Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | Q4 2025 ▲▼ | Q1 2026 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Revolution Medicines Inc(RVMD) | 295,000 | 2,375,000 | +2,080,000 | 23,497 | 230,969 | 6.46% | +207,472 |
| Neurocrine Biosciences Inc(NBIX) | 0 | 1,250,000 | +1,250,000 | 0 | 164,675 | 4.60% | +164,675 |
| Repligen Corp(RGEN) | 83,000 | 925,000 | +842,000 | 13,600 | 108,984 | 3.05% | +95,383 |
| Arrowhead Pharmaceuticals Inc(ARWR) | 900,000 | 2,275,000 | +1,375,000 | 59,751 | 142,643 | 3.99% | +82,892 |
| Dyne Therapeutics Inc(DYN) | 120,000 | 4,000,000 | +3,880,000 | 2,347 | 72,520 | 2.03% | +70,173 |
| Enliven Therapeutics Inc | 3,830,000 | 3,250,000 | -580,000 | 58,982 | 127,400 | 3.56% | +68,418 |
| Sanofi SA(SNY) | 0 | 1,400,000 | +1,400,000 | 0 | 67,452 | 1.89% | +67,452 |
| Immunocore Holdings PLC(IMCR) | 585,000 | 2,766,868 | +2,181,868 | 20,305 | 83,421 | 2.33% | +63,116 |
| Apogee Therapeutics Inc(APGE) | 550,000 | 1,100,000 | +550,000 | 41,514 | 92,587 | 2.59% | +51,073 |
| Boston Scientific Corp(BSX) | 0 | 800,000 | +800,000 | 0 | 50,200 | 1.40% | +50,200 |
| BioCryst Pharmaceuticals Inc(BCRX) | 2,250,000 | 7,025,000 | +4,775,000 | 17,550 | 66,878 | 1.87% | +49,328 |
| Ascendis Pharma A/S(ASND) | 0 | 375,000 | +375,000 | 0 | 85,774 | 2.40% | +85,774 |
| Bicara Therapeutics Inc | 3,575,000 | 5,425,000 | +1,850,000 | 60,167 | 107,903 | 3.02% | +47,736 |
| Cogent Biosciences Inc(COGT) | 0 | 1,230,888 | +1,230,888 | 0 | 47,377 | 1.32% | +47,377 |
| Bristol-Myers Squibb Co(BMY) | 250,000 | 1,000,000 | +750,000 | 13,485 | 60,650 | 1.70% | +47,165 |
| Monte Rosa Therapeutics Inc(GLUE) | 775,000 | 3,603,465 | +2,828,465 | 12,152 | 59,277 | 1.66% | +47,125 |
| Nuvalent Inc(NUVL) | 0 | 481,715 | +481,715 | 0 | 49,352 | 1.38% | +49,352 |
| United Therapeutics Corp(UTHR) | 0 | 75,000 | +75,000 | 0 | 44,474 | 1.24% | +44,474 |
| Bright Minds Biosciences Inc | 0 | 492,319 | +492,319 | 0 | 35,925 | 1.00% | +35,925 |
| Protagonist Therapeutics Inc | 0 | 326,159 | +326,159 | 0 | 34,377 | 0.96% | +34,377 |
| Scholar Rock Holding Corp(SRRK) | 700,000 | 1,324,422 | +624,422 | 30,835 | 65,109 | 1.82% | +34,274 |
| Regeneron Pharmaceuticals Inc(REGN) | 0 | 40,000 | +40,000 | 0 | 30,906 | 0.86% | +30,906 |
| Waters Corp(WAT) | 0 | 100,000 | +100,000 | 0 | 29,780 | 0.83% | +29,780 |
| Viking Therapeutics Inc(VKTX) | 0 | 914,147 | +914,147 | 0 | 29,746 | 0.83% | +29,746 |
| Inspire Medical Systems Inc(INSP) | 0 | 539,269 | +539,269 | 0 | 27,815 | 0.78% | +27,815 |
| Vera Therapeutics Inc(VERA) | 550,000 | 1,368,159 | +818,159 | 27,852 | 55,041 | 1.54% | +27,189 |
| Denali Therapeutics Inc(DNLI) | 465,000 | 1,773,326 | +1,308,326 | 7,677 | 34,048 | 0.95% | +26,371 |
| Trevi Therapeutics Inc(TRVI) | 0 | 2,166,504 | +2,166,504 | 0 | 25,846 | 0.72% | +25,846 |
| Soleno Therapeutics Inc | 0 | 730,000 | +730,000 | 0 | 24,440 | 0.68% | +24,440 |
| BioMarin Pharmaceutical Inc(BMRN) | 3,000,000 | 3,575,000 | +575,000 | 178,290 | 201,952 | 5.65% | +23,662 |
| Nektar Therapeutics(NKTR) | 0 | 285,000 | +285,000 | 0 | 20,506 | 0.57% | +20,506 |
| Cytokinetics Inc(CYTK) | 0 | 300,000 | +300,000 | 0 | 19,773 | 0.55% | +19,773 |
| AstraZeneca PLC(AZN) | 0 | 100,000 | +100,000 | 0 | 19,722 | 0.55% | +19,722 |
| West Pharmaceutical Services I(WST) | 0 | 75,000 | +75,000 | 0 | 18,798 | 0.53% | +18,798 |
| GE HealthCare Technologies Inc(GEHC) | 0 | 250,000 | +250,000 | 0 | 17,795 | 0.50% | +17,795 |
| SpyGlass Pharma Inc | 0 | 666,760 | +666,760 | 0 | 17,276 | 0.48% | +17,276 |
| Madrigal Pharmaceuticals Inc(MDGL) | 0 | 31,468 | +31,468 | 0 | 16,473 | 0.46% | +16,473 |
| GeneDx Holdings Corp(WGS) | 0 | 250,000 | +250,000 | 0 | 16,055 | 0.45% | +16,055 |
| Damora Therapeutics Inc(DMRA) | 0 | 600,000 | +600,000 | 0 | 15,540 | 0.43% | +15,540 |
| Tarsus Pharmaceuticals Inc(TARS) | 0 | 200,000 | +200,000 | 0 | 14,030 | 0.39% | +14,030 |
| Nurix Therapeutics Inc(NRIX) | 4,690,000 | 6,500,000 | +1,810,000 | 88,969 | 100,750 | 2.82% | +11,781 |
| Rapport Therapeutics Inc(RAPP) | 1,110,000 | 1,436,229 | +326,229 | 33,677 | 44,940 | 1.26% | +11,262 |
| Insulet Corp(PODD) | 0 | 50,601 | +50,601 | 0 | 10,618 | 0.30% | +10,618 |
| Xenon Pharmaceuticals Inc(XENE) | 600,000 | 639,900 | +39,900 | 26,892 | 37,210 | 1.04% | +10,318 |
| Surrozen Inc | 0 | 338,611 | +338,611 | 0 | 9,864 | 0.28% | +9,864 |
| Crescent Biopharma Inc | 1,500,000 | 1,500,000 | 0 | 17,790 | 27,555 | 0.77% | +9,765 |
| Arvinas Inc | 0 | 905,465 | +905,465 | 0 | 9,598 | 0.27% | +9,598 |
| Celldex Therapeutics Inc(CLDX) | 1,165,000 | 1,224,165 | +59,165 | 31,641 | 38,831 | 1.09% | +7,189 |
| KalVista Pharmaceuticals Inc | 1,890,000 | 1,850,000 | -40,000 | 30,524 | 37,241 | 1.04% | +6,717 |
| Agios Pharmaceuticals Inc(AGIO) | 325,000 | 450,000 | +125,000 | 8,847 | 15,224 | 0.43% | +6,377 |
| Anteris Technologies Global Co | 0 | 1,144,780 | +1,144,780 | 0 | 6,354 | 0.18% | +6,354 |
| uniQure NV(QURE) | 0 | 358,996 | +358,996 | 0 | 5,870 | 0.16% | +5,870 |
| Voyager Therapeutics Inc | 1,475,000 | 3,002,936 | +1,527,936 | 5,797 | 11,591 | 0.32% | +5,795 |
| OnKure Therapeutics Inc | 635,000 | 1,839,819 | +1,204,819 | 1,842 | 7,617 | 0.21% | +5,775 |
| Candel Therapeutics Inc | 0 | 1,125,000 | +1,125,000 | 0 | 5,513 | 0.15% | +5,513 |
| enGene Therapeutics Inc COM | 1,055,000 | 2,165,000 | +1,110,000 | 9,527 | 14,744 | 0.41% | +5,217 |
| Taysha Gene Therapies Inc(TSHA) | 13,750,000 | 18,000,000 | +4,250,000 | 75,625 | 80,460 | 2.25% | +4,835 |
| Savara Inc(SVRA) | 1,606,000 | 2,600,052 | +994,052 | 9,684 | 14,196 | 0.40% | +4,512 |
| Palisade Bio Inc | 0 | 2,500,000 | +2,500,000 | 0 | 4,375 | 0.12% | +4,375 |
| Veracyte Inc(VCYT) | 0 | 130,687 | +130,687 | 0 | 4,209 | 0.12% | +4,209 |
| Zenas Biopharma Inc(ZBIO) | 0 | 200,000 | +200,000 | 0 | 3,910 | 0.11% | +3,910 |
| Beta Bionics Inc | 600,000 | 2,211,518 | +1,611,518 | 18,282 | 22,159 | 0.62% | +3,877 |
| Zimmer Biomet Holdings Inc(ZBH) | 150,000 | 190,000 | +40,000 | 13,488 | 17,180 | 0.48% | +3,692 |
| Monopar Therapeutics Inc | 0 | 65,418 | +65,418 | 0 | 3,584 | 0.10% | +3,584 |
| Tectonic Therapeutic Inc | 328,000 | 328,000 | 0 | 6,842 | 10,138 | 0.28% | +3,296 |
| Solid Biosciences Inc | 5,815,000 | 5,000,000 | -815,000 | 32,797 | 36,000 | 1.01% | +3,203 |
| Zura Bio Ltd | 0 | 511,000 | +511,000 | 0 | 3,040 | 0.09% | +3,040 |
| UroGen Pharma Ltd(URGN) | 0 | 139,079 | +139,079 | 0 | 2,501 | 0.07% | +2,501 |
| Alto Neuroscience Inc(ANRO) | 2,485,000 | 2,064,075 | -420,925 | 44,233 | 46,400 | 1.30% | +2,167 |
| MapLight Therapeutics Inc(MPLT) | 385,000 | 420,000 | +35,000 | 6,763 | 8,539 | 0.24% | +1,776 |
| Absci Corp | 0 | 232,219 | +232,219 | 0 | 697 | 0.02% | +697 |
| REGENXBIO Inc | 34,000 | 108,525 | +74,525 | 490 | 909 | 0.03% | +420 |
| MacroGenics Inc | 280,000 | 280,000 | 0 | 451 | 809 | 0.02% | +358 |
| Aprea Therapeutics Inc | 0 | 350,000 | +350,000 | 0 | 267 | 0.01% | +267 |
| Tenax Therapeutics Inc | 53,439 | 53,439 | 0 | 651 | 854 | 0.02% | +203 |
| Myriad Genetics Inc | 1,223,000 | 1,648,000 | +425,000 | 7,521 | 7,416 | 0.21% | -105 |
| Alector Inc | 755,000 | 0 | -755,000 | 1,178 | 0 | — | -1,178 |
| Passage Bio Inc | 305,000 | 305,000 | 0 | 3,599 | 2,394 | 0.07% | -1,205 |
| Fate Therapeutics Inc | 1,725,000 | 0 | -1,725,000 | 1,695 | 0 | — | -1,695 |
| Black Diamond Therapeutics Inc | 870,000 | 0 | -870,000 | 2,114 | 0 | — | -2,114 |
| Fulcrum Therapeutics Inc | 950,000 | 1,100,000 | +150,000 | 10,745 | 8,437 | 0.24% | -2,307 |
| Structure Therapeutics Inc | 35,000 | 0 | -35,000 | 2,434 | 0 | — | -2,434 |
| Nyxoah SA SHS | 1,107,000 | 868,661 | -238,339 | 5,092 | 2,536 | 0.07% | -2,556 |
| Sutro Biopharma Inc | 243,000 | 0 | -243,000 | 2,812 | 0 | — | -2,812 |
| Immatics NV(IMTX) | 6,125,000 | 6,175,000 | +50,000 | 64,313 | 60,762 | 1.70% | -3,550 |
| Rezolute Inc | 1,686,000 | 0 | -1,686,000 | 3,979 | 0 | — | -3,979 |
| Novocure Ltd(NVCR) | 525,000 | 250,000 | -275,000 | 6,788 | 2,725 | 0.08% | -4,063 |
| LENZ Therapeutics Inc | 275,000 | 0 | -275,000 | 4,400 | 0 | — | -4,400 |
| Mirum Pharmaceuticals Inc(MIRM) | 66,000 | 0 | -66,000 | 5,213 | 0 | — | -5,213 |
| DBV Technologies SA | 300,000 | 0 | -300,000 | 5,751 | 0 | — | -5,751 |
| Gilead Sciences Inc(GILD) | 50,000 | 0 | -50,000 | 6,137 | 0 | — | -6,137 |
| Definium Therapeutics Inc | 637,000 | 0 | -637,000 | 8,529 | 0 | — | -8,529 |
| Geron Corp(GERN) | 11,320,000 | 2,540,000 | -8,780,000 | 14,942 | 3,785 | 0.11% | -11,158 |
| Disc Medicine Inc(IRON) | 735,000 | 700,000 | -35,000 | 58,366 | 44,758 | 1.25% | -13,608 |
| Penumbra Inc(PEN) | 50,000 | 0 | -50,000 | 15,546 | 0 | — | -15,545 |
| Lexeo Therapeutics Inc | 4,475,000 | 4,475,000 | 0 | 44,437 | 25,687 | 0.72% | -18,750 |
| Upstream Bio Inc | 720,000 | 0 | -720,000 | 19,548 | 0 | — | -19,548 |
| Zymeworks Inc(ZYME) | 865,000 | 0 | -865,000 | 22,775 | 0 | — | -22,775 |
| Lantheus Holdings Inc(LNTH) | 360,000 | 0 | -360,000 | 23,958 | 0 | — | -23,958 |
| Alcon AG(ALC) | 1,105,000 | 800,000 | -305,000 | 87,085 | 60,280 | 1.69% | -26,805 |