Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q1 2025 ▲▼ | Q2 2025 ▲▼ | Change ▲▼ | Q1 2025 ▲▼ | Q2 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| VERONA PHARMA PLC | 538,488 | 924,204 | +385,716 | 34,189 | 87,411 | 22.48% | +53,223 |
| INSMED INC(INSM) | 318,239 | 752,712 | +434,473 | 24,278 | 75,753 | 19.48% | +51,474 |
| ARGENX SE(ARGX) | 11,311 | 78,311 | +67,000 | 6,695 | 43,167 | 11.10% | +36,472 |
| TREVI THERAPEUTICS INC(TRVI) | 0 | 1,311,840 | +1,311,840 | 0 | 7,176 | 1.85% | +7,176 |
| SOLENO THERAPEUTICS INC | 498,473 | 494,424 | -4,049 | 35,616 | 41,423 | 10.65% | +5,807 |
| REGENERON PHARMACEUTICALS(REGN) | 0 | 10,671 | +10,671 | 0 | 5,602 | 1.44% | +5,602 |
| QUEST DIAGNOSTICS INC(DGX) | 56,717 | 81,717 | +25,000 | 9,597 | 14,679 | 3.78% | +5,082 |
| BOSTON SCIENTIFIC CORP(BSX) | 129,700 | 155,200 | +25,500 | 13,084 | 16,670 | 4.29% | +3,586 |
| ABBVIE INC(ABBV) | 0 | 14,500 | +14,500 | 0 | 2,691 | 0.69% | +2,691 |
| VERTEX PHARMACEUTICALS INC(VRTX) | 0 | 4,400 | +4,400 | 0 | 1,959 | 0.50% | +1,959 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 0 | 41,830 | +41,830 | 0 | 1,521 | 0.39% | +1,521 |
| EYEPOINT PHARMACEUTICALS INC(EYPT) | 316,700 | 316,700 | 0 | 1,717 | 2,980 | 0.77% | +1,264 |
| BIOHAVEN LTD(BHVN) | 0 | 80,000 | +80,000 | 0 | 1,129 | 0.29% | +1,129 |
| AVIDITY BIOSCIENCES INC | 0 | 34,600 | +34,600 | 0 | 983 | 0.25% | +983 |
| ASCENDIS PHARMA A/S(ASND) | 7,440 | 12,240 | +4,800 | 1,160 | 2,113 | 0.54% | +953 |
| KINIKSA PHARMACEUTICALS INTL(KNSA) | 0 | 29,200 | +29,200 | 0 | 808 | 0.21% | +808 |
| SPRINGWORKS THERAPEUTICS INC | 53,930 | 63,930 | +10,000 | 2,380 | 3,004 | 0.77% | +624 |
| MINERALYS THERAPEUTICS INC(MLYS) | 0 | 41,100 | +41,100 | 0 | 556 | 0.14% | +556 |
| NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES | 0 | 27,319 | +27,319 | 0 | 495 | 0.13% | +495 |
| VIKING THERAPEUTICS INC(VKTX) | 90,279 | 96,479 | +6,200 | 2,180 | 2,557 | 0.66% | +376 |
| MEREO BIOPHARMA GROUP PLC(MREO) | 421,359 | 475,361 | +54,002 | 948 | 1,288 | 0.33% | +340 |
| REVOLUTION MEDICINES INC(RVMD) | 104,190 | 104,190 | 0 | 3,684 | 3,833 | 0.99% | +149 |
| ORUKA THERAPEUTICS INC(ORKA) | 7,380 | 0 | -7,380 | 76 | 0 | — | -76 |
| XENON PHARMACEUTICALS INC(XENE) | 40,000 | 40,000 | 0 | 1,342 | 1,252 | 0.32% | -90 |
| TRAVERE THERAPEUTICS INC(TVTX) | 30,900 | 30,900 | 0 | 554 | 457 | 0.12% | -96 |
| UNITED THERAPEUTICS CORP DEL(UTHR) | 5,000 | 5,000 | 0 | 1,541 | 1,437 | 0.37% | -105 |
| TG THERAPEUTICS INC(TGTX) | 54,515 | 54,515 | 0 | 2,150 | 1,962 | 0.50% | -188 |
| CENTESSA PHARMACEUTICALS PLC | 35,226 | 0 | -35,226 | 507 | 0 | — | -507 |
| JANUX THERAPEUTICS INC(JANX) | 38,100 | 20,000 | -18,100 | 1,029 | 462 | 0.12% | -567 |
| ASTRAZENECA PLC(AZN) | 190,752 | 190,752 | 0 | 14,020 | 13,330 | 3.43% | -691 |
| ALNYLAM PHARMACEUTICALS INC(ALNY) | 28,600 | 20,970 | -7,630 | 7,723 | 6,838 | 1.76% | -884 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 172,185 | 126,285 | -45,900 | 5,536 | 4,473 | 1.15% | -1,063 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 14,700 | 0 | -14,700 | 1,626 | 0 | — | -1,626 |
| INTUITIVE SURGICAL INC | 3,500 | 0 | -3,500 | 1,733 | 0 | — | -1,733 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 160,000 | 0 | -160,000 | 2,157 | 0 | — | -2,157 |
| MERUS N V | 424,640 | 296,750 | -127,890 | 17,873 | 15,609 | 4.01% | -2,264 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 50,000 | 0 | -50,000 | 2,649 | 0 | — | -2,648 |
| NUVALENT INC | 90,745 | 0 | -90,745 | 6,436 | 0 | — | -6,436 |
| PROTAGONIST THERAPEUTICS INC | 333,851 | 22,951 | -310,900 | 16,145 | 1,269 | 0.33% | -14,877 |
| ARCELLX INC COMMON STOCK | 229,085 | 0 | -229,085 | 15,028 | 0 | — | -15,028 |
| INTRA-CELLULAR THERAPIES INC | 219,719 | 0 | -219,719 | 28,985 | 0 | — | -28,985 |
| ELI LILLY & CO(LLY) | 94,887 | 30,700 | -64,187 | 78,368 | 23,932 | 6.15% | -54,437 |