Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q3 2024 ▲▼ | Q4 2024 ▲▼ | Change ▲▼ | Q3 2024 ▲▼ | Q4 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Scholar Rock Holding Corporation(SRRK) | 11,259,438 | 9,250,005 | -2,009,433 | $90.19M | $399.79M | 17.66% | +$309.60M |
| BeOne Medicines AGADR(ONC) | 563,314 | 653,721 | +90,407 | $126.47M | $120.75M | 5.34% | -$5.72M |
| Kymera Therapeutics, Inc.(KYMR) | 2,969,733 | 2,969,733 | 0 | $140.56M | $119.47M | 5.28% | -$21.09M |
| Apellis Pharmaceuticals Inc COM | 2,167,224 | 2,816,258 | +649,034 | $62.50M | $89.87M | 3.97% | +$27.36M |
| Crinetics Pharmaceuticals Inc | 1,309,652 | 1,609,652 | +300,000 | $66.92M | $82.30M | 3.64% | +$15.38M |
| argenx SEADR(ARGX) | 143,647 | 115,045 | -28,602 | $77.87M | $70.75M | 3.13% | -$7.12M |
| Bicara Therapeutics Inc | 3,072,827 | 3,272,827 | +200,000 | $78.26M | $57.01M | 2.52% | -$21.25M |
| Arrowhead Pharmaceuticals, Inc.(ARWR) | 2,458,778 | 2,901,681 | +442,903 | $47.63M | $54.55M | 2.41% | +$6.93M |
| NewAmsterdam Pharma Company NV ORDINARY SHARES | 920,564 | 2,095,638 | +1,175,074 | $15.28M | $53.86M | 2.38% | +$38.58M |
| Septerna, Inc.(SEPN) | 0 | 2,202,514 | +2,202,514 | $0 | $50.44M | 2.23% | +$50.44M |
| Centessa Pharmaceuticals PLCADS | 3,258,677 | 3,004,677 | -254,000 | $52.11M | $50.33M | 2.22% | -$1.78M |
| SpringWorks Therapeutics Inc | 1,377,701 | 1,377,701 | 0 | $44.14M | $49.78M | 2.20% | +$5.63M |
| Neumora Therapeutics, Inc.(NMRA) | 2,606,571 | 4,396,100 | +1,789,529 | $34.43M | $46.60M | 2.06% | +$12.17M |
| Wave Life Sciences, Inc.SHS(WVE) | 5,721,172 | 3,750,491 | -1,970,681 | $46.91M | $46.39M | 2.05% | -$520.0K |
| Ascendis Pharma A/SADR(ASND) | 347,921 | 297,321 | -50,600 | $51.95M | $40.93M | 1.81% | -$11.02M |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 0 | 125,942 | +125,942 | $0 | $38.86M | 1.72% | +$38.86M |
| Taboola.com Ltd.(TBLA) | 9,969,495 | 9,969,495 | 0 | $33.50M | $36.39M | 1.61% | +$2.89M |
| Apogee Therapeutics Inc | 0 | 747,325 | +747,325 | $0 | $33.85M | 1.50% | +$33.85M |
| Merus NV | 682,201 | 784,412 | +102,211 | $34.08M | $32.98M | 1.46% | -$1.10M |
| Avidity Biosciences Inc | 1,440,736 | 1,127,295 | -313,441 | $66.17M | $32.78M | 1.45% | -$33.39M |
| Vera Therapeutics, Inc.CL A(VERA) | 837,928 | 758,465 | -79,463 | $37.04M | $32.08M | 1.42% | -$4.96M |
| Dyne Therapeutics, Inc.(DYN) | 1,134,664 | 1,347,456 | +212,792 | $40.76M | $31.75M | 1.40% | -$9.01M |
| Xenon Pharmaceuticals Inc.(XENE) | 743,769 | 743,769 | 0 | $29.28M | $29.16M | 1.29% | -$126.4K |
| Lexicon Pharmaceuticals, Inc.(LXRX) | 38,918,903 | 38,918,903 | 0 | $61.10M | $28.80M | 1.27% | -$32.30M |
| Bicycle Therapeutics PLCADS | 0 | 1,839,398 | +1,839,398 | $0 | $25.75M | 1.14% | +$25.75M |
| Revolution Medicines, Inc.(RVMD) | 753,601 | 571,548 | -182,053 | $34.18M | $25.00M | 1.10% | -$9.18M |
| Vaxcyte, Inc.(PCVX) | 299,991 | 299,991 | 0 | $34.28M | $24.56M | 1.09% | -$9.72M |
| Arcus Biosciences, Inc.(RCUS) | 1,612,077 | 1,612,077 | 0 | $24.65M | $24.00M | 1.06% | -$644.8K |
| Erasca, Inc.(ERAS) | 8,857,179 | 8,857,179 | 0 | $24.18M | $22.23M | 0.98% | -$1.95M |
| Stoke Therapeutics, Inc.(STOK) | 0 | 2,000,000 | +2,000,000 | $0 | $22.06M | 0.97% | +$22.06M |
| IGM Biosciences Inc | 3,330,422 | 3,330,422 | 0 | $55.09M | $20.35M | 0.90% | -$34.74M |
| Edgewise Therapeutics, Inc.(EWTX) | 404,113 | 734,343 | +330,230 | $10.79M | $19.61M | 0.87% | +$8.82M |
| Silence Therapeutics plcADS(SLN) | 2,831,770 | 2,831,770 | 0 | $51.48M | $19.48M | 0.86% | -$32.00M |
| Cytokinetics, Incorporated(CYTK) | 525,971 | 402,323 | -123,648 | $27.77M | $18.93M | 0.84% | -$8.85M |
| Denali Therapeutics Inc.(DNLI) | 834,028 | 834,028 | 0 | $24.30M | $17.00M | 0.75% | -$7.30M |
| Korro Bio, Inc.(KRRO) | 418,833 | 418,833 | 0 | $14.00M | $15.94M | 0.70% | +$1.95M |
| Soleno Therapeutics Inc | 0 | 351,818 | +351,818 | $0 | $15.81M | 0.70% | +$15.81M |
| Prothena Corporation PLCSHS SHS | 1,099,840 | 1,099,840 | 0 | $18.40M | $15.23M | 0.67% | -$3.17M |
| Solid Biosciences Inc | 2,749,041 | 3,749,041 | +1,000,000 | $19.16M | $15.00M | 0.66% | -$4.16M |
| Cullinan Therapeutics, Inc.(CGEM) | 1,211,357 | 1,211,357 | 0 | $20.28M | $14.75M | 0.65% | -$5.52M |
| Upstream Bio, Inc.(UPB) | 0 | 800,000 | +800,000 | $0 | $13.15M | 0.58% | +$13.15M |
| Trevi Therapeutics, Inc.(TRVI) | 0 | 2,906,060 | +2,906,060 | $0 | $11.97M | 0.53% | +$11.97M |
| Kura Oncology, Inc.(KURA) | 1,339,942 | 1,339,942 | 0 | $26.18M | $11.67M | 0.52% | -$14.51M |
| Taysha Gene Therapies, Inc.(TSHA) | 4,879,875 | 6,602,475 | +1,722,600 | $9.81M | $11.42M | 0.50% | +$1.61M |
| Remitly Global, Inc.(RELY) | 25,000 | 490,449 | +465,449 | $334.8K | $11.07M | 0.49% | +$10.73M |
| Cartesian Therapeutics, Inc.(RNAC) | 572,236 | 572,236 | 0 | $9.22M | $10.25M | 0.45% | +$1.02M |
| Microsoft Corporation(MSFT) | 22,000 | 23,000 | +1,000 | $9.46M | $9.69M | 0.43% | +$231.9K |
| Janux Therapeutics, Inc.(JANX) | 0 | 175,000 | +175,000 | $0 | $9.37M | 0.41% | +$9.37M |
| Seer, Inc.CL A(SEER) | 4,000,000 | 4,000,000 | 0 | $7.88M | $9.24M | 0.41% | +$1.36M |
| Ionis Pharmaceuticals, Inc.(IONS) | 250,000 | 250,000 | 0 | $10.02M | $8.74M | 0.39% | -$1.27M |
| Spyre Therapeutics, Inc.(SYRE) | 0 | 374,000 | +374,000 | $0 | $8.71M | 0.38% | +$8.71M |
| CrowdStrike Holdings, Inc.CL A(CRWD) | 25,000 | 24,000 | -1,000 | $7.01M | $8.21M | 0.36% | +$1.20M |
| Iovance Biotherapeutics, Inc.(IOVA) | 1,106,040 | 1,106,040 | 0 | $10.39M | $8.18M | 0.36% | -$2.20M |
| ORIC Pharmaceuticals, Inc.(ORIC) | 1,007,575 | 1,007,575 | 0 | $10.33M | $8.13M | 0.36% | -$2.20M |
| Tango Therapeutics, Inc.(TNGX) | 2,603,897 | 2,603,897 | 0 | $20.05M | $8.05M | 0.36% | -$12.00M |
| Amazon.com, Inc.(AMZN) | 34,750 | 36,500 | +1,750 | $6.47M | $8.01M | 0.35% | +$1.53M |
| Rocket Pharmaceuticals, Inc.(RCKT) | 0 | 600,000 | +600,000 | $0 | $7.54M | 0.33% | +$7.54M |
| IonQ, Inc.(IONQ) | 500,000 | 170,000 | -330,000 | $4.37M | $7.10M | 0.31% | +$2.73M |
| IHS Holding Limited ORD SHS | 2,357,520 | 2,357,520 | 0 | $7.05M | $6.88M | 0.30% | -$165.0K |
| Rapport Therapeutics, Inc.(RAPP) | 384,197 | 384,197 | 0 | $7.87M | $6.82M | 0.30% | -$1.05M |
| NVIDIA Corporation(NVDA) | 48,932 | 48,932 | 0 | $5.94M | $6.57M | 0.29% | +$629.0K |
| ServiceNow, Inc.(NOW) | 7,500 | 5,605 | -1,895 | $6.71M | $5.94M | 0.26% | -$766.0K |
| ACELYRIN Inc | 1,729,665 | 1,729,665 | 0 | $8.53M | $5.43M | 0.24% | -$3.10M |
| PDD Holdings Inc.ADS(PDD) | 40,401 | 52,901 | +12,500 | $5.45M | $5.13M | 0.23% | -$315.6K |
| Gossamer Bio, Inc.(GOSS) | 13,281,610 | 5,208,968 | -8,072,642 | $13.10M | $4.71M | 0.21% | -$8.39M |
| Dynatrace, Inc.(DT) | 82,729 | 82,729 | 0 | $4.42M | $4.50M | 0.20% | +$72.8K |
| The Boeing Company(BA) | 0 | 25,000 | +25,000 | $0 | $4.42M | 0.20% | +$4.42M |
| New Oriental Education & Technology Group Inc.ADR(EDU) | 38,500 | 68,500 | +30,000 | $2.92M | $4.40M | 0.19% | +$1.48M |
| Datadog, Inc.CL A(DDOG) | 32,925 | 30,425 | -2,500 | $3.79M | $4.35M | 0.19% | +$559.1K |
| ProQR Therapeutics NVSHS EURO SHS EURO | 0 | 1,575,000 | +1,575,000 | $0 | $4.17M | 0.18% | +$4.17M |
| Lexeo Therapeutics, Inc.(LXEO) | 603,435 | 603,435 | 0 | $5.46M | $3.97M | 0.18% | -$1.48M |
| Adobe Inc.(ADBE) | 1,000 | 8,798 | +7,798 | $517.8K | $3.91M | 0.17% | +$3.39M |
| Phathom Pharmaceuticals, Inc.(PHAT) | 460,753 | 460,753 | 0 | $8.33M | $3.74M | 0.17% | -$4.59M |
| Instil Bio, Inc.(TIL) | 192,433 | 192,433 | 0 | $12.95M | $3.67M | 0.16% | -$9.28M |
| JFrog Ltd.(FROG) | 61,000 | 120,116 | +59,116 | $1.77M | $3.53M | 0.16% | +$1.76M |
| Foghorn Therapeutics Inc.(FHTX) | 720,720 | 720,720 | 0 | $6.71M | $3.40M | 0.15% | -$3.31M |
| Vigil Neuroscience Inc | 1,991,038 | 1,991,038 | 0 | $6.77M | $3.38M | 0.15% | -$3.38M |
| Nebius Group N.V.CL A(NBIS) | 0 | 120,000 | +120,000 | $0 | $3.32M | 0.15% | +$3.32M |
| Sagimet Biosciences Inc.COM SER A(SGMT) | 724,771 | 724,771 | 0 | $2.01M | $3.26M | 0.14% | +$1.25M |
| Generation Bio Co | 2,982,733 | 2,982,733 | 0 | $7.37M | $3.16M | 0.14% | -$4.21M |
| Taiwan Semiconductor Manufacturing Company LimitedADS(TSM) | 25,000 | 15,000 | -10,000 | $4.34M | $2.96M | 0.13% | -$1.38M |
| Freeport-McMoRan Inc.CL B(FCX) | 0 | 75,000 | +75,000 | $0 | $2.86M | 0.13% | +$2.86M |
| Allovir Inc | 6,597,167 | 6,597,167 | 0 | $5.33M | $2.77M | 0.12% | -$2.56M |
| Ovid Therapeutics Inc.(OVID) | 2,850,000 | 2,850,000 | 0 | $3.36M | $2.66M | 0.12% | -$702.0K |
| Sea LimitedADS(SE) | 37,500 | 25,000 | -12,500 | $3.54M | $2.65M | 0.12% | -$883.0K |
| Elastic NV ORD SHS | 13,000 | 25,000 | +12,000 | $997.9K | $2.48M | 0.11% | +$1.48M |
| QUALCOMM Incorporated(QCOM) | 15,000 | 15,000 | 0 | $2.55M | $2.30M | 0.10% | -$246.4K |
| BioAge Labs, Inc.(BIOA) | 300,000 | 388,000 | +88,000 | $6.24M | $2.25M | 0.10% | -$3.99M |
| Black Diamond Therapeutics Inc | 1,046,517 | 1,046,517 | 0 | $4.55M | $2.24M | 0.10% | -$2.31M |
| REGENXBIO Inc.(RGNX) | 284,000 | 284,000 | 0 | $2.98M | $2.20M | 0.10% | -$783.8K |
| Tourmaline Bio Inc | 91,426 | 91,426 | 0 | $2.35M | $1.85M | 0.08% | -$496.4K |
| Procore Technologies, Inc.(PCOR) | 32,300 | 20,000 | -12,300 | $1.99M | $1.50M | 0.07% | -$495.0K |
| Applied Therapeutics Inc | 1,633,768 | 1,633,768 | 0 | $13.89M | $1.40M | 0.06% | -$12.49M |
| Alphabet Inc.CL A(GOOG) | 11,000 | 7,000 | -4,000 | $1.82M | $1.33M | 0.06% | -$499.0K |
| PayPal Holdings, Inc.(PYPL) | 15,000 | 15,000 | 0 | $1.17M | $1.28M | 0.06% | +$109.8K |
| HOOKIPA Pharma Inc | 566,640 | 566,640 | 0 | $2.44M | $1.14M | 0.05% | -$1.30M |
| HCA Healthcare, Inc.(HCA) | 0 | 3,750 | +3,750 | $0 | $1.13M | 0.05% | +$1.13M |
| KE Holdings Inc.ADS(BEKE) | 100,000 | 60,000 | -40,000 | $1.99M | $1.11M | 0.05% | -$885.8K |
| Workiva Inc.CL A(WK) | 0 | 10,000 | +10,000 | $0 | $1.09M | 0.05% | +$1.09M |
| Palo Alto Networks, Inc.(PANW) | 4,500 | 6,000 | +1,500 | $1.54M | $1.09M | 0.05% | -$446.3K |