Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | Q4 2025 ▲▼ | Q1 2026 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Erasca Inc(ERAS) | 8,757,249 | 11,244,246 | +2,486,997 | 32,577 | 181,932 | 5.04% | +149,355 |
| Veradermics Inc(MANE) | 0 | 1,505,374 | +1,505,374 | 0 | 95,064 | 2.64% | +95,064 |
| Scholar Rock Holding Corp(SRRK) | 10,825,013 | 10,825,013 | 0 | 476,842 | 532,158 | 14.75% | +55,316 |
| Tango Therapeutics Inc(TNGX) | 8,165,374 | 5,657,105 | -2,508,269 | 72,345 | 118,347 | 3.28% | +46,001 |
| Cytokinetics Inc(CYTK) | 0 | 613,952 | +613,952 | 0 | 40,466 | 1.12% | +40,466 |
| Xenon Pharmaceuticals Inc(XENE) | 812,761 | 1,318,564 | +505,803 | 36,428 | 76,674 | 2.13% | +40,247 |
| Oric Pharmaceuticals Inc(ORIC) | 1,007,575 | 2,998,192 | +1,990,617 | 8,242 | 37,987 | 1.05% | +29,745 |
| Enliven Therapeutics Inc | 0 | 746,226 | +746,226 | 0 | 29,252 | 0.81% | +29,252 |
| Bicara Therapeutics Inc | 5,216,969 | 5,802,970 | +586,001 | 87,802 | 115,421 | 3.20% | +27,619 |
| Edgewise Therapeutics Inc(EWTX) | 4,529,990 | 4,430,263 | -99,727 | 112,412 | 139,553 | 3.87% | +27,142 |
| Lexicon Pharmaceuticals Inc(LXRX) | 38,918,903 | 44,303,518 | +5,384,615 | 44,757 | 69,113 | 1.92% | +24,357 |
| Palvella Therapeutics Inc(PVLA) | 75,000 | 257,485 | +182,485 | 7,850 | 32,096 | 0.89% | +24,245 |
| Damora Therapeutics Inc(DMRA) | 0 | 900,000 | +900,000 | 0 | 23,310 | 0.65% | +23,310 |
| Annexon Inc(ANNX) | 0 | 3,958,646 | +3,958,646 | 0 | 21,931 | 0.61% | +21,931 |
| Definium Therapeutics Inc(DFTX) | 0 | 919,493 | +919,493 | 0 | 17,378 | 0.48% | +17,378 |
| Amylyx Pharmaceuticals Inc(AMLX) | 0 | 1,230,000 | +1,230,000 | 0 | 17,097 | 0.47% | +17,097 |
| Uniqure NV(QURE) | 0 | 1,000,000 | +1,000,000 | 0 | 16,350 | 0.45% | +16,350 |
| CytomX Therapeutics Inc(CTMX) | 0 | 3,457,711 | +3,457,711 | 0 | 16,251 | 0.45% | +16,251 |
| Zura Bio Ltd(ZURA) | 1,300,000 | 3,734,866 | +2,434,866 | 6,812 | 22,222 | 0.62% | +15,410 |
| Spyre Therapeutics Inc(SYRE) | 818,598 | 818,598 | 0 | 26,817 | 41,290 | 1.14% | +14,473 |
| Alphabet Inc(GOOG) | 20,703 | 65,703 | +45,000 | 6,480 | 18,894 | 0.52% | +12,414 |
| Solid Biosciences Inc | 7,690,405 | 7,690,405 | 0 | 43,374 | 55,371 | 1.53% | +11,997 |
| Rezolute Inc(RZLT) | 0 | 3,328,287 | +3,328,287 | 0 | 10,151 | 0.28% | +10,151 |
| Kymera Therapeutics Inc(KYMR) | 3,286,830 | 3,186,830 | -100,000 | 255,748 | 265,431 | 7.36% | +9,683 |
| Rhythm Pharmaceuticals Inc(RYTM) | 499,975 | 725,511 | +225,536 | 53,517 | 63,098 | 1.75% | +9,580 |
| Generate Biomedicines Inc(GENB) | 0 | 736,104 | +736,104 | 0 | 9,201 | 0.26% | +9,201 |
| NVIDIA Corp(NVDA) | 37,485 | 89,085 | +51,600 | 6,991 | 15,536 | 0.43% | +8,545 |
| Microsoft Corp(MSFT) | 15,000 | 41,380 | +26,380 | 7,254 | 15,318 | 0.42% | +8,063 |
| Cogent Biosciences Inc(COGT) | 1,629,279 | 1,709,279 | +80,000 | 57,872 | 65,790 | 1.82% | +7,918 |
| Tesla Inc(TSLA) | 1,500 | 21,500 | +20,000 | 675 | 7,993 | 0.22% | +7,318 |
| Taiwan Semiconductor Manufacturing Co Ltd(TSM) | 27,700 | 42,200 | +14,500 | 8,418 | 14,261 | 0.40% | +5,844 |
| enGene Holdings Inc COM | 3,336,264 | 5,253,159 | +1,916,895 | 30,126 | 35,774 | 0.99% | +5,648 |
| Nebius Group NV(NBIS) | 76,218 | 113,614 | +37,396 | 6,380 | 11,789 | 0.33% | +5,409 |
| Absci Corp | 0 | 1,800,000 | +1,800,000 | 0 | 5,400 | 0.15% | +5,400 |
| Neumora Therapeutics Inc(NMRA) | 6,288,783 | 8,497,822 | +2,209,039 | 11,257 | 16,571 | 0.46% | +5,314 |
| Satellos Bioscience Inc(MSLE) | 0 | 892,074 | +892,074 | 0 | 5,022 | 0.14% | +5,022 |
| Cullinan Therapeutics Inc(CGEM) | 1,193,410 | 1,193,410 | 0 | 12,352 | 16,958 | 0.47% | +4,607 |
| Agomab Therapeutics NV(AGMB) | 0 | 411,250 | +411,250 | 0 | 4,314 | 0.12% | +4,314 |
| Denali Therapeutics Inc(DNLI) | 1,396,513 | 1,396,513 | 0 | 23,056 | 26,813 | 0.74% | +3,757 |
| ServiceNow Inc(NOW) | 35,630 | 87,090 | +51,460 | 5,458 | 9,105 | 0.25% | +3,647 |
| Dbv Technologies SA(DBVT) | 1,857,362 | 1,857,362 | 0 | 35,606 | 38,800 | 1.08% | +3,195 |
| Forgent Power Solutions, Inc(FPS) | 0 | 100,000 | +100,000 | 0 | 2,927 | 0.08% | +2,927 |
| Broadcom Inc(AVGO) | 7,000 | 15,000 | +8,000 | 2,423 | 4,643 | 0.13% | +2,220 |
| Whitehawk Therapeutics Inc(WHWK) | 2,082,000 | 2,082,000 | 0 | 5,038 | 7,183 | 0.20% | +2,144 |
| Micron Technology Inc(MU) | 0 | 6,000 | +6,000 | 0 | 2,027 | 0.06% | +2,027 |
| Remitly Global Inc(RELY) | 1,618,271 | 1,543,271 | -75,000 | 22,332 | 24,183 | 0.67% | +1,851 |
| Revolution Medicines Inc(RVMD) | 1,335,075 | 1,110,980 | -224,095 | 106,339 | 108,043 | 3.00% | +1,704 |
| Arrowhead Pharmaceuticals Inc(ARWR) | 1,500,476 | 1,615,476 | +115,000 | 99,617 | 101,290 | 2.81% | +1,674 |
| Amer Sports Inc(AS) | 0 | 50,000 | +50,000 | 0 | 1,646 | 0.05% | +1,646 |
| Tenax Therapeutics Inc(TENX) | 427,141 | 427,141 | 0 | 5,207 | 6,830 | 0.19% | +1,623 |
| Cellebrite DI Ltd(CLBT) | 150,000 | 311,544 | +161,544 | 2,706 | 4,293 | 0.12% | +1,588 |
| Datadog Inc(DDOG) | 36,425 | 54,300 | +17,875 | 4,953 | 6,410 | 0.18% | +1,457 |
| Aeva Technologies Inc(AEVA) | 0 | 110,000 | +110,000 | 0 | 1,448 | 0.04% | +1,448 |
| PDD Holdings Inc(PDD) | 63,401 | 83,401 | +20,000 | 7,189 | 8,522 | 0.24% | +1,333 |
| CrowdStrike Holdings Inc(CRWD) | 16,500 | 23,070 | +6,570 | 7,735 | 9,007 | 0.25% | +1,272 |
| MapLight Therapeutics Inc(MPLT) | 450,000 | 450,000 | 0 | 7,904 | 9,149 | 0.25% | +1,244 |
| Korro Bio Inc(KRRO) | 347,718 | 347,718 | 0 | 2,785 | 3,936 | 0.11% | +1,151 |
| Monopar Therapeutics Inc(MNPR) | 212,298 | 270,118 | +57,820 | 13,863 | 14,800 | 0.41% | +937 |
| Dynatrace Inc(DT) | 115,229 | 150,000 | +34,771 | 4,994 | 5,547 | 0.15% | +553 |
| Nu Holdings Ltd.(NU) | 0 | 25,000 | +25,000 | 0 | 359 | 0.01% | +359 |
| Agenus Inc(AGEN) | 1,064,250 | 1,064,250 | 0 | 3,342 | 3,555 | 0.10% | +213 |
| Jfrog Ltd(FROG) | 93,616 | 128,816 | +35,200 | 5,847 | 6,045 | 0.17% | +198 |
| Figma Inc(FIG) | 25,000 | 50,000 | +25,000 | 934 | 1,057 | 0.03% | +123 |
| vTv Therapeutics Inc(VTVT) | 163,000 | 163,000 | 0 | 6,518 | 6,465 | 0.18% | -54 |
| Cyclerion Therapeutics Inc(CYCN) | 115,603 | 0 | -115,603 | 147 | 0 | — | -147 |
| IREN Ltd ORDINARY SHARES | 43,100 | 43,100 | 0 | 1,628 | 1,477 | 0.04% | -150 |
| Caribou Biosciences Inc(CRBU) | 105,347 | 0 | -105,347 | 168 | 0 | — | -168 |
| Primo Brands Corp(PRMB) | 75,000 | 50,000 | -25,000 | 1,226 | 942 | 0.03% | -285 |
| Sionna Therapeutics Inc(SION) | 300,000 | 300,000 | 0 | 12,342 | 12,027 | 0.33% | -315 |
| Foghorn Therapeutics Inc(FHTX) | 720,720 | 720,720 | 0 | 3,892 | 3,445 | 0.10% | -447 |
| monday.com Ltd SHS | 17,000 | 25,000 | +8,000 | 2,509 | 1,728 | 0.05% | -781 |
| KE Holdings Inc(BEKE) | 145,000 | 100,000 | -45,000 | 2,285 | 1,497 | 0.04% | -788 |
| Crinetics Pharmaceuticals Inc(CRNX) | 1,507,636 | 1,903,636 | +396,000 | 70,180 | 69,140 | 1.92% | -1,040 |
| Generation Bio Inc | 201,419 | 0 | -201,419 | 1,144 | 0 | — | -1,144 |
| Kalaris Therapeutics Inc(KLRS) | 435,798 | 435,798 | 0 | 3,678 | 2,515 | 0.07% | -1,164 |
| Varonis Systems Inc(VRNS) | 37,500 | 0 | -37,500 | 1,230 | 0 | — | -1,230 |
| Rani Therapeutics Holdings Inc(RANI) | 2,000,000 | 2,000,000 | 0 | 2,700 | 1,470 | 0.04% | -1,230 |
| Workiva Inc(WK) | 79,123 | 92,500 | +13,377 | 6,824 | 5,516 | 0.15% | -1,309 |
| Rapport Therapeutics Inc(RAPP) | 708,469 | 641,469 | -67,000 | 21,495 | 20,072 | 0.56% | -1,423 |
| GitLab Inc(GTLB) | 99,000 | 100,000 | +1,000 | 3,715 | 2,164 | 0.06% | -1,551 |
| CoreWeave Inc(CRWV) | 27,500 | 0 | -27,500 | 1,969 | 0 | — | -1,969 |
| Medline Inc(MDLN) | 75,000 | 25,000 | -50,000 | 3,150 | 1,113 | 0.03% | -2,037 |
| Palo Alto Networks Inc(PANW) | 11,450 | 0 | -11,450 | 2,109 | 0 | — | -2,109 |
| Inhibikase Therapeutics Inc(IKT) | 5,850,000 | 5,850,000 | 0 | 11,993 | 9,828 | 0.27% | -2,164 |
| Amazon.com Inc(AMZN) | 51,500 | 46,641 | -4,859 | 11,887 | 9,714 | 0.27% | -2,173 |
| Instil Bio Inc(TIL) | 203,933 | 0 | -203,933 | 2,243 | 0 | — | -2,243 |
| Arm Holdings PLC | 21,500 | 0 | -21,500 | 2,350 | 0 | — | -2,350 |
| Silence Therapeutics PLC(SLN) | 2,911,438 | 2,911,438 | 0 | 17,702 | 15,343 | 0.43% | -2,358 |
| Qualcomm Inc(QCOM) | 14,000 | 0 | -14,000 | 2,395 | 0 | — | -2,395 |
| Black Diamond Therapeutics Inc | 1,046,517 | 0 | -1,046,517 | 2,543 | 0 | — | -2,543 |
| Zscaler Inc(ZS) | 12,000 | 0 | -12,000 | 2,699 | 0 | — | -2,699 |
| IONQ Inc(IONQ) | 170,000 | 170,000 | 0 | 7,628 | 4,901 | 0.14% | -2,727 |
| Seer Inc(SEER) | 4,000,000 | 2,458,673 | -1,541,327 | 7,320 | 4,131 | 0.11% | -3,189 |
| New Oriental Education & Technology Group Inc(EDU) | 62,000 | 0 | -62,000 | 3,412 | 0 | — | -3,412 |
| Fulcrum Therapeutics Inc(FULC) | 1,950,000 | 2,350,000 | +400,000 | 22,055 | 18,025 | 0.50% | -4,030 |
| Adobe Inc(ADBE) | 12,051 | 0 | -12,051 | 4,218 | 0 | — | -4,218 |
| Sagimet Biosciences Inc(SGMT) | 724,771 | 0 | -724,771 | 4,291 | 0 | — | -4,291 |
| PepGen Inc(PEPG) | 700,000 | 0 | -700,000 | 4,557 | 0 | — | -4,557 |
| NovaBridge Biosciences(NBP) | 3,000,000 | 3,000,000 | 0 | 11,940 | 7,380 | 0.20% | -4,560 |
| Invivyd Inc(IVVD) | 4,000,000 | 4,000,000 | 0 | 9,880 | 5,200 | 0.14% | -4,680 |