Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| ABIVAX SA(ABVX) | 166,273 | 391,783 | +225,510 | 14,117 | 52,834 | 9.07% | +38,717 |
| STRUCTURE THERAPEUTICS INC | 129,335 | 351,073 | +221,738 | 3,621 | 24,417 | 4.19% | +20,796 |
| ARCELLX INC COMMON STOCK | 11,376 | 332,860 | +321,484 | 934 | 21,702 | 3.72% | +20,769 |
| TERNS PHARMACEUTICALS INC | 89,617 | 429,198 | +339,581 | 673 | 17,340 | 2.98% | +16,667 |
| TWIST BIOSCIENCE CORP(TWST) | 0 | 518,355 | +518,355 | 0 | 16,442 | 2.82% | +16,442 |
| CENTESSA PHARMACEUTICALS PLC | 655,385 | 1,154,114 | +498,729 | 15,893 | 28,864 | 4.95% | +12,971 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 726,204 | 886,893 | +160,689 | 27,044 | 39,068 | 6.70% | +12,024 |
| DYNE THERAPEUTICS INC(DYN) | 474,612 | 835,200 | +360,588 | 6,004 | 16,337 | 2.80% | +10,333 |
| ADAPTIVE BIOTECHNOLOGIES COR(ADPT) | 0 | 606,825 | +606,825 | 0 | 9,855 | 1.69% | +9,855 |
| PALISADE BIO INC(PALI) | 0 | 4,192,375 | +4,192,375 | 0 | 9,852 | 1.69% | +9,852 |
| CYTOKINETICS INC(CYTK) | 0 | 146,978 | +146,978 | 0 | 9,339 | 1.60% | +9,339 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 0 | 360,876 | +360,876 | 0 | 8,955 | 1.54% | +8,955 |
| XENON PHARMACEUTICALS INC(XENE) | 192,295 | 348,605 | +156,310 | 7,721 | 15,624 | 2.68% | +7,904 |
| BRIGHT MINDS BIOSCIENCES INC(DRUG) | 0 | 97,340 | +97,340 | 0 | 7,596 | 1.30% | +7,596 |
| JOHNSON & JOHNSON(JNJ) | 0 | 35,000 | +35,000 | 0 | 7,243 | 1.24% | +7,243 |
| SYNDAX PHARMACEUTICALS INC(SNDX) | 1,366,205 | 1,339,379 | -26,826 | 21,019 | 28,140 | 4.83% | +7,121 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 8,207 | 17,736 | +9,529 | 3,764 | 10,328 | 1.77% | +6,564 |
| EYEPOINT INC(EYPT) | 0 | 353,849 | +353,849 | 0 | 6,465 | 1.11% | +6,465 |
| IMMATICS N.V(IMTX) | 0 | 610,308 | +610,308 | 0 | 6,408 | 1.10% | +6,408 |
| CLEARPOINT NEURO INC(CLPT) | 16,651 | 481,858 | +465,207 | 363 | 6,592 | 1.13% | +6,229 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 0 | 21,067 | +21,067 | 0 | 6,209 | 1.07% | +6,209 |
| APOGEE THERAPEUTICS INC(APGE) | 0 | 80,574 | +80,574 | 0 | 6,082 | 1.04% | +6,082 |
| MAZE THERAPEUTICS INC(MAZE) | 0 | 125,877 | +125,877 | 0 | 5,215 | 0.89% | +5,215 |
| ELI LILLY & CO(LLY) | 0 | 4,759 | +4,759 | 0 | 5,114 | 0.88% | +5,114 |
| CELCUITY INC(CELC) | 136,710 | 118,333 | -18,377 | 6,753 | 11,803 | 2.03% | +5,049 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 0 | 154,320 | +154,320 | 0 | 4,802 | 0.82% | +4,802 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX) | 0 | 348,401 | +348,401 | 0 | 4,592 | 0.79% | +4,592 |
| MINERALYS THERAPEUTICS INC(MLYS) | 158,112 | 290,049 | +131,937 | 5,996 | 10,526 | 1.81% | +4,530 |
| NEKTAR THERAPEUTICS(NKTR) | 53,201 | 178,274 | +125,073 | 3,027 | 7,537 | 1.29% | +4,510 |
| CYTOMX THERAPEUTICS INC(CTMX) | 0 | 1,036,311 | +1,036,311 | 0 | 4,415 | 0.76% | +4,415 |
| ARBUTUS BIOPHARMA CORP(ABUS) | 205,388 | 986,751 | +781,363 | 932 | 4,746 | 0.81% | +3,814 |
| ASSEMBLY BIOSCIENCES INC | 66,130 | 156,728 | +90,598 | 1,693 | 5,330 | 0.91% | +3,637 |
| SURROZEN INC(SRZN) | 713,463 | 619,766 | -93,697 | 9,193 | 12,672 | 2.17% | +3,479 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 276,884 | 565,140 | +288,256 | 3,762 | 6,827 | 1.17% | +3,065 |
| WHITEHAWK THERAPEUTICS INC(WHWK) | 424,082 | 1,458,807 | +1,034,725 | 806 | 3,530 | 0.61% | +2,725 |
| REPLIGEN CORP(RGEN) | 0 | 15,707 | +15,707 | 0 | 2,574 | 0.44% | +2,574 |
| QUINCE THERAPEUTICS INC(QNCX) | 0 | 739,264 | +739,264 | 0 | 2,477 | 0.43% | +2,477 |
| AVALO THERAPEUTICS INC(AVTX) | 0 | 135,552 | +135,552 | 0 | 2,462 | 0.42% | +2,462 |
| INCYTE CORP(INCY) | 43,754 | 61,435 | +17,681 | 3,711 | 6,068 | 1.04% | +2,357 |
| OCULAR THERAPEUTIX INC(OCUL) | 359,470 | 522,693 | +163,223 | 4,202 | 6,345 | 1.09% | +2,143 |
| INVIVYD INC(IVVD) | 278,608 | 989,822 | +711,214 | 306 | 2,445 | 0.42% | +2,138 |
| ABBVIE INC(ABBV) | 0 | 9,325 | +9,325 | 0 | 2,131 | 0.37% | +2,131 |
| PROTAGONIST THERAPEUTICS INC | 47,954 | 59,430 | +11,476 | 3,186 | 5,191 | 0.89% | +2,005 |
| INVENTIVA SA(IVA) | 30,824 | 467,242 | +436,418 | 178 | 2,173 | 0.37% | +1,994 |
| TREVI THERAPEUTICS INC(TRVI) | 350,710 | 399,557 | +48,847 | 3,209 | 5,002 | 0.86% | +1,793 |
| MAPLIGHT THERAPEUTICS INC(MPLT) | 0 | 100,000 | +100,000 | 0 | 1,757 | 0.30% | +1,757 |
| X4 PHARMACEUTICALS INC(XFOR) | 555,411 | 898,465 | +343,054 | 1,900 | 3,594 | 0.62% | +1,694 |
| DIANTHUS THERAPEUTICS INC(DNTH) | 41,382 | 79,284 | +37,902 | 1,628 | 3,267 | 0.56% | +1,639 |
| PHARVARIS N V COM | 0 | 58,389 | +58,389 | 0 | 1,620 | 0.28% | +1,620 |
| MEIRAGTX HLDGS PLC(MGTX) | 81,858 | 287,689 | +205,831 | 674 | 2,287 | 0.39% | +1,613 |
| LEGEND BIOTECH CORP(LEGN) | 0 | 73,328 | +73,328 | 0 | 1,594 | 0.27% | +1,594 |
| BELITE BIO INC(BLTE) | 0 | 9,163 | +9,163 | 0 | 1,466 | 0.25% | +1,466 |
| XILIO THERAPEUTICS INC(XLO) | 0 | 2,030,028 | +2,030,028 | 0 | 1,300 | 0.22% | +1,300 |
| EVOMMUNE INC(EVMN) | 0 | 68,196 | +68,196 | 0 | 1,168 | 0.20% | +1,168 |
| MBX BIOSCIENCES INC(MBX) | 75,000 | 78,553 | +3,553 | 1,313 | 2,478 | 0.43% | +1,165 |
| SPYRE THERAPEUTICS INC(SYRE) | 0 | 32,377 | +32,377 | 0 | 1,061 | 0.18% | +1,061 |
| MONTE ROSA THERAPEUTICS INC(GLUE) | 0 | 61,577 | +61,577 | 0 | 966 | 0.17% | +966 |
| ADC THERAPEUTICS SA(ADCT) | 283,286 | 502,570 | +219,284 | 1,133 | 1,774 | 0.30% | +641 |
| SAB BIOTHERAPEUTICS INC(SABS) | 0 | 146,558 | +146,558 | 0 | 548 | 0.09% | +548 |
| VANDA PHARMACEUTICALS INC(VNDA) | 0 | 58,989 | +58,989 | 0 | 520 | 0.09% | +520 |
| CAPRICOR THERAPEUTICS INC(CAPR) | 0 | 17,853 | +17,853 | 0 | 515 | 0.09% | +515 |
| PASITHEA THERAPEUTICS CORP(KTTA) | 0 | 355,082 | +355,082 | 0 | 458 | 0.08% | +458 |
| ASCENDIS PHARMA A/S(ASND) | 15,149 | 14,842 | -307 | 3,012 | 3,165 | 0.54% | +153 |
| ATAI LIFE SCIENCES NV | 76,032 | 0 | -76,032 | 402 | 0 | — | -402 |
| VENTYX BIOSCIENCES INC | 167,470 | 0 | -167,470 | 521 | 0 | — | -521 |
| ARCTURUS THERAPEUTICS HLDGS(ARCT) | 35,606 | 0 | -35,606 | 656 | 0 | — | -656 |
| KALVISTA PHARMACEUTICALS INC | 56,770 | 0 | -56,770 | 691 | 0 | — | -691 |
| CORVUS PHARMACEUTICALS INC(CRVS) | 96,439 | 0 | -96,439 | 711 | 0 | — | -711 |
| ZENAS BIOPHARMA INC(ZBIO) | 38,742 | 0 | -38,742 | 860 | 0 | — | -860 |
| ENANTA PHARMACEUTICALS INC(ENTA) | 75,194 | 0 | -75,194 | 900 | 0 | — | -900 |
| MIND MEDICINE MINDMED INC | 76,875 | 0 | -76,875 | 906 | 0 | — | -906 |
| BRIDGEBIO ONCOLOGY THERAPEUT(BBOT) | 186,614 | 86,517 | -100,097 | 2,161 | 1,083 | 0.19% | -1,078 |
| ARCUTIS BIOTHERAPEUTICS INC(ARQT) | 411,893 | 224,740 | -187,153 | 7,764 | 6,526 | 1.12% | -1,238 |
| PYXIS ONCOLOGY INC(PYXS) | 689,538 | 0 | -689,538 | 1,531 | 0 | — | -1,531 |
| COMPASS PATHWAYS PLC(CMPS) | 275,620 | 0 | -275,620 | 1,579 | 0 | — | -1,579 |
| PROTARA THERAPEUTICS INC(TARA) | 363,666 | 0 | -363,666 | 1,582 | 0 | — | -1,582 |
| PERCEPTIVE CAP SOLUTIONS COR CL A ORD SHS | 150,000 | 0 | -150,000 | 1,590 | 0 | — | -1,590 |
| NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES | 150,573 | 73,106 | -77,467 | 4,282 | 2,565 | 0.44% | -1,718 |
| TAYSHA GENE THERAPIES INC(TSHA) | 839,669 | 182,130 | -657,539 | 2,746 | 1,002 | 0.17% | -1,744 |
| PEPGEN INC(PEPG) | 389,189 | 0 | -389,189 | 1,798 | 0 | — | -1,798 |
| ORIC PHARMACEUTICALS INC(ORIC) | 166,461 | 0 | -166,461 | 1,998 | 0 | — | -1,998 |
| TANGO THERAPEUTICS INC(TNGX) | 245,378 | 0 | -245,378 | 2,061 | 0 | — | -2,061 |
| INVESCO QQQ TR | 3,797 | 0 | -3,797 | 2,280 | 0 | — | -2,280 |
| CG ONCOLOGY INC(CGON) | 63,019 | 0 | -63,019 | 2,538 | 0 | — | -2,538 |
| UNITED THERAPEUTICS CORP DEL(UTHR) | 6,264 | 0 | -6,264 | 2,626 | 0 | — | -2,626 |
| EQUILLIUM INC(EQ) | 1,908,935 | 0 | -1,908,935 | 2,730 | 0 | — | -2,730 |
| HARROW INC(HROW) | 57,619 | 0 | -57,619 | 2,776 | 0 | — | -2,776 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 91,444 | 58,915 | -32,529 | 9,235 | 6,306 | 1.08% | -2,929 |
| TECTONIC THERAPEUTIC INC(TECX) | 188,999 | 0 | -188,999 | 2,965 | 0 | — | -2,965 |
| REVOLUTION MEDICINES INC(RVMD) | 185,380 | 62,032 | -123,348 | 8,657 | 4,941 | 0.85% | -3,716 |
| IDEAYA BIOSCIENCES INC(IDYA) | 371,825 | 161,659 | -210,166 | 10,117 | 5,589 | 0.96% | -4,529 |
| AVIDITY BIOSCIENCES INC | 114,053 | 0 | -114,053 | 4,969 | 0 | — | -4,969 |
| JAZZ PHARMACEUTICALS PLC(JAZZ) | 39,072 | 0 | -39,072 | 5,150 | 0 | — | -5,150 |
| AKERO THERAPEUTICS INC | 121,410 | 0 | -121,410 | 5,765 | 0 | — | -5,765 |
| INSMED INC(INSM) | 43,419 | 0 | -43,419 | 6,251 | 0 | — | -6,251 |
| BRIDGEBIO PHARMA INC(BBIO) | 127,435 | 0 | -127,435 | 6,619 | 0 | — | -6,619 |
| ALKERMES PLC(ALKS) | 241,637 | 0 | -241,637 | 7,249 | 0 | — | -7,249 |
| VISTAGEN THERAPEUTICS INC(VTGN) | 2,488,685 | 616,749 | -1,871,936 | 7,749 | 142 | 0.02% | -7,607 |
| GH RESEARCH PLC(GHRS) | 545,275 | 0 | -545,275 | 7,797 | 0 | — | -7,797 |
| REZOLUTE INC(RZLT) | 917,630 | 0 | -917,630 | 8,626 | 0 | — | -8,626 |