Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q2 2025 ▲▼ | Q3 2025 ▲▼ | Change ▲▼ | Q2 2025 ▲▼ | Q3 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Ascendis Pharma A/SADR(ASND) | 200,000 | 600,000 | +400,000 | $34.52M | $119.29M | 5.41% | +$84.77M |
| Arcellx Inc COMMON STOCK | 2,750,000 | 1,250,000 | -1,500,000 | $181.09M | $102.63M | 4.66% | -$78.46M |
| Nuvalent Inc | 1,075,000 | 1,100,000 | +25,000 | $82.02M | $95.13M | 4.32% | +$13.11M |
| ABIVAX Société AnonymeADS(ABVX) | 0 | 1,000,000 | +1,000,000 | $0 | $84.90M | 3.85% | +$84.90M |
| Alcon Inc.(ALC) | 525,000 | 1,100,000 | +575,000 | $46.35M | $81.96M | 3.72% | +$35.61M |
| Bicara Therapeutics Inc | 5,000,000 | 5,100,000 | +100,000 | $46.45M | $80.53M | 3.65% | +$34.08M |
| Amicus Therapeutics Inc COM | 11,900,000 | 9,750,000 | -2,150,000 | $68.19M | $76.83M | 3.49% | +$8.64M |
| Globus Medical, Inc.CL A(GMED) | 500,000 | 1,250,000 | +750,000 | $29.51M | $71.59M | 3.25% | +$42.08M |
| Ionis Pharmaceuticals, Inc.(IONS) | 500,000 | 1,075,000 | +575,000 | $19.75M | $70.33M | 3.19% | +$50.57M |
| Jazz Pharmaceuticals plcSHS USD(JAZZ) | 1,200,000 | 500,000 | -700,000 | $127.34M | $65.90M | 2.99% | -$61.44M |
| Becton, Dickinson and Company(BDX) | 25,000 | 325,000 | +300,000 | $4.31M | $60.83M | 2.76% | +$56.52M |
| Scholar Rock Holding Corporation(SRRK) | 1,500,000 | 1,500,000 | 0 | $53.13M | $55.86M | 2.53% | +$2.73M |
| Immatics N.V.SHS(IMTX) | 6,250,000 | 6,350,000 | +100,000 | $33.63M | $54.10M | 2.45% | +$20.48M |
| Repligen Corporation(RGEN) | 0 | 400,000 | +400,000 | $0 | $53.47M | 2.43% | +$53.47M |
| Dianthus Therapeutics, Inc.(DNTH) | 3,200,000 | 1,180,000 | -2,020,000 | $59.62M | $46.43M | 2.11% | -$13.18M |
| BioMarin Pharmaceutical Inc.(BMRN) | 500,000 | 830,000 | +330,000 | $27.48M | $44.95M | 2.04% | +$17.47M |
| Xenon Pharmaceuticals Inc.(XENE) | 2,000,000 | 1,100,000 | -900,000 | $62.60M | $44.16M | 2.00% | -$18.43M |
| DexCom, Inc.(DXCM) | 0 | 650,000 | +650,000 | $0 | $43.74M | 1.98% | +$43.74M |
| Cytokinetics, Incorporated(CYTK) | 2,975,000 | 725,000 | -2,250,000 | $98.29M | $39.85M | 1.81% | -$58.45M |
| Biogen Inc.(BIIB) | 0 | 275,000 | +275,000 | $0 | $38.52M | 1.75% | +$38.52M |
| Cidara Therapeutics Inc | 500,000 | 400,000 | -100,000 | $24.36M | $38.30M | 1.74% | +$13.95M |
| Astria Therapeutics Inc | 4,522,000 | 4,956,000 | +434,000 | $24.24M | $36.08M | 1.64% | +$11.84M |
| Dyne Therapeutics, Inc.(DYN) | 727,500 | 2,775,000 | +2,047,500 | $6.93M | $35.10M | 1.59% | +$28.18M |
| Tyra Biosciences, Inc.(TYRA) | 2,655,000 | 2,425,000 | -230,000 | $25.41M | $33.93M | 1.54% | +$8.52M |
| Abbott Laboratories | 175,000 | 250,000 | +75,000 | $23.80M | $33.48M | 1.52% | +$9.68M |
| Disc Medicine, Inc.(IRON) | 140,000 | 500,000 | +360,000 | $7.41M | $33.04M | 1.50% | +$25.63M |
| Nurix Therapeutics, Inc.(NRIX) | 2,000,000 | 3,475,000 | +1,475,000 | $22.78M | $32.11M | 1.46% | +$9.33M |
| Crinetics Pharmaceuticals Inc | 1,500,000 | 750,000 | -750,000 | $43.14M | $31.24M | 1.42% | -$11.90M |
| Celldex Therapeutics, Inc.(CLDX) | 1,750,000 | 1,205,000 | -545,000 | $35.61M | $31.17M | 1.41% | -$4.44M |
| Zymeworks Inc.(ZYME) | 1,150,000 | 1,765,000 | +615,000 | $14.43M | $30.15M | 1.37% | +$15.71M |
| Danaher Corporation(DHR) | 50,000 | 150,000 | +100,000 | $9.88M | $29.74M | 1.35% | +$19.86M |
| Revolution Medicines, Inc.(RVMD) | 1,200,000 | 630,000 | -570,000 | $44.15M | $29.42M | 1.33% | -$14.73M |
| Rapport Therapeutics, Inc.(RAPP) | 0 | 950,000 | +950,000 | $0 | $28.21M | 1.28% | +$28.21M |
| Enliven Therapeutics Inc | 250,000 | 1,160,000 | +910,000 | $5.01M | $23.75M | 1.08% | +$18.73M |
| Geron Corporation(GERN) | 23,775,000 | 17,225,000 | -6,550,000 | $33.52M | $23.60M | 1.07% | -$9.92M |
| Belite Bio, IncADS(BLTE) | 0 | 312,500 | +312,500 | $0 | $23.13M | 1.05% | +$23.13M |
| Ultragenyx Pharmaceutical Inc.(RARE) | 0 | 750,000 | +750,000 | $0 | $22.56M | 1.02% | +$22.56M |
| Vera Therapeutics, Inc.CL A(VERA) | 3,100,000 | 760,000 | -2,340,000 | $73.04M | $22.09M | 1.00% | -$50.95M |
| Lexeo Therapeutics, Inc.(LXEO) | 3,228,161 | 3,250,000 | +21,839 | $12.98M | $21.58M | 0.98% | +$8.60M |
| Black Diamond Therapeutics Inc | 5,600,000 | 5,550,000 | -50,000 | $13.89M | $21.03M | 0.95% | +$7.15M |
| Day One Biopharmaceuticals Inc COM | 3,000,000 | 2,675,000 | -325,000 | $19.50M | $18.86M | 0.86% | -$641.3K |
| Solid Biosciences Inc | 1,505,000 | 2,975,000 | +1,470,000 | $7.33M | $18.36M | 0.83% | +$11.03M |
| Axsome Therapeutics, Inc.(AXSM) | 0 | 150,000 | +150,000 | $0 | $18.22M | 0.83% | +$18.22M |
| Taysha Gene Therapies, Inc.(TSHA) | 3,000,000 | 5,500,000 | +2,500,000 | $6.93M | $17.98M | 0.82% | +$11.05M |
| Apogee Therapeutics Inc | 0 | 425,000 | +425,000 | $0 | $16.89M | 0.77% | +$16.89M |
| Savara Inc.(SVRA) | 11,015,000 | 4,015,000 | -7,000,000 | $25.11M | $14.33M | 0.65% | -$10.78M |
| Bruker Corporation(BRKR) | 500,000 | 440,000 | -60,000 | $20.60M | $14.30M | 0.65% | -$6.30M |
| Regeneron Pharmaceuticals, Inc.(REGN) | 0 | 25,000 | +25,000 | $0 | $14.06M | 0.64% | +$14.06M |
| uniQure N.V.SHS(QURE) | 3,700,000 | 225,000 | -3,475,000 | $51.58M | $13.13M | 0.60% | -$38.44M |
| Beta Bionics, Inc.(BBNX) | 550,000 | 600,000 | +50,000 | $8.01M | $11.92M | 0.54% | +$3.91M |
| Inspire Medical Systems, Inc.(INSP) | 0 | 135,000 | +135,000 | $0 | $10.02M | 0.45% | +$10.02M |
| KalVista Pharmaceuticals Inc | 4,675,000 | 750,000 | -3,925,000 | $52.85M | $9.13M | 0.41% | -$43.72M |
| Lantheus Holdings, Inc.(LNTH) | 50,000 | 170,000 | +120,000 | $4.09M | $8.72M | 0.40% | +$4.63M |
| Applied Therapeutics Inc | 11,500,000 | 14,250,000 | +2,750,000 | $3.58M | $8.62M | 0.39% | +$5.04M |
| CG Oncology, Inc.(CGON) | 0 | 175,000 | +175,000 | $0 | $7.05M | 0.32% | +$7.05M |
| Voyager Therapeutics, Inc.(VYGR) | 1,475,000 | 1,475,000 | 0 | $4.59M | $6.89M | 0.31% | +$2.30M |
| Tvardi Therapeutics, Inc.(TVRD) | 0 | 167,000 | +167,000 | $0 | $6.51M | 0.30% | +$6.51M |
| Ventyx Biosciences Inc | 2,000,000 | 2,050,000 | +50,000 | $4.28M | $6.38M | 0.29% | +$2.10M |
| Monte Rosa Therapeutics, Inc.(GLUE) | 0 | 800,000 | +800,000 | $0 | $5.93M | 0.27% | +$5.93M |
| GSK plcADR(GSK) | 0 | 125,000 | +125,000 | $0 | $5.39M | 0.24% | +$5.39M |
| NovoCure Limited(NVCR) | 0 | 400,000 | +400,000 | $0 | $5.17M | 0.23% | +$5.17M |
| Agios Pharmaceuticals, Inc.(AGIO) | 0 | 127,000 | +127,000 | $0 | $5.10M | 0.23% | +$5.10M |
| Nyxoah SASHS SHS | 1,402,002 | 1,107,413 | -294,589 | $10.49M | $5.09M | 0.23% | -$5.39M |
| Myriad Genetics, Inc.(MYGN) | 0 | 600,000 | +600,000 | $0 | $4.34M | 0.20% | +$4.34M |
| Endeavour Silver Corp.(EXK) | 700,000 | 75,000 | -625,000 | $37.20M | $4.10M | 0.19% | -$33.09M |
| Establishment Labs Holdings Inc.(ESTA) | 0 | 100,000 | +100,000 | $0 | $4.10M | 0.19% | +$4.10M |
| Kodiak Sciences Inc.(KOD) | 0 | 250,000 | +250,000 | $0 | $4.09M | 0.19% | +$4.09M |
| Alto Neuroscience, Inc.(ANRO) | 950,000 | 950,000 | 0 | $2.09M | $3.82M | 0.17% | +$1.73M |
| Arcutis Biotherapeutics, Inc.(ARQT) | 95,000 | 200,000 | +105,000 | $1.33M | $3.77M | 0.17% | +$2.44M |
| Arcus Biosciences, Inc.(RCUS) | 0 | 250,000 | +250,000 | $0 | $3.40M | 0.15% | +$3.40M |
| Fate Therapeutics, Inc.(FATE) | 2,515,000 | 2,515,000 | 0 | $2.82M | $3.17M | 0.14% | +$352.1K |
| Alector Inc | 976,992 | 980,000 | +3,008 | $1.37M | $2.90M | 0.13% | +$1.53M |
| Engene Holdings Inc COM | 370,000 | 370,000 | 0 | $1.35M | $2.53M | 0.11% | +$1.18M |
| Passage Bio, Inc.(PASG) | 0 | 305,000 | +305,000 | $0 | $2.45M | 0.11% | +$2.45M |
| Sutro Biopharma, Inc.(STRO) | 2,600,000 | 2,600,000 | 0 | $1.86M | $2.26M | 0.10% | +$401.7K |
| OnKure Therapeutics, Inc.CL A(OKUR) | 635,000 | 635,000 | 0 | $1.52M | $1.75M | 0.08% | +$228.6K |
| Pulmonx Corporation(LUNG) | 0 | 830,000 | +830,000 | $0 | $1.34M | 0.06% | +$1.34M |
| MacroGenics, Inc.(MGNX) | 280,000 | 280,000 | 0 | $338.8K | $470.4K | 0.02% | +$131.6K |
| Tenax Therapeutics, Inc.(TENX) | 53,439 | 53,439 | 0 | $307.8K | $406.7K | 0.02% | +$98.9K |
| Traws Pharma, Inc.(TRAW) | 149,800 | 150,000 | +200 | $221.7K | $277.5K | 0.01% | +$55.8K |
| Atara Biotherapeutics Inc | 94,085 | 0 | -94,085 | $726.3K | $0 | — | -$726.3K |
| Cogent Biosciences, Inc.(COGT) | 3,080,000 | 0 | -3,080,000 | $22.11M | $0 | — | -$22.11M |
| The Cooper Companies, Inc.(COO) | 350,000 | 0 | -350,000 | $24.91M | $0 | — | -$24.91M |
| Edwards Lifesciences Corp | 300,000 | 0 | -300,000 | $23.46M | $0 | — | -$23.46M |
| GE HealthCare Technologies Inc.(GEHC) | 700,000 | 0 | -700,000 | $51.85M | $0 | — | -$51.85M |
| Medtronic plcSHS(MDT) | 195,000 | 0 | -195,000 | $17.00M | $0 | — | -$17.00M |
| MoonLake ImmunotherapeuticsCL A(MLTX) | 550,000 | 0 | -550,000 | $25.96M | $0 | — | -$25.96M |
| Neurocrine Biosciences, Inc.(NBIX) | 30,000 | 0 | -30,000 | $3.77M | $0 | — | -$3.77M |
| Passage Bio, Inc.(PASG) | 6,100,000 | 0 | -6,100,000 | $2.44M | $0 | — | -$2.44M |
| Perrigo Company plcSHS(PRGO) | 625,000 | 0 | -625,000 | $16.70M | $0 | — | -$16.70M |
| Structure Therapeutics IncADS | 1,200,000 | 0 | -1,200,000 | $24.89M | $0 | — | -$24.89M |
| Thermo Fisher Scientific Inc.(TMO) | 25,000 | 0 | -25,000 | $10.14M | $0 | — | -$10.14M |
| Travere Therapeutics, Inc.(TVTX) | 355,000 | 0 | -355,000 | $5.25M | $0 | — | -$5.25M |
| Viridian Therapeutics, Inc.(VRDN) | 100,000 | 0 | -100,000 | $1.40M | $0 | — | -$1.40M |
| Zimmer Biomet Holdings, Inc.(ZBH) | 50,000 | 0 | -50,000 | $4.56M | $0 | — | -$4.56M |