Fund Holdings — Siren, L.L.C.

Total Portfolio Value
$2.56B
Total Bought
$364.69M
Total Sold
$255.41M
Net Transaction
+$109.28M
Filing Period:
Securities
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SharesValue ($K)
Q2 2025
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Q3 2025
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Change
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Q2 2025
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Q3 2025
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Weight (%)
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Change
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Arrowhead Pharmaceuticals Inc(ARWR)2,669,8802,669,880042,18492,0843.60%+49,900
Rezolute Inc(RZLT)04,870,000+4,870,000045,7781.79%+45,778
BeOne Medicines AG(ONC)509,990492,990-17,000123,453167,9626.57%+44,508
Kymera Therapeutics Inc(KYMR)3,428,1503,428,1500149,604194,0337.59%+44,429
Bicara Therapeutics Inc5,216,9695,216,969048,46682,3763.22%+33,910
Centessa Pharmaceuticals PLC3,460,0293,227,517-232,51245,46578,2673.06%+32,803
Tango Therapeutics Inc(TNGX)3,364,8145,883,188+2,518,37417,22849,4191.93%+32,191
Structure Therapeutics Inc01,026,811+1,026,811028,7511.12%+28,751
Stoke Therapeutics Inc(STOK)2,247,3472,247,347025,50752,8132.07%+27,305
Rapport Therapeutics Inc(RAPP)378,4691,053,469+675,0004,30331,2881.22%+26,985
Arcus Biosciences Inc(RCUS)1,612,0772,912,077+1,300,00013,12239,6041.55%+26,482
Rhythm Pharmaceuticals Inc(RYTM)409,742499,975+90,23325,89250,4921.98%+24,601
Avidity Biosciences Inc1,110,6101,285,610+175,00031,54156,0142.19%+24,473
Edgewise Therapeutics Inc(EWTX)3,160,2983,897,099+736,80141,43263,2112.47%+21,779
Crinetics Pharmaceuticals Inc(CRNX)1,688,6111,688,611048,56470,3312.75%+21,766
Cogent Biosciences Inc(COGT)854,3791,724,279+869,9006,13424,7610.97%+18,626
Septerna Inc(SEPN)2,202,5142,202,514023,28141,4291.62%+18,149
Scholar Rock Holding Corp(SRRK)9,250,0059,250,0050327,635344,47013.48%+16,835
Remitly Global Inc(RELY)515,4491,618,271+1,102,8229,67526,3781.03%+16,703
Uniqure NV(QURE)0275,200+275,200016,0630.63%+16,063
Lexicon Pharmaceuticals Inc(LXRX)38,918,90338,918,903036,80652,5412.06%+15,735
RAPT Therapeutics Inc0580,466+580,466014,9700.59%+14,970
Korro Bio Inc(KRRO)418,833418,83305,23120,0580.78%+14,827
Revolution Medicines Inc(RVMD)938,7551,043,720+104,96534,53748,7421.91%+14,205
Dyne Therapeutics Inc(DYN)4,836,4374,729,174-107,26346,04359,8242.34%+13,781
Apellis Pharmaceuticals Inc
COM
2,578,3962,578,396044,63258,3492.28%+13,717
Taysha Gene Therapies Inc(TSHA)11,014,73711,014,737025,44436,0181.41%+10,574
Solid Biosciences Inc7,415,9057,415,905036,11545,7561.79%+9,641
Erasca Inc(ERAS)8,757,2498,757,249011,12219,0910.75%+7,969
Gossamer Bio Inc(GOSS)5,208,9685,208,96806,40713,7000.54%+7,293
Xenon Pharmaceuticals Inc(XENE)812,761812,761025,43932,6321.28%+7,193
Upstream Bio Inc(UPB)788,450788,45008,65714,8310.58%+6,174
Nebius Group NV(NBIS)51,00072,600+21,6002,8228,1510.32%+5,329
Neumora Therapeutics Inc(NMRA)4,358,2834,358,28303,1967,9320.31%+4,736
Ascendis Pharma A/S(ASND)245,943235,862-10,08142,45046,8921.83%+4,442
I-Mab(NBP)01,165,957+1,165,95704,4070.17%+4,407
Sionna Therapeutics Inc(SION)325,000325,00005,6399,5580.37%+3,920
vTv Therapeutics Inc(VTVT)0163,000+163,00003,8060.15%+3,806
Eledon Pharmaceuticals Inc(ELDN)690,1702,072,767+1,382,5971,8705,3680.21%+3,498
CoreWeave Inc(CRWV)024,000+24,00003,2840.13%+3,284
PepGen Inc(PEPG)0700,000+700,00003,2340.13%+3,234
IONQ Inc(IONQ)170,000170,00007,30510,4550.41%+3,150
WAVE Life Sciences Ltd(WVE)3,696,3223,696,322024,02627,0571.06%+3,031
IHS Holding Limited
ORD SHS
2,357,5202,357,520013,10816,0780.63%+2,970
Tenax Therapeutics Inc(TENX)0352,441+352,44102,6820.10%+2,682
Disc Medicine Inc(IRON)1,099,401913,401-186,00058,22460,3582.36%+2,133
Keurig Dr Pepper Inc(KDP)077,050+77,05001,9660.08%+1,966
Oric Pharmaceuticals Inc(ORIC)1,007,5751,007,575010,22712,0910.47%+1,864
Chipotle Mexican Grill Inc(CMG)047,500+47,50001,8620.07%+1,862
Generation Bio Co0296,892+296,89201,8170.07%+1,817
Trevi Therapeutics Inc(TRVI)3,938,7932,536,867-1,401,92621,54523,2120.91%+1,667
Bicycle Therapeutics PLC2,012,7522,012,752013,98915,5790.61%+1,590
Lexeo Therapeutics Inc(LXEO)603,435603,43502,4264,0070.16%+1,581
Spotify Technology SA(SPOT)02,173+2,17301,5170.06%+1,517
NIQ Global Intelligence PLC(NIQ)095,000+95,00001,4920.06%+1,492
Black Diamond Therapeutics Inc1,046,5171,046,51702,5953,9660.16%+1,371
monday.com Ltd
SHS
07,000+7,00001,3560.05%+1,356
GitLab Inc(GTLB)35,00064,000+29,0001,5792,8850.11%+1,306
ServiceNow Inc(NOW)5,1267,126+2,0005,2706,5580.26%+1,288
Kalaris Therapeutics Inc(KLRS)282,586318,264+35,6787551,8400.07%+1,085
Elastic NV
ORD SHS
012,500+12,50001,0560.04%+1,056
Salesforce Inc(CRM)22,60030,100+7,5006,1637,1340.28%+971
Taiwan Semiconductor Manufacturing Co Ltd(TSM)30,50028,200-2,3006,9087,8760.31%+968
IREN Ltd
ORDINARY SHARES
020,000+20,00009380.04%+938
Ke Holdings Inc(BEKE)105,000145,000+40,0001,8632,7550.11%+892
Amer Sports Inc(AS)025,000+25,00008690.03%+869
Microsoft Corp(MSFT)16,15017,150+1,0008,0338,8830.35%+850
Pinterest Inc(PINS)025,000+25,00008040.03%+804
Figma Inc(FIG)015,000+15,00007780.03%+778
Confluent Inc037,500+37,50007430.03%+743
Cellebrite DI Ltd(CLBT)60,00090,000+30,0009601,6680.07%+708
Dynatrace Inc(DT)75,229100,229+25,0004,1534,8560.19%+703
Astera Labs Inc(ALAB)03,500+3,50006850.03%+685
BIOAGE Labs Inc(BIOA)382,406382,40601,5792,2490.09%+669
Workiva Inc(WK)28,00030,000+2,0001,9172,5820.10%+666
Spyre Therapeutics Inc(SYRE)368,598368,59805,5186,1780.24%+660
Primo Brands Corp(PRMB)37,50075,000+37,5001,1111,6580.06%+547
Chime Financial Inc(CHYM)025,000+25,00005040.02%+504
Amazon.com Inc(AMZN)56,50058,500+2,00012,39612,8450.50%+449
Denali Therapeutics Inc(DNLI)821,513821,513011,49311,9280.47%+435
Kenvue Inc(KVUE)025,000+25,00004060.02%+406
Palo Alto Networks Inc(PANW)11,50013,450+1,9502,3532,7390.11%+385
Jfrog Ltd(FROG)107,116107,11604,7005,0700.20%+370
HubSpot Inc(HUBS)3,0004,000+1,0001,6701,8710.07%+201
PDD Holdings Inc(PDD)52,90143,401-9,5005,5375,7360.22%+200
NewAmsterdam Pharma Company NV
ORDINARY SHARES
1,194,240765,705-428,53521,62821,7770.85%+149
ProQR Therapeutics NV
SHS EURO
1,552,1831,552,18303,1663,3060.13%+140
Foghorn Therapeutics Inc(FHTX)720,720720,72003,3873,5240.14%+137
Seer Inc(SEER)4,000,0004,000,00008,5608,6800.34%+120
Caribou Biosciences Inc(CRBU)105,347105,34701332450.01%+113
Qualcomm Inc(QCOM)14,00014,00002,2302,3290.09%+99
Ironwood Pharmaceuticals Inc(IRWD)110,532110,5320801450.01%+65
Whitehawk Therapeutics Inc(WHWK)2,082,0002,082,00003,8933,9560.15%+62
Procore Technologies Inc(PCOR)10,00010,00006847290.03%+45
Vertiv Holdings Co(VRT)2,0002,00002573020.01%+45
CCC Intelligent Solutions Holdings Inc(CCC)50,00050,00004714560.02%-15
SailPoint Inc(SAIL)50,00050,00001,1431,1040.04%-39
Cyclerion Therapeutics Inc(CYCN)116,155116,15503382670.01%-71
Cartesian Therapeutics Inc(RNAC)563,272563,27205,8525,7570.23%-96
Deckers Outdoor Corp(DECK)2,0000-2,0002060—-206
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Siren, L.L.C. — 13F Holdings — Q3 2025 | TickerTrail