Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| ABIVAX SA(ABVX) | 1,350,826 | 1,317,329 | -33,497 | 114,685 | 177,648 | 13.29% | +62,963 |
| AVIDITY BIOSCIENCES INC | 53,656 | 546,534 | +492,878 | 2,338 | 39,421 | 2.95% | +37,084 |
| IMMUNOVANT INC(IMVT) | 2,241,753 | 2,480,968 | +239,215 | 36,137 | 63,066 | 4.72% | +26,929 |
| PROTAGONIST THERAPEUTICS INC | 989,182 | 1,049,168 | +59,986 | 65,711 | 91,634 | 6.85% | +25,923 |
| ROIVANT SCIENCES LTD(ROIV) | 3,347,501 | 3,428,962 | +81,461 | 50,648 | 74,408 | 5.57% | +23,761 |
| TERNS PHARMACEUTICALS INC | 10,000 | 541,615 | +531,615 | 75 | 21,881 | 1.64% | +21,806 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 109,442 | 646,767 | +537,325 | 2,831 | 17,566 | 1.31% | +14,735 |
| ARBUTUS BIOPHARMA CORP(ABUS) | 2,903,226 | 5,415,109 | +2,511,883 | 13,181 | 26,047 | 1.95% | +12,866 |
| INVENTIVA SA(IVA) | 0 | 2,709,846 | +2,709,846 | 0 | 12,601 | 0.94% | +12,601 |
| CIDARA THERAPEUTICS INC | 21,522 | 59,677 | +38,155 | 2,061 | 13,182 | 0.99% | +11,121 |
| FULCRUM THERAPEUTICS INC(FULC) | 341,612 | 1,253,749 | +912,137 | 3,143 | 14,180 | 1.06% | +11,037 |
| SEPTERNA INC(SEPN) | 1,176,491 | 1,157,611 | -18,880 | 22,130 | 32,274 | 2.41% | +10,144 |
| TELEFLEX INCORPORATED(TFX) | 0 | 80,627 | +80,627 | 0 | 9,840 | 0.74% | +9,840 |
| ESTABLISHMENT LABS HLDGS INC(ESTA) | 90,688 | 171,422 | +80,734 | 3,717 | 12,493 | 0.93% | +8,776 |
| INHIBIKASE THERAPEUTICS INC(IKT) | 5,247,603 | 8,063,949 | +2,816,346 | 8,501 | 16,531 | 1.24% | +8,030 |
| REPLIMUNE GROUP INC(REPL) | 978,894 | 1,241,322 | +262,428 | 4,102 | 12,066 | 0.90% | +7,964 |
| CRESCENT BIOPHARMA INC.(CBIO) | 0 | 606,000 | +606,000 | 0 | 7,187 | 0.54% | +7,187 |
| OVID THERAPEUTICS INC(OVID) | 12,846 | 4,285,000 | +4,272,154 | 17 | 6,985 | 0.52% | +6,968 |
| VAXCYTE INC(PCVX) | 213,064 | 315,642 | +102,578 | 7,675 | 14,564 | 1.09% | +6,889 |
| MAZE THERAPEUTICS INC(MAZE) | 26,045 | 179,532 | +153,487 | 675 | 7,438 | 0.56% | +6,763 |
| BELITE BIO INC(BLTE) | 0 | 39,839 | +39,839 | 0 | 6,373 | 0.48% | +6,373 |
| PROTARA THERAPEUTICS INC(TARA) | 35,223 | 1,136,799 | +1,101,576 | 153 | 6,059 | 0.45% | +5,906 |
| DANAHER CORPORATION(DHR) | 0 | 25,600 | +25,600 | 0 | 5,860 | 0.44% | +5,860 |
| CYTOKINETICS INC(CYTK) | 518,921 | 540,166 | +21,245 | 28,520 | 34,322 | 2.57% | +5,802 |
| BRIGHTHOUSE FINL INC(BHF) | 10,000 | 95,523 | +85,523 | 531 | 6,189 | 0.46% | +5,658 |
| CLIMB BIO INC(CLYM) | 133,530 | 1,432,475 | +1,298,945 | 268 | 5,730 | 0.43% | +5,462 |
| ANTERIS TECHNOLOGIES GLOBAL(AVR) | 197,615 | 1,238,777 | +1,041,162 | 889 | 6,181 | 0.46% | +5,292 |
| REVOLUTION MEDICINES INC(RVMD) | 139,136 | 145,079 | +5,943 | 6,498 | 11,556 | 0.86% | +5,058 |
| SPRUCE BIOSCIENCES INC | 0 | 58,000 | +58,000 | 0 | 5,052 | 0.38% | +5,052 |
| CYTOMX THERAPEUTICS INC(CTMX) | 4,045,414 | 4,182,769 | +137,355 | 12,905 | 17,819 | 1.33% | +4,914 |
| PALISADE BIO INC(PALI) | 0 | 2,004,845 | +2,004,845 | 0 | 4,711 | 0.35% | +4,711 |
| MONOPAR THERAPEUTICS INC(MNPR) | 129,999 | 233,908 | +103,909 | 10,617 | 15,274 | 1.14% | +4,657 |
| TAYSHA GENE THERAPIES INC(TSHA) | 2,835,680 | 2,495,809 | -339,871 | 9,273 | 13,727 | 1.03% | +4,454 |
| RAPT THERAPEUTICS INC | 507,771 | 509,679 | +1,908 | 13,095 | 17,263 | 1.29% | +4,167 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 248,368 | 309,368 | +61,000 | 10,345 | 14,401 | 1.08% | +4,057 |
| ARS PHARMACEUTICALS INC(SPRY) | 59,230 | 369,569 | +310,339 | 595 | 4,305 | 0.32% | +3,710 |
| LEXEO THERAPEUTICS INC(LXEO) | 1,531,953 | 1,393,161 | -138,792 | 10,172 | 13,834 | 1.03% | +3,662 |
| AGIOS PHARMACEUTICALS INC(AGIO) | 37,000 | 188,000 | +151,000 | 1,485 | 5,117 | 0.38% | +3,632 |
| CORVUS PHARMACEUTICALS INC(CRVS) | 0 | 465,875 | +465,875 | 0 | 3,587 | 0.27% | +3,587 |
| AMERICAN EXCEPTIONALISM ACQU ORD CL A | 50,000 | 357,539 | +307,539 | 547 | 4,072 | 0.30% | +3,526 |
| VERTEX PHARMACEUTICALS INC(VRTX) | 7,000 | 13,716 | +6,716 | 2,741 | 6,218 | 0.47% | +3,477 |
| AVADEL PHARMACEUTICALS PLC | 0 | 150,532 | +150,532 | 0 | 3,244 | 0.24% | +3,244 |
| EVOMMUNE INC(EVMN) | 0 | 184,062 | +184,062 | 0 | 3,151 | 0.24% | +3,151 |
| ISHARES TR | 0 | 12,070 | +12,070 | 0 | 2,971 | 0.22% | +2,971 |
| ONKURE THERAPEUTICS INC(OKUR) | 0 | 1,014,158 | +1,014,158 | 0 | 2,941 | 0.22% | +2,941 |
| ATHIRA PHARMA INC(LONA) | 0 | 393,701 | +393,701 | 0 | 2,891 | 0.22% | +2,891 |
| IONIS PHARMACEUTICALS INC(IONS) | 133,818 | 147,130 | +13,312 | 8,754 | 11,639 | 0.87% | +2,885 |
| ELEDON PHARMACEUTICALS INC(ELDN) | 0 | 1,821,812 | +1,821,812 | 0 | 2,751 | 0.21% | +2,751 |
| ENGENE HOLDINGS INC COM | 0 | 303,686 | +303,686 | 0 | 2,742 | 0.21% | +2,742 |
| INOVIO PHARMACEUTICALS INC(INO) | 0 | 1,485,008 | +1,485,008 | 0 | 2,584 | 0.19% | +2,584 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 20,087 | 69,589 | +49,502 | 748 | 3,065 | 0.23% | +2,317 |
| CONTINEUM THERAPEUTICS INC(CTNM) | 77,961 | 278,961 | +201,000 | 916 | 3,189 | 0.24% | +2,272 |
| UROGEN PHARMA LTD(URGN) | 35,000 | 125,375 | +90,375 | 698 | 2,936 | 0.22% | +2,238 |
| CORBUS PHARMACEUTICALS HLDGS(CRBP) | 10,200 | 286,781 | +276,581 | 129 | 2,334 | 0.17% | +2,205 |
| ARROWHEAD PHARMACEUTICALS IN(ARWR) | 49,800 | 58,200 | +8,400 | 1,718 | 3,864 | 0.29% | +2,146 |
| BRIDGEBIO PHARMA INC(BBIO) | 273,414 | 213,414 | -60,000 | 14,201 | 16,324 | 1.22% | +2,123 |
| MINERALYS THERAPEUTICS INC(MLYS) | 78,238 | 136,231 | +57,993 | 2,967 | 4,944 | 0.37% | +1,977 |
| TEVA PHARMACEUTICAL INDS LTD(TEVA) | 267,816 | 235,971 | -31,845 | 5,410 | 7,365 | 0.55% | +1,955 |
| MONTE ROSA THERAPEUTICS INC(GLUE) | 215,752 | 215,752 | 0 | 1,599 | 3,383 | 0.25% | +1,784 |
| BIOGEN INC(BIIB) | 18,000 | 24,300 | +6,300 | 2,521 | 4,277 | 0.32% | +1,755 |
| GLOBUS MED INC(GMED) | 0 | 20,100 | +20,100 | 0 | 1,755 | 0.13% | +1,755 |
| CYBIN INC(HELP) | 33,278 | 238,390 | +205,112 | 196 | 1,950 | 0.15% | +1,754 |
| ALECTOR INC | 0 | 1,108,000 | +1,108,000 | 0 | 1,728 | 0.13% | +1,728 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 36,200 | 81,399 | +45,199 | 354 | 2,035 | 0.15% | +1,681 |
| KRYSTAL BIOTECH INC(KRYS) | 18,523 | 20,014 | +1,491 | 3,270 | 4,934 | 0.37% | +1,664 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 40,000 | 90,999 | +50,999 | 649 | 2,258 | 0.17% | +1,609 |
| XENON PHARMACEUTICALS INC(XENE) | 189,098 | 203,969 | +14,871 | 7,592 | 9,142 | 0.68% | +1,550 |
| INVIVYD INC(IVVD) | 7,370,987 | 3,899,397 | -3,471,590 | 8,108 | 9,632 | 0.72% | +1,523 |
| PHARVARIS N V COM | 34,124 | 85,528 | +51,404 | 851 | 2,373 | 0.18% | +1,522 |
| SAVARA INC(SVRA) | 1,988,288 | 1,405,452 | -582,836 | 7,098 | 8,475 | 0.63% | +1,377 |
| TANGO THERAPEUTICS INC(TNGX) | 0 | 140,021 | +140,021 | 0 | 1,241 | 0.09% | +1,241 |
| ADAGIO MED HLDGS INC(ADGM) | 0 | 1,159,614 | +1,159,614 | 0 | 1,206 | 0.09% | +1,206 |
| GRACE THERAPEUTICS INC(GRCE) | 350,450 | 641,988 | +291,538 | 1,043 | 2,221 | 0.17% | +1,178 |
| ACLARIS THERAPEUTICS INC(ACRS) | 373,682 | 613,986 | +240,304 | 710 | 1,848 | 0.14% | +1,138 |
| ADICET BIO INC | 0 | 128,646 | +128,646 | 0 | 1,083 | 0.08% | +1,083 |
| NURIX THERAPEUTICS INC(NRIX) | 31,200 | 72,070 | +40,870 | 288 | 1,367 | 0.10% | +1,079 |
| BRISTOL-MYERS SQUIBB CO(BMY) | 0 | 20,000 | +20,000 | 0 | 1,079 | 0.08% | +1,079 |
| TENAYA THERAPEUTICS INC(TNYA) | 0 | 1,505,300 | +1,505,300 | 0 | 1,071 | 0.08% | +1,071 |
| JAZZ PHARMACEUTICALS PLC(JAZZ) | 2,500 | 8,000 | +5,500 | 330 | 1,360 | 0.10% | +1,031 |
| CHURCHILL CAP CORP X | 0 | 64,887 | +64,887 | 0 | 1,012 | 0.08% | +1,012 |
| MCKESSON CORP(MCK) | 0 | 1,200 | +1,200 | 0 | 984 | 0.07% | +984 |
| INSPIRE MED SYS INC(INSP) | 6,000 | 15,000 | +9,000 | 445 | 1,383 | 0.10% | +938 |
| DYNAVAX TECHNOLOGIES CORP | 170,000 | 170,000 | 0 | 1,688 | 2,615 | 0.20% | +927 |
| NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES | 114,359 | 118,623 | +4,264 | 3,252 | 4,161 | 0.31% | +909 |
| PLYMOUTH INDL REIT INC | 0 | 41,065 | +41,065 | 0 | 899 | 0.07% | +899 |
| SPDR S&P 500 ETF TR(SPY) | 54,684 | 54,684 | 0 | 36,429 | 37,290 | 2.79% | +861 |
| ASTRIA THERAPEUTICS INC | 193,934 | 173,557 | -20,377 | 1,412 | 2,272 | 0.17% | +860 |
| KALARIS THERAPEUTICS INC(KLRS) | 0 | 100,000 | +100,000 | 0 | 844 | 0.06% | +844 |
| QUOIN PHARMACEUTICALS LTD(QNRX) | 0 | 58,230 | +58,230 | 0 | 840 | 0.06% | +840 |
| ASTRAZENECA PLC(AZN) | 0 | 9,000 | +9,000 | 0 | 827 | 0.06% | +827 |
| GILEAD SCIENCES INC(GILD) | 0 | 6,666 | +6,666 | 0 | 818 | 0.06% | +818 |
| ALEXANDRIA REAL ESTATE EQ IN | 0 | 16,300 | +16,300 | 0 | 798 | 0.06% | +798 |
| SUPERNUS PHARMACEUTICALS INC(SUPN) | 14,418 | 29,742 | +15,324 | 689 | 1,478 | 0.11% | +789 |
| SUTRO BIOPHARMA INC(STRO) | 0 | 67,077 | +67,077 | 0 | 776 | 0.06% | +776 |
| IBIO INC(IBIO) | 27,000 | 405,531 | +378,531 | 22 | 783 | 0.06% | +760 |
| VERA THERAPEUTICS INC(VERA) | 0 | 14,733 | +14,733 | 0 | 746 | 0.06% | +746 |
| EQUILLIUM INC(EQ) | 5,559,988 | 5,608,078 | +48,090 | 7,951 | 8,693 | 0.65% | +742 |
| 4D MOLECULAR THERAPEUTICS IN | 16,712 | 116,712 | +100,000 | 145 | 875 | 0.07% | +730 |
| CG ONCOLOGY INC(CGON) | 248,917 | 258,139 | +9,222 | 10,026 | 10,718 | 0.80% | +692 |
| PFIZER INC(PFE) | 44,400 | 72,400 | +28,000 | 1,131 | 1,803 | 0.13% | +671 |