Siren, L.L.C.
Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | Q4 2025 ▲▼ | Q1 2026 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Erasca Inc(ERAS) | 8,757,249 | 11,244,246 | +2,486,997 | 32,576,966 | 181,931,900 | 5.04% | +149,354,934 |
| Veradermics Inc(MANE) | 0 | 1,505,374 | +1,505,374 | 0 | 95,064,368 | 2.64% | +95,064,368 |
| Scholar Rock Holding Corp(SRRK) | 10,825,013 | 10,825,013 | 0 | 476,841,823 | 532,157,639 | 14.75% | +55,315,816 |
| Tango Therapeutics Inc(TNGX) | 8,165,374 | 5,657,105 | -2,508,269 | 72,345,214 | 118,346,637 | 3.28% | +46,001,423 |
| Cytokinetics Inc(CYTK) | 0 | 613,952 | +613,952 | 0 | 40,465,576 | 1.12% | +40,465,576 |
| Xenon Pharmaceuticals Inc(XENE) | 812,761 | 1,318,564 | +505,803 | 36,427,948 | 76,674,497 | 2.13% | +40,246,549 |
| Oric Pharmaceuticals Inc(ORIC) | 1,007,575 | 2,998,192 | +1,990,617 | 8,241,964 | 37,987,092 | 1.05% | +29,745,128 |
| Enliven Therapeutics Inc | 0 | 746,226 | +746,226 | 0 | 29,252,059 | 0.81% | +29,252,059 |
| Bicara Therapeutics Inc | 5,216,969 | 5,802,970 | +586,001 | 87,801,588 | 115,421,073 | 3.20% | +27,619,485 |
| Edgewise Therapeutics Inc(EWTX) | 4,529,990 | 4,430,263 | -99,727 | 112,411,702 | 139,553,285 | 3.87% | +27,141,583 |
| Lexicon Pharmaceuticals Inc(LXRX) | 38,918,903 | 44,303,518 | +5,384,615 | 44,756,738 | 69,113,488 | 1.92% | +24,356,750 |
| Palvella Therapeutics Inc(PVLA) | 75,000 | 257,485 | +182,485 | 7,850,250 | 32,095,505 | 0.89% | +24,245,255 |
| Damora Therapeutics Inc(DMRA) | 0 | 900,000 | +900,000 | 0 | 23,310,000 | 0.65% | +23,310,000 |
| Annexon Inc(ANNX) | 0 | 3,958,646 | +3,958,646 | 0 | 21,930,899 | 0.61% | +21,930,899 |
| Definium Therapeutics Inc(DFTX) | 0 | 919,493 | +919,493 | 0 | 17,378,418 | 0.48% | +17,378,418 |
| Amylyx Pharmaceuticals Inc(AMLX) | 0 | 1,230,000 | +1,230,000 | 0 | 17,097,000 | 0.47% | +17,097,000 |
| Uniqure NV(QURE) | 0 | 1,000,000 | +1,000,000 | 0 | 16,350,000 | 0.45% | +16,350,000 |
| CytomX Therapeutics Inc | 0 | 3,457,711 | +3,457,711 | 0 | 16,251,242 | 0.45% | +16,251,242 |
| Zura Bio Ltd | 1,300,000 | 3,734,866 | +2,434,866 | 6,812,000 | 22,222,453 | 0.62% | +15,410,453 |
| Spyre Therapeutics Inc(SYRE) | 818,598 | 818,598 | 0 | 26,817,270 | 41,290,083 | 1.14% | +14,472,813 |
| Alphabet Inc(GOOG) | 20,703 | 65,703 | +45,000 | 6,480,039 | 18,893,555 | 0.52% | +12,413,516 |
| Solid Biosciences Inc | 7,690,405 | 7,690,405 | 0 | 43,373,884 | 55,370,916 | 1.53% | +11,997,032 |
| Rezolute Inc | 0 | 3,328,287 | +3,328,287 | 0 | 10,151,275 | 0.28% | +10,151,275 |
| Kymera Therapeutics Inc(KYMR) | 3,286,830 | 3,186,830 | -100,000 | 255,748,242 | 265,431,071 | 7.36% | +9,682,829 |
| Rhythm Pharmaceuticals Inc(RYTM) | 499,975 | 725,511 | +225,536 | 53,517,324 | 63,097,692 | 1.75% | +9,580,368 |
| Generate Biomedicines Inc(GENB) | 0 | 736,104 | +736,104 | 0 | 9,201,300 | 0.26% | +9,201,300 |
| NVIDIA Corp(NVDA) | 37,485 | 89,085 | +51,600 | 6,990,953 | 15,536,424 | 0.43% | +8,545,471 |
| Microsoft Corp(MSFT) | 15,000 | 41,380 | +26,380 | 7,254,300 | 15,317,635 | 0.42% | +8,063,335 |
| Cogent Biosciences Inc(COGT) | 1,629,279 | 1,709,279 | +80,000 | 57,871,990 | 65,790,149 | 1.82% | +7,918,159 |
| Tesla Inc(TSLA) | 1,500 | 21,500 | +20,000 | 674,580 | 7,992,625 | 0.22% | +7,318,045 |
| Taiwan Semiconductor Manufacturing Co Ltd(TSM) | 27,700 | 42,200 | +14,500 | 8,417,753 | 14,261,490 | 0.40% | +5,843,737 |
| enGene Holdings Inc COM | 3,336,264 | 5,253,159 | +1,916,895 | 30,126,464 | 35,774,013 | 0.99% | +5,647,549 |
| Nebius Group NV(NBIS) | 76,218 | 113,614 | +37,396 | 6,379,828 | 11,788,589 | 0.33% | +5,408,761 |
| Absci Corp | 0 | 1,800,000 | +1,800,000 | 0 | 5,400,000 | 0.15% | +5,400,000 |
| Neumora Therapeutics Inc | 6,288,783 | 8,497,822 | +2,209,039 | 11,256,922 | 16,570,753 | 0.46% | +5,313,831 |
| Satellos Bioscience Inc | 0 | 892,074 | +892,074 | 0 | 5,022,377 | 0.14% | +5,022,377 |
| Cullinan Therapeutics Inc(CGEM) | 1,193,410 | 1,193,410 | 0 | 12,351,794 | 16,958,356 | 0.47% | +4,606,562 |
| Agomab Therapeutics NV | 0 | 411,250 | +411,250 | 0 | 4,314,013 | 0.12% | +4,314,013 |
| Denali Therapeutics Inc(DNLI) | 1,396,513 | 1,396,513 | 0 | 23,056,430 | 26,813,050 | 0.74% | +3,756,620 |
| ServiceNow Inc(NOW) | 35,630 | 87,090 | +51,460 | 5,458,160 | 9,105,260 | 0.25% | +3,647,100 |
| Dbv Technologies SA | 1,857,362 | 1,857,362 | 0 | 35,605,630 | 38,800,292 | 1.08% | +3,194,662 |
| Forgent Power Solutions, Inc(FPS) | 0 | 100,000 | +100,000 | 0 | 2,927,000 | 0.08% | +2,927,000 |
| Broadcom Inc(AVGO) | 7,000 | 15,000 | +8,000 | 2,422,700 | 4,642,650 | 0.13% | +2,219,950 |
| Whitehawk Therapeutics Inc | 2,082,000 | 2,082,000 | 0 | 5,038,440 | 7,182,900 | 0.20% | +2,144,460 |
| Micron Technology Inc(MU) | 0 | 6,000 | +6,000 | 0 | 2,027,040 | 0.06% | +2,027,040 |
| Remitly Global Inc(RELY) | 1,618,271 | 1,543,271 | -75,000 | 22,332,140 | 24,183,057 | 0.67% | +1,850,917 |
| Revolution Medicines Inc(RVMD) | 1,335,075 | 1,110,980 | -224,095 | 106,338,724 | 108,042,805 | 3.00% | +1,704,081 |
| Arrowhead Pharmaceuticals Inc(ARWR) | 1,500,476 | 1,615,476 | +115,000 | 99,616,602 | 101,290,345 | 2.81% | +1,673,743 |
| Amer Sports Inc(AS) | 0 | 50,000 | +50,000 | 0 | 1,646,000 | 0.05% | +1,646,000 |
| Tenax Therapeutics Inc | 427,141 | 427,141 | 0 | 5,206,849 | 6,829,985 | 0.19% | +1,623,136 |
| Cellebrite DI Ltd(CLBT) | 150,000 | 311,544 | +161,544 | 2,705,550 | 4,293,076 | 0.12% | +1,587,526 |
| Datadog Inc(DDOG) | 36,425 | 54,300 | +17,875 | 4,953,436 | 6,410,115 | 0.18% | +1,456,679 |
| Aeva Technologies Inc(AEVA) | 0 | 110,000 | +110,000 | 0 | 1,447,600 | 0.04% | +1,447,600 |
| PDD Holdings Inc(PDD) | 63,401 | 83,401 | +20,000 | 7,189,039 | 8,521,914 | 0.24% | +1,332,875 |
| CrowdStrike Holdings Inc(CRWD) | 16,500 | 23,070 | +6,570 | 7,734,540 | 9,006,759 | 0.25% | +1,272,219 |
| MapLight Therapeutics Inc(MPLT) | 450,000 | 450,000 | 0 | 7,904,250 | 9,148,500 | 0.25% | +1,244,250 |
| Korro Bio Inc | 347,718 | 347,718 | 0 | 2,785,221 | 3,936,168 | 0.11% | +1,150,947 |
| Monopar Therapeutics Inc | 212,298 | 270,118 | +57,820 | 13,863,059 | 14,799,765 | 0.41% | +936,706 |
| Dynatrace Inc(DT) | 115,229 | 150,000 | +34,771 | 4,994,025 | 5,547,000 | 0.15% | +552,975 |
| Nu Holdings Ltd.(NU) | 0 | 25,000 | +25,000 | 0 | 359,250 | 0.01% | +359,250 |
| Agenus Inc | 1,064,250 | 1,064,250 | 0 | 3,341,745 | 3,554,595 | 0.10% | +212,850 |
| Jfrog Ltd(FROG) | 93,616 | 128,816 | +35,200 | 5,847,255 | 6,045,335 | 0.17% | +198,080 |
| Figma Inc(FIG) | 25,000 | 50,000 | +25,000 | 934,250 | 1,057,000 | 0.03% | +122,750 |
| vTv Therapeutics Inc | 163,000 | 163,000 | 0 | 6,518,370 | 6,464,580 | 0.18% | -53,790 |
| Cyclerion Therapeutics Inc | 115,603 | 0 | -115,603 | 146,816 | 0 | — | -146,816 |
| IREN Ltd ORDINARY SHARES | 43,100 | 43,100 | 0 | 1,627,887 | 1,477,468 | 0.04% | -150,419 |
| Caribou Biosciences Inc | 105,347 | 0 | -105,347 | 167,502 | 0 | — | -167,502 |
| Primo Brands Corp(PRMB) | 75,000 | 50,000 | -25,000 | 1,226,250 | 941,500 | 0.03% | -284,750 |
| Sionna Therapeutics Inc(SION) | 300,000 | 300,000 | 0 | 12,342,000 | 12,027,000 | 0.33% | -315,000 |
| Foghorn Therapeutics Inc | 720,720 | 720,720 | 0 | 3,891,888 | 3,445,042 | 0.10% | -446,846 |
| monday.com Ltd SHS | 17,000 | 25,000 | +8,000 | 2,508,520 | 1,727,750 | 0.05% | -780,770 |
| KE Holdings Inc(BEKE) | 145,000 | 100,000 | -45,000 | 2,285,200 | 1,497,000 | 0.04% | -788,200 |
| Crinetics Pharmaceuticals Inc(CRNX) | 1,507,636 | 1,903,636 | +396,000 | 70,180,456 | 69,140,060 | 1.92% | -1,040,396 |
| Generation Bio Inc | 201,419 | 0 | -201,419 | 1,144,060 | 0 | — | -1,144,060 |
| Kalaris Therapeutics Inc | 435,798 | 435,798 | 0 | 3,678,135 | 2,514,554 | 0.07% | -1,163,581 |
| Varonis Systems Inc(VRNS) | 37,500 | 0 | -37,500 | 1,230,000 | 0 | — | -1,230,000 |
| Rani Therapeutics Holdings Inc | 2,000,000 | 2,000,000 | 0 | 2,700,000 | 1,469,600 | 0.04% | -1,230,400 |
| Workiva Inc(WK) | 79,123 | 92,500 | +13,377 | 6,824,359 | 5,515,775 | 0.15% | -1,308,584 |
| Rapport Therapeutics Inc(RAPP) | 708,469 | 641,469 | -67,000 | 21,494,949 | 20,071,565 | 0.56% | -1,423,384 |
| GitLab Inc(GTLB) | 99,000 | 100,000 | +1,000 | 3,715,470 | 2,164,000 | 0.06% | -1,551,470 |
| CoreWeave Inc(CRWV) | 27,500 | 0 | -27,500 | 1,969,275 | 0 | — | -1,969,275 |
| Medline Inc(MDLN) | 75,000 | 25,000 | -50,000 | 3,150,000 | 1,112,500 | 0.03% | -2,037,500 |
| Palo Alto Networks Inc(PANW) | 11,450 | 0 | -11,450 | 2,109,090 | 0 | — | -2,109,090 |
| Inhibikase Therapeutics Inc | 5,850,000 | 5,850,000 | 0 | 11,992,500 | 9,828,000 | 0.27% | -2,164,500 |
| Amazon.com Inc(AMZN) | 51,500 | 46,641 | -4,859 | 11,887,230 | 9,713,921 | 0.27% | -2,173,309 |
| Instil Bio Inc | 203,933 | 0 | -203,933 | 2,243,263 | 0 | — | -2,243,263 |
| Arm Holdings PLC | 21,500 | 0 | -21,500 | 2,350,165 | 0 | — | -2,350,165 |
| Silence Therapeutics PLC | 2,911,438 | 2,911,438 | 0 | 17,701,543 | 15,343,278 | 0.43% | -2,358,265 |
| Qualcomm Inc(QCOM) | 14,000 | 0 | -14,000 | 2,394,700 | 0 | — | -2,394,700 |
| Black Diamond Therapeutics Inc | 1,046,517 | 0 | -1,046,517 | 2,543,036 | 0 | — | -2,543,036 |
| Zscaler Inc(ZS) | 12,000 | 0 | -12,000 | 2,699,040 | 0 | — | -2,699,040 |
| IONQ Inc(IONQ) | 170,000 | 170,000 | 0 | 7,627,900 | 4,901,100 | 0.14% | -2,726,800 |
| Seer Inc | 4,000,000 | 2,458,673 | -1,541,327 | 7,320,000 | 4,130,571 | 0.11% | -3,189,429 |
| New Oriental Education & Technology Group Inc(EDU) | 62,000 | 0 | -62,000 | 3,411,860 | 0 | — | -3,411,860 |
| Fulcrum Therapeutics Inc | 1,950,000 | 2,350,000 | +400,000 | 22,054,500 | 18,024,500 | 0.50% | -4,030,000 |
| Adobe Inc(ADBE) | 12,051 | 0 | -12,051 | 4,217,729 | 0 | — | -4,217,729 |
| Sagimet Biosciences Inc | 724,771 | 0 | -724,771 | 4,290,644 | 0 | — | -4,290,644 |
| PepGen Inc | 700,000 | 0 | -700,000 | 4,557,000 | 0 | — | -4,557,000 |
| NovaBridge Biosciences | 3,000,000 | 3,000,000 | 0 | 11,940,000 | 7,380,000 | 0.20% | -4,560,000 |
| Invivyd Inc | 4,000,000 | 4,000,000 | 0 | 9,880,000 | 5,200,000 | 0.14% | -4,680,000 |