Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | Q4 2025 ▲▼ | Q1 2026 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| BRIDGEBIO PHARMA INC(BBIO) | 0 | 432,014 | +432,014 | 0 | 32,081 | 6.70% | +32,081 |
| DIANTHUS THERAPEUTICS INC(DNTH) | 653,572 | 560,308 | -93,264 | 26,934 | 47,021 | 9.82% | +20,087 |
| DEFINIUM THERAPEUTICS INC(DFTX) | 0 | 1,037,984 | +1,037,984 | 0 | 19,618 | 4.10% | +19,618 |
| INCYTE CORP(INCY) | 0 | 182,101 | +182,101 | 0 | 17,139 | 3.58% | +17,139 |
| TERNS PHARMACEUTICALS INC | 136,958 | 409,031 | +272,073 | 5,533 | 21,564 | 4.50% | +16,031 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 162,550 | 850,797 | +688,247 | 3,739 | 17,824 | 3.72% | +14,086 |
| CORVUS PHARMACEUTICALS INC(CRVS) | 0 | 891,933 | +891,933 | 0 | 13,049 | 2.73% | +13,049 |
| VERADERMICS INC(MANE) | 0 | 173,582 | +173,582 | 0 | 10,962 | 2.29% | +10,962 |
| KALVISTA PHARMACEUTICALS INC | 0 | 426,551 | +426,551 | 0 | 8,586 | 1.79% | +8,586 |
| HEARTFLOW INC(HTFL) | 113,857 | 403,588 | +289,731 | 3,319 | 9,819 | 2.05% | +6,500 |
| ASCENDIS PHARMA A/S(ASND) | 119,265 | 129,111 | +9,846 | 25,432 | 29,532 | 6.17% | +4,099 |
| KARYOPHARM THERAPEUTICS INC | 142,984 | 897,709 | +754,725 | 1,052 | 5,000 | 1.04% | +3,948 |
| ELEDON PHARMACEUTICALS INC | 1,259,820 | 1,639,816 | +379,996 | 1,902 | 5,051 | 1.06% | +3,148 |
| NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES | 0 | 83,554 | +83,554 | 0 | 2,675 | 0.56% | +2,675 |
| SOLENO THERAPEUTICS INC | 360,340 | 577,808 | +217,468 | 16,684 | 19,345 | 4.04% | +2,661 |
| TYRA BIOSCIENCES INC(TYRA) | 0 | 67,285 | +67,285 | 0 | 2,577 | 0.54% | +2,577 |
| IMMUNOCORE HLDGS PLC(IMCR) | 0 | 84,352 | +84,352 | 0 | 2,543 | 0.53% | +2,543 |
| UNIQURE NV(QURE) | 288,345 | 491,116 | +202,771 | 6,900 | 8,030 | 1.68% | +1,130 |
| ATAIBECKLEY INC(ATAI) | 0 | 196,858 | +196,858 | 0 | 697 | 0.15% | +697 |
| SENSEI BIOTHERAPEUTICS INC | 14,718 | 14,718 | 0 | 157 | 464 | 0.10% | +307 |
| HYPERFINE INC | 1,320,041 | 1,320,041 | 0 | 1,293 | 1,426 | 0.30% | +133 |
| OUTSET MED INC | 118,279 | 118,279 | 0 | 439 | 454 | 0.09% | +15 |
| NATERA INC(NTRA) | 62,273 | 70,907 | +8,634 | 14,266 | 14,181 | 2.96% | -85 |
| METAGENOMI THERAPEUTICS INC | 528,993 | 528,993 | 0 | 857 | 709 | 0.15% | -148 |
| MINERALYS THERAPEUTICS INC(MLYS) | 331,849 | 439,041 | +107,192 | 12,043 | 11,894 | 2.48% | -149 |
| SYNDAX PHARMACEUTICALS INC(SNDX) | 1,196,807 | 1,043,670 | -153,137 | 25,145 | 24,380 | 5.09% | -765 |
| ATAI BECKLEY NV | 196,858 | 0 | -196,858 | 805 | 0 | — | -805 |
| DISC MEDICINE INC(IRON) | 110,427 | 122,978 | +12,551 | 8,769 | 7,863 | 1.64% | -906 |
| PALVELLA THERAPEUTICS INC NE(PVLA) | 10,452 | 0 | -10,452 | 1,094 | 0 | — | -1,094 |
| SEPTERNA INC(SEPN) | 294,360 | 294,360 | 0 | 8,207 | 7,073 | 1.48% | -1,133 |
| BILLIONTOONE INC | 25,505 | 0 | -25,505 | 2,087 | 0 | — | -2,087 |
| CYTOKINETICS INC(CYTK) | 258,381 | 215,501 | -42,880 | 16,418 | 14,204 | 2.97% | -2,214 |
| FULCRUM THERAPEUTICS INC | 201,301 | 0 | -201,301 | 2,277 | 0 | — | -2,277 |
| GRAIL INC(GRAL) | 30,313 | 0 | -30,313 | 2,594 | 0 | — | -2,594 |
| ADAPTIVE BIOTECHNOLOGIES COR(ADPT) | 821,195 | 722,784 | -98,411 | 13,336 | 10,032 | 2.10% | -3,304 |
| EDWARDS LIFESCIENCES CORP | 187,048 | 144,607 | -42,441 | 15,946 | 11,580 | 2.42% | -4,366 |
| PROTARA THERAPEUTICS INC | 1,446,254 | 580,024 | -866,230 | 7,709 | 3,022 | 0.63% | -4,687 |
| DYNE THERAPEUTICS INC(DYN) | 519,715 | 282,954 | -236,761 | 10,166 | 5,130 | 1.07% | -5,036 |
| STRUCTURE THERAPEUTICS INC | 252,901 | 255,379 | +2,478 | 17,589 | 12,309 | 2.57% | -5,280 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 267,058 | 0 | -267,058 | 6,676 | 0 | — | -6,676 |
| ABIVAX SA(ABVX) | 98,514 | 47,193 | -51,321 | 13,285 | 5,255 | 1.10% | -8,030 |
| OCULAR THERAPEUTIX INC(OCUL) | 714,501 | 0 | -714,501 | 8,674 | 0 | — | -8,674 |
| PHATHOM PHARMACEUTICALS INC(PHAT) | 698,996 | 247,767 | -451,229 | 11,596 | 2,753 | 0.58% | -8,844 |
| BRISTOL-MYERS SQUIBB CO(BMY) | 647,899 | 420,727 | -227,172 | 34,948 | 25,517 | 5.33% | -9,431 |
| FRACTYL HEALTH INC | 5,491,866 | 5,491,866 | 0 | 12,082 | 2,514 | 0.53% | -9,568 |
| SUPERNUS PHARMACEUTICALS(SUPN) | 257,465 | 62,019 | -195,446 | 12,796 | 3,206 | 0.67% | -9,590 |
| ARCELLX INC COMMON STOCK | 156,109 | 0 | -156,109 | 10,178 | 0 | — | -10,178 |
| ADMA BIOLOGICS INC | 564,461 | 0 | -564,461 | 10,296 | 0 | — | -10,296 |
| GILEAD SCIENCES INC(GILD) | 289,312 | 163,905 | -125,407 | 35,510 | 22,843 | 4.77% | -12,667 |
| INTUITIVE SURGICAL INC | 27,209 | 0 | -27,209 | 15,410 | 0 | — | -15,410 |
| BOSTON SCIENTIFIC CORP(BSX) | 360,428 | 299,318 | -61,110 | 34,367 | 18,782 | 3.92% | -15,585 |
| REGENERON PHARMACEUTICALS(REGN) | 29,797 | 0 | -29,797 | 22,999 | 0 | — | -22,999 |
| JOHNSON & JOHNSON(JNJ) | 120,840 | 0 | -120,840 | 25,008 | 0 | — | -25,008 |
| ELI LILLY & CO(LLY) | 25,923 | 0 | -25,923 | 27,859 | 0 | — | -27,859 |
| BRIDGEBIO ONCOLOGY THERAPEUT | 410,700 | 0 | -410,700 | 31,414 | 0 | — | -31,414 |