Fund HoldingsSiren, L.L.C.

Total Portfolio Value
$3.35B
Total Bought
$864.70M
Total Sold
$423.75M
Net Transaction
+$440.94M
Filing Period:
Securities
SharesValue ($K)
Q3 2025
Q4 2025
Change
Q3 2025
Q4 2025
Weight (%)
Change
Scholar Rock Holding Corp(SRRK)9,250,00510,825,013+1,575,008344,470476,84214.22%+132,372
Olema Pharmaceuticals Inc(OLMA)03,300,700+3,300,700082,5182.46%+82,518
Kymera Therapeutics Inc(KYMR)3,428,1503,286,830-141,320194,033255,7487.63%+61,715
Revolution Medicines Inc(RVMD)1,043,7201,335,075+291,35548,742106,3393.17%+57,597
Edgewise Therapeutics Inc(EWTX)3,897,0994,529,990+632,89163,211112,4123.35%+49,201
Structure Therapeutics Inc1,026,8111,078,698+51,88728,75175,0232.24%+46,273
Zymeworks Inc(ZYME)01,680,121+1,680,121044,2381.32%+44,238
Dbv Technologies SA01,857,362+1,857,362035,6061.06%+35,606
Cogent Biosciences Inc(COGT)1,724,2791,629,279-95,00024,76157,8721.73%+33,111
Arcus Biosciences Inc(RCUS)2,912,0773,007,077+95,00039,60471,6592.14%+32,054
RAPT Therapeutics Inc580,4661,375,000+794,53414,97046,5711.39%+31,601
enGene Holdings Inc
COM
03,336,264+3,336,264030,1260.90%+30,126
Mineralys Therapeutics Inc(MLYS)0699,999+699,999025,4030.76%+25,403
Tango Therapeutics Inc(TNGX)5,883,1888,165,374+2,282,18649,41972,3452.16%+22,926
Centessa Pharmaceuticals PLC3,227,5174,027,517+800,00078,267100,7283.00%+22,461
Fulcrum Therapeutics Inc01,950,000+1,950,000022,0550.66%+22,055
Spyre Therapeutics Inc(SYRE)368,598818,598+450,0006,17826,8170.80%+20,640
Taysha Gene Therapies Inc(TSHA)11,014,73710,129,913-884,82436,01855,7151.66%+19,696
Stoke Therapeutics Inc(STOK)2,247,3472,247,347052,81371,3312.13%+18,518
Disc Medicine Inc(IRON)913,401988,401+75,00060,35878,4892.34%+18,131
WAVE Life Sciences Ltd(WVE)3,696,3222,450,000-1,246,32227,05741,6501.24%+14,593
Septerna Inc(SEPN)2,202,5142,000,000-202,51441,42955,7601.66%+14,331
Monopar Therapeutics Inc0212,298+212,298013,8630.41%+13,863
Erasca Inc(ERAS)8,757,2498,757,249019,09132,5770.97%+13,486
Inhibikase Therapeutics Inc05,850,000+5,850,000011,9930.36%+11,993
Taboola.com Ltd(TBLA)09,969,495+9,969,495045,9591.37%+45,959
Denali Therapeutics Inc(DNLI)821,5131,396,513+575,00011,92823,0560.69%+11,128
Mind Medicine (MindMed) Inc0800,000+800,000010,7120.32%+10,712
Benitec Biopharma Inc0775,000+775,000010,4390.31%+10,439
Invivyd Inc04,000,000+4,000,00009,8800.29%+9,880
Dyne Therapeutics Inc(DYN)4,729,1743,502,941-1,226,23359,82468,5182.04%+8,693
MapLight Therapeutics Inc(MPLT)0450,000+450,00007,9040.24%+7,904
Palvella Therapeutics Inc(PVLA)075,000+75,00007,8500.23%+7,850
NovaBridge Biosciences1,165,9573,000,000+1,834,0434,40711,9400.36%+7,533
Arrowhead Pharmaceuticals Inc(ARWR)2,669,8801,500,476-1,169,40492,08499,6172.97%+7,532
Compass Pathways PLC(CMPS)01,000,000+1,000,00006,9000.21%+6,900
BillionToOne Inc083,833+83,83306,8610.20%+6,861
Zura Bio Ltd01,300,000+1,300,00006,8120.20%+6,812
Apellis Pharmaceuticals Inc
COM
2,578,3962,578,396058,34964,7691.93%+6,420
Savara Inc(SVRA)01,000,000+1,000,00006,0300.18%+6,030
X4 Pharmaceuticals Inc01,500,000+1,500,00006,0000.18%+6,000
Bicara Therapeutics Inc5,216,9695,216,969082,37687,8022.62%+5,426
Trevi Therapeutics Inc(TRVI)2,536,8672,286,867-250,00023,21228,6320.85%+5,419
Cullinan Therapeutics Inc(CGEM)01,193,410+1,193,410012,3520.37%+12,352
Alumis Inc0500,000+500,00004,8800.15%+4,880
Meta Platforms Inc(META)07,169+7,16904,7320.14%+4,732
Workiva Inc(WK)30,00079,123+49,1232,5826,8240.20%+4,242
Xenon Pharmaceuticals Inc(XENE)812,761812,761032,63236,4281.09%+3,796
Ascendis Pharma A/S(ASND)235,862235,862046,89250,2951.50%+3,403
Neumora Therapeutics Inc4,358,2836,288,783+1,930,5007,93211,2570.34%+3,325
Medline Inc(MDLN)075,000+75,00003,1500.09%+3,150
Lexeo Therapeutics Inc603,435720,622+117,1874,0077,1560.21%+3,149
Rhythm Pharmaceuticals Inc(RYTM)499,975499,975050,49253,5171.60%+3,025
Sionna Therapeutics Inc(SION)325,000300,000-25,0009,55812,3420.37%+2,784
vTv Therapeutics Inc163,000163,00003,8066,5180.19%+2,712
Rani Therapeutics Holdings Inc02,000,000+2,000,00002,7000.08%+2,700
Zscaler Inc(ZS)012,000+12,00002,6990.08%+2,699
Silence Therapeutics PLC02,911,438+2,911,438017,7020.53%+17,702
Tenax Therapeutics Inc352,441427,141+74,7002,6825,2070.16%+2,525
Gossamer Bio Inc5,208,9685,208,968013,70016,1480.48%+2,448
Broadcom Inc(AVGO)07,000+7,00002,4230.07%+2,423
Arm Holdings PLC021,500+21,50002,3500.07%+2,350
Kalaris Therapeutics Inc318,264435,798+117,5341,8403,6780.11%+1,839
IHS Holding Limited
ORD SHS
2,357,5202,357,520016,07817,5870.52%+1,509
PDD Holdings Inc(PDD)43,40163,401+20,0005,7367,1890.21%+1,453
Alphabet Inc(GOOG)020,703+20,70306,4800.19%+6,480
PepGen Inc700,000700,00003,2344,5570.14%+1,323
Varonis Systems Inc(VRNS)037,500+37,50001,2300.04%+1,230
monday.com Ltd
SHS
7,00017,000+10,0001,3562,5090.07%+1,153
Upstream Bio Inc788,450588,450-200,00014,83115,9760.48%+1,146
Whitehawk Therapeutics Inc2,082,0002,082,00003,9565,0380.15%+1,083
Cellebrite DI Ltd(CLBT)90,000150,000+60,0001,6682,7060.08%+1,038
GitLab Inc(GTLB)64,00099,000+35,0002,8853,7150.11%+830
Jfrog Ltd(FROG)107,11693,616-13,5005,0705,8470.17%+777
IREN Ltd
ORDINARY SHARES
20,00043,100+23,1009381,6280.05%+690
Taiwan Semiconductor Manufacturing Co Ltd(TSM)28,20027,700-5007,8768,4180.25%+542
Foghorn Therapeutics Inc720,720720,72003,5243,8920.12%+368
Datadog Inc(DDOG)036,425+36,42504,9530.15%+4,953
Figma Inc(FIG)15,00025,000+10,0007789340.03%+156
Dynatrace Inc(DT)100,229115,229+15,0004,8564,9940.15%+138
New Oriental Education & Technology Group Inc(EDU)062,000+62,00003,4120.10%+3,412
Qualcomm Inc(QCOM)14,00014,00002,3292,3950.07%+66
Tesla Inc(TSLA)01,500+1,50006750.02%+675
NVIDIA Corp(NVDA)037,485+37,48506,9910.21%+6,991
Caribou Biosciences Inc105,347105,34702451680.00%-78
Cyclerion Therapeutics Inc116,155115,603-5522671470.00%-120
Ironwood Pharmaceuticals Inc110,5320-110,5321450-145
Crinetics Pharmaceuticals Inc(CRNX)1,688,6111,507,636-180,97570,33170,1802.09%-150
Salesforce Inc(CRM)30,10026,100-4,0007,1346,9140.21%-220
Vertiv Holdings Co(VRT)2,0000-2,0003020-302
Kenvue Inc(KVUE)25,0000-25,0004060-406
Primo Brands Corp(PRMB)75,00075,00001,6581,2260.04%-431
CCC Intelligent Solutions Holdings Inc(CCC)50,0000-50,0004560-455
Ke Holdings Inc(BEKE)145,000145,00002,7552,2850.07%-470
Chime Financial Inc(CHYM)25,0000-25,0005040-504
Palo Alto Networks Inc(PANW)13,45011,450-2,0002,7392,1090.06%-630
Generation Bio Inc296,892201,419-95,4731,8171,1440.03%-673
Sagimet Biosciences Inc0724,771+724,77104,2910.13%+4,291
Astera Labs Inc(ALAB)3,5000-3,5006850-685
Procore Technologies Inc(PCOR)10,0000-10,0007290-729
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