5,100,0005,100,000031,51827,7950.75%-3,723
SILENCE THERAPEUTICS PLC970,1300-970,1305,0350-5,035
MACROGENICS INC3,175,6650-3,175,6655,3350-5,335
VALNEVA SE2,291,6662,291,666027,95820,2120.54%-7,746
ENGENE HOLDINGS INC
COM
1,157,3800-1,157,3807,9050-7,905
ADVERUM BIOTECHNOLOGIES INC2,077,4310-2,077,4319,4110-9,411
TARSUS PHARMACEUTICALS INC(TARS)1,167,527728,644-438,88369,38659,6611.60%-9,725
DESIGN THERAPEUTICS INC1,953,547521,000-1,432,54714,7104,8870.13%-9,823
ASSEMBLY BIOSCIENCES INC456,2490-456,24911,6800-11,680
JADE BIOSCIENCES INC1,413,2800-1,413,28012,1970-12,197
AGIOS PHARMACEUTICALS INC(AGIO)1,279,7541,279,754051,36934,8350.94%-16,534
VAXCYTE INC(PCVX)474,4050-474,40517,0880-17,088
AKERO THERAPEUTICS INC366,7840-366,78417,4150-17,415
MEREO BIOPHARMA GROUP PLC9,440,1120-9,440,11219,4470-19,447
ZAI LAB LTD(ZLAB)1,627,3201,902,320+275,00055,15033,5570.90%-21,593
ULTRAGENYX PHARMACEUTICAL IN(RARE)983,7150-983,71529,5900-29,590
VERONA PHARMA PLC3,383,9500-3,383,950361,1010-361,101
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