Fund HoldingsSiren, L.L.C.

Total Portfolio Value
$2.26B
Total Bought
$435.21M
Total Sold
$490.06M
Net Transaction
-$54.86M
Filing Period:
Securities
SharesValue ($K)
Q3 2024
Q4 2024
Change
Q3 2024
Q4 2024
Weight (%)
Change
Scholar Rock Holding Corp(SRRK)11,259,4389,250,005-2,009,43390,188399,78517.66%+309,597
Septerna Inc(SEPN)02,202,514+2,202,514050,4382.23%+50,438
Madrigal Pharmaceuticals Inc(MDGL)0125,942+125,942038,8621.72%+38,862
NewAmsterdam Pharma Company NV
ORDINARY SHARES
920,5642,095,638+1,175,07415,28153,8582.38%+38,577
Apogee Therapeutics Inc(APGE)0747,325+747,325033,8541.50%+33,854
Apellis Pharmaceuticals Inc
COM
2,167,2242,816,258+649,03462,50389,8673.97%+27,364
Bicycle Therapeutics PLC01,839,398+1,839,398025,7521.14%+25,752
Stoke Therapeutics Inc(STOK)02,000,000+2,000,000022,0600.97%+22,060
Soleno Therapeutics Inc0351,818+351,818015,8140.70%+15,814
Crinetics Pharmaceuticals Inc(CRNX)1,309,6521,609,652+300,00066,92382,3023.64%+15,378
Upstream Bio Inc0800,000+800,000013,1520.58%+13,152
Neumora Therapeutics Inc2,606,5714,396,100+1,789,52934,43346,5992.06%+12,166
Trevi Therapeutics Inc(TRVI)02,906,060+2,906,060011,9730.53%+11,973
Remitly Global Inc(RELY)0490,449+490,449011,0690.49%+11,069
Janux Therapeutics Inc(JANX)0175,000+175,00009,3700.41%+9,370
Edgewise Therapeutics Inc(EWTX)404,113734,343+330,23010,78619,6070.87%+8,821
Spyre Therapeutics Inc(SYRE)0374,000+374,00008,7070.38%+8,707
Rocket Pharmaceuticals Inc0600,000+600,00007,5420.33%+7,542
Arrowhead Pharmaceuticals Inc(ARWR)2,458,7782,901,681+442,90347,62754,5522.41%+6,925
SpringWorks Therapeutics Inc1,377,7011,377,701044,14249,7762.20%+5,635
Boeing Co(BA)025,000+25,00004,4250.20%+4,425
ProQR Therapeutics NV
SHS EURO
01,575,000+1,575,00004,1740.18%+4,174
Adobe Inc(ADBE)08,798+8,79803,9120.17%+3,912
Nebius Group NV(NBIS)0120,000+120,00003,3240.15%+3,324
Taboola.com Ltd(TBLA)9,969,4959,969,495033,49836,3891.61%+2,891
Freeport-McMoRan Inc(FCX)075,000+75,00002,8560.13%+2,856
IONQ Inc(IONQ)500,000170,000-330,0004,3707,1010.31%+2,731
Korro Bio Inc418,833418,833013,99715,9450.70%+1,948
Jfrog Ltd(FROG)61,000120,116+59,1161,7713,5330.16%+1,761
Taysha Gene Therapies Inc(TSHA)4,879,8756,602,475+1,722,6009,80911,4220.50%+1,614
Amazon.com Inc(AMZN)34,75036,500+1,7506,4758,0080.35%+1,533
Elastic NV
ORD SHS
13,00025,000+12,0009982,4770.11%+1,479
New Oriental Education & Technology Group Inc(EDU)38,50068,500+30,0002,9204,3960.19%+1,476
Seer Inc4,000,0004,000,00007,8809,2400.41%+1,360
Sagimet Biosciences Inc724,771724,77102,0083,2610.14%+1,254
CrowdStrike Holdings Inc(CRWD)25,00024,000-1,0007,0128,2120.36%+1,200
HCA Healthcare Inc(HCA)03,750+3,75001,1260.05%+1,126
Workiva Inc(WK)010,000+10,00001,0950.05%+1,095
Cartesian Therapeutics Inc572,236572,23609,22410,2490.45%+1,024
Couchbase Inc060,000+60,00009350.04%+935
Ferrari NV
COM
02,000+2,00008540.04%+854
NVIDIA Corp(NVDA)48,93248,93205,9426,5710.29%+629
Datadog Inc(DDOG)32,92530,425-2,5003,7884,3470.19%+559
Marvell Technology Inc(MRVL)05,000+5,00005520.02%+552
Monday.Com Ltd
SHS
02,000+2,00004710.02%+471
SEMrush Holdings Inc
CL A COM
035,000+35,00004160.02%+416
Microsoft Corp(MSFT)22,00023,000+1,0009,4639,6950.43%+232
PayPal Holdings Inc(PYPL)15,00015,00001,1701,2800.06%+110
Achilles Therapeutics PLC0755,375+755,37508610.04%+861
Cyclerion Therapeutics Inc0116,155+116,15503740.02%+374
Dynatrace Inc(DT)82,72982,72904,4244,4960.20%+73
Dollar Tree Inc(DLTR)010,000+10,00007490.03%+749
Ironwood Pharmaceuticals Inc0110,532+110,53204900.02%+490
Perception Capital Corp III(Call)000000
Gossamer Bio Inc(Call)0207,000+207,0000187+187
Caribou Biosciences Inc0105,347+105,34701680.01%+168
Kronos Bio Inc842,954842,95408438010.04%-42
Kanzhun Ltd(BZ)025,000+25,00003450.02%+345
Xenon Pharmaceuticals Inc(XENE)743,769743,769029,28229,1561.29%-126
Intel Corp(INTC)40,00040,00009388020.04%-136
Nu Holdings Ltd(NU)050,000+50,00005180.02%+518
IHS Holding Limited
ORD SHS
2,357,5202,357,52007,0496,8840.30%-165
Qualcomm Inc(QCOM)15,00015,00002,5512,3040.10%-246
Meta Platforms Inc(META)1,5001,000-5008595860.03%-273
PDD Holdings Inc(PDD)40,40152,901+12,5005,4465,1310.23%-316
GlycoMimetics Inc000000
Palo Alto Networks Inc(PANW)4,5006,000+1,5001,5381,0920.05%-446
Procore Technologies Inc(PCOR)32,30020,000-12,3001,9941,4990.07%-495
Tourmaline Bio Inc91,42691,42602,3511,8540.08%-496
Alphabet Inc(GOOG)11,0007,000-4,0001,8241,3250.06%-499
WAVE Life Sciences Ltd(WVE)5,721,1723,750,491-1,970,68146,91446,3942.05%-520
Omega Therapeutics Inc1,323,5301,323,53001,6159870.04%-628
Arcus Biosciences Inc(RCUS)1,612,0771,612,077024,64924,0041.06%-645
Ovid Therapeutics Inc2,850,0002,850,00003,3632,6610.12%-702
ServiceNow Inc(NOW)7,5005,605-1,8956,7085,9420.26%-766
Regenxbio Inc284,000284,00002,9792,1950.10%-784
Rubrik Inc(RBRK)25,0000-25,0008040-804
Terns Pharmaceuticals Inc100,0000-100,0008340-834
Sea Ltd(SE)37,50025,000-12,5003,5362,6530.12%-883
Ke Holdings Inc(BEKE)100,00060,000-40,0001,9911,1050.05%-886
Rapport Therapeutics Inc(RAPP)384,197384,19707,8686,8160.30%-1,053
Occidental Petroleum Corp(OXY)35,00015,000-20,0001,8047410.03%-1,063
Merus NV682,201784,412+102,21134,08332,9851.46%-1,098
Ionis Pharmaceuticals Inc(IONS)250,000250,000010,0158,7400.39%-1,275
HOOKIPA Pharma Inc566,640566,64002,4371,1390.05%-1,298
Taiwan Semiconductor Manufacturing Co Ltd(TSM)25,00015,000-10,0004,3422,9620.13%-1,379
Lexeo Therapeutics Inc603,435603,43505,4553,9710.18%-1,484
Natera Inc(NTRA)12,5940-12,5941,5990-1,599
Centessa Pharmaceuticals PLC3,258,6773,004,677-254,00052,10650,3282.22%-1,778
Gritstone bio Inc3,318,0930-3,318,0931,9240-1,924
Visa Inc(V)7,0000-7,0001,9250-1,925
Erasca Inc(ERAS)8,857,1798,857,179024,18022,2320.98%-1,949
PayPal Holdings Inc(PYPL)(Call)26,0000-26,0002,0290-2,029
Oric Pharmaceuticals Inc(ORIC)1,007,5751,007,575010,3288,1310.36%-2,197
Iovance Biotherapeutics Inc(IOVA)1,106,0401,106,040010,3868,1850.36%-2,201
Black Diamond Therapeutics Inc1,046,5171,046,51704,5522,2400.10%-2,313
Allovir Inc6,597,1676,597,16705,3342,7710.12%-2,563
ACELYRIN Inc1,729,6651,729,66508,5275,4310.24%-3,096
Prothena Corporation PLC
SHS
1,099,8401,099,840018,40015,2330.67%-3,168
Foghorn Therapeutics Inc.720,720720,72006,7103,4020.15%-3,308
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