Knott David M Jr
Securities ▲▼ | Shares | Value ($K) | ||||
|---|---|---|---|---|---|---|
Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | |
| Iovance Biotherapeutics, Inc. | 0 | 1,600,000 | +1,600,000 | 0 | 5,616,000 | +5,616,000 |
| LPL Financial Holdings Inc. | 0 | 16,500 | +16,500 | 0 | 4,963,695 | +4,963,695 |
| Relmada Therapeutics, Inc. | 0 | 439,300 | +439,300 | 0 | 3,057,528 | +3,057,528 |
| Agios Pharmaceutical, Inc. | 18,000 | 93,058 | +75,058 | 489,960 | 3,148,152 | +2,658,192 |
| TG Therapeutics, Inc. | 45,000 | 90,001 | +45,001 | 1,341,450 | 2,989,833 | +1,648,383 |
| Alkermes PLC | 95,000 | 120,000 | +25,000 | 2,658,100 | 4,243,200 | +1,585,100 |
| Centessa Pharmaceuticals PLC | 4,000 | 39,000 | +35,000 | 100,040 | 1,549,080 | +1,449,040 |
| Ardelyx, Inc. | 0 | 207,000 | +207,000 | 0 | 1,239,930 | +1,239,930 |
| Syndax Pharmaceutical, Inc. | 415,000 | 422,000 | +7,000 | 8,719,150 | 9,857,920 | +1,138,770 |
| Arcellx Inc | 25,700 | 19,433 | -6,267 | 1,675,640 | 2,231,297 | +555,657 |
| Verastem Inc. | 0 | 104,000 | +104,000 | 0 | 551,200 | +551,200 |
| Biohaven Pharmaceutical Holding Co. Ltd | 0 | 60,720 | +60,720 | 0 | 513,691 | +513,691 |
| Connect Biopharma Holdings Limited | 200,000 | 387,835 | +187,835 | 564,000 | 1,016,128 | +452,128 |
| Cogent Biosciences Inc. | 102,000 | 104,000 | +2,000 | 3,623,040 | 4,002,960 | +379,920 |
| Cullinan Therapeutics, Inc. | 0 | 24,200 | +24,200 | 0 | 343,882 | +343,882 |
| SPDR S&P Biotech ETF | 13,000 | 15,000 | +2,000 | 1,585,090 | 1,916,100 | +331,010 |
| Rezolute, Inc. | 340,000 | 370,000 | +30,000 | 802,400 | 1,128,500 | +326,100 |
| Protagonist Therapeutics, Inc | 73,000 | 63,000 | -10,000 | 6,375,820 | 6,640,200 | +264,380 |
| Rain Enhancement Technologies Holdco Inc | 0 | 101,686 | +101,686 | 0 | 258,282 | +258,282 |
| Canadian Natural Resources Limited | 16,800 | 16,800 | 0 | 568,680 | 818,664 | +249,984 |
| Ultragenyx Pharmaceutical Inc. | 20,006 | 33,069 | +13,063 | 460,138 | 692,796 | +232,658 |
| Bridgebio Pharma, Inc. | 85,000 | 90,000 | +5,000 | 6,501,650 | 6,683,400 | +181,750 |
| Pfizer Inc. | 32,337 | 32,337 | 0 | 805,191 | 908,023 | +102,832 |
| Orchestra Biomed Holdings, Inc. | 250,000 | 253,651 | +3,651 | 1,037,500 | 1,078,017 | +40,517 |
| Brightstar Lottery PLC | 0 | 2,500 | +2,500 | 0 | 31,850 | +31,850 |
| FS KKR Capital Corp. | 0 | 2,875 | +2,875 | 0 | 29,267 | +29,267 |
| Quanta Services, Inc. | 176 | 176 | 0 | 74,283 | 96,628 | +22,345 |
| Dow Inc. | 1,206 | 1,206 | 0 | 28,196 | 50,230 | +22,034 |
| Kura Oncology, Inc. | 39,209 | 52,767 | +13,558 | 407,382 | 428,996 | +21,614 |
| DuPont de Nemours, Inc. | 3,767 | 3,767 | 0 | 151,433 | 172,529 | +21,096 |
| Corteva, Inc. | 1,206 | 1,206 | 0 | 80,838 | 100,954 | +20,116 |
| Mondelez International, Inc. | 3,000 | 3,000 | 0 | 161,430 | 172,920 | +11,490 |
| Occidental Petroleum Corporation | 663 | 663 | 0 | 23,553 | 34,730 | +11,177 |
| Eastern Bankshares Inc | 5,000 | 5,000 | 0 | 92,150 | 97,800 | +5,650 |
| Legacy Housing Corporation | 4,000 | 4,000 | 0 | 78,080 | 81,720 | +3,640 |
| iShares Biotechnology ETF | 5,500 | 5,500 | 0 | 928,235 | 928,675 | +440 |
| Wabtec Corporation | 6 | 6 | 0 | 1,281 | 1,499 | +218 |
| Starwood Property Trust, Inc. | 400 | 400 | 0 | 7,204 | 6,888 | -316 |
| GE HealthCare Technologies Inc | 50 | 50 | 0 | 4,101 | 3,559 | -542 |
| United Healthcare Corp. | 57 | 57 | 0 | 18,816 | 15,424 | -3,392 |
| Thermo Fisher Scientific, Inc. | 45 | 45 | 0 | 26,075 | 22,119 | -3,956 |
| Ryman Hospitality Properties, Inc. | 2,400 | 2,400 | 0 | 227,088 | 221,448 | -5,640 |
| Kyndryl Holdings Inc. | 428 | 428 | 0 | 11,368 | 5,615 | -5,753 |
| Salesforce, Inc. | 77 | 77 | 0 | 20,398 | 14,374 | -6,024 |
| iShares Russell Mid-Cap Growth | 695 | 695 | 0 | 95,173 | 89,043 | -6,130 |
| United Rental, Inc. | 78 | 78 | 0 | 63,127 | 56,828 | -6,299 |
| Amazon.com Inc. | 300 | 300 | 0 | 69,246 | 62,493 | -6,753 |
| Danaher Corporation | 180 | 180 | 0 | 41,206 | 34,128 | -7,078 |
| Alphabet Inc CL A | 300 | 300 | 0 | 93,900 | 86,268 | -7,632 |
| Blackstone Group LP | 210 | 210 | 0 | 32,369 | 24,148 | -8,221 |
| Kimberly-Clark Corporation | 2,400 | 2,400 | 0 | 242,136 | 231,528 | -10,608 |
| Nvidia Corp | 1,280 | 1,280 | 0 | 238,720 | 223,290 | -15,430 |
| Janus Henderson AAA CLO ETF | 93,528 | 93,528 | 0 | 4,730,646 | 4,711,005 | -19,641 |
| Broadcom, Inc. | 710 | 710 | 0 | 245,731 | 219,859 | -25,872 |
| Mereo BioPharm Group PLC | 300,337 | 300,337 | 0 | 125,150 | 99,111 | -26,039 |
| International Game Technology PLC | 2,500 | 0 | -2,500 | 38,700 | 0 | -38,700 |
| The Panagram BBB-B CLO ETF | 47,807 | 47,807 | 0 | 1,265,929 | 1,226,250 | -39,679 |
| FS KKR Capital Corp. | 2,875 | 0 | -2,875 | 42,579 | 0 | -42,579 |
| Apple Inc. | 2,494 | 2,494 | 0 | 678,019 | 632,952 | -45,067 |
| AllianceBernstein Holding L.P. | 48,000 | 48,000 | 0 | 1,847,040 | 1,797,120 | -49,920 |
| uniQure N.V. | 4,000 | 0 | -4,000 | 95,720 | 0 | -95,720 |
| International Business Machines | 2,142 | 2,142 | 0 | 634,482 | 519,285 | -115,197 |
| Invivyd, Inc. | 100,000 | 100,000 | 0 | 247,000 | 130,000 | -117,000 |
| Madrigal Pharmaaceuticals, Inc. | 2,000 | 2,000 | 0 | 1,164,680 | 1,046,940 | -117,740 |
| Pelthos Therapeutics, Inc. | 19,281 | 21,073 | +1,792 | 597,711 | 442,744 | -154,967 |
| Microsoft Corporation | 1,600 | 1,600 | 0 | 773,792 | 592,272 | -181,520 |
| Jasper Therapeutics, Inc. | 181,389 | 160,789 | -20,600 | 331,942 | 140,883 | -191,059 |
| Johnson & Johnson | 6,922 | 4,922 | -2,000 | 1,432,508 | 1,203,134 | -229,374 |
| Day One Biopharmaceuticals, Inc. | 25,884 | 0 | -25,884 | 241,239 | 0 | -241,239 |
| Evolus, Inc. | 99,338 | 99,338 | 0 | 660,598 | 408,279 | -252,319 |
| Vera Therapeutics, Inc. | 26,000 | 26,000 | 0 | 1,316,640 | 1,045,980 | -270,660 |
| Biogen Inc. | 6,000 | 4,000 | -2,000 | 1,055,940 | 733,320 | -322,620 |
| Fate Therapeutics, Inc. | 365,000 | 0 | -365,000 | 358,649 | 0 | -358,649 |
| Bristol-Myers Squibb Company | 22,000 | 13,622 | -8,378 | 1,186,680 | 826,174 | -360,506 |
| Mersana Therapeutics, Inc. | 111,686 | 0 | -111,686 | 437,762 | 0 | -437,762 |
| Xenon Pharmaceuticals Inc. | 10,962 | 0 | -10,962 | 491,317 | 0 | -491,317 |
| JPMorgan Chase & Co. | 19,477 | 19,477 | 0 | 6,275,879 | 5,729,354 | -546,525 |
| LENZ Therapeutics, Inc. | 53,732 | 33,732 | -20,000 | 859,712 | 308,648 | -551,064 |
| ADMA Biologics, Inc. | 60,200 | 60,200 | 0 | 1,098,048 | 542,402 | -555,646 |
| AtriCure, Inc. | 51,400 | 51,400 | 0 | 2,033,384 | 1,466,442 | -566,942 |
| Solid Bioscience Inc. | 162,440 | 47,143 | -115,297 | 916,162 | 339,430 | -576,732 |
| Cytokinetics, Incorporated | 34,000 | 23,644 | -10,356 | 2,160,360 | 1,558,376 | -601,984 |
| Scholar Rock Holding Corporation | 13,913 | 0 | -13,913 | 612,868 | 0 | -612,868 |
| Cybin Inc | 285,182 | 350,000 | +64,818 | 2,332,789 | 1,680,000 | -652,789 |
| Nektar Therapeutics | 15,500 | 0 | -15,500 | 655,340 | 0 | -655,340 |
| DocGo, Inc. | 2,670,850 | 2,670,850 | 0 | 2,344,472 | 1,680,232 | -664,240 |
| Viridian Therapeutics, Inc. | 145,000 | 181,000 | +36,000 | 4,512,400 | 3,540,360 | -972,040 |
| Arcus Biosciences, Inc. | 121,241 | 81,241 | -40,000 | 2,889,173 | 1,754,806 | -1,134,367 |
| Wave Life Science Ltd. | 90,000 | 40,000 | -50,000 | 1,530,000 | 290,000 | -1,240,000 |
| Biohaven LTD | 110,720 | 0 | -110,720 | 1,250,029 | 0 | -1,250,029 |
| Catalyst Pharmaceuticals, Inc. | 189,000 | 120,000 | -69,000 | 4,411,260 | 2,971,200 | -1,440,060 |
| Xeris Biopharma Holdings, Inc. | 970,000 | 1,060,000 | +90,000 | 7,614,500 | 6,148,000 | -1,466,500 |
| Tectonic Therapeutic, Inc. | 74,000 | 0 | -74,000 | 1,543,640 | 0 | -1,543,640 |
| Alphabet Inc-Cl C | 91,420 | 91,420 | 0 | 28,687,596 | 26,228,398 | -2,459,198 |
| Travere Therapeutics, Inc. | 186,000 | 140,633 | -45,367 | 7,107,060 | 4,178,206 | -2,928,854 |
| Apollo Global Management, Inc. | 225,000 | 225,000 | 0 | 32,571,000 | 25,069,500 | -7,501,500 |
| Calumet, Inc. | 2,214,969 | 0 | -2,214,969 | 44,011,434 | 0 | -44,011,434 |