Fund Holdings — Siren, L.L.C.

Total Portfolio Value:
$4.93B
Total Bought:
$1.20B
Total Sold:
$448.37M
Net Transaction:
+$752.13M
Securities
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SharesValue
Q1 2026
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Q2 2026
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Change
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Q1 2026
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Q2 2026
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Weight (%)
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Change
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Scholar Rock Holding Corporation(SRRK)10,825,0139,575,013-1,250,000$532.16M$526.63M10.69%-$5.53M
Kymera Therapeutics, Inc.(KYMR)3,186,8302,935,830-251,000$265.43M$336.65M6.83%+$71.22M
Erasca, Inc.(ERAS)11,244,24611,397,781+153,535$181.93M$208.81M4.24%+$26.88M
Veradermics, Incorporated(MANE)1,505,3741,655,374+150,000$95.06M$203.51M4.13%+$108.45M
Tango Therapeutics, Inc.(TNGX)5,657,1056,179,364+522,259$118.35M$193.17M3.92%+$74.82M
Revolution Medicines, Inc.(RVMD)1,110,980900,000-210,980$108.04M$168.55M3.42%+$60.51M
Bicara Therapeutics Inc5,802,9705,602,970-200,000$115.42M$166.35M3.38%+$50.93M
Arrowhead Pharmaceuticals, Inc.(ARWR)1,615,4761,715,476+100,000$101.29M$139.83M2.84%+$38.54M
BeOne Medicines AG(ONC)465,000465,0000$138.09M$132.51M2.69%-$5.58M
Edgewise Therapeutics, Inc.(EWTX)4,430,2633,184,629-1,245,634$139.55M$129.39M2.63%-$10.16M
Rhythm Pharmaceuticals, Inc.(RYTM)725,5111,136,275+410,764$63.10M$126.16M2.56%+$63.06M
Lexicon Pharmaceuticals Inc44,303,51844,303,5180$69.11M$106.33M2.16%+$37.21M
Enliven Therapeutics Inc746,2261,774,411+1,028,185$29.25M$90.05M1.83%+$60.80M
Spyre Therapeutics, Inc.(SYRE)818,598968,598+150,000$41.29M$85.99M1.75%+$44.70M
Parabilis Medicines Inc02,992,259+2,992,259$0$81.90M1.66%+$81.90M
Xenon Pharmaceuticals Inc.(XENE)1,318,5641,318,5640$76.67M$79.59M1.62%+$2.91M
Solid Biosciences Inc7,690,4057,690,4050$55.37M$76.83M1.56%+$21.46M
ABIVAX Société Anonyme(ABVX)0576,000+576,000$0$76.76M1.56%+$76.76M
Hemab Therapeutics Holdings Inc02,086,834+2,086,834$0$76.65M1.56%+$76.65M
Arcus Biosciences, Inc.(RCUS)3,007,0772,420,430-586,647$64.95M$74.62M1.51%+$9.67M
Cogent Biosciences, Inc.(COGT)1,709,2791,859,279+150,000$65.79M$71.95M1.46%+$6.16M
Relay Therapeutics, Inc.(RLAY)03,650,000+3,650,000$0$68.29M1.39%+$68.29M
Taysha Gene Therapies, Inc.(TSHA)8,829,9139,846,579+1,016,666$39.47M$67.06M1.36%+$27.59M
Definium Therapeutics, Inc.(DFTX)919,4931,419,493+500,000$17.38M$66.77M1.36%+$49.39M
Stoke Therapeutics, Inc.(STOK)1,995,3471,995,3470$64.97M$65.29M1.33%+$319.3K
Disc Medicine, Inc.(IRON)988,401888,401-100,000$63.20M$64.98M1.32%+$1.78M
Cytokinetics, Incorporated(CYTK)613,952758,952+145,000$40.47M$64.66M1.31%+$24.19M
Septerna, Inc.(SEPN)2,000,0001,900,000-100,000$48.06M$63.63M1.29%+$15.57M
Olema Pharmaceuticals Inc4,756,9494,856,949+100,000$70.93M$60.76M1.23%-$10.17M
Crinetics Pharmaceuticals Inc1,903,6361,420,788-482,848$69.14M$53.17M1.08%-$15.97M
Kailera Therapeutics Inc02,214,286+2,214,286$0$48.78M0.99%+$48.78M
Dyne Therapeutics, Inc.(DYN)2,229,1252,129,125-100,000$40.41M$47.29M0.96%+$6.87M
Structure Therapeutics Inc1,328,698872,967-455,731$64.04M$46.85M0.95%-$17.19M
Taboola.com Ltd.(TBLA)9,969,4958,423,410-1,546,085$30.91M$42.12M0.86%+$11.21M
Palvella Therapeutics, Inc.(PVLA)257,485257,4850$32.10M$39.35M0.80%+$7.25M
Silence Therapeutics PLC2,911,4383,311,438+400,000$15.34M$36.36M0.74%+$21.02M
Denali Therapeutics Inc.(DNLI)1,396,5131,396,5130$26.81M$35.92M0.73%+$9.11M
Remitly Global, Inc.(RELY)1,543,2711,543,2710$24.18M$34.58M0.70%+$10.40M
Cullinan Therapeutics, Inc.(CGEM)1,193,4101,893,410+700,000$16.96M$34.48M0.70%+$17.52M
Capital One Financial Corporation(COF)0171,615+171,615$0$34.43M0.70%+$34.43M
Trevi Therapeutics, Inc.(TRVI)1,786,8671,786,8670$21.32M$33.33M0.68%+$12.01M
ORIC Pharmaceuticals, Inc.(ORIC)2,998,1922,998,1920$37.99M$32.47M0.66%-$5.52M
Alphabet Inc.(GOOG)65,70390,000+24,297$18.89M$32.16M0.65%+$13.27M
Dbv Technologies SA1,857,3621,857,3620$38.80M$30.46M0.62%-$8.34M
Absci Corp1,800,0002,474,764+674,764$5.40M$28.68M0.58%+$23.28M
Sionna Therapeutics Inc300,000610,515+310,515$12.03M$26.86M0.55%+$14.83M
Rapport Therapeutics, Inc.(RAPP)641,469641,4690$20.07M$26.73M0.54%+$6.66M
Amylyx Pharmaceuticals, Inc.(AMLX)1,230,0001,480,586+250,586$17.10M$26.59M0.54%+$9.49M
Annexon Inc3,958,6464,458,646+500,000$21.93M$25.46M0.52%+$3.53M
Monopar Therapeutics Inc270,118270,1180$14.80M$25.01M0.51%+$10.21M
Oruka Therapeutics, Inc.(ORKA)0250,000+250,000$0$23.79M0.48%+$23.79M
Seaport Therapeutics Inc01,095,316+1,095,316$0$23.79M0.48%+$23.79M
Damora Therapeutics, Inc.(DMRA)900,000900,0000$23.31M$23.41M0.48%+$99.0K
Tyra Biosciences, Inc.(TYRA)0725,000+725,000$0$23.16M0.47%+$23.16M
Zura Bio Ltd3,734,8663,734,8660$22.22M$22.04M0.45%-$186.7K
Taiwan Semiconductor Manufacturing Company Limited(TSM)42,20044,700+2,500$14.26M$21.35M0.43%+$7.09M
NVIDIA Corporation(NVDA)89,08595,000+5,915$15.54M$19.01M0.39%+$3.47M
Rezolute Inc3,328,2873,328,2870$10.15M$17.31M0.35%+$7.16M
MapLight Therapeutics Inc450,000450,0000$9.15M$16.13M0.33%+$6.98M
Neumora Therapeutics Inc8,497,8228,497,8220$16.57M$14.45M0.29%-$2.12M
Nebius Group N.V.(NBIS)113,61452,000-61,614$11.79M$14.36M0.29%+$2.57M
Microsoft Corporation(MSFT)41,38037,500-3,880$15.32M$13.99M0.28%-$1.33M
CytomX Therapeutics Inc3,457,7113,457,7110$16.25M$12.97M0.26%-$3.28M
Generate Biomedicines, Inc.(GENB)736,104736,1040$9.20M$12.42M0.25%+$3.22M
Inhibikase Therapeutics Inc5,850,0005,850,0000$9.83M$11.88M0.24%+$2.05M
Adagene Inc02,666,666+2,666,666$0$11.20M0.23%+$11.20M
enGene Therapeutics Inc06,256,662+6,256,662$0$10.82M0.22%+$10.82M
Whitehawk Therapeutics Inc2,082,0002,337,102+255,102$7.18M$10.70M0.22%+$3.52M
Datadog, Inc.(DDOG)54,30040,000-14,300$6.41M$10.41M0.21%+$4.00M
ServiceNow, Inc.(NOW)87,090100,000+12,910$9.11M$9.93M0.20%+$822.7K
Broadcom Inc.(AVGO)15,00025,000+10,000$4.64M$9.44M0.19%+$4.80M
IonQ, Inc.(IONQ)170,000170,0000$4.90M$9.05M0.18%+$4.15M
JFrog Ltd.(FROG)128,81695,500-33,316$6.05M$8.68M0.18%+$2.63M
Oculis Holding AG0625,000+625,000$0$8.67M0.18%+$8.67M
IREN Ltd
ORDINARY SHARES
43,100175,000+131,900$1.48M$8.00M0.16%+$6.53M
Amazon.com, Inc.(AMZN)46,64132,500-14,141$9.71M$7.75M0.16%-$1.97M
CrowdStrike Holdings, Inc.(CRWD)23,07010,000-13,070$9.01M$7.63M0.15%-$1.38M
Design Therapeutics Inc0523,212+523,212$0$7.57M0.15%+$7.57M
PDD Holdings Inc.(PDD)83,40195,000+11,599$8.52M$7.25M0.15%-$1.28M
Satellos Bioscience Inc892,074892,0740$5.02M$6.94M0.14%+$1.91M
Dynatrace, Inc.(DT)150,000155,000+5,000$5.55M$6.81M0.14%+$1.26M
Tenax Therapeutics Inc427,141427,1410$6.83M$6.21M0.13%-$615.1K
vTv Therapeutics Inc163,000163,0000$6.46M$6.14M0.12%-$327.6K
Eloxx Pharmaceuticals Inc0400,000+400,000$0$5.55M0.11%+$5.55M
Agomab Therapeutics NV411,250411,2500$4.31M$5.34M0.11%+$1.02M
Alibaba Group Holding Limited(BABA)050,000+50,000$0$4.80M0.10%+$4.80M
Korro Bio Inc347,718347,7180$3.94M$4.58M0.09%+$646.8K
Cellebrite DI Ltd.(CLBT)311,544311,5440$4.29M$4.55M0.09%+$255.5K
Invivyd Inc4,000,0005,000,000+1,000,000$5.20M$4.36M0.09%-$838.0K
Ouster, Inc.(OUST)067,500+67,500$0$4.22M0.09%+$4.22M
Palisade Bio Inc02,000,000+2,000,000$0$4.18M0.08%+$4.18M
Aeva Technologies, Inc.(AEVA)110,000145,459+35,459$1.45M$4.18M0.08%+$2.73M
Seer Inc2,458,6732,458,6730$4.13M$4.08M0.08%-$49.2K
NovaBridge Biosciences3,000,0002,004,739-995,261$7.38M$3.91M0.08%-$3.47M
GitLab Inc.(GTLB)100,000125,000+25,000$2.16M$3.82M0.08%+$1.65M
Odyssey Therapeutics Inc0200,000+200,000$0$3.74M0.08%+$3.74M
Foghorn Therapeutics Inc720,720720,7200$3.45M$3.52M0.07%+$72.1K
Agenus Inc1,064,2501,064,2500$3.55M$3.26M0.07%-$298.0K
monday.com Ltd
SHS
25,00042,500+17,500$1.73M$3.08M0.06%+$1.35M
Zoetis Inc.(ZTS)035,000+35,000$0$2.52M0.05%+$2.52M
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Siren, L.L.C. — 13F Holdings — Q2 2026 | TickerTrail