Fund Holdings — Siren, L.L.C.

Total Portfolio Value:
$1.93B
Total Bought:
$269.82M
Total Sold:
$173.88M
Net Transaction:
+$95.94M
Securities
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SharesValue
Q1 2025
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Q2 2025
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Change
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Q1 2025
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Q2 2025
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Weight (%)
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Change
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Scholar Rock Holding Corporation(SRRK)9,250,0059,250,0050$297.39M$327.64M16.95%+$30.25M
Kymera Therapeutics, Inc.(KYMR)3,240,3133,428,150+187,837$88.69M$149.60M7.74%+$60.92M
BeOne Medicines AGADS(ONC)498,689509,990+11,301$135.73M$123.45M6.39%-$12.27M
Disc Medicine, Inc.(IRON)1,071,8651,099,401+27,536$53.21M$58.22M3.01%+$5.02M
Crinetics Pharmaceuticals Inc1,688,6111,688,6110$56.64M$48.56M2.51%-$8.07M
Bicara Therapeutics Inc3,267,0835,216,969+1,949,886$42.57M$48.47M2.51%+$5.90M
Dyne Therapeutics, Inc.(DYN)2,717,9874,836,437+2,118,450$28.43M$46.04M2.38%+$17.61M
Centessa Pharmaceuticals PLCADS2,960,0293,460,029+500,000$42.57M$45.46M2.35%+$2.90M
Merus NV1,043,467853,467-190,000$43.92M$44.89M2.32%+$972.8K
Apellis Pharmaceuticals Inc
COM
2,578,3962,578,3960$56.39M$44.63M2.31%-$11.76M
Ascendis Pharma A/SADR(ASND)287,366245,943-41,423$44.79M$42.45M2.20%-$2.34M
Arrowhead Pharmaceuticals, Inc.(ARWR)2,669,8802,669,8800$34.01M$42.18M2.18%+$8.17M
Edgewise Therapeutics, Inc.(EWTX)1,696,4443,160,298+1,463,854$37.32M$41.43M2.14%+$4.11M
Soleno Therapeutics Inc727,337467,342-259,995$51.97M$39.15M2.03%-$12.81M
Lexicon Pharmaceuticals, Inc.(LXRX)38,918,90338,918,9030$17.93M$36.81M1.90%+$18.87M
Taboola.com Ltd.(TBLA)9,969,4959,969,4950$29.41M$36.49M1.89%+$7.08M
Solid Biosciences Inc7,415,9057,415,9050$27.44M$36.12M1.87%+$8.68M
Revolution Medicines, Inc.(RVMD)563,755938,755+375,000$19.93M$34.54M1.79%+$14.60M
Avidity Biosciences Inc1,110,6101,110,6100$32.79M$31.54M1.63%-$1.24M
Rhythm Pharmaceuticals, Inc.(RYTM)277,533409,742+132,209$14.70M$25.89M1.34%+$11.19M
Apogee Therapeutics Inc594,994594,9940$22.23M$25.84M1.34%+$3.61M
Stoke Therapeutics, Inc.(STOK)2,247,3472,247,3470$14.94M$25.51M1.32%+$10.56M
Taysha Gene Therapies, Inc.(TSHA)6,514,73711,014,737+4,500,000$9.06M$25.44M1.32%+$16.39M
Xenon Pharmaceuticals Inc.(XENE)732,761812,761+80,000$24.58M$25.44M1.32%+$855.3K
Wave Life Sciences, Inc.SHS(WVE)3,696,3223,696,3220$29.87M$24.03M1.24%-$5.84M
MoonLake ImmunotherapeuticsCL A(MLTX)0508,267+508,267$0$23.99M1.24%+$23.99M
Septerna, Inc.(SEPN)2,202,5142,202,5140$12.75M$23.28M1.20%+$10.53M
NewAmsterdam Pharma Company NV
ORDINARY SHARES
1,912,0301,194,240-717,790$39.14M$21.63M1.12%-$17.51M
Trevi Therapeutics, Inc.(TRVI)2,863,7933,938,793+1,075,000$18.01M$21.55M1.11%+$3.53M
Tango Therapeutics, Inc.(TNGX)2,565,3423,364,814+799,472$3.51M$17.23M0.89%+$13.71M
Akero Therapeutics Inc0318,647+318,647$0$17.00M0.88%+$17.00M
Silence Therapeutics plcADS(SLN)2,789,8332,911,438+121,605$7.87M$16.89M0.87%+$9.02M
ArriVent BioPharma, Inc.(AVBP)0700,000+700,000$0$15.24M0.79%+$15.24M
Bicycle Therapeutics PLCADS1,812,7522,012,752+200,000$15.39M$13.99M0.72%-$1.40M
Arcus Biosciences, Inc.(RCUS)1,612,0771,612,0770$12.65M$13.12M0.68%+$467.5K
IHS Holding Limited
ORD SHS
2,357,5202,357,5200$12.31M$13.11M0.68%+$801.6K
Amazon.com, Inc.(AMZN)56,50056,5000$10.75M$12.40M0.64%+$1.65M
Denali Therapeutics Inc.(DNLI)821,513821,5130$11.17M$11.49M0.59%+$324.5K
Erasca, Inc.(ERAS)8,757,2498,757,2490$12.00M$11.12M0.58%-$875.7K
ORIC Pharmaceuticals, Inc.(ORIC)1,007,5751,007,5750$5.62M$10.23M0.53%+$4.60M
Remitly Global, Inc.(RELY)490,449515,449+25,000$10.20M$9.67M0.50%-$526.4K
Vaxcyte, Inc.(PCVX)295,543295,5430$11.16M$9.61M0.50%-$1.55M
CrowdStrike Holdings, Inc.CL A(CRWD)25,00018,500-6,500$8.81M$9.42M0.49%+$607.7K
Cullinan Therapeutics, Inc.(CGEM)1,193,4101,193,4100$9.03M$8.99M0.47%-$47.7K
Alphabet Inc.CL A(GOOG)50,70350,7030$7.84M$8.93M0.46%+$1.09M
Upstream Bio, Inc.(UPB)788,450788,4500$4.83M$8.66M0.45%+$3.83M
Seer, Inc.CL A(SEER)4,000,0004,000,0000$6.76M$8.56M0.44%+$1.80M
Microsoft Corporation(MSFT)28,50016,150-12,350$10.70M$8.03M0.42%-$2.67M
NVIDIA Corporation(NVDA)44,43249,985+5,553$4.82M$7.90M0.41%+$3.08M
IonQ, Inc.(IONQ)170,000170,0000$3.75M$7.30M0.38%+$3.55M
Taiwan Semiconductor Manufacturing Company LimitedADS(TSM)28,50030,500+2,000$4.73M$6.91M0.36%+$2.18M
Gossamer Bio, Inc.(GOSS)5,208,9685,208,9680$5.73M$6.41M0.33%+$677.2K
Salesforce, Inc.(CRM)14,60022,600+8,000$3.92M$6.16M0.32%+$2.24M
Cogent Biosciences, Inc.(COGT)0854,379+854,379$0$6.13M0.32%+$6.13M
Cartesian Therapeutics, Inc.(RNAC)563,272563,2720$7.42M$5.85M0.30%-$1.57M
Vera Therapeutics, Inc.CL A(VERA)747,216247,216-500,000$17.95M$5.82M0.30%-$12.12M
Adobe Inc.(ADBE)19,29815,051-4,247$7.40M$5.82M0.30%-$1.58M
Sionna Therapeutics, Inc.(SION)325,000325,0000$3.40M$5.64M0.29%+$2.24M
PDD Holdings Inc.ADS(PDD)52,90152,9010$6.26M$5.54M0.29%-$724.2K
Sagimet Biosciences Inc.COM SER A(SGMT)724,771724,7710$2.36M$5.52M0.29%+$3.16M
Spyre Therapeutics, Inc.(SYRE)368,598368,5980$5.95M$5.52M0.29%-$429.4K
Pacira BioSciences, Inc.(PCRX)0225,000+225,000$0$5.38M0.28%+$5.38M
ServiceNow, Inc.(NOW)9,1265,126-4,000$7.27M$5.27M0.27%-$2.00M
Korro Bio, Inc.(KRRO)418,833418,8330$7.29M$5.23M0.27%-$2.06M
Datadog, Inc.CL A(DDOG)47,42538,425-9,000$4.71M$5.16M0.27%+$456.6K
Agenus Inc.(AGEN)500,0001,064,250+564,250$752.5K$4.86M0.25%+$4.11M
JFrog Ltd.(FROG)131,616107,116-24,500$4.21M$4.70M0.24%+$488.5K
Rapport Therapeutics, Inc.(RAPP)378,469378,4690$3.80M$4.30M0.22%+$507.1K
Instil Bio, Inc.(TIL)203,933203,9330$3.54M$4.25M0.22%+$707.6K
Dynatrace, Inc.(DT)87,72975,229-12,500$4.14M$4.15M0.21%+$17.0K
Whitehawk Therapeutics, Inc.(WHWK)2,082,0002,082,0000$3.71M$3.89M0.20%+$187.4K
New Oriental Education & Technology Group Inc.ADR(EDU)79,50072,000-7,500$3.80M$3.88M0.20%+$83.5K
IGM Biosciences Inc3,255,8263,255,8260$3.74M$3.65M0.19%-$97.7K
Foghorn Therapeutics Inc.(FHTX)720,720720,7200$2.63M$3.39M0.18%+$756.8K
Vigil Neuroscience Inc1,967,064411,191-1,555,873$3.50M$3.27M0.17%-$232.4K
Neumora Therapeutics, Inc.(NMRA)4,358,2834,358,2830$4.36M$3.20M0.17%-$1.16M
ProQR Therapeutics NVSHS EURO
SHS EURO
1,552,1831,552,1830$2.06M$3.17M0.16%+$1.10M
Nebius Group N.V.CL A(NBIS)140,00051,000-89,000$2.96M$2.82M0.15%-$133.6K
Black Diamond Therapeutics Inc1,046,5171,046,5170$1.62M$2.60M0.13%+$973.3K
Lexeo Therapeutics, Inc.(LXEO)603,435603,4350$2.09M$2.43M0.13%+$331.9K
Palo Alto Networks, Inc.(PANW)11,50011,5000$1.96M$2.35M0.12%+$391.0K
QUALCOMM Incorporated(QCOM)14,00014,0000$2.15M$2.23M0.12%+$79.1K
Workiva Inc.CL A(WK)17,50028,000+10,500$1.33M$1.92M0.10%+$588.2K
Eledon Pharmaceuticals, Inc.(ELDN)690,170690,1700$2.34M$1.87M0.10%-$469.3K
KE Holdings Inc.ADS(BEKE)105,000105,0000$2.11M$1.86M0.10%-$246.8K
HubSpot, Inc.(HUBS)03,000+3,000$0$1.67M0.09%+$1.67M
UnitedHealth Group Incorporated(UNH)05,076+5,076$0$1.58M0.08%+$1.58M
BioAge Labs, Inc.(BIOA)382,406382,4060$1.44M$1.58M0.08%+$141.5K
GitLab Inc.CL A(GTLB)035,000+35,000$0$1.58M0.08%+$1.58M
Tourmaline Bio Inc91,42691,4260$1.39M$1.46M0.08%+$71.3K
Rocket Pharmaceuticals, Inc.(RCKT)591,263591,2630$3.94M$1.45M0.07%-$2.50M
Tesla, Inc.(TSLA)9,0004,000-5,000$2.33M$1.27M0.07%-$1.06M
Birkenstock Holding plc(BIRK)025,000+25,000$0$1.23M0.06%+$1.23M
SailPoint, Inc.(SAIL)95,00050,000-45,000$1.78M$1.14M0.06%-$638.3K
SEMrush Holdings IncCL A
CL A COM
125,000125,0000$1.17M$1.13M0.06%-$35.0K
Primo Brands CorporationCL A(PRMB)037,500+37,500$0$1.11M0.06%+$1.11M
Cellebrite DI Ltd.(CLBT)060,000+60,000$0$960.0K0.05%+$960.0K
Generation Bio Co2,968,9252,968,9250$1.20M$950.4K0.05%-$252.1K
Kalaris Therapeutics, Inc.(KLRS)282,586282,5860$2.27M$754.5K0.04%-$1.51M
HOOKIPA Pharma Inc566,640566,6400$612.0K$711.1K0.04%+$99.2K
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Siren, L.L.C. — 13F Holdings — Q2 2025 | TickerTrail