Fund HoldingsSiren, L.L.C.

Total Portfolio Value
$1.93B
Total Bought
$269.82M
Total Sold
$173.88M
Net Transaction
+$95.94M
Filing Period:
Securities
SharesValue ($K)
Q1 2025
Q2 2025
Change
Q1 2025
Q2 2025
Weight (%)
Change
Kymera Therapeutics Inc(KYMR)03,428,150+3,428,1500149,6047.74%+149,604
Scholar Rock Holding Corp(SRRK)09,250,005+9,250,0050327,63516.95%+327,635
MoonLake Immunotherapeutics(MLTX)0508,267+508,267023,9901.24%+23,990
Lexicon Pharmaceuticals Inc(LXRX)038,918,903+38,918,903036,8061.90%+36,806
Dyne Therapeutics Inc(DYN)2,717,9874,836,437+2,118,45028,43046,0432.38%+17,613
Akero Therapeutics Inc0318,647+318,647017,0030.88%+17,003
Taysha Gene Therapies Inc(TSHA)6,514,73711,014,737+4,500,0009,05525,4441.32%+16,389
Arrivent Biopharma Inc(AVBP)0700,000+700,000015,2390.79%+15,239
Revolution Medicines Inc(RVMD)0938,755+938,755034,5371.79%+34,537
Tango Therapeutics Inc(TNGX)03,364,814+3,364,814017,2280.89%+17,228
Rhythm Pharmaceuticals Inc(RYTM)277,533409,742+132,20914,70125,8921.34%+11,191
Stoke Therapeutics Inc(STOK)02,247,347+2,247,347025,5071.32%+25,507
Septerna Inc(SEPN)02,202,514+2,202,514023,2811.20%+23,281
Silence Therapeutics PLC02,911,438+2,911,438016,8860.87%+16,886
Solid Biosciences Inc7,415,9057,415,905027,43936,1151.87%+8,677
Arrowhead Pharmaceuticals Inc(ARWR)02,669,880+2,669,880042,1842.18%+42,184
Taboola.com Ltd(TBLA)09,969,495+9,969,495036,4881.89%+36,488
Cogent Biosciences Inc(COGT)0854,379+854,37906,1340.32%+6,134
Bicara Therapeutics Inc05,216,969+5,216,969048,4662.51%+48,466
Pacira Biosciences Inc(PCRX)0225,000+225,00005,3780.28%+5,378
Disc Medicine Inc(IRON)1,071,8651,099,401+27,53653,20758,2243.01%+5,017
Oric Pharmaceuticals Inc(ORIC)1,007,5751,007,57505,62210,2270.53%+4,605
Agenus Inc500,0001,064,250+564,2507534,8640.25%+4,111
Edgewise Therapeutics Inc(EWTX)1,696,4443,160,298+1,463,85437,32241,4322.14%+4,110
Upstream Bio Inc0788,450+788,45008,6570.45%+8,657
Apogee Therapeutics Inc(APGE)0594,994+594,994025,8411.34%+25,841
IONQ Inc(IONQ)0170,000+170,00007,3050.38%+7,305
Trevi Therapeutics Inc(TRVI)2,863,7933,938,793+1,075,00018,01321,5451.11%+3,532
Sagimet Biosciences Inc724,771724,77102,3635,5230.29%+3,160
NVIDIA Corp(NVDA)44,43249,985+5,5534,8167,8970.41%+3,082
Centessa Pharmaceuticals PLC03,460,029+3,460,029045,4652.35%+45,465
Salesforce Inc(CRM)14,60022,600+8,0003,9186,1630.32%+2,245
Sionna Therapeutics Inc(SION)325,000325,00003,4005,6390.29%+2,239
Taiwan Semiconductor Manufacturing Co Ltd(TSM)28,50030,500+2,0004,7316,9080.36%+2,177
Seer Inc4,000,0004,000,00006,7608,5600.44%+1,800
HubSpot Inc(HUBS)03,000+3,00001,6700.09%+1,670
Amazon.com Inc(AMZN)56,50056,500010,75012,3960.64%+1,646
UnitedHealth Group Inc(UNH)05,076+5,07601,5840.08%+1,584
GitLab Inc(GTLB)035,000+35,00001,5790.08%+1,579
Birkenstock Holding PLC(BIRK)025,000+25,00001,2300.06%+1,230
Primo Brands Corp(PRMB)037,500+37,50001,1110.06%+1,111
ProQR Therapeutics NV
SHS EURO
1,552,1831,552,18302,0643,1660.16%+1,102
Alphabet Inc(GOOG)50,70350,70307,8418,9340.46%+1,093
Black Diamond Therapeutics Inc1,046,5171,046,51701,6222,5950.13%+973
Merus NV1,043,467853,467-190,00043,92044,8922.32%+973
Cellebrite DI Ltd(CLBT)060,000+60,00009600.05%+960
Xenon Pharmaceuticals Inc(XENE)0812,761+812,761025,4391.32%+25,439
IHS Holding Limited
ORD SHS
2,357,5202,357,520012,30613,1080.68%+802
Foghorn Therapeutics Inc720,720720,72002,6313,3870.18%+757
Atlassian Corp03,500+3,50007110.04%+711
Instil Bio Inc203,933203,93303,5404,2480.22%+708
Gossamer Bio Inc5,208,9685,208,96805,7306,4070.33%+677
CrowdStrike Holdings Inc(CRWD)25,00018,500-6,5008,8159,4220.49%+608
Workiva Inc(WK)17,50028,000+10,5001,3281,9170.10%+588
Rapport Therapeutics Inc(RAPP)378,469378,46903,7964,3030.22%+507
Jfrog Ltd(FROG)131,616107,116-24,5004,2124,7000.24%+489
CCC Intelligent Solutions Holdings Inc(CCC)050,000+50,00004710.02%+471
Arcus Biosciences Inc(RCUS)01,612,077+1,612,077013,1220.68%+13,122
Datadog Inc(DDOG)47,42538,425-9,0004,7055,1620.27%+457
Palo Alto Networks Inc(PANW)11,50011,50001,9622,3530.12%+391
PG&E Corp(PCG)025,000+25,00003490.02%+349
Lexeo Therapeutics Inc603,435603,43502,0942,4260.13%+332
Denali Therapeutics Inc(DNLI)0821,513+821,513011,4930.59%+11,493
Vertiv Holdings Co(VRT)02,000+2,00002570.01%+257
Whitehawk Therapeutics Inc2,082,0002,082,00003,7063,8930.20%+187
BIOAGE Labs Inc(BIOA)382,406382,40601,4381,5790.08%+141
HOOKIPA Pharma Inc566,640566,64006127110.04%+99
New Oriental Education & Technology Group Inc(EDU)79,50072,000-7,5003,8013,8840.20%+84
Qualcomm Inc(QCOM)14,00014,00002,1512,2300.12%+79
Tourmaline Bio Inc91,42691,42601,3911,4620.08%+71
Cyclerion Therapeutics Inc116,155116,15502903380.02%+48
Caribou Biosciences Inc105,347105,3470961330.01%+37
Procore Technologies Inc(PCOR)10,00010,00006606840.04%+24
Dynatrace Inc(DT)87,72975,229-12,5004,1364,1530.21%+17
SEMrush Holdings Inc
CL A COM
125,000125,00001,1661,1310.06%-35
Cullinan Therapeutics Inc(CGEM)01,193,410+1,193,41008,9860.47%+8,986
Ironwood Pharmaceuticals Inc110,532110,5320162800.00%-83
IGM Biosciences Inc03,255,826+3,255,82603,6470.19%+3,647
Nebius Group NV(NBIS)140,00051,000-89,0002,9552,8220.15%-134
Vigil Neuroscience Inc1,967,064411,191-1,555,8733,5013,2690.17%-232
Ke Holdings Inc(BEKE)105,000105,00002,1091,8630.10%-247
Generation Bio Co2,968,9252,968,92501,2029500.05%-252
GDS Holdings Ltd(GDS)12,5000-12,5003170-317
Deckers Outdoor Corp(DECK)5,0002,000-3,0005592060.01%-353
Spyre Therapeutics Inc(SYRE)368,598368,59805,9475,5180.29%-429
Eledon Pharmaceuticals Inc690,170690,17002,3401,8700.10%-469
Occidental Petroleum Corp(OXY)10,0000-10,0004940-494
Remitly Global Inc(RELY)490,449515,449+25,00010,2019,6750.50%-526
US Bancorp(USB)12,5000-12,5005280-528
Ferrari NV
COM
1,5000-1,5006360-636
SailPoint Inc(SAIL)95,00050,000-45,0001,7811,1430.06%-638
Kronos Bio Inc842,9540-842,9546950-695
PDD Holdings Inc(PDD)52,90152,90106,2615,5370.29%-724
Couchbase Inc49,8500-49,8507850-785
Boeing Co(BA)000000
Informatica Inc50,0000-50,0008730-872
Erasca Inc(ERAS)08,757,249+8,757,249011,1220.58%+11,122
Intel Corp(INTC)40,0000-40,0009080-908
Nike Inc(NKE)15,0000-15,0009520-952
MongoDB Inc(MDB)5,5000-5,5009650-965
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