Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Caris Life Sciences, Inc.(CAI) | 7,316,142 | 7,816,142 | +500,000 | $221.31M | $210.88M | 6.74% | -$10.43M |
| Guardant Health, Inc.DEBT 1 250 2 1(GH) | 0 | 0 | 0 | $286.28M | $192.31M | 6.15% | -$93.97M |
| Edgewise Therapeutics, Inc.(EWTX) | 5,210,831 | 5,210,831 | 0 | $84.52M | $129.31M | 4.14% | +$44.79M |
| Repligen CorporationNOTE 1 000 12 1(RGEN) | 0 | 0 | 0 | $101.81M | $110.85M | 3.54% | +$9.04M |
| Neurocrine Biosciences, Inc.(NBIX) | 880,282 | 751,534 | -128,748 | $123.57M | $106.59M | 3.41% | -$16.98M |
| Glaukos Corporation(GKOS) | 780,164 | 921,979 | +141,815 | $63.62M | $104.10M | 3.33% | +$40.48M |
| NeoGenomics, Inc.NOTE 0 250 1 1(NEO) | 0 | 0 | 0 | $86.83M | $89.72M | 2.87% | +$2.89M |
| Nuvalent Inc | 1,012,982 | 821,406 | -191,576 | $87.60M | $82.63M | 2.64% | -$4.98M |
| Xenon Pharmaceuticals Inc.(XENE) | 3,605,029 | 1,825,076 | -1,779,953 | $144.74M | $81.80M | 2.62% | -$62.94M |
| CG Oncology, Inc.(CGON) | 3,283,317 | 1,870,571 | -1,412,746 | $132.25M | $77.67M | 2.48% | -$54.59M |
| iRhythm Holdings, Inc.NOTE 1 500 9 0(IRTC) | 0 | 0 | 0 | $85.37M | $72.80M | 2.33% | -$12.57M |
| Hinge Health, Inc.CL A(HNGE) | 910,476 | 1,304,623 | +394,147 | $44.69M | $60.60M | 1.94% | +$15.91M |
| Align Technology Inc | 409,691 | 381,004 | -28,687 | $51.30M | $59.49M | 1.90% | +$8.19M |
| Kodiak Sciences Inc.(KOD) | 0 | 2,072,788 | +2,072,788 | $0 | $57.96M | 1.85% | +$57.96M |
| Soleno Therapeutics Inc | 1,281,989 | 1,187,859 | -94,130 | $86.66M | $55.00M | 1.76% | -$31.66M |
| Centessa Pharmaceuticals PlcADS | 0 | 2,188,320 | +2,188,320 | $0 | $54.73M | 1.75% | +$54.73M |
| NeoGenomics, Inc.(NEO) | 1,771,146 | 4,632,801 | +2,861,655 | $13.67M | $54.48M | 1.74% | +$40.81M |
| Acadia Pharmaceuticals Inc | 2,378,655 | 2,032,021 | -346,634 | $50.76M | $54.28M | 1.74% | +$3.51M |
| Spyre Therapeutics, Inc.(SYRE) | 2,578,404 | 1,634,615 | -943,789 | $43.21M | $53.55M | 1.71% | +$10.34M |
| Dianthus Therapeutics, Inc.(DNTH) | 835,057 | 1,273,935 | +438,878 | $32.86M | $52.50M | 1.68% | +$19.64M |
| Ironwood Pharmaceuticals, Inc.NOTE 1 500 6 1(IRWD) | 0 | 0 | 0 | $72.90M | $50.47M | 1.61% | -$22.43M |
| Celldex Therapeutics, Inc.(CLDX) | 591,689 | 1,858,109 | +1,266,420 | $15.31M | $50.47M | 1.61% | +$35.16M |
| Inspire Medical Systems, Inc.(INSP) | 883,747 | 540,890 | -342,857 | $65.57M | $49.89M | 1.60% | -$15.69M |
| Krystal Biotech, Inc.(KRYS) | 520,401 | 202,101 | -318,300 | $91.87M | $49.83M | 1.59% | -$42.04M |
| Intuitive Surgical, Inc.(ISRG) | 130,227 | 83,417 | -46,810 | $58.24M | $47.24M | 1.51% | -$11.00M |
| Thermo Fisher Scientific Inc.(TMO) | 113,933 | 80,725 | -33,208 | $55.26M | $46.78M | 1.50% | -$8.48M |
| BrightSpring Health Services, Inc.(BTSG) | 0 | 1,195,786 | +1,195,786 | $0 | $44.78M | 1.43% | +$44.78M |
| CVS Health Corporation(CVS) | 438,600 | 564,200 | +125,600 | $33.07M | $44.77M | 1.43% | +$11.71M |
| Apogee Therapeutics Inc | 1,438,745 | 575,067 | -863,678 | $57.16M | $43.41M | 1.39% | -$13.76M |
| Nurix Therapeutics, Inc.(NRIX) | 0 | 2,183,864 | +2,183,864 | $0 | $41.43M | 1.32% | +$41.43M |
| Vera Therapeutics, Inc.CL A(VERA) | 472,739 | 784,742 | +312,003 | $13.74M | $39.74M | 1.27% | +$26.00M |
| iRhythm Holdings, Inc.(IRTC) | 225,845 | 217,345 | -8,500 | $38.84M | $38.57M | 1.23% | -$277.4K |
| TransMedics Group, Inc.(TMDX) | 351,248 | 315,341 | -35,907 | $39.41M | $38.36M | 1.23% | -$1.05M |
| BioMarin Pharmaceutical Inc.(BMRN) | 528,000 | 601,520 | +73,520 | $28.60M | $35.75M | 1.14% | +$7.15M |
| Illumina, Inc.(ILMN) | 0 | 269,673 | +269,673 | $0 | $35.37M | 1.13% | +$35.37M |
| Kymera Therapeutics, Inc.(KYMR) | 276,692 | 454,259 | +177,567 | $15.66M | $35.35M | 1.13% | +$19.69M |
| Fulcrum Therapeutics, Inc.(FULC) | 219,488 | 3,061,222 | +2,841,734 | $2.02M | $34.62M | 1.11% | +$32.60M |
| Penumbra, Inc.(PEN) | 141,528 | 110,152 | -31,376 | $35.85M | $34.25M | 1.10% | -$1.60M |
| MBX Biosciences, Inc.(MBX) | 0 | 1,018,600 | +1,018,600 | $0 | $32.13M | 1.03% | +$32.13M |
| Rapt Therapeutics Inc | 0 | 929,694 | +929,694 | $0 | $31.49M | 1.01% | +$31.49M |
| CareDx, Inc.(CDNA) | 2,182,781 | 1,585,220 | -597,561 | $31.74M | $29.87M | 0.96% | -$1.87M |
| Dyne Therapeutics, Inc.(DYN) | 2,730,481 | 1,478,329 | -1,252,152 | $34.54M | $28.92M | 0.92% | -$5.62M |
| Engene Holdings Inc COM | 2,266,319 | 3,131,319 | +865,000 | $15.48M | $28.28M | 0.90% | +$12.80M |
| Legend Biotech CorporationADS(LEGN) | 1,826,155 | 1,298,142 | -528,013 | $59.55M | $28.22M | 0.90% | -$31.33M |
| Maravai LifeSciences Holdings, Inc.CL A(MRVI) | 8,353,287 | 8,353,287 | 0 | $23.97M | $27.15M | 0.87% | +$3.17M |
| Danaher Corporation(DHR) | 309,339 | 118,227 | -191,112 | $61.33M | $27.06M | 0.87% | -$34.27M |
| argenx SEADR(ARGX) | 76,091 | 31,007 | -45,084 | $56.12M | $26.08M | 0.83% | -$30.05M |
| Natera, Inc.(NTRA) | 0 | 111,500 | +111,500 | $0 | $25.54M | 0.82% | +$25.54M |
| Bright Minds Biosciences Inc.(DRUG) | 303,685 | 324,358 | +20,673 | $18.42M | $25.31M | 0.81% | +$6.89M |
| Terns Pharmaceuticals Inc | 0 | 575,321 | +575,321 | $0 | $23.24M | 0.74% | +$23.24M |
| Evolus, Inc.(EOLS) | 0 | 3,105,209 | +3,105,209 | $0 | $20.65M | 0.66% | +$20.65M |
| Biogen Inc.(BIIB) | 0 | 115,700 | +115,700 | $0 | $20.36M | 0.65% | +$20.36M |
| OrthoPediatrics Corp.(KIDS) | 1,107,770 | 1,100,370 | -7,400 | $20.53M | $19.54M | 0.62% | -$984.4K |
| Tectonic Therapeutic, Inc.(TECX) | 736,867 | 927,524 | +190,657 | $11.56M | $19.35M | 0.62% | +$7.79M |
| Ventyx Biosciences Inc | 0 | 1,920,255 | +1,920,255 | $0 | $17.34M | 0.55% | +$17.34M |
| Zura Bio LimitedCL A(ZURA) | 2,472,806 | 3,180,389 | +707,583 | $10.71M | $16.67M | 0.53% | +$5.96M |
| Compass Therapeutics, Inc.(CMPX) | 0 | 2,786,778 | +2,786,778 | $0 | $14.96M | 0.48% | +$14.96M |
| Monte Rosa Therapeutics, Inc.(GLUE) | 0 | 948,316 | +948,316 | $0 | $14.87M | 0.48% | +$14.87M |
| Harrow, Inc.(HROW) | 342,391 | 295,291 | -47,100 | $16.50M | $14.47M | 0.46% | -$2.03M |
| X4 Pharmaceuticals, Inc.(XFOR) | 0 | 3,368,904 | +3,368,904 | $0 | $13.48M | 0.43% | +$13.48M |
| Repligen Corporation(RGEN) | 195,656 | 81,790 | -113,866 | $26.15M | $13.40M | 0.43% | -$12.75M |
| ICON Public Limited CompanySHS(ICLR) | 0 | 73,370 | +73,370 | $0 | $13.37M | 0.43% | +$13.37M |
| Kiniksa Pharmaceuticals International, plcCL A(KNSA) | 643,180 | 313,823 | -329,357 | $24.97M | $12.95M | 0.41% | -$12.03M |
| GRAIL, Inc.(GRAL) | 0 | 142,755 | +142,755 | $0 | $12.22M | 0.39% | +$12.22M |
| Surrozen, Inc.(SRZN) | 140,000 | 470,000 | +330,000 | $1.80M | $10.62M | 0.34% | +$8.82M |
| Relmada Therapeutics, Inc.(RLMD) | 0 | 1,582,257 | +1,582,257 | $0 | $7.64M | 0.24% | +$7.64M |
| Xencor, Inc.(XNCR) | 1,246,280 | 459,166 | -787,114 | $14.62M | $7.03M | 0.22% | -$7.59M |
| Castle Biosciences, Inc.(CSTL) | 822,735 | 177,183 | -645,552 | $18.73M | $6.89M | 0.22% | -$11.84M |
| Adaptive Biotechnologies Corporation(ADPT) | 736,014 | 311,991 | -424,023 | $11.01M | $5.07M | 0.16% | -$5.94M |
| Billiontoone IncCL A | 0 | 50,000 | +50,000 | $0 | $4.09M | 0.13% | +$4.09M |
| Oruka Therapeutics, Inc.(ORKA) | 1,382,350 | 84,795 | -1,297,555 | $26.58M | $2.57M | 0.08% | -$24.01M |
| Karyopharm Therapeutics Inc.(KPTI) | 0 | 303,370 | +303,370 | $0 | $2.23M | 0.07% | +$2.23M |
| Pulmonx Corporation(LUNG) | 752,541 | 752,541 | 0 | $1.22M | $1.66M | 0.05% | +$444.0K |
| Akero Therapeutics Inc | 475,400 | 0 | -475,400 | $22.57M | $0 | — | -$22.57M |
| Alphatec Holdings, Inc.(ATEC) | 1,514,604 | 0 | -1,514,604 | $22.02M | $0 | — | -$22.02M |
| Amylyx Pharmaceuticals, Inc.(AMLX) | 612,841 | 0 | -612,841 | $8.33M | $0 | — | -$8.33M |
| Avidity Biosciences Inc | 331,907 | 0 | -331,907 | $14.46M | $0 | — | -$14.46M |
| Day One Biopharmaceuticals I COM | 2,181,598 | 0 | -2,181,598 | $15.38M | $0 | — | -$15.38M |
| DexCom, Inc.NOTE 0 250 11 1(DXCM) | 0 | 0 | 0 | $13.41M | $0 | — | -$13.41M |
| Encompass Health Corporation(EHC) | 113,335 | 0 | -113,335 | $14.40M | $0 | — | -$14.40M |
| Endeavour Silver Corp.(EXK) | 414,600 | 0 | -414,600 | $22.68M | $0 | — | -$22.68M |
| Globus Medical, Inc.CL A(GMED) | 498,000 | 0 | -498,000 | $28.52M | $0 | — | -$28.52M |
| Heartflow, Inc.(HTFL) | 50,000 | 0 | -50,000 | $1.68M | $0 | — | -$1.68M |
| Immunocore Holdings plcNOTE 2 500 2 0(IMCR) | 0 | 0 | 0 | $6.19M | $0 | — | -$6.19M |
| Karyopharm Therapeutics IncNOTE 6 000 5 1 | 0 | 0 | 0 | $34.96M | $0 | — | -$34.96M |
| NovoCure LimitedNOTE 11 0(NVCR) | 0 | 0 | 0 | $210.04M | $0 | — | -$210.04M |
| Replimune Group, Inc.(REPL) | 2,750,092 | 0 | -2,750,092 | $11.52M | $0 | — | -$11.52M |
| Royalty Pharma plcCL A(RPRX) | 182,068 | 0 | -182,068 | $6.42M | $0 | — | -$6.42M |
| Sarepta Therapeutics, Inc.(SRPT) | 832,100 | 0 | -832,100 | $16.03M | $0 | — | -$16.03M |
| Sionna Therapeutics, Inc.(SION) | 314,013 | 0 | -314,013 | $9.24M | $0 | — | -$9.24M |
| Tenet Healthcare Corporation(THC) | 121,700 | 0 | -121,700 | $24.71M | $0 | — | -$24.71M |
| Ultragenyx Pharmaceutical Inc.(RARE) | 588,700 | 0 | -588,700 | $17.71M | $0 | — | -$17.71M |
| Viking Therapeutics, Inc.(VKTX) | 759,455 | 0 | -759,455 | $19.96M | $0 | — | -$19.96M |