Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2024 ▲▼ | Q4 2024 ▲▼ | Change ▲▼ | Q3 2024 ▲▼ | Q4 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Merck & Co Inc(MRK) | 0 | 800,000 | +800,000 | 0 | 79,584 | 4.72% | +79,584 |
| Nuvalent Inc(NUVL) | 0 | 600,000 | +600,000 | 0 | 46,968 | 2.78% | +46,968 |
| Vera Therapeutics Inc(VERA) | 0 | 1,075,000 | +1,075,000 | 0 | 45,462 | 2.70% | +45,462 |
| Ascendis Pharma A/S(ASND) | 250,000 | 520,000 | +270,000 | 37,328 | 71,588 | 4.24% | +34,261 |
| Geron Corp(GERN) | 1,050,000 | 11,000,000 | +9,950,000 | 4,767 | 38,940 | 2.31% | +34,173 |
| Amicus Therapeutics Inc COM | 0 | 3,350,000 | +3,350,000 | 0 | 31,557 | 1.87% | +31,557 |
| Cytokinetics Inc(CYTK) | 1,500,000 | 2,350,000 | +850,000 | 79,200 | 110,544 | 6.55% | +31,344 |
| AstraZeneca PLC(AZN) | 0 | 475,000 | +475,000 | 0 | 31,122 | 1.85% | +31,122 |
| Sarepta Therapeutics Inc(SRPT) | 0 | 250,000 | +250,000 | 0 | 30,398 | 1.80% | +30,398 |
| uniQure NV(QURE) | 4,750,000 | 3,025,000 | -1,725,000 | 23,418 | 53,422 | 3.17% | +30,004 |
| BioMarin Pharmaceutical Inc(BMRN) | 400,000 | 860,000 | +460,000 | 28,116 | 56,528 | 3.35% | +28,412 |
| Sanofi SA(SNY) | 150,000 | 750,000 | +600,000 | 8,645 | 36,173 | 2.14% | +27,528 |
| Globus Medical Inc(GMED) | 0 | 325,000 | +325,000 | 0 | 26,881 | 1.59% | +26,881 |
| Nyxoah SA SHS | 0 | 2,924,216 | +2,924,216 | 0 | 23,394 | 1.39% | +23,394 |
| Verona Pharma PLC | 0 | 495,000 | +495,000 | 0 | 22,988 | 1.36% | +22,988 |
| Madrigal Pharmaceuticals Inc(MDGL) | 30,000 | 95,000 | +65,000 | 6,367 | 29,314 | 1.74% | +22,948 |
| GSK PLC(GSK) | 300,000 | 1,000,000 | +700,000 | 12,264 | 33,820 | 2.01% | +21,556 |
| Ultragenyx Pharmaceutical Inc(RARE) | 750,000 | 1,500,000 | +750,000 | 41,663 | 63,105 | 3.74% | +21,443 |
| Ionis Pharmaceuticals Inc(IONS) | 0 | 595,000 | +595,000 | 0 | 20,801 | 1.23% | +20,801 |
| Jazz Pharmaceuticals PLC(JAZZ) | 900,000 | 975,000 | +75,000 | 100,269 | 120,071 | 7.12% | +19,802 |
| Roivant Sciences Ltd(ROIV) | 0 | 1,250,000 | +1,250,000 | 0 | 14,788 | 0.88% | +14,788 |
| Regeneron Pharmaceuticals Inc(REGN) | 0 | 20,000 | +20,000 | 0 | 14,247 | 0.84% | +14,247 |
| Tyra Biosciences Inc(TYRA) | 0 | 990,000 | +990,000 | 0 | 13,761 | 0.82% | +13,761 |
| Dianthus Therapeutics Inc(DNTH) | 395,000 | 1,075,000 | +680,000 | 10,815 | 23,435 | 1.39% | +12,620 |
| UroGen Pharma Ltd(URGN) | 400,000 | 1,630,000 | +1,230,000 | 5,080 | 17,360 | 1.03% | +12,280 |
| Establishment Labs Holdings In(ESTA) | 40,000 | 300,000 | +260,000 | 1,731 | 13,821 | 0.82% | +12,090 |
| Soleno Therapeutics Inc | 720,000 | 1,060,000 | +340,000 | 36,353 | 47,647 | 2.82% | +11,294 |
| Perrigo Co PLC(PRGO) | 0 | 375,000 | +375,000 | 0 | 9,641 | 0.57% | +9,641 |
| Legend Biotech Corp(LEGN) | 125,000 | 475,000 | +350,000 | 6,091 | 15,457 | 0.92% | +9,365 |
| Zai Lab Ltd(ZLAB) | 0 | 300,000 | +300,000 | 0 | 7,857 | 0.47% | +7,857 |
| Celldex Therapeutics Inc(CLDX) | 0 | 305,000 | +305,000 | 0 | 7,707 | 0.46% | +7,707 |
| Intellia Therapeutics Inc(NTLA) | 0 | 525,000 | +525,000 | 0 | 6,122 | 0.36% | +6,122 |
| Liquidia Corp(LQDA) | 1,500,000 | 1,760,000 | +260,000 | 15,000 | 20,698 | 1.23% | +5,698 |
| OnKure Therapeutics Inc | 0 | 635,000 | +635,000 | 0 | 5,461 | 0.32% | +5,461 |
| Sutro Biopharma Inc | 0 | 2,570,000 | +2,570,000 | 0 | 4,729 | 0.28% | +4,729 |
| Voyager Therapeutics Inc | 490,000 | 1,230,000 | +740,000 | 2,867 | 6,974 | 0.41% | +4,108 |
| Chimerix Inc | 1,400,000 | 1,400,000 | 0 | 1,302 | 4,872 | 0.29% | +3,570 |
| TransMedics Group Inc(TMDX) | 0 | 50,000 | +50,000 | 0 | 3,118 | 0.18% | +3,118 |
| Engene Holdings Inc COM | 0 | 370,000 | +370,000 | 0 | 2,461 | 0.15% | +2,461 |
| Bausch Health Cos Inc | 0 | 250,000 | +250,000 | 0 | 2,015 | 0.12% | +2,015 |
| Neurogene Inc | 0 | 80,000 | +80,000 | 0 | 1,829 | 0.11% | +1,829 |
| Immatics NV(IMTX) | 3,750,000 | 6,275,000 | +2,525,000 | 42,788 | 44,615 | 2.65% | +1,828 |
| Bicara Therapeutics Inc | 425,000 | 710,000 | +285,000 | 10,825 | 12,368 | 0.73% | +1,543 |
| Immunovant Inc(IMVT) | 0 | 45,000 | +45,000 | 0 | 1,115 | 0.07% | +1,115 |
| Verve Therapeutics Inc | 525,000 | 645,000 | +120,000 | 2,541 | 3,638 | 0.22% | +1,097 |
| Traws Pharma Inc | 0 | 75,000 | +75,000 | 0 | 666 | 0.04% | +666 |
| Atara Biotherapeutics Inc | 124,677 | 125,000 | +323 | 1,014 | 1,664 | 0.10% | +650 |
| Ventyx Biosciences Inc | 1,725,000 | 2,000,000 | +275,000 | 3,761 | 4,380 | 0.26% | +620 |
| Lexeo Therapeutics Inc | 850,000 | 1,200,000 | +350,000 | 7,684 | 7,896 | 0.47% | +212 |
| Achilles Therapeutics PLC | 1,500,000 | 1,500,000 | 0 | 1,530 | 1,710 | 0.10% | +180 |
| Applied Therapeutics Inc | 1,145,000 | 11,500,000 | +10,355,000 | 9,733 | 9,846 | 0.58% | +114 |
| Tenax Therapeutics Inc | 83,333 | 55,189 | -28,144 | 288 | 342 | 0.02% | +53 |
| Galapagos NV(LKFT) | 180,000 | 180,000 | 0 | 5,182 | 4,950 | 0.29% | -232 |
| Nurix Therapeutics Inc(NRIX) | 425,000 | 485,000 | +60,000 | 9,550 | 9,137 | 0.54% | -412 |
| Xenon Pharmaceuticals Inc(XENE) | 825,000 | 810,000 | -15,000 | 32,480 | 31,752 | 1.88% | -728 |
| Passage Bio Inc | 6,100,000 | 6,100,000 | 0 | 4,270 | 3,459 | 0.21% | -811 |
| Allogene Therapeutics Inc | 1,500,000 | 1,500,000 | 0 | 4,200 | 3,195 | 0.19% | -1,005 |
| Savara Inc(SVRA) | 8,090,000 | 10,775,000 | +2,685,000 | 34,302 | 33,079 | 1.96% | -1,222 |
| Reneo Pharmaceuticals Inc | 799,400 | 0 | -799,400 | 1,359 | 0 | — | -1,359 |
| Relmada Therapeutics Inc | 490,000 | 0 | -490,000 | 1,588 | 0 | — | -1,588 |
| MacroGenics Inc | 830,000 | 280,000 | -550,000 | 2,731 | 910 | 0.05% | -1,821 |
| Fate Therapeutics Inc | 1,685,000 | 2,465,000 | +780,000 | 5,898 | 4,067 | 0.24% | -1,830 |
| Monte Rosa Therapeutics Inc(GLUE) | 930,000 | 425,000 | -505,000 | 4,929 | 2,950 | 0.17% | -1,979 |
| Intra-Cellular Therapies Inc | 30,000 | 0 | -30,000 | 2,195 | 0 | — | -2,195 |
| Penumbra Inc(PEN) | 15,000 | 0 | -15,000 | 2,915 | 0 | — | -2,915 |
| PTC Therapeutics Inc(PTCT) | 80,000 | 0 | -80,000 | 2,968 | 0 | — | -2,968 |
| Ardelyx Inc | 500,000 | 0 | -500,000 | 3,445 | 0 | — | -3,445 |
| iTeos Therapeutics Inc | 1,025,000 | 900,000 | -125,000 | 10,465 | 6,912 | 0.41% | -3,553 |
| Alto Neuroscience Inc(ANRO) | 650,000 | 915,000 | +265,000 | 7,436 | 3,870 | 0.23% | -3,566 |
| Zevra Therapeutics Inc | 525,000 | 0 | -525,000 | 3,644 | 0 | — | -3,643 |
| Structure Therapeutics Inc | 1,150,000 | 1,725,000 | +575,000 | 50,474 | 46,782 | 2.77% | -3,691 |
| Prime Medicine Inc | 1,070,000 | 0 | -1,070,000 | 4,141 | 0 | — | -4,141 |
| Agilent Technologies Inc(A) | 100,000 | 75,000 | -25,000 | 14,848 | 10,076 | 0.60% | -4,772 |
| Zymeworks Inc(ZYME) | 615,000 | 185,000 | -430,000 | 7,718 | 2,708 | 0.16% | -5,010 |
| KalVista Pharmaceuticals Inc | 4,000,000 | 4,770,000 | +770,000 | 46,320 | 40,402 | 2.40% | -5,918 |
| Astria Therapeutics Inc | 4,000,000 | 4,180,000 | +180,000 | 44,040 | 37,369 | 2.22% | -6,671 |
| Becton Dickinson & Co(BDX) | 30,000 | 0 | -30,000 | 7,233 | 0 | — | -7,233 |
| Tarsus Pharmaceuticals Inc(TARS) | 230,000 | 0 | -230,000 | 7,565 | 0 | — | -7,565 |
| Apogee Therapeutics Inc(APGE) | 136,500 | 0 | -136,500 | 8,018 | 0 | — | -8,018 |
| Solid Biosciences Inc | 2,800,000 | 2,850,000 | +50,000 | 19,516 | 11,400 | 0.68% | -8,116 |
| Bruker Corp(BRKR) | 125,000 | 0 | -125,000 | 8,633 | 0 | — | -8,632 |
| Black Diamond Therapeutics Inc | 5,028,500 | 5,600,000 | +571,500 | 21,874 | 11,984 | 0.71% | -9,890 |
| Crinetics Pharmaceuticals Inc(CRNX) | 205,000 | 0 | -205,000 | 10,476 | 0 | — | -10,475 |
| Bristol-Myers Squibb Co(BMY) | 250,000 | 0 | -250,000 | 12,935 | 0 | — | -12,935 |
| Day One Biopharmaceuticals Inc COM | 2,500,000 | 1,440,000 | -1,060,000 | 34,825 | 18,245 | 1.08% | -16,580 |
| Gilead Sciences Inc(GILD) | 200,000 | 0 | -200,000 | 16,768 | 0 | — | -16,768 |
| Edwards Lifesciences Corp | 275,000 | 0 | -275,000 | 18,147 | 0 | — | -18,147 |
| Arcellx Inc COMMON STOCK | 675,000 | 475,000 | -200,000 | 56,369 | 36,428 | 2.16% | -19,941 |
| Janux Therapeutics Inc(JANX) | 485,000 | 0 | -485,000 | 22,034 | 0 | — | -22,034 |
| Biohaven Ltd(BHVN)(Call) | 500,000 | 0 | -500,000 | 24,985 | 0 | — | -24,985 |
| Avadel Pharmaceuticals PLC(Put) | 2,000,000 | 0 | -2,000,000 | 26,230 | 0 | — | -26,230 |
| Agios Pharmaceuticals Inc(AGIO) | 760,000 | 0 | -760,000 | 33,767 | 0 | — | -33,767 |
| Insmed Inc(INSM) | 1,600,000 | 900,000 | -700,000 | 116,800 | 62,136 | 3.68% | -54,664 |
| Inari Medical Inc | 1,550,000 | 0 | -1,550,000 | 63,922 | 0 | — | -63,922 |