Fund HoldingsSiren, L.L.C.

Total Portfolio Value
$3.61B
Total Bought
$752.91M
Total Sold
$604.95M
Net Transaction
+$147.96M
Filing Period:
Securities
SharesValue ($K)
Q4 2025
Q1 2026
Change
Q4 2025
Q1 2026
Weight (%)
Change
Erasca Inc(ERAS)8,757,24911,244,246+2,486,99732,577181,9325.04%+149,355
Veradermics Inc(MANE)01,505,374+1,505,374095,0642.64%+95,064
Scholar Rock Holding Corp(SRRK)10,825,01310,825,0130476,842532,15814.75%+55,316
Tango Therapeutics Inc(TNGX)8,165,3745,657,105-2,508,26972,345118,3473.28%+46,001
Cytokinetics Inc(CYTK)0613,952+613,952040,4661.12%+40,466
Xenon Pharmaceuticals Inc(XENE)812,7611,318,564+505,80336,42876,6742.13%+40,247
Oric Pharmaceuticals Inc(ORIC)02,998,192+2,998,192037,9871.05%+37,987
Enliven Therapeutics Inc0746,226+746,226029,2520.81%+29,252
Bicara Therapeutics Inc5,216,9695,802,970+586,00187,802115,4213.20%+27,619
Edgewise Therapeutics Inc(EWTX)4,529,9904,430,263-99,727112,412139,5533.87%+27,142
Lexicon Pharmaceuticals Inc(LXRX)044,303,518+44,303,518069,1131.92%+69,113
Palvella Therapeutics Inc(PVLA)75,000257,485+182,4857,85032,0960.89%+24,245
Damora Therapeutics Inc(DMRA)0900,000+900,000023,3100.65%+23,310
Annexon Inc(ANNX)03,958,646+3,958,646021,9310.61%+21,931
Definium Therapeutics Inc(DFTX)0919,493+919,493017,3780.48%+17,378
Amylyx Pharmaceuticals Inc(AMLX)01,230,000+1,230,000017,0970.47%+17,097
Uniqure NV(QURE)01,000,000+1,000,000016,3500.45%+16,350
CytomX Therapeutics Inc03,457,711+3,457,711016,2510.45%+16,251
Zura Bio Ltd1,300,0003,734,866+2,434,8666,81222,2220.62%+15,410
Spyre Therapeutics Inc(SYRE)818,598818,598026,81741,2901.14%+14,473
Alphabet Inc(GOOG)20,70365,703+45,0006,48018,8940.52%+12,414
Solid Biosciences Inc07,690,405+7,690,405055,3711.53%+55,371
Rezolute Inc03,328,287+3,328,287010,1510.28%+10,151
Kymera Therapeutics Inc(KYMR)3,286,8303,186,830-100,000255,748265,4317.36%+9,683
Rhythm Pharmaceuticals Inc(RYTM)499,975725,511+225,53653,51763,0981.75%+9,580
Generate Biomedicines Inc(GENB)0736,104+736,10409,2010.26%+9,201
NVIDIA Corp(NVDA)37,48589,085+51,6006,99115,5360.43%+8,545
Microsoft Corp(MSFT)041,380+41,380015,3180.42%+15,318
Cogent Biosciences Inc(COGT)1,629,2791,709,279+80,00057,87265,7901.82%+7,918
Tesla Inc(TSLA)1,50021,500+20,0006757,9930.22%+7,318
Taiwan Semiconductor Manufacturing Co Ltd(TSM)27,70042,200+14,5008,41814,2610.40%+5,844
enGene Holdings Inc
COM
3,336,2645,253,159+1,916,89530,12635,7740.99%+5,648
Nebius Group NV(NBIS)0113,614+113,614011,7890.33%+11,789
Absci Corp01,800,000+1,800,00005,4000.15%+5,400
Neumora Therapeutics Inc6,288,7838,497,822+2,209,03911,25716,5710.46%+5,314
Satellos Bioscience Inc0892,074+892,07405,0220.14%+5,022
Cullinan Therapeutics Inc(CGEM)1,193,4101,193,410012,35216,9580.47%+4,607
Agomab Therapeutics NV0411,250+411,25004,3140.12%+4,314
Denali Therapeutics Inc(DNLI)1,396,5131,396,513023,05626,8130.74%+3,757
ServiceNow Inc(NOW)087,090+87,09009,1050.25%+9,105
Dbv Technologies SA1,857,3621,857,362035,60638,8001.08%+3,195
Forgent Power Solutions, Inc(FPS)0100,000+100,00002,9270.08%+2,927
Broadcom Inc(AVGO)7,00015,000+8,0002,4234,6430.13%+2,220
Whitehawk Therapeutics Inc2,082,0002,082,00005,0387,1830.20%+2,144
Micron Technology Inc(MU)06,000+6,00002,0270.06%+2,027
Remitly Global Inc(RELY)01,543,271+1,543,271024,1830.67%+24,183
Revolution Medicines Inc(RVMD)1,335,0751,110,980-224,095106,339108,0433.00%+1,704
Arrowhead Pharmaceuticals Inc(ARWR)1,500,4761,615,476+115,00099,617101,2902.81%+1,674
Amer Sports Inc(AS)050,000+50,00001,6460.05%+1,646
Tenax Therapeutics Inc427,141427,14105,2076,8300.19%+1,623
Cellebrite DI Ltd(CLBT)150,000311,544+161,5442,7064,2930.12%+1,588
Datadog Inc(DDOG)36,42554,300+17,8754,9536,4100.18%+1,457
Aeva Technologies Inc(AEVA)0110,000+110,00001,4480.04%+1,448
PDD Holdings Inc(PDD)63,40183,401+20,0007,1898,5220.24%+1,333
CrowdStrike Holdings Inc(CRWD)023,070+23,07009,0070.25%+9,007
MapLight Therapeutics Inc(MPLT)450,000450,00007,9049,1490.25%+1,244
Korro Bio Inc0347,718+347,71803,9360.11%+3,936
Monopar Therapeutics Inc212,298270,118+57,82013,86314,8000.41%+937
Dynatrace Inc(DT)115,229150,000+34,7714,9945,5470.15%+553
Nu Holdings Ltd.(NU)025,000+25,00003590.01%+359
Agenus Inc01,064,250+1,064,25003,5550.10%+3,555
Jfrog Ltd(FROG)93,616128,816+35,2005,8476,0450.17%+198
Figma Inc(FIG)25,00050,000+25,0009341,0570.03%+123
vTv Therapeutics Inc163,000163,00006,5186,4650.18%-54
Cyclerion Therapeutics Inc115,6030-115,6031470-147
IREN Ltd
ORDINARY SHARES
43,10043,10001,6281,4770.04%-150
Caribou Biosciences Inc105,3470-105,3471680-168
Primo Brands Corp(PRMB)75,00050,000-25,0001,2269420.03%-285
Sionna Therapeutics Inc(SION)300,000300,000012,34212,0270.33%-315
Foghorn Therapeutics Inc720,720720,72003,8923,4450.10%-447
monday.com Ltd
SHS
17,00025,000+8,0002,5091,7280.05%-781
KE Holdings Inc(BEKE)145,000100,000-45,0002,2851,4970.04%-788
Crinetics Pharmaceuticals Inc(CRNX)1,507,6361,903,636+396,00070,18069,1401.92%-1,040
Generation Bio Inc201,4190-201,4191,1440-1,144
Kalaris Therapeutics Inc435,798435,79803,6782,5150.07%-1,164
Varonis Systems Inc(VRNS)37,5000-37,5001,2300-1,230
Rani Therapeutics Holdings Inc2,000,0002,000,00002,7001,4700.04%-1,230
Workiva Inc(WK)79,12392,500+13,3776,8245,5160.15%-1,309
Rapport Therapeutics Inc(RAPP)0641,469+641,469020,0720.56%+20,072
GitLab Inc(GTLB)99,000100,000+1,0003,7152,1640.06%-1,551
CoreWeave Inc(CRWV)000000
Medline Inc(MDLN)75,00025,000-50,0003,1501,1130.03%-2,037
Palo Alto Networks Inc(PANW)11,4500-11,4502,1090-2,109
Inhibikase Therapeutics Inc5,850,0005,850,000011,9939,8280.27%-2,164
Amazon.com Inc(AMZN)046,641+46,64109,7140.27%+9,714
Instil Bio Inc000000
Arm Holdings PLC21,5000-21,5002,3500-2,350
Silence Therapeutics PLC2,911,4382,911,438017,70215,3430.43%-2,358
Qualcomm Inc(QCOM)14,0000-14,0002,3950-2,395
Black Diamond Therapeutics Inc000000
Zscaler Inc(ZS)12,0000-12,0002,6990-2,699
IONQ Inc(IONQ)0170,000+170,00004,9010.14%+4,901
Seer Inc02,458,673+2,458,67304,1310.11%+4,131
New Oriental Education & Technology Group Inc(EDU)62,0000-62,0003,4120-3,412
Fulcrum Therapeutics Inc1,950,0002,350,000+400,00022,05518,0250.50%-4,030
Adobe Inc(ADBE)000000
Sagimet Biosciences Inc724,7710-724,7714,2910-4,291
PepGen Inc700,0000-700,0004,5570-4,557
NovaBridge Biosciences3,000,0003,000,000011,9407,3800.20%-4,560
Invivyd Inc4,000,0004,000,00009,8805,2000.14%-4,680
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