Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | Q4 2025 ▲▼ | Q1 2026 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Revolution Medicines, Inc.(RVMD) | 295,000 | 2,375,000 | +2,080,000 | $23.50M | $230.97M | 6.46% | +$207.47M |
| BioMarin Pharmaceutical Inc.(BMRN) | 3,000,000 | 3,575,000 | +575,000 | $178.29M | $201.95M | 5.65% | +$23.66M |
| ABIVAX Société AnonymeADS(ABVX) | 1,900,000 | 1,500,000 | -400,000 | $256.22M | $167.03M | 4.67% | -$89.20M |
| Neurocrine Biosciences, Inc.(NBIX) | 0 | 1,250,000 | +1,250,000 | $0 | $164.68M | 4.60% | +$164.68M |
| Arrowhead Pharmaceuticals, Inc.(ARWR) | 900,000 | 2,275,000 | +1,375,000 | $59.75M | $142.64M | 3.99% | +$82.89M |
| Enliven Therapeutics Inc | 3,830,000 | 3,250,000 | -580,000 | $58.98M | $127.40M | 3.56% | +$68.42M |
| Repligen Corporation(RGEN) | 83,000 | 925,000 | +842,000 | $13.60M | $108.98M | 3.05% | +$95.38M |
| Bicara Therapeutics Inc | 3,575,000 | 5,425,000 | +1,850,000 | $60.17M | $107.90M | 3.02% | +$47.74M |
| Nurix Therapeutics, Inc.(NRIX) | 4,690,000 | 6,500,000 | +1,810,000 | $88.97M | $100.75M | 2.82% | +$11.78M |
| Apogee Therapeutics Inc | 550,000 | 1,100,000 | +550,000 | $41.51M | $92.59M | 2.59% | +$51.07M |
| Ascendis Pharma A/SADR(ASND) | 175,000 | 375,000 | +200,000 | $37.32M | $85.77M | 2.40% | +$48.46M |
| Immunocore Holdings plcADS(IMCR) | 585,000 | 2,766,868 | +2,181,868 | $20.31M | $83.42M | 2.33% | +$63.12M |
| Taysha Gene Therapies, Inc.(TSHA) | 13,750,000 | 18,000,000 | +4,250,000 | $75.63M | $80.46M | 2.25% | +$4.83M |
| Dyne Therapeutics, Inc.(DYN) | 120,000 | 4,000,000 | +3,880,000 | $2.35M | $72.52M | 2.03% | +$70.17M |
| SanofiADR(SNY) | 0 | 1,400,000 | +1,400,000 | $0 | $67.45M | 1.89% | +$67.45M |
| BioCryst Pharmaceuticals, Inc.(BCRX) | 2,250,000 | 7,025,000 | +4,775,000 | $17.55M | $66.88M | 1.87% | +$49.33M |
| Scholar Rock Holding Corporation(SRRK) | 700,000 | 1,324,422 | +624,422 | $30.84M | $65.11M | 1.82% | +$34.27M |
| Immatics N.V.SHS(IMTX) | 6,125,000 | 6,175,000 | +50,000 | $64.31M | $60.76M | 1.70% | -$3.55M |
| Bristol-Myers Squibb Company(BMY) | 250,000 | 1,000,000 | +750,000 | $13.48M | $60.65M | 1.70% | +$47.16M |
| Alcon Inc.(ALC) | 1,105,000 | 800,000 | -305,000 | $87.09M | $60.28M | 1.69% | -$26.81M |
| Monte Rosa Therapeutics, Inc.(GLUE) | 775,000 | 3,603,465 | +2,828,465 | $12.15M | $59.28M | 1.66% | +$47.12M |
| Vera Therapeutics, Inc.CL A(VERA) | 550,000 | 1,368,159 | +818,159 | $27.85M | $55.04M | 1.54% | +$27.19M |
| Terns Pharmaceuticals Inc | 4,500,000 | 1,000,000 | -3,500,000 | $181.80M | $52.72M | 1.47% | -$129.08M |
| Globus Medical, Inc.CL A(GMED) | 1,275,000 | 610,520 | -664,480 | $111.32M | $52.60M | 1.47% | -$58.72M |
| Boston Scientific Corporation(BSX) | 0 | 800,000 | +800,000 | $0 | $50.20M | 1.40% | +$50.20M |
| Nuvalent Inc | 46,000 | 481,715 | +435,715 | $4.63M | $49.35M | 1.38% | +$44.72M |
| Cogent Biosciences, Inc.(COGT) | 0 | 1,230,888 | +1,230,888 | $0 | $47.38M | 1.32% | +$47.38M |
| Alto Neuroscience, Inc.(ANRO) | 2,485,000 | 2,064,075 | -420,925 | $44.23M | $46.40M | 1.30% | +$2.17M |
| Rapport Therapeutics, Inc.(RAPP) | 1,110,000 | 1,436,229 | +326,229 | $33.68M | $44.94M | 1.26% | +$11.26M |
| Disc Medicine, Inc.(IRON) | 735,000 | 700,000 | -35,000 | $58.37M | $44.76M | 1.25% | -$13.61M |
| United Therapeutics Corporation(UTHR) | 0 | 75,000 | +75,000 | $0 | $44.47M | 1.24% | +$44.47M |
| Celldex Therapeutics, Inc.(CLDX) | 1,165,000 | 1,224,165 | +59,165 | $31.64M | $38.83M | 1.09% | +$7.19M |
| KalVista Pharmaceuticals Inc | 1,890,000 | 1,850,000 | -40,000 | $30.52M | $37.24M | 1.04% | +$6.72M |
| Xenon Pharmaceuticals Inc.(XENE) | 600,000 | 639,900 | +39,900 | $26.89M | $37.21M | 1.04% | +$10.32M |
| Solid Biosciences Inc | 5,815,000 | 5,000,000 | -815,000 | $32.80M | $36.00M | 1.01% | +$3.20M |
| Bright Minds Biosciences Inc.(DRUG) | 0 | 492,319 | +492,319 | $0 | $35.92M | 1.00% | +$35.92M |
| Protagonist Therapeutics Inc | 0 | 326,159 | +326,159 | $0 | $34.38M | 0.96% | +$34.38M |
| Denali Therapeutics Inc.(DNLI) | 465,000 | 1,773,326 | +1,308,326 | $7.68M | $34.05M | 0.95% | +$26.37M |
| Regeneron Pharmaceuticals, Inc.(REGN) | 0 | 40,000 | +40,000 | $0 | $30.91M | 0.86% | +$30.91M |
| Waters Corporation(WAT) | 0 | 100,000 | +100,000 | $0 | $29.78M | 0.83% | +$29.78M |
| Viking Therapeutics, Inc.(VKTX) | 0 | 914,147 | +914,147 | $0 | $29.75M | 0.83% | +$29.75M |
| Inspire Medical Systems, Inc.(INSP) | 0 | 539,269 | +539,269 | $0 | $27.82M | 0.78% | +$27.82M |
| Crescent Biopharma, Inc.(CBIO) | 1,500,000 | 1,500,000 | 0 | $17.79M | $27.55M | 0.77% | +$9.77M |
| Trevi Therapeutics, Inc.(TRVI) | 0 | 2,166,504 | +2,166,504 | $0 | $25.85M | 0.72% | +$25.85M |
| Lexeo Therapeutics, Inc.(LXEO) | 4,475,000 | 4,475,000 | 0 | $44.44M | $25.69M | 0.72% | -$18.75M |
| Soleno Therapeutics Inc | 0 | 730,000 | +730,000 | $0 | $24.44M | 0.68% | +$24.44M |
| Beta Bionics, Inc.(BBNX) | 600,000 | 2,211,518 | +1,611,518 | $18.28M | $22.16M | 0.62% | +$3.88M |
| Nektar Therapeutics(NKTR) | 0 | 285,000 | +285,000 | $0 | $20.51M | 0.57% | +$20.51M |
| Cytokinetics, Incorporated(CYTK) | 0 | 300,000 | +300,000 | $0 | $19.77M | 0.55% | +$19.77M |
| AstraZeneca PLC(AZN) | 0 | 100,000 | +100,000 | $0 | $19.72M | 0.55% | +$19.72M |
| West Pharmaceutical Services, Inc.(WST) | 0 | 75,000 | +75,000 | $0 | $18.80M | 0.53% | +$18.80M |
| GE HealthCare Technologies Inc.(GEHC) | 0 | 250,000 | +250,000 | $0 | $17.80M | 0.50% | +$17.80M |
| SpyGlass Pharma, Inc.(SGP) | 0 | 666,760 | +666,760 | $0 | $17.28M | 0.48% | +$17.28M |
| Zimmer Biomet Holdings, Inc.(ZBH) | 150,000 | 190,000 | +40,000 | $13.49M | $17.18M | 0.48% | +$3.69M |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 0 | 31,468 | +31,468 | $0 | $16.47M | 0.46% | +$16.47M |
| GeneDx Holdings Corp.CL A(WGS) | 0 | 250,000 | +250,000 | $0 | $16.05M | 0.45% | +$16.05M |
| Damora Therapeutics, Inc.(DMRA) | 0 | 600,000 | +600,000 | $0 | $15.54M | 0.43% | +$15.54M |
| Agios Pharmaceuticals, Inc.(AGIO) | 325,000 | 450,000 | +125,000 | $8.85M | $15.22M | 0.43% | +$6.38M |
| enGene Therapeutics Inc COM | 1,055,000 | 2,165,000 | +1,110,000 | $9.53M | $14.74M | 0.41% | +$5.22M |
| Savara Inc.(SVRA) | 1,606,000 | 2,600,052 | +994,052 | $9.68M | $14.20M | 0.40% | +$4.51M |
| Tarsus Pharmaceuticals, Inc.(TARS) | 0 | 200,000 | +200,000 | $0 | $14.03M | 0.39% | +$14.03M |
| Voyager Therapeutics, Inc.(VYGR) | 1,475,000 | 3,002,936 | +1,527,936 | $5.80M | $11.59M | 0.32% | +$5.79M |
| Insulet Corporation(PODD) | 0 | 50,601 | +50,601 | $0 | $10.62M | 0.30% | +$10.62M |
| Tectonic Therapeutic, Inc.(TECX) | 328,000 | 328,000 | 0 | $6.84M | $10.14M | 0.28% | +$3.30M |
| Surrozen, Inc.(SRZN) | 0 | 338,611 | +338,611 | $0 | $9.86M | 0.28% | +$9.86M |
| Arvinas, Inc.(ARVN) | 0 | 905,465 | +905,465 | $0 | $9.60M | 0.27% | +$9.60M |
| MapLight Therapeutics, Inc.(MPLT) | 385,000 | 420,000 | +35,000 | $6.76M | $8.54M | 0.24% | +$1.78M |
| Fulcrum Therapeutics, Inc.(FULC) | 950,000 | 1,100,000 | +150,000 | $10.74M | $8.44M | 0.24% | -$2.31M |
| OnKure Therapeutics, Inc.CL A(OKUR) | 635,000 | 1,839,819 | +1,204,819 | $1.84M | $7.62M | 0.21% | +$5.78M |
| Myriad Genetics, Inc.(MYGN) | 1,223,000 | 1,648,000 | +425,000 | $7.52M | $7.42M | 0.21% | -$105.5K |
| Olema Pharmaceuticals, Inc.(OLMA) | 1,650,000 | 428,551 | -1,221,449 | $41.25M | $6.39M | 0.18% | -$34.86M |
| Anteris Technologies Global Corp.(AVR) | 0 | 1,144,780 | +1,144,780 | $0 | $6.35M | 0.18% | +$6.35M |
| uniQure N.V.SHS(QURE) | 0 | 358,996 | +358,996 | $0 | $5.87M | 0.16% | +$5.87M |
| Candel Therapeutics, Inc.(CADL) | 0 | 1,125,000 | +1,125,000 | $0 | $5.51M | 0.15% | +$5.51M |
| Palisade Bio, Inc.(PALI) | 0 | 2,500,000 | +2,500,000 | $0 | $4.38M | 0.12% | +$4.38M |
| Veracyte, Inc.(VCYT) | 0 | 130,687 | +130,687 | $0 | $4.21M | 0.12% | +$4.21M |
| Zenas BioPharma, Inc.(ZBIO) | 0 | 200,000 | +200,000 | $0 | $3.91M | 0.11% | +$3.91M |
| Geron Corporation(GERN) | 11,320,000 | 2,540,000 | -8,780,000 | $14.94M | $3.78M | 0.11% | -$11.16M |
| Monopar Therapeutics Inc.(MNPR) | 0 | 65,418 | +65,418 | $0 | $3.58M | 0.10% | +$3.58M |
| Zura Bio LimitedCL A(ZURA) | 0 | 511,000 | +511,000 | $0 | $3.04M | 0.09% | +$3.04M |
| NovoCure Limited(NVCR) | 525,000 | 250,000 | -275,000 | $6.79M | $2.73M | 0.08% | -$4.06M |
| Nyxoah SASHS SHS | 1,107,000 | 868,661 | -238,339 | $5.09M | $2.54M | 0.07% | -$2.56M |
| UroGen Pharma Ltd.(URGN) | 0 | 139,079 | +139,079 | $0 | $2.50M | 0.07% | +$2.50M |
| Passage Bio, Inc.(PASG) | 305,000 | 305,000 | 0 | $3.60M | $2.39M | 0.07% | -$1.20M |
| Tyra Biosciences, Inc.(TYRA) | 2,425,000 | 54,000 | -2,371,000 | $63.75M | $2.07M | 0.06% | -$61.69M |
| REGENXBIO Inc.(RGNX) | 34,000 | 108,525 | +74,525 | $489.6K | $909.4K | 0.03% | +$419.8K |
| Tenax Therapeutics, Inc.(TENX) | 53,439 | 53,439 | 0 | $651.4K | $854.5K | 0.02% | +$203.1K |
| MacroGenics, Inc.(MGNX) | 280,000 | 280,000 | 0 | $450.8K | $809.2K | 0.02% | +$358.4K |
| Absci Corp | 0 | 232,219 | +232,219 | $0 | $696.7K | 0.02% | +$696.7K |
| Aprea Therapeutics, Inc.(APRE) | 0 | 350,000 | +350,000 | $0 | $267.0K | 0.01% | +$267.0K |
| Abbott Laboratories | 600,000 | 0 | -600,000 | $75.17M | $0 | — | -$75.17M |
| Alector Inc | 755,000 | 0 | -755,000 | $1.18M | $0 | — | -$1.18M |
| Arcellx Inc COMMON STOCK | 2,925,000 | 0 | -2,925,000 | $190.71M | $0 | — | -$190.71M |
| Axsome Therapeutics, Inc.(AXSM) | 210,000 | 0 | -210,000 | $38.35M | $0 | — | -$38.35M |
| Black Diamond Therapeutics Inc | 870,000 | 0 | -870,000 | $2.11M | $0 | — | -$2.11M |
| Day One Biopharmaceuticals Inc COM | 5,200,000 | 0 | -5,200,000 | $48.46M | $0 | — | -$48.46M |
| DBV Technologies S.A.ADS(DBVT) | 300,000 | 0 | -300,000 | $5.75M | $0 | — | -$5.75M |
| Definium Therapeutics Inc | 637,000 | 0 | -637,000 | $8.53M | $0 | — | -$8.53M |
| DexCom, Inc.(DXCM) | 1,275,000 | 0 | -1,275,000 | $84.62M | $0 | — | -$84.62M |
| Fate Therapeutics, Inc.(FATE) | 1,725,000 | 0 | -1,725,000 | $1.69M | $0 | — | -$1.69M |