Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q1 2025 ▲▼ | Q2 2025 ▲▼ | Change ▲▼ | Q1 2025 ▲▼ | Q2 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Guardant Health, Inc.DEBT 1 250 2 1(GH) | 0 | 0 | 0 | $227.41M | $256.36M | 8.77% | +$28.94M |
| Caris Life Sciences, Inc.(CAI) | 0 | 7,316,142 | +7,316,142 | $0 | $195.49M | 6.69% | +$195.49M |
| Neurocrine Biosciences, Inc.(NBIX) | 1,191,925 | 1,160,425 | -31,500 | $131.83M | $145.85M | 4.99% | +$14.03M |
| NovoCure LimitedNOTE 11 0(NVCR) | 0 | 0 | 0 | $136.61M | $137.85M | 4.71% | +$1.24M |
| Xenon Pharmaceuticals Inc.(XENE) | 2,709,875 | 3,605,029 | +895,154 | $90.92M | $112.84M | 3.86% | +$21.92M |
| argenx SEADR(ARGX) | 160,849 | 194,491 | +33,642 | $95.20M | $107.21M | 3.67% | +$12.01M |
| Repligen CorporationNOTE 1 000 12 1(RGEN) | 0 | 0 | 0 | $95.84M | $100.55M | 3.44% | +$4.70M |
| Krystal Biotech, Inc.(KRYS) | 400,744 | 727,811 | +327,067 | $72.25M | $100.04M | 3.42% | +$27.79M |
| Align Technology Inc | 530,530 | 496,730 | -33,800 | $84.28M | $94.05M | 3.22% | +$9.77M |
| Legend Biotech CorporationADS(LEGN) | 2,977,951 | 2,542,104 | -435,847 | $101.04M | $90.22M | 3.09% | -$10.82M |
| iRhythm Holdings, Inc.NOTE 1 500 9 0(IRTC) | 0 | 0 | 0 | $89.74M | $89.98M | 3.08% | +$244.0K |
| Nuvalent Inc | 840,945 | 1,175,876 | +334,931 | $59.64M | $89.72M | 3.07% | +$30.08M |
| NeoGenomics, Inc.NOTE 0 250 1 1(NEO) | 0 | 0 | 0 | $87.95M | $87.06M | 2.98% | -$887.1K |
| CG Oncology, Inc.(CGON) | 3,283,317 | 3,283,317 | 0 | $80.41M | $85.37M | 2.92% | +$4.96M |
| Ironwood Pharmaceuticals, Inc.NOTE 1 500 6 1(IRWD) | 0 | 0 | 0 | $82.54M | $78.37M | 2.68% | -$4.17M |
| Edgewise Therapeutics, Inc.(EWTX) | 2,458,808 | 5,210,831 | +2,752,023 | $54.09M | $68.31M | 2.34% | +$14.22M |
| Inspire Medical Systems, Inc.(INSP) | 302,410 | 522,410 | +220,000 | $48.17M | $67.79M | 2.32% | +$19.63M |
| Apogee Therapeutics Inc | 1,540,362 | 1,478,512 | -61,850 | $57.55M | $64.21M | 2.20% | +$6.66M |
| Glaukos Corporation(GKOS) | 624,435 | 603,414 | -21,021 | $61.46M | $62.33M | 2.13% | +$869.7K |
| Danaher Corporation(DHR) | 309,339 | 309,339 | 0 | $63.41M | $61.11M | 2.09% | -$2.31M |
| Thermo Fisher Scientific Inc.(TMO) | 127,733 | 135,233 | +7,500 | $63.56M | $54.83M | 1.88% | -$8.73M |
| Intuitive Surgical, Inc.(ISRG) | 88,000 | 89,600 | +1,600 | $43.58M | $48.69M | 1.67% | +$5.11M |
| iRhythm Holdings, Inc.(IRTC) | 556,391 | 300,029 | -256,362 | $58.24M | $46.19M | 1.58% | -$12.05M |
| Adaptive Biotechnologies Corporation(ADPT) | 4,803,794 | 3,863,107 | -940,687 | $35.69M | $45.01M | 1.54% | +$9.31M |
| Guardant Health, Inc.(GH) | 1,327,327 | 837,800 | -489,527 | $56.54M | $43.60M | 1.49% | -$12.95M |
| Alphatec Holdings, Inc.(ATEC) | 4,259,429 | 3,635,172 | -624,257 | $43.19M | $40.35M | 1.38% | -$2.84M |
| Spyre Therapeutics, Inc.(SYRE) | 2,578,404 | 2,578,404 | 0 | $41.60M | $38.60M | 1.32% | -$3.00M |
| Viking Therapeutics, Inc.(VKTX) | 1,435,955 | 1,437,555 | +1,600 | $34.68M | $38.10M | 1.30% | +$3.42M |
| Karyopharm Therapeutics IncNOTE 6 000 5 1 | 0 | 0 | 0 | $0 | $35.54M | 1.22% | +$35.54M |
| TransMedics Group, Inc.(TMDX) | 854,884 | 255,048 | -599,836 | $57.52M | $34.18M | 1.17% | -$23.34M |
| Penumbra, Inc.(PEN) | 110,128 | 129,628 | +19,500 | $29.45M | $33.27M | 1.14% | +$3.82M |
| Dyne Therapeutics, Inc.(DYN) | 3,621,344 | 3,273,349 | -347,995 | $37.88M | $31.16M | 1.07% | -$6.72M |
| Kiniksa Pharmaceuticals International, plcCL A(KNSA) | 1,962,909 | 1,102,580 | -860,329 | $43.60M | $30.51M | 1.04% | -$13.09M |
| Harrow, Inc.(HROW) | 956,839 | 872,246 | -84,593 | $25.45M | $26.64M | 0.91% | +$1.19M |
| OrthoPediatrics Corp.(KIDS) | 1,107,770 | 1,107,770 | 0 | $27.28M | $23.79M | 0.81% | -$3.49M |
| Immunocore Holdings plcNOTE 2 500 2 0(IMCR) | 0 | 0 | 0 | $43.77M | $23.27M | 0.80% | -$20.50M |
| Maravai LifeSciences Holdings, Inc.CL A(MRVI) | 8,353,287 | 8,353,287 | 0 | $18.46M | $20.13M | 0.69% | +$1.67M |
| Apellis Pharmaceuticals Inc COM | 1,652,334 | 1,121,034 | -531,300 | $36.14M | $19.41M | 0.66% | -$16.73M |
| Sionna Therapeutics, Inc.(SION) | 0 | 1,081,855 | +1,081,855 | $0 | $18.77M | 0.64% | +$18.77M |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 48,690 | 60,781 | +12,091 | $16.13M | $18.39M | 0.63% | +$2.27M |
| DexCom, Inc.NOTE 0 250 11 1(DXCM) | 0 | 0 | 0 | $18.04M | $18.22M | 0.62% | +$175.8K |
| Repligen Corporation(RGEN) | 81,656 | 144,556 | +62,900 | $10.39M | $17.98M | 0.61% | +$7.59M |
| Oruka Therapeutics, Inc.(ORKA) | 1,572,426 | 1,524,842 | -47,584 | $16.13M | $17.09M | 0.58% | +$960.4K |
| Castle Biosciences, Inc.(CSTL) | 365,247 | 822,735 | +457,488 | $7.31M | $16.80M | 0.57% | +$9.49M |
| UnitedHealth Group Incorporated(UNH) | 0 | 49,400 | +49,400 | $0 | $15.41M | 0.53% | +$15.41M |
| Globus Medical, Inc.CL A(GMED) | 0 | 247,200 | +247,200 | $0 | $14.59M | 0.50% | +$14.59M |
| Day One Biopharmaceuticals I COM | 3,536,853 | 2,181,598 | -1,355,255 | $28.05M | $14.18M | 0.48% | -$13.87M |
| Xencor, Inc.(XNCR) | 1,655,690 | 1,655,690 | 0 | $17.62M | $13.01M | 0.45% | -$4.60M |
| Celcuity Inc.(CELC) | 884,306 | 884,306 | 0 | $8.94M | $11.81M | 0.40% | +$2.87M |
| Alphatec Holdings, Inc.NOTE 0 750 8 0(ATEC) | 0 | 0 | 0 | $5.79M | $5.77M | 0.20% | -$24.2K |
| Crescent Biopharma, Inc.(CBIO) | 0 | 261,504 | +261,504 | $0 | $4.22M | 0.14% | +$4.22M |
| Replimune Group, Inc.(REPL) | 1,461,826 | 422,887 | -1,038,939 | $14.25M | $3.93M | 0.13% | -$10.32M |
| Zura Bio LimitedCL A(ZURA) | 2,472,806 | 2,472,806 | 0 | $3.19M | $2.60M | 0.09% | -$593.5K |
| Pulmonx Corporation(LUNG) | 752,541 | 752,541 | 0 | $5.06M | $1.95M | 0.07% | -$3.12M |
| Surrozen, Inc.(SRZN) | 0 | 140,000 | +140,000 | $0 | $1.25M | 0.04% | +$1.25M |
| Aardvark Therapeutics Inc | 500,000 | 0 | -500,000 | $3.75M | $0 | — | -$3.75M |
| Aerovate Therapeutics Inc | 1,440,499 | 0 | -1,440,499 | $3.62M | $0 | — | -$3.62M |
| Ascendis Pharma A/SADR(ASND) | 106,713 | 0 | -106,713 | $16.63M | $0 | — | -$16.63M |
| Beta Bionics, Inc.(BBNX) | 140,000 | 0 | -140,000 | $1.71M | $0 | — | -$1.71M |
| Bicara Therapeutics Inc | 2,162,803 | 0 | -2,162,803 | $28.18M | $0 | — | -$28.18M |
| Blueprint Medicines Corp | 439,968 | 0 | -439,968 | $38.94M | $0 | — | -$38.94M |
| BridgeBio Pharma, Inc.NOTE 2 250 2 0(BBIO) | 0 | 0 | 0 | $43.81M | $0 | — | -$43.81M |
| BridgeBio Pharma, Inc.NOTE 2 500 3 1(BBIO) | 0 | 0 | 0 | $72.00M | $0 | — | -$72.00M |
| Cullinan Therapeutics, Inc.(CGEM) | 980,773 | 0 | -980,773 | $7.42M | $0 | — | -$7.42M |
| DexCom, Inc.NOTE 0 375 5 1(DXCM) | 0 | 0 | 0 | $22.80M | $0 | — | -$22.80M |
| Dianthus Therapeutics, Inc.(DNTH) | 375,355 | 0 | -375,355 | $6.81M | $0 | — | -$6.81M |
| Ironwood Pharmaceuticals, Inc.CL A(IRWD) | 6,622,584 | 0 | -6,622,584 | $9.74M | $0 | — | -$9.74M |
| Metsera Inc | 175,000 | 0 | -175,000 | $4.76M | $0 | — | -$4.76M |
| Sarepta Therapeutics, Inc.(SRPT) | 234,500 | 0 | -234,500 | $14.97M | $0 | — | -$14.97M |
| Skye Bioscience, Inc.(SKYE) | 825,732 | 0 | -825,732 | $1.31M | $0 | — | -$1.31M |
| Trevi Therapeutics, Inc.(TRVI) | 72,083 | 0 | -72,083 | $453.4K | $0 | — | -$453.4K |