Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2024 ▲▼ | Q1 2025 ▲▼ | Change ▲▼ | Q4 2024 ▲▼ | Q1 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Blueprint Medicines Corp | 0 | 726,167 | +726,167 | 0 | 64,273 | 3.63% | +64,273 |
| Disc Medicine Inc(IRON) | 0 | 1,071,865 | +1,071,865 | 0 | 53,207 | 3.00% | +53,207 |
| Soleno Therapeutics Inc | 351,818 | 727,337 | +375,519 | 15,814 | 51,968 | 2.93% | +36,154 |
| Edgewise Therapeutics Inc(EWTX) | 734,343 | 1,696,444 | +962,101 | 19,607 | 37,322 | 2.11% | +17,715 |
| Beigene Ltd(ONC) | 653,721 | 498,689 | -155,032 | 120,749 | 135,728 | 7.66% | +14,979 |
| Rhythm Pharmaceuticals Inc(RYTM) | 0 | 277,533 | +277,533 | 0 | 14,701 | 0.83% | +14,701 |
| Summit Therapeutics Inc(SMMT) | 0 | 695,000 | +695,000 | 0 | 13,407 | 0.76% | +13,407 |
| Solid Biosciences Inc | 3,749,041 | 7,415,905 | +3,666,864 | 14,996 | 27,439 | 1.55% | +12,443 |
| Merus NV | 784,412 | 1,043,467 | +259,055 | 32,985 | 43,920 | 2.48% | +10,935 |
| Alphabet Inc(GOOG) | 7,000 | 50,703 | +43,703 | 1,325 | 7,841 | 0.44% | +6,516 |
| Trevi Therapeutics Inc(TRVI) | 2,906,060 | 2,863,793 | -42,267 | 11,973 | 18,013 | 1.02% | +6,040 |
| IHS Holding Limited ORD SHS | 2,357,520 | 2,357,520 | 0 | 6,884 | 12,306 | 0.69% | +5,422 |
| Metsera Inc | 0 | 150,000 | +150,000 | 0 | 4,083 | 0.23% | +4,083 |
| Salesforce Inc(CRM) | 0 | 14,600 | +14,600 | 0 | 3,918 | 0.22% | +3,918 |
| Ascendis Pharma A/S(ASND) | 297,321 | 287,366 | -9,955 | 40,932 | 44,789 | 2.53% | +3,857 |
| Whitehawk Therapeutics Inc(WHWK) | 0 | 2,082,000 | +2,082,000 | 0 | 3,706 | 0.21% | +3,706 |
| Adobe Inc(ADBE) | 8,798 | 19,298 | +10,500 | 3,912 | 7,401 | 0.42% | +3,489 |
| Sionna Therapeutics Inc(SION) | 0 | 325,000 | +325,000 | 0 | 3,400 | 0.19% | +3,400 |
| Amazon.com Inc(AMZN) | 36,500 | 56,500 | +20,000 | 8,008 | 10,750 | 0.61% | +2,742 |
| Reddit Inc(RDDT) | 0 | 23,500 | +23,500 | 0 | 2,465 | 0.14% | +2,465 |
| LPL Financial Holdings Inc(LPLA) | 0 | 7,500 | +7,500 | 0 | 2,454 | 0.14% | +2,454 |
| Eledon Pharmaceuticals Inc(ELDN) | 0 | 690,170 | +690,170 | 0 | 2,340 | 0.13% | +2,340 |
| Tesla Inc(TSLA) | 0 | 9,000 | +9,000 | 0 | 2,332 | 0.13% | +2,332 |
| Kalaris Therapeutics Inc(KLRS) | 0 | 282,586 | +282,586 | 0 | 2,269 | 0.13% | +2,269 |
| SailPoint Inc(SAIL) | 0 | 95,000 | +95,000 | 0 | 1,781 | 0.10% | +1,781 |
| Taiwan Semiconductor Manufacturing Co Ltd(TSM) | 15,000 | 28,500 | +13,500 | 2,962 | 4,731 | 0.27% | +1,769 |
| Marvell Technology Inc(MRVL) | 5,000 | 36,808 | +31,808 | 552 | 2,266 | 0.13% | +1,714 |
| StandardAero, Inc.(SARO) | 0 | 56,855 | +56,855 | 0 | 1,515 | 0.09% | +1,515 |
| ServiceNow Inc(NOW) | 5,605 | 9,126 | +3,521 | 5,942 | 7,266 | 0.41% | +1,324 |
| BILL Holdings Inc | 0 | 28,500 | +28,500 | 0 | 1,308 | 0.07% | +1,308 |
| Pegasystems Inc(PEGA) | 0 | 16,500 | +16,500 | 0 | 1,147 | 0.06% | +1,147 |
| PDD Holdings Inc(PDD) | 52,901 | 52,901 | 0 | 5,131 | 6,261 | 0.35% | +1,130 |
| Gossamer Bio Inc(GOSS) | 5,208,968 | 5,208,968 | 0 | 4,712 | 5,730 | 0.32% | +1,018 |
| Ke Holdings Inc(BEKE) | 60,000 | 105,000 | +45,000 | 1,105 | 2,109 | 0.12% | +1,004 |
| Microsoft Corp(MSFT) | 23,000 | 28,500 | +5,500 | 9,695 | 10,699 | 0.60% | +1,004 |
| MongoDB Inc(MDB) | 0 | 5,500 | +5,500 | 0 | 965 | 0.05% | +965 |
| Nike Inc(NKE) | 0 | 15,000 | +15,000 | 0 | 952 | 0.05% | +952 |
| Informatica Inc | 0 | 50,000 | +50,000 | 0 | 873 | 0.05% | +873 |
| Palo Alto Networks Inc(PANW) | 6,000 | 11,500 | +5,500 | 1,092 | 1,962 | 0.11% | +871 |
| Agenus Inc(AGEN) | 0 | 500,000 | +500,000 | 0 | 753 | 0.04% | +753 |
| SEMrush Holdings Inc CL A COM | 35,000 | 125,000 | +90,000 | 416 | 1,166 | 0.07% | +750 |
| Jfrog Ltd(FROG) | 120,116 | 131,616 | +11,500 | 3,533 | 4,212 | 0.24% | +679 |
| Prothena Corporation PLC SHS | 1,099,840 | 1,283,555 | +183,715 | 15,233 | 15,884 | 0.90% | +651 |
| CrowdStrike Holdings Inc(CRWD) | 24,000 | 25,000 | +1,000 | 8,212 | 8,815 | 0.50% | +603 |
| Deckers Outdoor Corp(DECK) | 0 | 5,000 | +5,000 | 0 | 559 | 0.03% | +559 |
| US Bancorp(USB) | 0 | 12,500 | +12,500 | 0 | 528 | 0.03% | +528 |
| Datadog Inc(DDOG) | 30,425 | 47,425 | +17,000 | 4,347 | 4,705 | 0.27% | +358 |
| GDS Holdings Ltd(GDS) | 0 | 12,500 | +12,500 | 0 | 317 | 0.02% | +317 |
| Workiva Inc(WK) | 10,000 | 17,500 | +7,500 | 1,095 | 1,328 | 0.07% | +233 |
| Vigil Neuroscience Inc | 1,991,038 | 1,967,064 | -23,974 | 3,385 | 3,501 | 0.20% | +117 |
| Intel Corp(INTC) | 40,000 | 40,000 | 0 | 802 | 908 | 0.05% | +106 |
| PayPal Holdings Inc(PYPL) | 15,000 | 20,000 | +5,000 | 1,280 | 1,305 | 0.07% | +25 |
| Avidity Biosciences Inc | 1,127,295 | 1,110,610 | -16,685 | 32,782 | 32,785 | 1.85% | +3 |
| Caribou Biosciences Inc(CRBU) | 105,347 | 105,347 | 0 | 168 | 96 | 0.01% | -71 |
| Cyclerion Therapeutics Inc(CYCN) | 116,155 | 116,155 | 0 | 374 | 290 | 0.02% | -84 |
| Kronos Bio Inc | 842,954 | 842,954 | 0 | 801 | 695 | 0.04% | -105 |
| Instil Bio Inc(TIL) | 192,433 | 203,933 | +11,500 | 3,674 | 3,540 | 0.20% | -133 |
| Couchbase Inc | 60,000 | 49,850 | -10,150 | 935 | 785 | 0.04% | -150 |
| Qualcomm Inc(QCOM) | 15,000 | 14,000 | -1,000 | 2,304 | 2,151 | 0.12% | -154 |
| Ferrari NV COM | 2,000 | 1,500 | -500 | 854 | 636 | 0.04% | -218 |
| Occidental Petroleum Corp(OXY) | 15,000 | 10,000 | -5,000 | 741 | 494 | 0.03% | -248 |
| Ironwood Pharmaceuticals Inc(IRWD) | 110,532 | 110,532 | 0 | 490 | 162 | 0.01% | -327 |
| Kanzhun Ltd(BZ) | 25,000 | 0 | -25,000 | 345 | 0 | — | -345 |
| Dynatrace Inc(DT) | 82,729 | 87,729 | +5,000 | 4,496 | 4,136 | 0.23% | -360 |
| Nebius Group NV(NBIS) | 120,000 | 140,000 | +20,000 | 3,324 | 2,955 | 0.17% | -369 |
| Tourmaline Bio Inc | 91,426 | 91,426 | 0 | 1,854 | 1,391 | 0.08% | -464 |
| Monday.Com Ltd SHS | 2,000 | 0 | -2,000 | 471 | 0 | — | -471 |
| Nu Holdings Ltd(NU) | 50,000 | 0 | -50,000 | 518 | 0 | — | -518 |
| HOOKIPA Pharma Inc | 566,640 | 566,640 | 0 | 1,139 | 612 | 0.03% | -527 |
| Meta Platforms Inc(META) | 1,000 | 0 | -1,000 | 586 | 0 | — | -586 |
| New Oriental Education & Technology Group Inc(EDU) | 68,500 | 79,500 | +11,000 | 4,396 | 3,801 | 0.21% | -595 |
| Black Diamond Therapeutics Inc | 1,046,517 | 1,046,517 | 0 | 2,240 | 1,622 | 0.09% | -617 |
| Dollar Tree Inc(DLTR) | 10,000 | 0 | -10,000 | 749 | 0 | — | -749 |
| Foghorn Therapeutics Inc.(FHTX) | 720,720 | 720,720 | 0 | 3,402 | 2,631 | 0.15% | -771 |
| BIOAGE Labs Inc(BIOA) | 388,000 | 382,406 | -5,594 | 2,247 | 1,438 | 0.08% | -809 |
| Procore Technologies Inc(PCOR) | 20,000 | 10,000 | -10,000 | 1,499 | 660 | 0.04% | -838 |
| Achilles Therapeutics PLC | 755,375 | 0 | -755,375 | 861 | 0 | — | -861 |
| Remitly Global Inc(RELY) | 490,449 | 490,449 | 0 | 11,069 | 10,201 | 0.58% | -868 |
| Sagimet Biosciences Inc(SGMT) | 724,771 | 724,771 | 0 | 3,261 | 2,363 | 0.13% | -899 |
| Omega Therapeutics Inc | 1,323,530 | 0 | -1,323,530 | 987 | 0 | — | -987 |
| HCA Healthcare Inc(HCA) | 3,750 | 0 | -3,750 | 1,126 | 0 | — | -1,126 |
| Applied Therapeutics Inc | 1,633,768 | 0 | -1,633,768 | 1,399 | 0 | — | -1,399 |
| NVIDIA Corp(NVDA) | 48,932 | 44,432 | -4,500 | 6,571 | 4,816 | 0.27% | -1,756 |
| Lexeo Therapeutics Inc(LXEO) | 603,435 | 603,435 | 0 | 3,971 | 2,094 | 0.12% | -1,877 |
| Generation Bio Co | 2,982,733 | 2,968,925 | -13,808 | 3,162 | 1,202 | 0.07% | -1,959 |
| ProQR Therapeutics NV SHS EURO | 1,575,000 | 1,552,183 | -22,817 | 4,174 | 2,064 | 0.12% | -2,109 |
| Regenxbio Inc(RGNX) | 284,000 | 0 | -284,000 | 2,195 | 0 | — | -2,195 |
| Taysha Gene Therapies Inc(TSHA) | 6,602,475 | 6,514,737 | -87,738 | 11,422 | 9,055 | 0.51% | -2,367 |
| Elastic NV ORD SHS | 25,000 | 0 | -25,000 | 2,477 | 0 | — | -2,477 |
| Seer Inc(SEER) | 4,000,000 | 4,000,000 | 0 | 9,240 | 6,760 | 0.38% | -2,480 |
| Oric Pharmaceuticals Inc(ORIC) | 1,007,575 | 1,007,575 | 0 | 8,131 | 5,622 | 0.32% | -2,509 |
| Sea Ltd(SE) | 25,000 | 0 | -25,000 | 2,653 | 0 | — | -2,652 |
| Ovid Therapeutics Inc(OVID) | 2,850,000 | 0 | -2,850,000 | 2,661 | 0 | — | -2,661 |
| Spyre Therapeutics Inc(SYRE) | 374,000 | 368,598 | -5,402 | 8,707 | 5,947 | 0.34% | -2,759 |
| Allovir Inc | 6,597,167 | 0 | -6,597,167 | 2,771 | 0 | — | -2,771 |
| Cartesian Therapeutics Inc(RNAC) | 572,236 | 563,272 | -8,964 | 10,249 | 7,424 | 0.42% | -2,825 |
| Freeport-McMoRan Inc(FCX) | 75,000 | 0 | -75,000 | 2,856 | 0 | — | -2,856 |
| Rapport Therapeutics Inc(RAPP) | 384,197 | 378,469 | -5,728 | 6,816 | 3,796 | 0.21% | -3,020 |
| Dyne Therapeutics Inc(DYN) | 1,347,456 | 2,717,987 | +1,370,531 | 31,746 | 28,430 | 1.60% | -3,316 |
| IONQ Inc(IONQ) | 170,000 | 170,000 | 0 | 7,101 | 3,752 | 0.21% | -3,349 |