Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| ABIVAX Société AnonymeADS(ABVX) | 1,000,000 | 1,900,000 | +900,000 | $84.90M | $256.22M | 9.40% | +$171.32M |
| Arcellx Inc COMMON STOCK | 1,250,000 | 2,925,000 | +1,675,000 | $102.63M | $190.71M | 7.00% | +$88.08M |
| Terns Pharmaceuticals Inc | 0 | 4,500,000 | +4,500,000 | $0 | $181.80M | 6.67% | +$181.80M |
| BioMarin Pharmaceutical Inc.(BMRN) | 830,000 | 3,000,000 | +2,170,000 | $44.95M | $178.29M | 6.54% | +$133.34M |
| Globus Medical, Inc.CL A(GMED) | 1,250,000 | 1,275,000 | +25,000 | $71.59M | $111.32M | 4.08% | +$39.73M |
| Nurix Therapeutics, Inc.(NRIX) | 3,475,000 | 4,690,000 | +1,215,000 | $32.11M | $88.97M | 3.26% | +$56.86M |
| Alcon Inc.(ALC) | 1,100,000 | 1,105,000 | +5,000 | $81.96M | $87.09M | 3.19% | +$5.12M |
| DexCom, Inc.(DXCM) | 650,000 | 1,275,000 | +625,000 | $43.74M | $84.62M | 3.10% | +$40.88M |
| Merck & Co., Inc.(MRK) | 0 | 775,000 | +775,000 | $0 | $81.58M | 2.99% | +$81.58M |
| Taysha Gene Therapies, Inc.(TSHA) | 5,500,000 | 13,750,000 | +8,250,000 | $17.98M | $75.63M | 2.77% | +$57.64M |
| Abbott Laboratories | 250,000 | 600,000 | +350,000 | $33.48M | $75.17M | 2.76% | +$41.69M |
| Immatics N.V.SHS(IMTX) | 6,350,000 | 6,125,000 | -225,000 | $54.10M | $64.31M | 2.36% | +$10.21M |
| Tyra Biosciences, Inc.(TYRA) | 2,425,000 | 2,425,000 | 0 | $33.93M | $63.75M | 2.34% | +$29.83M |
| Bicara Therapeutics Inc | 5,100,000 | 3,575,000 | -1,525,000 | $80.53M | $60.17M | 2.21% | -$20.36M |
| Arrowhead Pharmaceuticals, Inc.(ARWR) | 0 | 900,000 | +900,000 | $0 | $59.75M | 2.19% | +$59.75M |
| Enliven Therapeutics Inc | 1,160,000 | 3,830,000 | +2,670,000 | $23.75M | $58.98M | 2.16% | +$35.24M |
| Disc Medicine, Inc.(IRON) | 500,000 | 735,000 | +235,000 | $33.04M | $58.37M | 2.14% | +$25.33M |
| Jazz Pharmaceuticals plcSHS USD(JAZZ) | 500,000 | 290,000 | -210,000 | $65.90M | $49.30M | 1.81% | -$16.60M |
| Day One Biopharmaceuticals Inc COM | 2,675,000 | 5,200,000 | +2,525,000 | $18.86M | $48.46M | 1.78% | +$29.61M |
| Lexeo Therapeutics, Inc.(LXEO) | 3,250,000 | 4,475,000 | +1,225,000 | $21.58M | $44.44M | 1.63% | +$22.86M |
| Alto Neuroscience, Inc.(ANRO) | 950,000 | 2,485,000 | +1,535,000 | $3.82M | $44.23M | 1.62% | +$40.41M |
| Apogee Therapeutics Inc | 425,000 | 550,000 | +125,000 | $16.89M | $41.51M | 1.52% | +$24.63M |
| Olema Pharmaceuticals, Inc.(OLMA) | 0 | 1,650,000 | +1,650,000 | $0 | $41.25M | 1.51% | +$41.25M |
| Axsome Therapeutics, Inc.(AXSM) | 150,000 | 210,000 | +60,000 | $18.22M | $38.35M | 1.41% | +$20.14M |
| Ascendis Pharma A/SADR(ASND) | 600,000 | 175,000 | -425,000 | $119.29M | $37.32M | 1.37% | -$81.97M |
| Rapport Therapeutics, Inc.(RAPP) | 950,000 | 1,110,000 | +160,000 | $28.21M | $33.68M | 1.24% | +$5.46M |
| Solid Biosciences Inc | 2,975,000 | 5,815,000 | +2,840,000 | $18.36M | $32.80M | 1.20% | +$14.44M |
| Celldex Therapeutics, Inc.(CLDX) | 1,205,000 | 1,165,000 | -40,000 | $31.17M | $31.64M | 1.16% | +$468.1K |
| Scholar Rock Holding Corporation(SRRK) | 1,500,000 | 700,000 | -800,000 | $55.86M | $30.84M | 1.13% | -$25.02M |
| KalVista Pharmaceuticals Inc | 750,000 | 1,890,000 | +1,140,000 | $9.13M | $30.52M | 1.12% | +$21.39M |
| Vera Therapeutics, Inc.CL A(VERA) | 760,000 | 550,000 | -210,000 | $22.09M | $27.85M | 1.02% | +$5.77M |
| Xenon Pharmaceuticals Inc.(XENE) | 1,100,000 | 600,000 | -500,000 | $44.16M | $26.89M | 0.99% | -$17.27M |
| Lantheus Holdings, Inc.(LNTH) | 170,000 | 360,000 | +190,000 | $8.72M | $23.96M | 0.88% | +$15.24M |
| Revolution Medicines, Inc.(RVMD) | 630,000 | 295,000 | -335,000 | $29.42M | $23.50M | 0.86% | -$5.92M |
| Zymeworks Inc.(ZYME) | 1,765,000 | 865,000 | -900,000 | $30.15M | $22.78M | 0.84% | -$7.37M |
| Immunocore Holdings plcADS(IMCR) | 0 | 585,000 | +585,000 | $0 | $20.31M | 0.74% | +$20.31M |
| Upstream Bio, Inc.(UPB) | 0 | 720,000 | +720,000 | $0 | $19.55M | 0.72% | +$19.55M |
| Beta Bionics, Inc.(BBNX) | 600,000 | 600,000 | 0 | $11.92M | $18.28M | 0.67% | +$6.36M |
| Crescent Biopharma, Inc.(CBIO) | 0 | 1,500,000 | +1,500,000 | $0 | $17.79M | 0.65% | +$17.79M |
| BioCryst Pharmaceuticals, Inc.(BCRX) | 0 | 2,250,000 | +2,250,000 | $0 | $17.55M | 0.64% | +$17.55M |
| Penumbra, Inc.(PEN) | 0 | 50,000 | +50,000 | $0 | $15.55M | 0.57% | +$15.55M |
| Geron Corporation(GERN) | 17,225,000 | 11,320,000 | -5,905,000 | $23.60M | $14.94M | 0.55% | -$8.66M |
| Repligen Corporation(RGEN) | 400,000 | 83,000 | -317,000 | $53.47M | $13.60M | 0.50% | -$39.87M |
| Zimmer Biomet Holdings, Inc.(ZBH) | 0 | 150,000 | +150,000 | $0 | $13.49M | 0.49% | +$13.49M |
| Bristol-Myers Squibb Company(BMY) | 0 | 250,000 | +250,000 | $0 | $13.48M | 0.49% | +$13.48M |
| Monte Rosa Therapeutics, Inc.(GLUE) | 800,000 | 775,000 | -25,000 | $5.93M | $12.15M | 0.45% | +$6.22M |
| Fulcrum Therapeutics, Inc.(FULC) | 0 | 950,000 | +950,000 | $0 | $10.74M | 0.39% | +$10.74M |
| Savara Inc.(SVRA) | 4,015,000 | 1,606,000 | -2,409,000 | $14.33M | $9.68M | 0.36% | -$4.65M |
| Engene Holdings Inc COM | 370,000 | 1,055,000 | +685,000 | $2.53M | $9.53M | 0.35% | +$7.00M |
| Agios Pharmaceuticals, Inc.(AGIO) | 127,000 | 325,000 | +198,000 | $5.10M | $8.85M | 0.32% | +$3.75M |
| Definium Therapeutics Inc | 0 | 637,000 | +637,000 | $0 | $8.53M | 0.31% | +$8.53M |
| Denali Therapeutics Inc.(DNLI) | 0 | 465,000 | +465,000 | $0 | $7.68M | 0.28% | +$7.68M |
| Myriad Genetics, Inc.(MYGN) | 600,000 | 1,223,000 | +623,000 | $4.34M | $7.52M | 0.28% | +$3.18M |
| Tectonic Therapeutic, Inc.(TECX) | 0 | 328,000 | +328,000 | $0 | $6.84M | 0.25% | +$6.84M |
| NovoCure Limited(NVCR) | 400,000 | 525,000 | +125,000 | $5.17M | $6.79M | 0.25% | +$1.62M |
| MapLight Therapeutics, Inc.(MPLT) | 0 | 385,000 | +385,000 | $0 | $6.76M | 0.25% | +$6.76M |
| Gilead Sciences, Inc.(GILD) | 0 | 50,000 | +50,000 | $0 | $6.14M | 0.23% | +$6.14M |
| Voyager Therapeutics, Inc.(VYGR) | 1,475,000 | 1,475,000 | 0 | $6.89M | $5.80M | 0.21% | -$1.09M |
| DBV Technologies S.A.ADS(DBVT) | 0 | 300,000 | +300,000 | $0 | $5.75M | 0.21% | +$5.75M |
| Mirum Pharmaceuticals, Inc.(MIRM) | 0 | 66,000 | +66,000 | $0 | $5.21M | 0.19% | +$5.21M |
| Nyxoah SASHS SHS | 1,107,413 | 1,107,000 | -413 | $5.09M | $5.09M | 0.19% | -$1.9K |
| Nuvalent Inc | 1,100,000 | 46,000 | -1,054,000 | $95.13M | $4.63M | 0.17% | -$90.50M |
| LENZ Therapeutics, Inc.(LENZ) | 0 | 275,000 | +275,000 | $0 | $4.40M | 0.16% | +$4.40M |
| Rezolute, Inc.(RZLT) | 0 | 1,686,000 | +1,686,000 | $0 | $3.98M | 0.15% | +$3.98M |
| Passage Bio, Inc.(PASG) | 305,000 | 305,000 | 0 | $2.45M | $3.60M | 0.13% | +$1.15M |
| Sutro Biopharma, Inc.(STRO) | 0 | 243,000 | +243,000 | $0 | $2.81M | 0.10% | +$2.81M |
| Structure Therapeutics IncADS | 0 | 35,000 | +35,000 | $0 | $2.43M | 0.09% | +$2.43M |
| Dyne Therapeutics, Inc.(DYN) | 2,775,000 | 120,000 | -2,655,000 | $35.10M | $2.35M | 0.09% | -$32.76M |
| Black Diamond Therapeutics Inc | 5,550,000 | 870,000 | -4,680,000 | $21.03M | $2.11M | 0.08% | -$18.92M |
| OnKure Therapeutics, Inc.CL A(OKUR) | 635,000 | 635,000 | 0 | $1.75M | $1.84M | 0.07% | +$95.3K |
| Fate Therapeutics, Inc.(FATE) | 2,515,000 | 1,725,000 | -790,000 | $3.17M | $1.69M | 0.06% | -$1.47M |
| Alector Inc | 980,000 | 755,000 | -225,000 | $2.90M | $1.18M | 0.04% | -$1.72M |
| Tenax Therapeutics, Inc.(TENX) | 53,439 | 53,439 | 0 | $406.7K | $651.4K | 0.02% | +$244.8K |
| REGENXBIO Inc.(RGNX) | 0 | 34,000 | +34,000 | $0 | $489.6K | 0.02% | +$489.6K |
| MacroGenics, Inc.(MGNX) | 280,000 | 280,000 | 0 | $470.4K | $450.8K | 0.02% | -$19.6K |
| Amicus Therapeutics Inc COM | 9,750,000 | 0 | -9,750,000 | $76.83M | $0 | — | -$76.83M |
| Applied Therapeutics Inc | 14,250,000 | 0 | -14,250,000 | $8.62M | $0 | — | -$8.62M |
| Arcus Biosciences, Inc.(RCUS) | 250,000 | 0 | -250,000 | $3.40M | $0 | — | -$3.40M |
| Arcutis Biotherapeutics, Inc.(ARQT) | 200,000 | 0 | -200,000 | $3.77M | $0 | — | -$3.77M |
| Astria Therapeutics Inc | 4,956,000 | 0 | -4,956,000 | $36.08M | $0 | — | -$36.08M |
| Becton, Dickinson and Company(BDX) | 325,000 | 0 | -325,000 | $60.83M | $0 | — | -$60.83M |
| Belite Bio, IncADS(BLTE) | 312,500 | 0 | -312,500 | $23.13M | $0 | — | -$23.13M |
| Biogen Inc.(BIIB) | 275,000 | 0 | -275,000 | $38.52M | $0 | — | -$38.52M |
| Bruker Corporation(BRKR) | 440,000 | 0 | -440,000 | $14.30M | $0 | — | -$14.30M |
| CG Oncology, Inc.(CGON) | 175,000 | 0 | -175,000 | $7.05M | $0 | — | -$7.05M |
| Cidara Therapeutics Inc | 400,000 | 0 | -400,000 | $38.30M | $0 | — | -$38.30M |
| Crinetics Pharmaceuticals Inc | 750,000 | 0 | -750,000 | $31.24M | $0 | — | -$31.24M |
| Cytokinetics, Incorporated(CYTK) | 725,000 | 0 | -725,000 | $39.85M | $0 | — | -$39.85M |
| Danaher Corporation(DHR) | 150,000 | 0 | -150,000 | $29.74M | $0 | — | -$29.74M |
| Dianthus Therapeutics, Inc.(DNTH) | 1,180,000 | 0 | -1,180,000 | $46.43M | $0 | — | -$46.43M |
| Establishment Labs Holdings Inc.(ESTA) | 100,000 | 0 | -100,000 | $4.10M | $0 | — | -$4.10M |
| Endeavour Silver Corp.(EXK) | 75,000 | 0 | -75,000 | $4.10M | $0 | — | -$4.10M |
| GSK plcADR(GSK) | 125,000 | 0 | -125,000 | $5.39M | $0 | — | -$5.39M |
| Inspire Medical Systems, Inc.(INSP) | 135,000 | 0 | -135,000 | $10.02M | $0 | — | -$10.02M |
| Ionis Pharmaceuticals, Inc.(IONS) | 1,075,000 | 0 | -1,075,000 | $70.33M | $0 | — | -$70.33M |
| Kodiak Sciences Inc.(KOD) | 250,000 | 0 | -250,000 | $4.09M | $0 | — | -$4.09M |
| Pulmonx Corporation(LUNG) | 830,000 | 0 | -830,000 | $1.34M | $0 | — | -$1.34M |
| Regeneron Pharmaceuticals, Inc.(REGN) | 25,000 | 0 | -25,000 | $14.06M | $0 | — | -$14.06M |
| Sutro Biopharma, Inc.(STRO) | 2,600,000 | 0 | -2,600,000 | $2.26M | $0 | — | -$2.26M |
| Traws Pharma, Inc.(TRAW) | 150,000 | 0 | -150,000 | $277.5K | $0 | — | -$277.5K |