Siren, L.L.C.
Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q2 2025 ▲▼ | Q3 2025 ▲▼ | Change ▲▼ | Q2 2025 ▲▼ | Q3 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Arrowhead Pharmaceuticals Inc(ARWR) | 2,669,880 | 2,669,880 | 0 | 42,184,104 | 92,084,161 | 3.60% | +49,900,057 |
| Rezolute Inc | 0 | 4,870,000 | +4,870,000 | 0 | 45,778,000 | 1.79% | +45,778,000 |
| BeOne Medicines AG(ONC) | 509,990 | 492,990 | -17,000 | 123,453,279 | 167,961,693 | 6.57% | +44,508,414 |
| Kymera Therapeutics Inc(KYMR) | 3,428,150 | 3,428,150 | 0 | 149,604,466 | 194,033,290 | 7.59% | +44,428,824 |
| Bicara Therapeutics Inc | 5,216,969 | 5,216,969 | 0 | 48,465,642 | 82,375,941 | 3.22% | +33,910,299 |
| Centessa Pharmaceuticals PLC | 3,460,029 | 3,227,517 | -232,512 | 45,464,781 | 78,267,287 | 3.06% | +32,802,506 |
| Tango Therapeutics Inc(TNGX) | 3,364,814 | 5,883,188 | +2,518,374 | 17,227,848 | 49,418,779 | 1.93% | +32,190,931 |
| Structure Therapeutics Inc | 0 | 1,026,811 | +1,026,811 | 0 | 28,750,708 | 1.12% | +28,750,708 |
| Stoke Therapeutics Inc(STOK) | 2,247,347 | 2,247,347 | 0 | 25,507,388 | 52,812,655 | 2.07% | +27,305,267 |
| Rapport Therapeutics Inc(RAPP) | 378,469 | 1,053,469 | +675,000 | 4,303,193 | 31,288,029 | 1.22% | +26,984,836 |
| Arcus Biosciences Inc(RCUS) | 1,612,077 | 2,912,077 | +1,300,000 | 13,122,307 | 39,604,247 | 1.55% | +26,481,940 |
| Rhythm Pharmaceuticals Inc(RYTM) | 409,742 | 499,975 | +90,233 | 25,891,597 | 50,492,475 | 1.98% | +24,600,878 |
| Avidity Biosciences Inc | 1,110,610 | 1,285,610 | +175,000 | 31,541,324 | 56,014,028 | 2.19% | +24,472,704 |
| Edgewise Therapeutics Inc(EWTX) | 3,160,298 | 3,897,099 | +736,801 | 41,431,507 | 63,210,946 | 2.47% | +21,779,439 |
| Crinetics Pharmaceuticals Inc(CRNX) | 1,688,611 | 1,688,611 | 0 | 48,564,452 | 70,330,648 | 2.75% | +21,766,196 |
| Cogent Biosciences Inc(COGT) | 854,379 | 1,724,279 | +869,900 | 6,134,441 | 24,760,646 | 0.97% | +18,626,205 |
| Septerna Inc(SEPN) | 2,202,514 | 2,202,514 | 0 | 23,280,573 | 41,429,288 | 1.62% | +18,148,715 |
| Scholar Rock Holding Corp(SRRK) | 9,250,005 | 9,250,005 | 0 | 327,635,177 | 344,470,186 | 13.48% | +16,835,009 |
| Remitly Global Inc(RELY) | 515,449 | 1,618,271 | +1,102,822 | 9,674,978 | 26,377,817 | 1.03% | +16,702,839 |
| Uniqure NV(QURE) | 0 | 275,200 | +275,200 | 0 | 16,063,424 | 0.63% | +16,063,424 |
| Lexicon Pharmaceuticals Inc(LXRX) | 38,918,903 | 38,918,903 | 0 | 36,805,607 | 52,540,519 | 2.06% | +15,734,912 |
| RAPT Therapeutics Inc | 0 | 580,466 | +580,466 | 0 | 14,970,218 | 0.59% | +14,970,218 |
| Korro Bio Inc | 418,833 | 418,833 | 0 | 5,231,224 | 20,057,912 | 0.78% | +14,826,688 |
| Revolution Medicines Inc(RVMD) | 938,755 | 1,043,720 | +104,965 | 34,536,796 | 48,741,724 | 1.91% | +14,204,928 |
| Dyne Therapeutics Inc(DYN) | 4,836,437 | 4,729,174 | -107,263 | 46,042,880 | 59,824,051 | 2.34% | +13,781,171 |
| Apellis Pharmaceuticals Inc | 2,578,396 | 2,578,396 | 0 | 44,632,035 | 58,349,101 | 2.28% | +13,717,066 |
| Taysha Gene Therapies Inc(TSHA) | 11,014,737 | 11,014,737 | 0 | 25,444,042 | 36,018,190 | 1.41% | +10,574,148 |
| Solid Biosciences Inc | 7,415,905 | 7,415,905 | 0 | 36,115,457 | 45,756,134 | 1.79% | +9,640,677 |
| Erasca Inc(ERAS) | 8,757,249 | 8,757,249 | 0 | 11,121,706 | 19,090,803 | 0.75% | +7,969,097 |
| Gossamer Bio Inc | 5,208,968 | 5,208,968 | 0 | 6,407,031 | 13,699,586 | 0.54% | +7,292,555 |
| Xenon Pharmaceuticals Inc(XENE) | 812,761 | 812,761 | 0 | 25,439,419 | 32,632,354 | 1.28% | +7,192,935 |
| Upstream Bio Inc | 788,450 | 788,450 | 0 | 8,657,181 | 14,830,745 | 0.58% | +6,173,564 |
| Nebius Group NV(NBIS) | 51,000 | 72,600 | +21,600 | 2,821,830 | 8,150,802 | 0.32% | +5,328,972 |
| Neumora Therapeutics Inc | 4,358,283 | 4,358,283 | 0 | 3,195,929 | 7,932,075 | 0.31% | +4,736,146 |
| Ascendis Pharma A/S(ASND) | 245,943 | 235,862 | -10,081 | 42,449,762 | 46,891,724 | 1.83% | +4,441,962 |
| I-Mab | 0 | 1,165,957 | +1,165,957 | 0 | 4,407,317 | 0.17% | +4,407,317 |
| Sionna Therapeutics Inc(SION) | 325,000 | 325,000 | 0 | 5,638,750 | 9,558,250 | 0.37% | +3,919,500 |
| vTv Therapeutics Inc | 0 | 163,000 | +163,000 | 0 | 3,806,050 | 0.15% | +3,806,050 |
| Eledon Pharmaceuticals Inc | 690,170 | 2,072,767 | +1,382,597 | 1,870,361 | 5,368,467 | 0.21% | +3,498,106 |
| CoreWeave Inc(CRWV) | 0 | 24,000 | +24,000 | 0 | 3,284,400 | 0.13% | +3,284,400 |
| PepGen Inc | 0 | 700,000 | +700,000 | 0 | 3,234,000 | 0.13% | +3,234,000 |
| IONQ Inc(IONQ) | 170,000 | 170,000 | 0 | 7,304,900 | 10,455,000 | 0.41% | +3,150,100 |
| WAVE Life Sciences Ltd(WVE) | 3,696,322 | 3,696,322 | 0 | 24,026,093 | 27,057,077 | 1.06% | +3,030,984 |
| IHS Holding Limited | 2,357,520 | 2,357,520 | 0 | 13,107,811 | 16,078,286 | 0.63% | +2,970,475 |
| Tenax Therapeutics Inc | 0 | 352,441 | +352,441 | 0 | 2,682,076 | 0.10% | +2,682,076 |
| Disc Medicine Inc(IRON) | 1,099,401 | 913,401 | -186,000 | 58,224,277 | 60,357,538 | 2.36% | +2,133,261 |
| Keurig Dr Pepper Inc(KDP) | 0 | 77,050 | +77,050 | 0 | 1,965,546 | 0.08% | +1,965,546 |
| Oric Pharmaceuticals Inc(ORIC) | 1,007,575 | 1,007,575 | 0 | 10,226,886 | 12,090,900 | 0.47% | +1,864,014 |
| Chipotle Mexican Grill Inc(CMG) | 0 | 47,500 | +47,500 | 0 | 1,861,525 | 0.07% | +1,861,525 |
| Generation Bio Co | 0 | 296,892 | +296,892 | 0 | 1,816,979 | 0.07% | +1,816,979 |
| Trevi Therapeutics Inc(TRVI) | 3,938,793 | 2,536,867 | -1,401,926 | 21,545,198 | 23,212,333 | 0.91% | +1,667,135 |
| Bicycle Therapeutics PLC | 2,012,752 | 2,012,752 | 0 | 13,988,626 | 15,578,700 | 0.61% | +1,590,074 |
| Lexeo Therapeutics Inc | 603,435 | 603,435 | 0 | 2,425,809 | 4,006,808 | 0.16% | +1,580,999 |
| Spotify Technology SA(SPOT) | 0 | 2,173 | +2,173 | 0 | 1,516,754 | 0.06% | +1,516,754 |
| NIQ Global Intelligence PLC(NIQ) | 0 | 95,000 | +95,000 | 0 | 1,491,500 | 0.06% | +1,491,500 |
| Black Diamond Therapeutics Inc | 1,046,517 | 1,046,517 | 0 | 2,595,362 | 3,966,299 | 0.16% | +1,370,937 |
| monday.com Ltd | 0 | 7,000 | +7,000 | 0 | 1,355,830 | 0.05% | +1,355,830 |
| GitLab Inc(GTLB) | 35,000 | 64,000 | +29,000 | 1,578,850 | 2,885,120 | 0.11% | +1,306,270 |
| ServiceNow Inc(NOW) | 5,126 | 7,126 | +2,000 | 5,269,938 | 6,557,915 | 0.26% | +1,287,977 |
| Kalaris Therapeutics Inc | 282,586 | 318,264 | +35,678 | 754,505 | 1,839,566 | 0.07% | +1,085,061 |
| Elastic NV | 0 | 12,500 | +12,500 | 0 | 1,056,125 | 0.04% | +1,056,125 |
| Salesforce Inc(CRM) | 22,600 | 30,100 | +7,500 | 6,162,794 | 7,133,700 | 0.28% | +970,906 |
| Taiwan Semiconductor Manufacturing Co Ltd(TSM) | 30,500 | 28,200 | -2,300 | 6,907,945 | 7,875,978 | 0.31% | +968,033 |
| IREN Ltd | 0 | 20,000 | +20,000 | 0 | 938,100 | 0.04% | +938,100 |
| Ke Holdings Inc(BEKE) | 105,000 | 145,000 | +40,000 | 1,862,700 | 2,755,000 | 0.11% | +892,300 |
| Amer Sports Inc(AS) | 0 | 25,000 | +25,000 | 0 | 868,750 | 0.03% | +868,750 |
| Microsoft Corp(MSFT) | 16,150 | 17,150 | +1,000 | 8,033,172 | 8,882,843 | 0.35% | +849,671 |
| Pinterest Inc(PINS) | 0 | 25,000 | +25,000 | 0 | 804,250 | 0.03% | +804,250 |
| Figma Inc(FIG) | 0 | 15,000 | +15,000 | 0 | 778,050 | 0.03% | +778,050 |
| Confluent Inc | 0 | 37,500 | +37,500 | 0 | 742,500 | 0.03% | +742,500 |
| Cellebrite DI Ltd(CLBT) | 60,000 | 90,000 | +30,000 | 960,000 | 1,667,700 | 0.07% | +707,700 |
| Dynatrace Inc(DT) | 75,229 | 100,229 | +25,000 | 4,153,393 | 4,856,095 | 0.19% | +702,702 |
| Astera Labs Inc(ALAB) | 0 | 3,500 | +3,500 | 0 | 685,300 | 0.03% | +685,300 |
| BIOAGE Labs Inc(BIOA) | 382,406 | 382,406 | 0 | 1,579,337 | 2,248,547 | 0.09% | +669,210 |
| Workiva Inc(WK) | 28,000 | 30,000 | +2,000 | 1,916,600 | 2,582,400 | 0.10% | +665,800 |
| Spyre Therapeutics Inc(SYRE) | 368,598 | 368,598 | 0 | 5,517,912 | 6,177,702 | 0.24% | +659,790 |
| Primo Brands Corp(PRMB) | 37,500 | 75,000 | +37,500 | 1,110,750 | 1,657,500 | 0.06% | +546,750 |
| Chime Financial Inc(CHYM) | 0 | 25,000 | +25,000 | 0 | 504,250 | 0.02% | +504,250 |
| Amazon.com Inc(AMZN) | 56,500 | 58,500 | +2,000 | 12,395,535 | 12,844,845 | 0.50% | +449,310 |
| Denali Therapeutics Inc(DNLI) | 821,513 | 821,513 | 0 | 11,492,967 | 11,928,369 | 0.47% | +435,402 |
| Kenvue Inc(KVUE) | 0 | 25,000 | +25,000 | 0 | 405,750 | 0.02% | +405,750 |
| Palo Alto Networks Inc(PANW) | 11,500 | 13,450 | +1,950 | 2,353,360 | 2,738,689 | 0.11% | +385,329 |
| Jfrog Ltd(FROG) | 107,116 | 107,116 | 0 | 4,700,250 | 5,069,800 | 0.20% | +369,550 |
| HubSpot Inc(HUBS) | 3,000 | 4,000 | +1,000 | 1,669,890 | 1,871,200 | 0.07% | +201,310 |
| PDD Holdings Inc(PDD) | 52,901 | 43,401 | -9,500 | 5,536,619 | 5,736,310 | 0.22% | +199,691 |
| NewAmsterdam Pharma Company NV | 1,194,240 | 765,705 | -428,535 | 21,627,686 | 21,776,650 | 0.85% | +148,964 |
| ProQR Therapeutics NV | 1,552,183 | 1,552,183 | 0 | 3,166,453 | 3,306,150 | 0.13% | +139,697 |
| Foghorn Therapeutics Inc | 720,720 | 720,720 | 0 | 3,387,384 | 3,524,321 | 0.14% | +136,937 |
| Seer Inc | 4,000,000 | 4,000,000 | 0 | 8,560,000 | 8,680,000 | 0.34% | +120,000 |
| Caribou Biosciences Inc | 105,347 | 105,347 | 0 | 132,737 | 245,459 | 0.01% | +112,722 |
| Qualcomm Inc(QCOM) | 14,000 | 14,000 | 0 | 2,229,640 | 2,329,040 | 0.09% | +99,400 |
| Ironwood Pharmaceuticals Inc | 110,532 | 110,532 | 0 | 79,583 | 144,797 | 0.01% | +65,214 |
| Whitehawk Therapeutics Inc | 2,082,000 | 2,082,000 | 0 | 3,893,340 | 3,955,800 | 0.15% | +62,460 |
| Procore Technologies Inc(PCOR) | 10,000 | 10,000 | 0 | 684,200 | 729,200 | 0.03% | +45,000 |
| Vertiv Holdings Co(VRT) | 2,000 | 2,000 | 0 | 256,820 | 301,720 | 0.01% | +44,900 |
| CCC Intelligent Solutions Holdings Inc(CCC) | 50,000 | 50,000 | 0 | 470,500 | 455,500 | 0.02% | -15,000 |
| SailPoint Inc(SAIL) | 50,000 | 50,000 | 0 | 1,143,000 | 1,104,000 | 0.04% | -39,000 |
| Cyclerion Therapeutics Inc | 116,155 | 116,155 | 0 | 338,011 | 267,157 | 0.01% | -70,854 |
| Cartesian Therapeutics Inc | 563,272 | 563,272 | 0 | 5,852,396 | 5,756,640 | 0.23% | -95,756 |
| Deckers Outdoor Corp(DECK) | 2,000 | 0 | -2,000 | 206,140 | 0 | — | -206,140 |