Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| INSMED INC(INSM)(Put) | 0 | 420,000 | +420,000 | 0 | 73,097 | — | +73,097 |
| ABIVAX SA(ABVX) | 225,453 | 600,747 | +375,294 | 19,141 | 81,014 | 13.02% | +61,873 |
| ELI LILLY & CO(LLY) | 28,700 | 50,500 | +21,800 | 21,898 | 54,271 | 8.72% | +32,373 |
| VIKING THERAPEUTICS INC(VKTX) | 146,179 | 719,365 | +573,186 | 3,842 | 25,307 | 4.07% | +21,466 |
| CIDARA THERAPEUTICS INC | 0 | 70,824 | +70,824 | 0 | 15,644 | 2.51% | +15,644 |
| INSMED INC(INSM) | 732,212 | 682,212 | -50,000 | 105,446 | 118,732 | 19.08% | +13,286 |
| NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES | 194,838 | 503,936 | +309,098 | 5,541 | 17,678 | 2.84% | +12,137 |
| IONIS PHARMACEUTICALS INC(IONS) | 60,176 | 144,376 | +84,200 | 3,937 | 11,422 | 1.84% | +7,485 |
| TREVI THERAPEUTICS INC(TRVI) | 1,999,702 | 2,013,602 | +13,900 | 18,297 | 25,210 | 4.05% | +6,913 |
| VENTYX BIOSCIENCES INC | 0 | 695,982 | +695,982 | 0 | 6,285 | 1.01% | +6,285 |
| PALVELLA THERAPEUTICS INC NE(PVLA) | 0 | 59,200 | +59,200 | 0 | 6,196 | 1.00% | +6,196 |
| PROSHARES TR II(AGQ)(Put) | 0 | 100,000 | +100,000 | 0 | 5,552 | — | +5,552 |
| EYEPOINT PHARMACEUTICALS INC(EYPT) | 628,367 | 767,098 | +138,731 | 8,948 | 14,015 | 2.25% | +5,067 |
| SIONNA THERAPEUTICS INC(SION) | 0 | 119,741 | +119,741 | 0 | 4,926 | 0.79% | +4,926 |
| PALISADE BIO INC | 0 | 1,992,367 | +1,992,367 | 0 | 4,682 | 0.75% | +4,682 |
| DIANTHUS THERAPEUTICS INC(DNTH) | 108,723 | 205,090 | +96,367 | 4,278 | 8,452 | 1.36% | +4,174 |
| PROKIDNEY CORP | 0 | 1,838,411 | +1,838,411 | 0 | 4,118 | 0.66% | +4,118 |
| REVOLUTION MEDICINES INC(RVMD) | 104,190 | 104,190 | 0 | 4,866 | 8,299 | 1.33% | +3,433 |
| ASTRAZENECA PLC(AZN) | 190,752 | 190,752 | 0 | 14,634 | 17,536 | 2.82% | +2,901 |
| BELITE BIO INC(BLTE) | 0 | 17,989 | +17,989 | 0 | 2,878 | 0.46% | +2,878 |
| MINERALYS THERAPEUTICS INC(MLYS) | 56,600 | 137,800 | +81,200 | 2,146 | 5,001 | 0.80% | +2,854 |
| ROIVANT SCIENCES LTD(ROIV) | 0 | 129,800 | +129,800 | 0 | 2,817 | 0.45% | +2,817 |
| BRIGHT MINDS BIOSCIENCES INC | 0 | 33,407 | +33,407 | 0 | 2,607 | 0.42% | +2,607 |
| SOLENO THERAPEUTICS INC(Call) | 0 | 50,000 | +50,000 | 0 | 2,315 | — | +2,315 |
| RAPPORT THERAPEUTICS INC(RAPP) | 64,608 | 138,508 | +73,900 | 1,919 | 4,202 | 0.68% | +2,283 |
| TRAVERE THERAPEUTICS INC(TVTX) | 30,900 | 70,700 | +39,800 | 739 | 2,701 | 0.43% | +1,963 |
| UPSTREAM BIO INC | 0 | 68,653 | +68,653 | 0 | 1,864 | 0.30% | +1,864 |
| ASCENDIS PHARMA A/S(ASND) | 12,240 | 17,740 | +5,500 | 2,433 | 3,783 | 0.61% | +1,349 |
| PEPGEN INC | 0 | 205,324 | +205,324 | 0 | 1,337 | 0.21% | +1,337 |
| ABIVAX SA(ABVX)(Call) | 0 | 9,900 | +9,900 | 0 | 1,335 | — | +1,335 |
| CELCUITY INC(CELC) | 0 | 12,900 | +12,900 | 0 | 1,287 | 0.21% | +1,287 |
| OCULAR THERAPEUTIX INC(OCUL)(Call) | 0 | 85,200 | +85,200 | 0 | 1,034 | — | +1,034 |
| NUVALENT INC(NUVL) | 0 | 8,100 | +8,100 | 0 | 815 | 0.13% | +815 |
| AVALO THERAPEUTICS INC(AVTX) | 0 | 41,570 | +41,570 | 0 | 755 | 0.12% | +755 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 0 | 2,500 | +2,500 | 0 | 737 | 0.12% | +737 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 96,285 | 96,285 | 0 | 3,586 | 4,241 | 0.68% | +656 |
| ALTO NEUROSCIENCE INC(ANRO) | 0 | 29,192 | +29,192 | 0 | 520 | 0.08% | +520 |
| TENAX THERAPEUTICS INC | 0 | 42,080 | +42,080 | 0 | 513 | 0.08% | +513 |
| BRIDGEBIO PHARMA INC(BBIO) | 20,400 | 20,400 | 0 | 1,060 | 1,560 | 0.25% | +501 |
| PROTAGONIST THERAPEUTICS INC | 22,951 | 22,951 | 0 | 1,525 | 2,005 | 0.32% | +480 |
| KODIAK SCIENCES INC(KOD) | 0 | 17,019 | +17,019 | 0 | 476 | 0.08% | +476 |
| UNITED THERAPEUTICS CORP DEL(UTHR) | 5,000 | 5,000 | 0 | 2,096 | 2,436 | 0.39% | +340 |
| BRIGHTSPRING HEALTH SVCS INC(BTSG) | 41,600 | 41,600 | 0 | 1,230 | 1,558 | 0.25% | +328 |
| XENON PHARMACEUTICALS INC(XENE) | 40,000 | 40,000 | 0 | 1,606 | 1,793 | 0.29% | +187 |
| KINIKSA PHARMACEUTICALS INTL(KNSA) | 29,200 | 29,200 | 0 | 1,134 | 1,205 | 0.19% | +71 |
| OCULAR THERAPEUTIX INC(OCUL) | 141,061 | 141,061 | 0 | 1,649 | 1,712 | 0.28% | +63 |
| LYRA THERAPEUTICS INC | 0 | 8,756 | +8,756 | 0 | 27 | 0.00% | +27 |
| ABBVIE INC(ABBV) | 14,500 | 14,500 | 0 | 3,357 | 3,313 | 0.53% | -44 |
| PROSHARES TR II(AGQ) | 537,372 | 442,119 | -95,253 | 24,751 | 24,546 | 3.94% | -205 |
| ALECTOR INC | 71,029 | 0 | -71,029 | 210 | 0 | — | -210 |
| ATYR PHARMA INC | 372,276 | 0 | -372,276 | 269 | 0 | — | -269 |
| ATYR PHARMA INC(Call) | 600,000 | 0 | -600,000 | 433 | 0 | — | -433 |
| AVIDITY BIOSCIENCES INC | 110,100 | 60,100 | -50,000 | 4,797 | 4,335 | 0.70% | -462 |
| KALVISTA PHARMACEUTICALS INC | 41,555 | 0 | -41,555 | 506 | 0 | — | -506 |
| MODERNA INC(MRNA) | 23,800 | 0 | -23,800 | 615 | 0 | — | -615 |
| SAREPTA THERAPEUTICS INC(SRPT) | 44,900 | 0 | -44,900 | 865 | 0 | — | -865 |
| MEREO BIOPHARMA GROUP PLC | 475,361 | 0 | -475,361 | 979 | 0 | — | -979 |
| BIOHAVEN LTD(BHVN) | 80,000 | 0 | -80,000 | 1,201 | 0 | — | -1,201 |
| IREN LIMITED ORDINARY SHARES | 33,200 | 0 | -33,200 | 1,558 | 0 | — | -1,558 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 64,502 | 0 | -64,502 | 1,940 | 0 | — | -1,940 |
| TG THERAPEUTICS INC(TGTX) | 54,515 | 0 | -54,515 | 1,969 | 0 | — | -1,969 |
| CENTESSA PHARMACEUTICALS PLC | 133,291 | 0 | -133,291 | 3,232 | 0 | — | -3,232 |
| NEKTAR THERAPEUTICS(NKTR) | 57,999 | 0 | -57,999 | 3,300 | 0 | — | -3,300 |
| ARGENX SE(ARGX) | 78,311 | 64,699 | -13,612 | 57,759 | 54,409 | 8.74% | -3,350 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE)(Call) | 150,000 | 0 | -150,000 | 4,512 | 0 | — | -4,512 |
| REGENERON PHARMACEUTICALS(REGN) | 10,671 | 0 | -10,671 | 6,000 | 0 | — | -6,000 |
| QUEST DIAGNOSTICS INC(DGX) | 81,717 | 40,817 | -40,900 | 15,574 | 7,083 | 1.14% | -8,491 |
| ALNYLAM PHARMACEUTICALS INC(ALNY) | 34,570 | 17,400 | -17,170 | 15,764 | 6,919 | 1.11% | -8,845 |
| UNIQURE NV(QURE) | 658,839 | 1,023,539 | +364,700 | 38,456 | 24,493 | 3.94% | -13,963 |
| BOSTON SCIENTIFIC CORP(BSX) | 183,200 | 0 | -183,200 | 17,886 | 0 | — | -17,886 |
| SOLENO THERAPEUTICS INC | 672,176 | 533,698 | -138,478 | 45,439 | 24,710 | 3.97% | -20,729 |
| VERTEX PHARMACEUTICALS INC(VRTX) | 55,100 | 0 | -55,100 | 21,579 | 0 | — | -21,579 |
| MERUS N V | 296,750 | 0 | -296,750 | 27,939 | 0 | — | -27,939 |
| VERONA PHARMA PLC | 379,004 | 0 | -379,004 | 40,444 | 0 | — | -40,444 |
| INSMED INC(INSM)(Call) | 400,000 | 0 | -400,000 | 57,604 | 0 | — | -57,604 |