Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Invesco QQQ Trust Series 1(Put) | 0 | 350,000 | +350,000 | 0 | 215,009 | — | +215,009 |
| Terns Pharmaceuticals Inc | 0 | 4,500,000 | +4,500,000 | 0 | 181,800 | 6.67% | +181,800 |
| Abivax SA(ABVX) | 1,000,000 | 1,900,000 | +900,000 | 84,900 | 256,225 | 9.40% | +171,325 |
| BioMarin Pharmaceutical Inc(BMRN) | 830,000 | 3,000,000 | +2,170,000 | 44,953 | 178,290 | 6.54% | +133,337 |
| Arcellx Inc COMMON STOCK | 1,250,000 | 2,925,000 | +1,675,000 | 102,625 | 190,710 | 7.00% | +88,085 |
| Merck & Co Inc(MRK) | 0 | 775,000 | +775,000 | 0 | 81,577 | 2.99% | +81,577 |
| Arrowhead Pharmaceuticals Inc(ARWR) | 0 | 900,000 | +900,000 | 0 | 59,751 | 2.19% | +59,751 |
| Taysha Gene Therapies Inc(TSHA) | 5,500,000 | 13,750,000 | +8,250,000 | 17,985 | 75,625 | 2.77% | +57,640 |
| Nurix Therapeutics Inc(NRIX) | 3,475,000 | 4,690,000 | +1,215,000 | 32,109 | 88,969 | 3.26% | +56,860 |
| Abbott Laboratories | 250,000 | 600,000 | +350,000 | 33,485 | 75,174 | 2.76% | +41,689 |
| Olema Pharmaceuticals Inc(OLMA) | 0 | 1,650,000 | +1,650,000 | 0 | 41,250 | 1.51% | +41,250 |
| Dexcom Inc(DXCM) | 650,000 | 1,275,000 | +625,000 | 43,739 | 84,622 | 3.10% | +40,883 |
| Alto Neuroscience Inc(ANRO) | 950,000 | 2,485,000 | +1,535,000 | 3,819 | 44,233 | 1.62% | +40,414 |
| Globus Medical Inc(GMED) | 1,250,000 | 1,275,000 | +25,000 | 71,588 | 111,320 | 4.08% | +39,733 |
| Enliven Therapeutics Inc | 1,160,000 | 3,830,000 | +2,670,000 | 23,745 | 58,982 | 2.16% | +35,237 |
| Tyra Biosciences Inc(TYRA) | 2,425,000 | 2,425,000 | 0 | 33,926 | 63,753 | 2.34% | +29,828 |
| Day One Biopharmaceuticals Inc COM | 2,675,000 | 5,200,000 | +2,525,000 | 18,859 | 48,464 | 1.78% | +29,605 |
| Disc Medicine Inc(IRON) | 500,000 | 735,000 | +235,000 | 33,040 | 58,366 | 2.14% | +25,326 |
| Apogee Therapeutics Inc(APGE) | 425,000 | 550,000 | +125,000 | 16,885 | 41,514 | 1.52% | +24,629 |
| Lexeo Therapeutics Inc | 3,250,000 | 4,475,000 | +1,225,000 | 21,580 | 44,437 | 1.63% | +22,857 |
| KalVista Pharmaceuticals Inc | 750,000 | 1,890,000 | +1,140,000 | 9,135 | 30,524 | 1.12% | +21,389 |
| Immunocore Holdings PLC(IMCR) | 0 | 585,000 | +585,000 | 0 | 20,305 | 0.74% | +20,305 |
| Axsome Therapeutics Inc(AXSM) | 150,000 | 210,000 | +60,000 | 18,218 | 38,354 | 1.41% | +20,137 |
| Upstream Bio Inc | 0 | 720,000 | +720,000 | 0 | 19,548 | 0.72% | +19,548 |
| Crescent Biopharma Inc | 0 | 1,500,000 | +1,500,000 | 0 | 17,790 | 0.65% | +17,790 |
| BioCryst Pharmaceuticals Inc(BCRX) | 0 | 2,250,000 | +2,250,000 | 0 | 17,550 | 0.64% | +17,550 |
| Penumbra Inc(PEN) | 0 | 50,000 | +50,000 | 0 | 15,546 | 0.57% | +15,546 |
| Lantheus Holdings Inc(LNTH) | 170,000 | 360,000 | +190,000 | 8,719 | 23,958 | 0.88% | +15,239 |
| Solid Biosciences Inc | 2,975,000 | 5,815,000 | +2,840,000 | 18,356 | 32,797 | 1.20% | +14,441 |
| Zimmer Biomet Holdings Inc(ZBH) | 0 | 150,000 | +150,000 | 0 | 13,488 | 0.49% | +13,488 |
| Bristol-Myers Squibb Co(BMY) | 0 | 250,000 | +250,000 | 0 | 13,485 | 0.49% | +13,485 |
| Fulcrum Therapeutics Inc | 0 | 950,000 | +950,000 | 0 | 10,745 | 0.39% | +10,745 |
| Immatics NV(IMTX) | 6,350,000 | 6,125,000 | -225,000 | 54,102 | 64,313 | 2.36% | +10,211 |
| Definium Therapeutics Inc | 0 | 637,000 | +637,000 | 0 | 8,529 | 0.31% | +8,529 |
| Denali Therapeutics Inc(DNLI) | 0 | 465,000 | +465,000 | 0 | 7,677 | 0.28% | +7,677 |
| Engene Holdings Inc COM | 370,000 | 1,055,000 | +685,000 | 2,527 | 9,527 | 0.35% | +7,000 |
| Tectonic Therapeutic Inc | 0 | 328,000 | +328,000 | 0 | 6,842 | 0.25% | +6,842 |
| MapLight Therapeutics Inc(MPLT) | 0 | 385,000 | +385,000 | 0 | 6,763 | 0.25% | +6,763 |
| Beta Bionics Inc | 600,000 | 600,000 | 0 | 11,922 | 18,282 | 0.67% | +6,360 |
| Monte Rosa Therapeutics Inc(GLUE) | 800,000 | 775,000 | -25,000 | 5,928 | 12,152 | 0.45% | +6,224 |
| Gilead Sciences Inc(GILD) | 0 | 50,000 | +50,000 | 0 | 6,137 | 0.23% | +6,137 |
| Vera Therapeutics Inc(VERA) | 760,000 | 550,000 | -210,000 | 22,086 | 27,852 | 1.02% | +5,766 |
| DBV Technologies SA | 0 | 300,000 | +300,000 | 0 | 5,751 | 0.21% | +5,751 |
| Rapport Therapeutics Inc(RAPP) | 950,000 | 1,110,000 | +160,000 | 28,215 | 33,677 | 1.24% | +5,462 |
| Mirum Pharmaceuticals Inc(MIRM) | 0 | 66,000 | +66,000 | 0 | 5,213 | 0.19% | +5,213 |
| Alcon AG(ALC) | 1,100,000 | 1,105,000 | +5,000 | 81,961 | 87,085 | 3.19% | +5,124 |
| LENZ Therapeutics Inc | 0 | 275,000 | +275,000 | 0 | 4,400 | 0.16% | +4,400 |
| Rezolute Inc | 0 | 1,686,000 | +1,686,000 | 0 | 3,979 | 0.15% | +3,979 |
| Agios Pharmaceuticals Inc(AGIO) | 127,000 | 325,000 | +198,000 | 5,098 | 8,847 | 0.32% | +3,749 |
| Myriad Genetics Inc | 600,000 | 1,223,000 | +623,000 | 4,338 | 7,521 | 0.28% | +3,183 |
| Sutro Biopharma Inc | 0 | 243,000 | +243,000 | 0 | 2,812 | 0.10% | +2,812 |
| Structure Therapeutics Inc | 0 | 35,000 | +35,000 | 0 | 2,434 | 0.09% | +2,434 |
| Novocure Ltd(NVCR) | 400,000 | 525,000 | +125,000 | 5,168 | 6,788 | 0.25% | +1,620 |
| Passage Bio Inc | 305,000 | 305,000 | 0 | 2,449 | 3,599 | 0.13% | +1,150 |
| REGENXBIO Inc | 0 | 34,000 | +34,000 | 0 | 490 | 0.02% | +490 |
| Celldex Therapeutics Inc(CLDX) | 1,205,000 | 1,165,000 | -40,000 | 31,173 | 31,641 | 1.16% | +468 |
| Tenax Therapeutics Inc | 53,439 | 53,439 | 0 | 407 | 651 | 0.02% | +245 |
| OnKure Therapeutics Inc | 635,000 | 635,000 | 0 | 1,746 | 1,842 | 0.07% | +95 |
| Nyxoah SA SHS | 1,107,413 | 1,107,000 | -413 | 5,094 | 5,092 | 0.19% | -2 |
| MacroGenics Inc | 280,000 | 280,000 | 0 | 470 | 451 | 0.02% | -20 |
| Traws Pharma Inc | 150,000 | 0 | -150,000 | 278 | 0 | — | -277 |
| Voyager Therapeutics Inc | 1,475,000 | 1,475,000 | 0 | 6,888 | 5,797 | 0.21% | -1,091 |
| Pulmonx Corp | 830,000 | 0 | -830,000 | 1,345 | 0 | — | -1,345 |
| Fate Therapeutics Inc | 2,515,000 | 1,725,000 | -790,000 | 3,169 | 1,695 | 0.06% | -1,474 |
| Alector Inc | 980,000 | 755,000 | -225,000 | 2,901 | 1,178 | 0.04% | -1,723 |
| Sutro Biopharma Inc | 2,600,000 | 0 | -2,600,000 | 2,258 | 0 | — | -2,258 |
| Arcus Biosciences Inc(RCUS) | 250,000 | 0 | -250,000 | 3,400 | 0 | — | -3,400 |
| Arcutis Biotherapeutics Inc(ARQT) | 200,000 | 0 | -200,000 | 3,770 | 0 | — | -3,770 |
| Kodiak Sciences Inc(KOD) | 250,000 | 0 | -250,000 | 4,093 | 0 | — | -4,092 |
| Establishment Labs Holdings In(ESTA) | 100,000 | 0 | -100,000 | 4,099 | 0 | — | -4,099 |
| Exact Sciences Corp(EXK) | 75,000 | 0 | -75,000 | 4,103 | 0 | — | -4,103 |
| Savara Inc(SVRA) | 4,015,000 | 1,606,000 | -2,409,000 | 14,334 | 9,684 | 0.36% | -4,649 |
| GSK PLC(GSK) | 125,000 | 0 | -125,000 | 5,395 | 0 | — | -5,395 |
| Revolution Medicines Inc(RVMD) | 630,000 | 295,000 | -335,000 | 29,421 | 23,497 | 0.86% | -5,924 |
| Ventyx Biosciences Inc | 2,050,000 | 0 | -2,050,000 | 6,376 | 0 | — | -6,375 |
| Tvardi Therapeutics Inc | 167,000 | 0 | -167,000 | 6,508 | 0 | — | -6,508 |
| CG Oncology Inc(CGON) | 175,000 | 0 | -175,000 | 7,049 | 0 | — | -7,049 |
| Zymeworks Inc(ZYME) | 1,765,000 | 865,000 | -900,000 | 30,146 | 22,775 | 0.84% | -7,371 |
| Applied Therapeutics Inc | 14,250,000 | 0 | -14,250,000 | 8,620 | 0 | — | -8,620 |
| Geron Corp(GERN) | 17,225,000 | 11,320,000 | -5,905,000 | 23,598 | 14,942 | 0.55% | -8,656 |
| Inspire Medical Systems Inc(INSP) | 135,000 | 0 | -135,000 | 10,017 | 0 | — | -10,017 |
| Biohaven Ltd(BHVN)(Put) | 701,700 | 0 | -701,700 | 10,533 | 0 | — | -10,533 |
| uniQure NV(QURE) | 225,000 | 0 | -225,000 | 13,133 | 0 | — | -13,133 |
| Regeneron Pharmaceuticals Inc(REGN) | 25,000 | 0 | -25,000 | 14,057 | 0 | — | -14,057 |
| Bruker Corp(BRKR) | 440,000 | 0 | -440,000 | 14,296 | 0 | — | -14,296 |
| Jazz Pharmaceuticals PLC(JAZZ) | 500,000 | 290,000 | -210,000 | 65,900 | 49,300 | 1.81% | -16,600 |
| Xenon Pharmaceuticals Inc(XENE) | 1,100,000 | 600,000 | -500,000 | 44,165 | 26,892 | 0.99% | -17,273 |
| Black Diamond Therapeutics Inc | 5,550,000 | 870,000 | -4,680,000 | 21,035 | 2,114 | 0.08% | -18,920 |
| Bicara Therapeutics Inc | 5,100,000 | 3,575,000 | -1,525,000 | 80,529 | 60,167 | 2.21% | -20,362 |
| Ultragenyx Pharmaceutical Inc(RARE) | 750,000 | 0 | -750,000 | 22,560 | 0 | — | -22,560 |
| Belite Bio Inc(BLTE) | 312,500 | 0 | -312,500 | 23,125 | 0 | — | -23,125 |
| Scholar Rock Holding Corp(SRRK) | 1,500,000 | 700,000 | -800,000 | 55,860 | 30,835 | 1.13% | -25,025 |
| Danaher Corp(DHR) | 150,000 | 0 | -150,000 | 29,739 | 0 | — | -29,739 |
| Crinetics Pharmaceuticals Inc(CRNX) | 750,000 | 0 | -750,000 | 31,238 | 0 | — | -31,237 |
| Dyne Therapeutics Inc(DYN) | 2,775,000 | 120,000 | -2,655,000 | 35,104 | 2,347 | 0.09% | -32,757 |
| Astria Therapeutics Inc | 4,956,000 | 0 | -4,956,000 | 36,080 | 0 | — | -36,080 |
| Cidara Therapeutics Inc | 400,000 | 0 | -400,000 | 38,304 | 0 | — | -38,304 |
| Biogen Inc(BIIB) | 275,000 | 0 | -275,000 | 38,522 | 0 | — | -38,522 |
| Cytokinetics Inc(CYTK) | 725,000 | 0 | -725,000 | 39,846 | 0 | — | -39,846 |
| Repligen Corp(RGEN) | 400,000 | 83,000 | -317,000 | 53,468 | 13,600 | 0.50% | -39,868 |