Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | Q4 2025 ▲▼ | Q1 2026 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| REVOLUTION MEDICINES INC(RVMD) | 0 | 281,632 | +281,632 | 0 | 27,389 | 5.26% | +27,389 |
| ENLIVEN THERAPEUTICS INC | 0 | 363,438 | +363,438 | 0 | 14,247 | 2.74% | +14,247 |
| CG ONCOLOGY INC(CGON) | 0 | 205,622 | +205,622 | 0 | 13,916 | 2.67% | +13,916 |
| BIOHAVEN LTD(BHVN) | 0 | 1,594,491 | +1,594,491 | 0 | 13,489 | 2.59% | +13,489 |
| MBX BIOSCIENCES INC(MBX) | 78,553 | 499,469 | +420,916 | 2,478 | 14,909 | 2.87% | +12,432 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 21,067 | 56,267 | +35,200 | 6,209 | 18,129 | 3.48% | +11,919 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 886,893 | 1,035,496 | +148,603 | 39,068 | 50,905 | 9.78% | +11,837 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 0 | 254,267 | +254,267 | 0 | 8,065 | 1.55% | +8,065 |
| TYRA BIOSCIENCES INC(TYRA) | 0 | 193,177 | +193,177 | 0 | 7,399 | 1.42% | +7,399 |
| SPYRE THERAPEUTICS INC(SYRE) | 32,377 | 167,606 | +135,229 | 1,061 | 8,454 | 1.62% | +7,393 |
| DEFINIUM THERAPEUTICS INC(DFTX) | 0 | 325,483 | +325,483 | 0 | 6,152 | 1.18% | +6,152 |
| BIOAGE LABS INC(BIOA) | 0 | 338,654 | +338,654 | 0 | 5,923 | 1.14% | +5,923 |
| ACADIA PHARMACEUTICALS INC | 0 | 242,566 | +242,566 | 0 | 5,400 | 1.04% | +5,400 |
| ALUMIS INC | 0 | 229,566 | +229,566 | 0 | 5,057 | 0.97% | +5,057 |
| NURIX THERAPEUTICS INC(NRIX) | 0 | 315,226 | +315,226 | 0 | 4,886 | 0.94% | +4,886 |
| ZURA BIO LTD | 0 | 753,520 | +753,520 | 0 | 4,483 | 0.86% | +4,483 |
| TANGO THERAPEUTICS INC(TNGX) | 0 | 200,919 | +200,919 | 0 | 4,203 | 0.81% | +4,203 |
| SENSEI BIOTHERAPEUTICS INC | 0 | 132,873 | +132,873 | 0 | 4,188 | 0.81% | +4,188 |
| RELMADA THERAPEUTICS INC | 0 | 597,409 | +597,409 | 0 | 4,158 | 0.80% | +4,158 |
| EYEPOINT INC(EYPT) | 353,849 | 810,764 | +456,915 | 6,465 | 10,451 | 2.01% | +3,986 |
| MINERALYS THERAPEUTICS INC(MLYS) | 290,049 | 533,378 | +243,329 | 10,526 | 14,449 | 2.78% | +3,923 |
| DIANTHUS THERAPEUTICS INC(DNTH) | 79,284 | 85,502 | +6,218 | 3,267 | 7,175 | 1.38% | +3,908 |
| ERASCA INC(ERAS) | 0 | 239,861 | +239,861 | 0 | 3,881 | 0.75% | +3,881 |
| VAXCYTE INC(PCVX) | 0 | 59,061 | +59,061 | 0 | 3,432 | 0.66% | +3,432 |
| ARCUTIS BIOTHERAPEUTICS INC(ARQT) | 224,740 | 413,792 | +189,052 | 6,526 | 9,749 | 1.87% | +3,222 |
| NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES | 73,106 | 180,658 | +107,552 | 2,565 | 5,783 | 1.11% | +3,218 |
| EVOMMUNE INC | 68,196 | 193,777 | +125,581 | 1,168 | 4,385 | 0.84% | +3,218 |
| HELIX ACQUISITION CORP III | 0 | 305,028 | +305,028 | 0 | 3,099 | 0.60% | +3,099 |
| TENAX THERAPEUTICS INC | 0 | 188,700 | +188,700 | 0 | 3,017 | 0.58% | +3,017 |
| ALKERMES PLC(ALKS) | 0 | 80,492 | +80,492 | 0 | 2,846 | 0.55% | +2,846 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 565,140 | 669,685 | +104,545 | 6,827 | 9,309 | 1.79% | +2,482 |
| PROTAGONIST THERAPEUTICS INC | 59,430 | 72,577 | +13,147 | 5,191 | 7,650 | 1.47% | +2,459 |
| JADE BIOSCIENCES INC | 0 | 154,034 | +154,034 | 0 | 2,164 | 0.42% | +2,164 |
| IMMUNOVANT INC(IMVT) | 0 | 746,494 | +746,494 | 0 | 18,543 | 3.56% | +18,543 |
| IONIS PHARMACEUTICALS INC(IONS) | 0 | 26,385 | +26,385 | 0 | 1,981 | 0.38% | +1,981 |
| IMMUNOCORE HLDGS PLC(IMCR) | 0 | 63,543 | +63,543 | 0 | 1,916 | 0.37% | +1,916 |
| FORTE BIOSCIENCES INC(FBRX) | 0 | 58,020 | +58,020 | 0 | 1,503 | 0.29% | +1,503 |
| SIONNA THERAPEUTICS INC(SION) | 0 | 36,540 | +36,540 | 0 | 1,465 | 0.28% | +1,465 |
| SOLID BIOSCIENCES INC | 0 | 195,403 | +195,403 | 0 | 1,407 | 0.27% | +1,407 |
| LIPOCINE INC NEW | 0 | 160,420 | +160,420 | 0 | 1,282 | 0.25% | +1,282 |
| DENALI THERAPEUTICS INC(DNLI) | 0 | 426,561 | +426,561 | 0 | 8,190 | 1.57% | +8,190 |
| LB PHARMACEUTICALS INC(LBRX) | 0 | 50,000 | +50,000 | 0 | 1,233 | 0.24% | +1,233 |
| C4 THERAPEUTICS INC | 0 | 453,236 | +453,236 | 0 | 1,192 | 0.23% | +1,192 |
| EDWARDS LIFESCIENCES CORP | 0 | 14,588 | +14,588 | 0 | 1,168 | 0.22% | +1,168 |
| BIODESIX INC | 0 | 70,004 | +70,004 | 0 | 1,015 | 0.20% | +1,015 |
| SAB BIOTHERAPEUTICS INC | 146,558 | 375,000 | +228,442 | 548 | 1,436 | 0.28% | +888 |
| PHARVARIS N V COM | 58,389 | 86,637 | +28,248 | 1,620 | 2,447 | 0.47% | +827 |
| SURROZEN INC | 619,766 | 525,639 | -94,127 | 12,672 | 13,461 | 2.59% | +789 |
| CAPRICOR THERAPEUTICS INC(CAPR) | 17,853 | 37,592 | +19,739 | 515 | 1,143 | 0.22% | +628 |
| SUTRO BIOPHARMA INC | 0 | 23,295 | +23,295 | 0 | 580 | 0.11% | +580 |
| REVOLUTION MEDICINES INC(RVMD)(Put) | 0 | 100,000 | +100,000 | 0 | 525 | — | +525 |
| SPRUCE BIOSCIENCES INC | 0 | 6,360 | +6,360 | 0 | 416 | 0.08% | +416 |
| TYRA BIOSCIENCES INC(TYRA)(Call) | 0 | 100,000 | +100,000 | 0 | 290 | — | +290 |
| MAPLIGHT THERAPEUTICS INC(MPLT) | 100,000 | 100,000 | 0 | 1,757 | 2,033 | 0.39% | +277 |
| SYNDAX PHARMACEUTICALS INC(SNDX) | 1,339,379 | 1,215,743 | -123,636 | 28,140 | 28,400 | 5.46% | +259 |
| IMMUNOVANT INC(IMVT)(Call) | 0 | 100,000 | +100,000 | 0 | 255 | — | +255 |
| UNIQURE NV(QURE) | 0 | 78,066 | +78,066 | 0 | 1,276 | 0.25% | +1,276 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 360,876 | 290,864 | -70,012 | 8,955 | 9,162 | 1.76% | +207 |
| SPDR SERIES TRUST(Call) ST STR SP BIOT | 0 | 150,000 | +150,000 | 0 | 164 | — | +164 |
| SCHOLAR ROCK HLDG CORP(SRRK)(Call) | 277,000 | 100,000 | -177,000 | 485 | 588 | — | +103 |
| SYNDAX PHARMACEUTICALS INC(SNDX)(Call) | 0 | 150,000 | +150,000 | 0 | 90 | — | +90 |
| STATE STR SPDR S&P 500 ETF T(SPY)(Call) | 0 | 50,000 | +50,000 | 0 | 86 | — | +86 |
| INVESCO QQQ TR(Call) | 0 | 40,000 | +40,000 | 0 | 74 | — | +74 |
| BOSTON SCIENTIFIC CORP(BSX)(Call) | 0 | 250,000 | +250,000 | 0 | 13 | — | +13 |
| TERNS PHARMACEUTICALS INC(Call) | 0 | 100,000 | +100,000 | 0 | 8 | — | +8 |
| OLEMA PHARMACEUTICALS INC(OLMA)(Call) | 0 | 25,000 | +25,000 | 0 | 4 | — | +4 |
| EDWARDS LIFESCIENCES CORP(Call) | 0 | 10,000 | +10,000 | 0 | 1 | — | +1 |
| INVIVYD INC | 989,822 | 1,874,546 | +884,724 | 2,445 | 2,437 | 0.47% | -8 |
| CENTESSA PHARMACEUTICALS PLC(Call) | 75,000 | 0 | -75,000 | 26 | 0 | — | -26 |
| X4 PHARMACEUTICALS INC | 898,465 | 850,742 | -47,723 | 3,594 | 3,514 | 0.68% | -80 |
| VISTAGEN THERAPEUTICS INC | 0 | 616,749 | +616,749 | 0 | 58 | 0.01% | +58 |
| ASSEMBLY BIOSCIENCES INC | 156,728 | 185,435 | +28,707 | 5,330 | 5,146 | 0.99% | -184 |
| WHITEHAWK THERAPEUTICS INC | 1,458,807 | 939,369 | -519,438 | 3,530 | 3,241 | 0.62% | -289 |
| AVALO THERAPEUTICS INC(AVTX) | 135,552 | 134,742 | -810 | 2,462 | 2,012 | 0.39% | -450 |
| PASITHEA THERAPEUTICS CORP | 355,082 | 0 | -355,082 | 458 | 0 | — | -458 |
| VANDA PHARMACEUTICALS INC | 58,989 | 0 | -58,989 | 520 | 0 | — | -520 |
| CYTOKINETICS INC(CYTK) | 146,978 | 129,577 | -17,401 | 9,339 | 8,540 | 1.64% | -799 |
| MONTE ROSA THERAPEUTICS INC(GLUE) | 61,577 | 0 | -61,577 | 966 | 0 | — | -966 |
| TAYSHA GENE THERAPIES INC(TSHA) | 182,130 | 0 | -182,130 | 1,002 | 0 | — | -1,002 |
| BRIDGEBIO ONCOLOGY THERAPEUT | 86,517 | 0 | -86,517 | 1,083 | 0 | — | -1,083 |
| XILIO THERAPEUTICS INC | 2,030,028 | 0 | -2,030,028 | 1,300 | 0 | — | -1,300 |
| BELITE BIO INC(BLTE) | 9,163 | 0 | -9,163 | 1,466 | 0 | — | -1,466 |
| LEGEND BIOTECH CORP(LEGN) | 73,328 | 0 | -73,328 | 1,594 | 0 | — | -1,594 |
| ADC THERAPEUTICS SA | 502,570 | 0 | -502,570 | 1,774 | 0 | — | -1,774 |
| ABBVIE INC(ABBV) | 9,325 | 0 | -9,325 | 2,131 | 0 | — | -2,131 |
| INVENTIVA SA(IVA) | 467,242 | 0 | -467,242 | 2,173 | 0 | — | -2,173 |
| MEIRAGTX HLDGS PLC(MGTX) | 287,689 | 0 | -287,689 | 2,287 | 0 | — | -2,287 |
| QUINCE THERAPEUTICS INC | 739,264 | 0 | -739,264 | 2,477 | 0 | — | -2,477 |
| REPLIGEN CORP(RGEN) | 15,707 | 0 | -15,707 | 2,574 | 0 | — | -2,574 |
| ASCENDIS PHARMA A/S(ASND) | 14,842 | 0 | -14,842 | 3,165 | 0 | — | -3,165 |
| JOHNSON & JOHNSON(JNJ) | 35,000 | 15,415 | -19,585 | 7,243 | 3,768 | 0.72% | -3,475 |
| CYTOMX THERAPEUTICS INC | 1,036,311 | 0 | -1,036,311 | 4,415 | 0 | — | -4,415 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX) | 348,401 | 0 | -348,401 | 4,592 | 0 | — | -4,592 |
| ARBUTUS BIOPHARMA CORP(ABUS) | 986,751 | 0 | -986,751 | 4,746 | 0 | — | -4,746 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 154,320 | 0 | -154,320 | 4,802 | 0 | — | -4,802 |
| CELCUITY INC(CELC) | 118,333 | 60,062 | -58,271 | 11,803 | 6,855 | 1.32% | -4,947 |
| TREVI THERAPEUTICS INC(TRVI) | 399,557 | 0 | -399,557 | 5,002 | 0 | — | -5,002 |
| ELI LILLY & CO(LLY) | 4,759 | 0 | -4,759 | 5,114 | 0 | — | -5,114 |
| MAZE THERAPEUTICS INC(MAZE) | 125,877 | 0 | -125,877 | 5,215 | 0 | — | -5,215 |
| IDEAYA BIOSCIENCES INC(IDYA) | 0 | 0 | 0 | 0 | 0 | — | 0 |