Fund HoldingsSiren, L.L.C.

Total Portfolio Value
$4.93B
Total Bought
$1.20B
Total Sold
$448.37M
Net Transaction
+$752.13M
Filing Period:
Securities
SharesValue ($K)
Q1 2026
Q2 2026
Change
Q1 2026
Q2 2026
Weight (%)
Change
Veradermics Inc(MANE)1,505,3741,655,374+150,00095,064203,5124.13%+108,447
Parabilis Medicines Inc02,992,259+2,992,259081,8981.66%+81,898
Abivax SA(ABVX)0576,000+576,000076,7581.56%+76,758
Hemab Therapeutics Holdings Inc02,086,834+2,086,834076,6491.56%+76,649
Tango Therapeutics Inc(TNGX)5,657,1056,179,364+522,259118,347193,1673.92%+74,820
Kymera Therapeutics Inc(KYMR)3,186,8302,935,830-251,000265,431336,6526.83%+71,221
Relay Therapeutics Inc(RLAY)03,650,000+3,650,000068,2921.39%+68,292
Rhythm Pharmaceuticals Inc(RYTM)725,5111,136,275+410,76463,098126,1612.56%+63,063
Enliven Therapeutics Inc746,2261,774,411+1,028,18529,25290,0511.83%+60,799
Revolution Medicines Inc(RVMD)1,110,980900,000-210,980108,043168,5523.42%+60,509
Bicara Therapeutics Inc5,802,9705,602,970-200,000115,421166,3523.38%+50,931
Definium Therapeutics Inc(DFTX)919,4931,419,493+500,00017,37866,7731.36%+49,395
Kailera Therapeutics Inc02,214,286+2,214,286048,7810.99%+48,781
Spyre Therapeutics Inc(SYRE)818,598968,598+150,00041,29085,9921.75%+44,702
Arrowhead Pharmaceuticals Inc(ARWR)1,615,4761,715,476+100,000101,290139,8282.84%+38,538
Lexicon Pharmaceuticals Inc(LXRX)44,303,51844,303,518069,113106,3282.16%+37,215
Capital One Finl Corp(COF)0171,615+171,615034,4290.70%+34,429
Taysha Gene Therapies Inc(TSHA)8,829,9139,846,579+1,016,66639,47067,0551.36%+27,585
Erasca Inc(ERAS)11,244,24611,397,781+153,535181,932208,8074.24%+26,875
Cytokinetics Inc(CYTK)613,952758,952+145,00040,46664,6551.31%+24,190
Oruka Therapeutics Inc(ORKA)0250,000+250,000023,7930.48%+23,793
Seaport Therapeutics Inc01,095,316+1,095,316023,7900.48%+23,790
Absci Corp1,800,0002,474,764+674,7645,40028,6830.58%+23,283
Tyra Biosciences Inc(TYRA)0725,000+725,000023,1570.47%+23,157
Solid Biosciences Inc7,690,4057,690,405055,37176,8271.56%+21,456
Silence Therapeutics PLC(SLN)2,911,4383,311,438+400,00015,34336,3600.74%+21,016
Cullinan Therapeutics Inc(CGEM)1,193,4101,893,410+700,00016,95834,4790.70%+17,521
Septerna Inc(SEPN)2,000,0001,900,000-100,00048,06063,6311.29%+15,571
Sionna Therapeutics Inc(SION)300,000610,515+310,51512,02726,8570.55%+14,830
Alphabet Inc(GOOG)65,70390,000+24,29718,89432,1630.65%+13,270
Trevi Therapeutics Inc(TRVI)1,786,8671,786,867021,31733,3250.68%+12,008
Taboola.com Ltd(TBLA)9,969,4958,423,410-1,546,08530,90542,1170.86%+11,212
Adagene Inc02,666,666+2,666,666011,2000.23%+11,200
enGene Therapeutics Inc(ENGN)06,256,662+6,256,662010,8240.22%+10,824
Remitly Global Inc(RELY)1,543,2711,543,271024,18334,5850.70%+10,402
Monopar Therapeutics Inc(MNPR)270,118270,118014,80025,0100.51%+10,210
Arcus Biosciences Inc(RCUS)3,007,0772,420,430-586,64764,95374,6221.51%+9,669
Amylyx Pharmaceuticals Inc(AMLX)1,230,0001,480,586+250,58617,09726,5910.54%+9,494
Denali Therapeutics Inc(DNLI)1,396,5131,396,513026,81335,9180.73%+9,105
Oculis Holding AG(OCS)0625,000+625,00008,6690.18%+8,669
Design Therapeutics Inc(DSGN)0523,212+523,21207,5710.15%+7,571
Palvella Therapeutics Inc(PVLA)257,485257,485032,09639,3490.80%+7,253
Rezolute Inc(RZLT)3,328,2873,328,287010,15117,3070.35%+7,156
Taiwan Semiconductor Manufacturing Co Ltd(TSM)42,20044,700+2,50014,26121,3470.43%+7,086
MapLight Therapeutics Inc(MPLT)450,000450,00009,14916,1280.33%+6,980
Dyne Therapeutics, Inc(DYN)2,229,1252,129,125-100,00040,41447,2880.96%+6,874
Rapport Therapeutics Inc(RAPP)641,469641,469020,07226,7300.54%+6,658
IREN Ltd
ORDINARY SHARES
43,100175,000+131,9001,4778,0030.16%+6,525
Cogent Biosciences Inc(COGT)1,709,2791,859,279+150,00065,79071,9541.46%+6,164
Eloxx Pharmaceuticals Inc0400,000+400,00005,5520.11%+5,552
Broadcom Inc(AVGO)15,00025,000+10,0004,6439,4440.19%+4,801
Alibaba Group Holding Ltd(BABA)050,000+50,00004,7990.10%+4,799
Ouster Inc(OUST)067,500+67,50004,2200.09%+4,220
Palisade Bio Inc(PALI)02,000,000+2,000,00004,1800.08%+4,180
IONQ Inc(IONQ)170,000170,00004,9019,0540.18%+4,153
Datadog Inc(DDOG)54,30040,000-14,3006,41010,4140.21%+4,004
Odyssey Therapeutics Inc0200,000+200,00003,7420.08%+3,742
Annexon Inc(ANNX)3,958,6464,458,646+500,00021,93125,4590.52%+3,528
Whitehawk Therapeutics Inc(WHWK)2,082,0002,337,102+255,1027,18310,7040.22%+3,521
NVIDIA Corp(NVDA)89,08595,000+5,91515,53619,0090.39%+3,472
Generate Biomedicines Inc(GENB)736,104736,10409,20112,4180.25%+3,217
Xenon Pharmaceuticals Inc(XENE)1,318,5641,318,564076,67479,5891.62%+2,914
Aeva Technologies Inc(AEVA)110,000145,459+35,4591,4484,1780.08%+2,730
Jfrog Ltd(FROG)128,81695,500-33,3166,0458,6790.18%+2,634
Nebius Group NV(NBIS)113,61452,000-61,61411,78914,3610.29%+2,572
Zoetis Inc(ZTS)035,000+35,00002,5150.05%+2,515
Inhibikase Therapeutics Inc(IKT)5,850,0005,850,00009,82811,8760.24%+2,048
Satellos Bioscience Inc(MSLE)892,074892,07405,0226,9360.14%+1,913
Netflix Inc(NFLX)025,000+25,00001,7850.04%+1,785
Disc Medicine Inc(IRON)988,401888,401-100,00063,19864,9781.32%+1,779
GitLab Inc(GTLB)100,000125,000+25,0002,1643,8160.08%+1,652
Quantinuum Inc020,000+20,00001,6350.03%+1,635
monday.com Ltd
SHS
25,00042,500+17,5001,7283,0770.06%+1,349
Entera Bio Ltd(ENTX)0736,457+736,45701,3040.03%+1,304
Dynatrace, Inc(DT)150,000155,000+5,0005,5476,8060.14%+1,259
Agomab Therapeutics NV(AGMB)411,250411,25004,3145,3380.11%+1,024
Lumentum Holdings Inc(LITE)01,055+1,05509050.02%+905
ServiceNow Inc(NOW)87,090100,000+12,9109,1059,9280.20%+823
Korro Bio Inc(KRRO)347,718347,71803,9364,5830.09%+647
Fox Corp(FOX)010,000+10,00005220.01%+522
AT&T Inc(T)025,000+25,00005180.01%+518
Stoke Therapeutics Inc(STOK)1,995,3471,995,347064,96865,2881.33%+319
Cellebrite DI Ltd(CLBT)311,544311,54404,2934,5490.09%+255
Damora Therapeutics Inc(DMRA)900,000900,000023,31023,4090.48%+99
Foghorn Therapeutics Inc(FHTX)720,720720,72003,4453,5170.07%+72
Rani Therapeutics Holdings Inc(RANI)2,000,0002,000,00001,4701,5210.03%+51
Nu Holdings Ltd.(NU)25,00025,00003593340.01%-25
KE Holdings Inc(BEKE)100,000100,00001,4971,4530.03%-44
Seer Inc(SEER)2,458,6732,458,67304,1314,0810.08%-49
Medline Inc(MDLN)25,00025,00001,1139860.02%-126
Figma Inc(FIG)50,00050,00001,0579050.02%-152
Zura Bio Ltd(ZURA)3,734,8663,734,866022,22222,0360.45%-187
Agenus Inc(AGEN)1,064,2501,064,25003,5553,2570.07%-298
vTv Therapeutics Inc(VTVT)163,000163,00006,4656,1370.12%-328
Tenax Therapeutics Inc(TENX)427,141427,14106,8306,2150.13%-615
Kalaris Therapeutics Inc(KLRS)435,798435,79802,5151,7740.04%-741
Invivyd Inc(IVVD)4,000,0005,000,000+1,000,0005,2004,3620.09%-838
Gossamer Bio Inc(GOSS)5,208,9685,208,96801,7118570.02%-854
Primo Brands Corp(PRMB)50,0000-50,0009420-941
PDD Holdings Inc(PDD)83,40195,000+11,5998,5227,2470.15%-1,275
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Siren, L.L.C. — 13F Holdings — Q2 2026 | TickerTrail