Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2024 ▲▼ | Q4 2024 ▲▼ | Change ▲▼ | Q3 2024 ▲▼ | Q4 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| ARCELLX INC COMMON STOCK | 0 | 229,785 | +229,785 | 0 | 17,622 | 7.11% | +17,622 |
| MERUS N V | 80,171 | 463,840 | +383,669 | 4,005 | 19,504 | 7.87% | +15,499 |
| NUVALENT INC | 15,437 | 204,045 | +188,608 | 1,579 | 15,973 | 6.44% | +14,393 |
| JANUX THERAPEUTICS INC(JANX) | 0 | 162,976 | +162,976 | 0 | 8,726 | 3.52% | +8,726 |
| SOLENO THERAPEUTICS INC | 274,424 | 494,424 | +220,000 | 13,856 | 22,224 | 8.96% | +8,369 |
| REVOLUTION MEDICINES INC(RVMD) | 95,885 | 284,190 | +188,305 | 4,348 | 12,430 | 5.01% | +8,082 |
| INSMED INC(INSM) | 52,939 | 167,939 | +115,000 | 3,865 | 11,595 | 4.68% | +7,730 |
| VERONA PHARMA PLC | 148,590 | 255,318 | +106,728 | 4,275 | 11,857 | 4.78% | +7,582 |
| PROTAGONIST THERAPEUTICS INC | 124,440 | 293,851 | +169,411 | 5,600 | 11,343 | 4.57% | +5,743 |
| VAXCYTE INC(PCVX) | 76,255 | 162,255 | +86,000 | 8,714 | 13,282 | 5.36% | +4,569 |
| ALNYLAM PHARMACEUTICALS INC(ALNY) | 35,000 | 56,400 | +21,400 | 9,626 | 13,271 | 5.35% | +3,645 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 0 | 50,000 | +50,000 | 0 | 2,799 | 1.13% | +2,799 |
| INTRA-CELLULAR THERAPIES INC | 216,519 | 219,719 | +3,200 | 15,843 | 18,351 | 7.40% | +2,508 |
| ENLIVEN THERAPEUTICS INC | 0 | 102,900 | +102,900 | 0 | 2,315 | 0.93% | +2,315 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 0 | 100,000 | +100,000 | 0 | 1,917 | 0.77% | +1,917 |
| TG THERAPEUTICS INC(TGTX) | 0 | 54,515 | +54,515 | 0 | 1,641 | 0.66% | +1,641 |
| TARSUS PHARMACEUTICALS INC(TARS) | 0 | 20,811 | +20,811 | 0 | 1,152 | 0.46% | +1,152 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 45,000 | 45,000 | 0 | 5,185 | 6,143 | 2.48% | +958 |
| TECTONIC THERAPEUTIC INC(TECX) | 0 | 16,650 | +16,650 | 0 | 769 | 0.31% | +769 |
| NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES | 54,285 | 54,285 | 0 | 901 | 1,395 | 0.56% | +494 |
| EYEPOINT PHARMACEUTICALS INC(EYPT) | 156,300 | 216,700 | +60,400 | 1,249 | 1,614 | 0.65% | +366 |
| SPRINGWORKS THERAPEUTICS INC | 53,930 | 53,930 | 0 | 1,728 | 1,948 | 0.79% | +221 |
| CENTESSA PHARMACEUTICALS PLC | 80,380 | 80,380 | 0 | 1,285 | 1,346 | 0.54% | +61 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 45,765 | 45,765 | 0 | 2,339 | 2,340 | 0.94% | +1 |
| XENON PHARMACEUTICALS INC(XENE) | 40,000 | 40,000 | 0 | 1,575 | 1,568 | 0.63% | -7 |
| CHARLES RIV LABS INTL INC(CRL) | 6,305 | 6,305 | 0 | 1,242 | 1,164 | 0.47% | -78 |
| ASCENDIS PHARMA A/S(ASND) | 7,440 | 7,440 | 0 | 1,111 | 1,024 | 0.41% | -87 |
| ANNEXON INC(ANNX) | 172,226 | 172,226 | 0 | 1,020 | 884 | 0.36% | -136 |
| Q32 BIO INC(FIXX) | 4,705 | 0 | -4,705 | 210 | 0 | — | -210 |
| MEREO BIOPHARMA GROUP PLC(MREO) | 421,359 | 421,359 | 0 | 1,732 | 1,475 | 0.59% | -257 |
| SUMMIT THERAPEUTICS INC(SMMT) | 14,512 | 0 | -14,512 | 318 | 0 | — | -318 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 1,557 | 0 | -1,557 | 330 | 0 | — | -330 |
| ACELYRIN INC | 93,114 | 0 | -93,114 | 459 | 0 | — | -459 |
| LARIMAR THERAPEUTICS INC(LRMR) | 90,490 | 0 | -90,490 | 593 | 0 | — | -593 |
| DISC MEDICINE INC(IRON) | 13,440 | 0 | -13,440 | 660 | 0 | — | -660 |
| ALECTOR INC | 193,317 | 0 | -193,317 | 901 | 0 | — | -901 |
| SYNDAX PHARMACEUTICALS INC(SNDX) | 48,263 | 0 | -48,263 | 929 | 0 | — | -929 |
| SILENCE THERAPEUTICS PLC(SLN) | 52,476 | 0 | -52,476 | 954 | 0 | — | -954 |
| CORBUS PHARMACEUTICALS HLDGS(CRBP) | 47,400 | 0 | -47,400 | 978 | 0 | — | -978 |
| KURA ONCOLOGY INC(KURA) | 57,178 | 0 | -57,178 | 1,117 | 0 | — | -1,117 |
| KEROS THERAPEUTICS INC(KROS) | 20,000 | 0 | -20,000 | 1,161 | 0 | — | -1,161 |
| IONIS PHARMACEUTICALS INC(IONS) | 30,479 | 0 | -30,479 | 1,221 | 0 | — | -1,221 |
| ARGENX SE(ARGX) | 15,138 | 11,311 | -3,827 | 8,206 | 6,956 | 2.81% | -1,250 |
| IDEAYA BIOSCIENCES INC(IDYA) | 62,992 | 0 | -62,992 | 1,996 | 0 | — | -1,996 |
| ASTRAZENECA PLC(AZN) | 190,752 | 190,752 | 0 | 14,861 | 12,498 | 5.04% | -2,363 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 75,300 | 0 | -75,300 | 2,559 | 0 | — | -2,559 |
| DYNE THERAPEUTICS INC(DYN) | 119,488 | 0 | -119,488 | 4,292 | 0 | — | -4,292 |
| AXSOME THERAPEUTICS INC(AXSM) | 87,848 | 0 | -87,848 | 7,895 | 0 | — | -7,895 |
| VERTEX PHARMACEUTICALS INC(VRTX) | 18,900 | 0 | -18,900 | 8,790 | 0 | — | -8,790 |
| VIKING THERAPEUTICS INC(VKTX) | 532,879 | 90,279 | -442,600 | 33,737 | 3,633 | 1.47% | -30,104 |
| NOVO-NORDISK A S(NVO) | 741,743 | 200,000 | -541,743 | 88,319 | 17,204 | 6.94% | -71,115 |
| ELI LILLY & CO(LLY) | 92,593 | 0 | -92,593 | 82,032 | 0 | — | -82,032 |