Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2024 ▲▼ | Q1 2025 ▲▼ | Change ▲▼ | Q4 2024 ▲▼ | Q1 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| KEROS THERAPEUTICS INC(KROS) | 23,246 | 1,486,461 | +1,463,215 | 368 | 15,147 | 2.91% | +14,779 |
| SPRINGWORKS THERAPEUTICS INC | 0 | 207,778 | +207,778 | 0 | 9,169 | 1.76% | +9,169 |
| ISHARES TR | 0 | 103,337 | +103,337 | 0 | 8,549 | 1.64% | +8,549 |
| ZAI LAB LTD(ZLAB) | 1,045,837 | 940,858 | -104,979 | 27,390 | 34,003 | 6.54% | +6,612 |
| INTRA-CELLULAR THERAPIES INC | 0 | 48,044 | +48,044 | 0 | 6,338 | 1.22% | +6,338 |
| PROTAGONIST THERAPEUTICS INC | 1,020,333 | 939,669 | -80,664 | 39,385 | 45,442 | 8.74% | +6,058 |
| SAGE THERAPEUTICS INC | 19,200 | 742,495 | +723,295 | 104 | 5,903 | 1.14% | +5,799 |
| RAPT THERAPEUTICS INC | 1,174,313 | 5,970,768 | +4,796,455 | 1,855 | 7,284 | 1.40% | +5,429 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 0 | 1,471,587 | +1,471,587 | 0 | 5,209 | 1.00% | +5,209 |
| TEVA PHARMACEUTICAL INDS LTD(TEVA) | 146,671 | 523,767 | +377,096 | 3,233 | 8,050 | 1.55% | +4,818 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 19,505 | 157,079 | +137,574 | 843 | 5,050 | 0.97% | +4,207 |
| SEPTERNA INC(SEPN) | 0 | 720,848 | +720,848 | 0 | 4,174 | 0.80% | +4,174 |
| SAREPTA THERAPEUTICS INC(SRPT) | 40,002 | 122,921 | +82,919 | 4,864 | 7,845 | 1.51% | +2,981 |
| BIOAGE LABS INC(BIOA) | 123,037 | 971,100 | +848,063 | 712 | 3,651 | 0.70% | +2,939 |
| BRIDGEBIO PHARMA INC | 0 | 0 | 0 | 0 | 2,741 | 0.53% | +2,741 |
| ABIVAX SA(ABVX) | 1,513,393 | 2,210,019 | +696,626 | 11,078 | 13,813 | 2.66% | +2,735 |
| ASTRIA THERAPEUTICS INC | 90,984 | 641,690 | +550,706 | 813 | 3,427 | 0.66% | +2,613 |
| JANUX THERAPEUTICS INC(JANX) | 31,509 | 153,767 | +122,258 | 1,687 | 4,152 | 0.80% | +2,465 |
| AKERO THERAPEUTICS INC | 15,307 | 71,143 | +55,836 | 426 | 2,880 | 0.55% | +2,454 |
| XENON PHARMACEUTICALS INC(XENE) | 50,547 | 127,548 | +77,001 | 1,981 | 4,279 | 0.82% | +2,298 |
| ARDELYX INC | 31,035 | 490,743 | +459,708 | 157 | 2,410 | 0.46% | +2,252 |
| DYNAVAX TECHNOLOGIES CORP | 0 | 170,000 | +170,000 | 0 | 2,205 | 0.42% | +2,205 |
| ARVINAS INC(ARVN) | 0 | 313,354 | +313,354 | 0 | 2,200 | 0.42% | +2,200 |
| A SPAC III ACQUISITION CORP ORD SHS CL A | 0 | 215,000 | +215,000 | 0 | 2,163 | 0.42% | +2,163 |
| APOGEE THERAPEUTICS INC(APGE) | 41,274 | 104,853 | +63,579 | 1,870 | 3,917 | 0.75% | +2,048 |
| 89BIO INC | 515,138 | 804,220 | +289,082 | 4,028 | 5,847 | 1.12% | +1,818 |
| EA SERIES TRUST ALPHA ARCH 1-3 | 325,450 | 337,125 | +11,675 | 35,891 | 37,586 | 7.23% | +1,695 |
| ARBUTUS BIOPHARMA CORP(ABUS) | 1,554,802 | 1,879,114 | +324,312 | 5,084 | 6,558 | 1.26% | +1,474 |
| CARGO THERAPEUTICS INC | 0 | 341,515 | +341,515 | 0 | 1,390 | 0.27% | +1,390 |
| ORUKA THERAPEUTICS INC(ORKA) | 0 | 132,780 | +132,780 | 0 | 1,362 | 0.26% | +1,362 |
| CHECKPOINT THERAPEUTICS INC | 0 | 305,800 | +305,800 | 0 | 1,235 | 0.24% | +1,235 |
| AEROVATE THERAPEUTICS INC | 928,016 | 1,461,234 | +533,218 | 2,459 | 3,668 | 0.71% | +1,208 |
| REGENXBIO INC(RGNX) | 170,129 | 350,352 | +180,223 | 1,315 | 2,505 | 0.48% | +1,190 |
| CG ONCOLOGY INC(CGON) | 215,750 | 301,134 | +85,384 | 6,188 | 7,375 | 1.42% | +1,187 |
| TAYSHA GENE THERAPIES INC(TSHA) | 177,707 | 1,066,309 | +888,602 | 307 | 1,482 | 0.29% | +1,175 |
| VIR BIOTECHNOLOGY INC(VIR) | 64,067 | 250,000 | +185,933 | 470 | 1,620 | 0.31% | +1,150 |
| HELIX ACQUISITION CORP II | 404,138 | 469,729 | +65,591 | 4,243 | 5,308 | 1.02% | +1,064 |
| VIKING THERAPEUTICS INC(VKTX) | 9,300 | 59,413 | +50,113 | 374 | 1,435 | 0.28% | +1,061 |
| SURGERY PARTNERS INC(SGRY) | 0 | 40,000 | +40,000 | 0 | 950 | 0.18% | +950 |
| AGIOS PHARMACEUTICALS INC(AGIO) | 0 | 27,900 | +27,900 | 0 | 817 | 0.16% | +817 |
| MONOPAR THERAPEUTICS INC(MNPR) | 130,037 | 100,774 | -29,263 | 2,861 | 3,669 | 0.71% | +808 |
| SAVARA INC(SVRA) | 988,468 | 1,360,291 | +371,823 | 3,035 | 3,768 | 0.73% | +733 |
| VISTAGEN THERAPEUTICS INC(VTGN) | 121,461 | 420,765 | +299,304 | 358 | 1,052 | 0.20% | +694 |
| ARCELLX INC COMMON STOCK | 3,962 | 13,962 | +10,000 | 304 | 916 | 0.18% | +612 |
| NATERA INC(NTRA) | 0 | 4,250 | +4,250 | 0 | 601 | 0.12% | +601 |
| ZYMEWORKS INC(ZYME) | 0 | 50,000 | +50,000 | 0 | 596 | 0.11% | +596 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 26,000 | 79,000 | +53,000 | 498 | 1,065 | 0.20% | +567 |
| BIOHAVEN LTD(BHVN) | 0 | 22,641 | +22,641 | 0 | 544 | 0.10% | +544 |
| CENTESSA PHARMACEUTICALS PLC | 154,027 | 216,166 | +62,139 | 2,580 | 3,108 | 0.60% | +529 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 0 | 1,490 | +1,490 | 0 | 494 | 0.09% | +494 |
| FULCRUM THERAPEUTICS INC(FULC) | 196,248 | 490,532 | +294,284 | 922 | 1,413 | 0.27% | +490 |
| VAXCYTE INC(PCVX) | 0 | 12,800 | +12,800 | 0 | 483 | 0.09% | +483 |
| ARROWHEAD PHARMACEUTICALS IN(ARWR) | 12,900 | 56,300 | +43,400 | 243 | 717 | 0.14% | +475 |
| BIONTECH SE(BNTX) | 0 | 5,000 | +5,000 | 0 | 455 | 0.09% | +455 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 0 | 20,000 | +20,000 | 0 | 440 | 0.08% | +440 |
| SPDR SER TR ST STR BLO 1 ETF | 131,786 | 135,585 | +3,799 | 12,049 | 12,437 | 2.39% | +388 |
| PTC THERAPEUTICS INC(PTCT) | 48,023 | 50,023 | +2,000 | 2,168 | 2,549 | 0.49% | +381 |
| AA MISSION ACQUISITION CORP | 560,199 | 578,359 | +18,160 | 5,658 | 6,032 | 1.16% | +374 |
| ARGENX SE(ARGX) | 0 | 600 | +600 | 0 | 355 | 0.07% | +355 |
| THIRD HARMONIC BIO INC | 0 | 100,000 | +100,000 | 0 | 347 | 0.07% | +347 |
| INTUITIVE SURGICAL INC | 0 | 700 | +700 | 0 | 347 | 0.07% | +347 |
| BIOMARIN PHARMACEUTICAL INC(BMRN) | 0 | 4,900 | +4,900 | 0 | 346 | 0.07% | +346 |
| OAKTREE ACQUISITION CORP III UNIT 10/04/2029 | 500,000 | 516,482 | +16,482 | 5,065 | 5,392 | 1.04% | +327 |
| NEUROGENE INC(NGNE) | 0 | 27,925 | +27,925 | 0 | 327 | 0.06% | +327 |
| ESTABLISHMENT LABS HLDGS INC(ESTA) | 0 | 8,000 | +8,000 | 0 | 326 | 0.06% | +326 |
| DYNE THERAPEUTICS INC(DYN) | 0 | 30,099 | +30,099 | 0 | 315 | 0.06% | +315 |
| NORDSTROM INC | 0 | 12,000 | +12,000 | 0 | 293 | 0.06% | +293 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 0 | 14,600 | +14,600 | 0 | 265 | 0.05% | +265 |
| SPYRE THERAPEUTICS INC(SYRE) | 0 | 15,033 | +15,033 | 0 | 243 | 0.05% | +243 |
| TENAX THERAPEUTICS INC(TENX) | 34,693 | 68,741 | +34,048 | 215 | 450 | 0.09% | +236 |
| ANTERIS TECHNOLOGIES GLOBAL(AVR) | 1,052,968 | 1,678,063 | +625,095 | 5,876 | 6,108 | 1.18% | +233 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 30,941 | 36,890 | +5,949 | 1,732 | 1,954 | 0.38% | +222 |
| RENOVORX INC(RNXT) | 197,250 | 479,883 | +282,633 | 254 | 475 | 0.09% | +221 |
| STOKE THERAPEUTICS INC(STOK) | 0 | 30,085 | +30,085 | 0 | 200 | 0.04% | +200 |
| COLOMBIER ACQUISITION CORP I | 0 | 18,513 | +18,513 | 0 | 197 | 0.04% | +197 |
| KALA BIO INC(KALA) | 220,373 | 298,955 | +78,582 | 1,529 | 1,713 | 0.33% | +184 |
| BRIDGEBIO PHARMA INC(BBIO) | 0 | 0 | 0 | 2,104 | 2,282 | 0.44% | +178 |
| BRIDGEBIO PHARMA INC(BBIO) | 0 | 0 | 0 | 3,861 | 4,034 | 0.78% | +173 |
| BIOMX INC(PHGE) | 0 | 299,598 | +299,598 | 0 | 166 | 0.03% | +166 |
| KURA ONCOLOGY INC(KURA) | 0 | 25,000 | +25,000 | 0 | 165 | 0.03% | +165 |
| BIOGEN INC(BIIB) | 3,045 | 4,500 | +1,455 | 466 | 616 | 0.12% | +150 |
| IMMUNOME INC(IMNM) | 0 | 20,000 | +20,000 | 0 | 135 | 0.03% | +135 |
| VYNE THERAPEUTICS INC(YARW) | 0 | 70,419 | +70,419 | 0 | 111 | 0.02% | +111 |
| PFIZER INC(PFE) | 35,050 | 41,050 | +6,000 | 930 | 1,040 | 0.20% | +110 |
| KALVISTA PHARMACEUTICALS INC | 35,843 | 35,743 | -100 | 304 | 412 | 0.08% | +109 |
| ENGENE HOLDINGS INC COM | 0 | 23,799 | +23,799 | 0 | 107 | 0.02% | +107 |
| DELCATH SYS INC(DCTH) | 149,385 | 149,385 | 0 | 1,799 | 1,902 | 0.37% | +103 |
| SHATTUCK LABS INC(STTK) | 0 | 102,156 | +102,156 | 0 | 97 | 0.02% | +97 |
| UPSTREAM BIO INC(UPB) | 0 | 15,000 | +15,000 | 0 | 92 | 0.02% | +92 |
| PERCEPTIVE CAP SOLUTIONS COR CL A ORD SHS | 750,000 | 750,000 | 0 | 7,635 | 7,725 | 1.49% | +90 |
| AVALO THERAPEUTICS INC(AVTX) | 0 | 10,000 | +10,000 | 0 | 80 | 0.02% | +80 |
| ACHIEVE LIFE SCIENCES INC | 13,173 | 43,173 | +30,000 | 46 | 115 | 0.02% | +69 |
| CLIMB BIO INC(CLYM) | 48,125 | 119,320 | +71,195 | 87 | 146 | 0.03% | +59 |
| TANGO THERAPEUTICS INC(TNGX) | 0 | 41,346 | +41,346 | 0 | 57 | 0.01% | +57 |
| VENTYX BIOSCIENCES INC | 124,530 | 281,600 | +157,070 | 273 | 324 | 0.06% | +51 |
| NURIX THERAPEUTICS INC(NRIX) | 11,000 | 21,200 | +10,200 | 207 | 252 | 0.05% | +45 |
| ONKURE THERAPEUTICS INC(OKUR) | 0 | 10,000 | +10,000 | 0 | 43 | 0.01% | +43 |
| A SPAC III ACQUISITION CORP RIGHT 01/02/2026 | 0 | 215,000 | +215,000 | 0 | 30 | 0.01% | +30 |
| XILIO THERAPEUTICS INC(XLO) | 0 | 40,000 | +40,000 | 0 | 29 | 0.01% | +29 |
| PEPGEN INC(PEPG) | 0 | 20,352 | +20,352 | 0 | 29 | 0.01% | +29 |