Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Scholar Rock Holding Corporation(SRRK) | 9,250,005 | 10,825,013 | +1,575,008 | $344.47M | $476.84M | 14.22% | +$132.37M |
| Kymera Therapeutics, Inc.(KYMR) | 3,428,150 | 3,286,830 | -141,320 | $194.03M | $255.75M | 7.63% | +$61.71M |
| BeOne Medicines AGADS(ONC) | 492,990 | 500,000 | +7,010 | $167.96M | $151.91M | 4.53% | -$16.06M |
| Edgewise Therapeutics, Inc.(EWTX) | 3,897,099 | 4,529,990 | +632,891 | $63.21M | $112.41M | 3.35% | +$49.20M |
| Revolution Medicines, Inc.(RVMD) | 1,043,720 | 1,335,075 | +291,355 | $48.74M | $106.34M | 3.17% | +$57.60M |
| Centessa Pharmaceuticals PLCADS | 3,227,517 | 4,027,517 | +800,000 | $78.27M | $100.73M | 3.00% | +$22.46M |
| Arrowhead Pharmaceuticals, Inc.(ARWR) | 2,669,880 | 1,500,476 | -1,169,404 | $92.08M | $99.62M | 2.97% | +$7.53M |
| Bicara Therapeutics Inc | 5,216,969 | 5,216,969 | 0 | $82.38M | $87.80M | 2.62% | +$5.43M |
| Olema Pharmaceuticals, Inc.(OLMA) | 0 | 3,300,700 | +3,300,700 | $0 | $82.52M | 2.46% | +$82.52M |
| Disc Medicine, Inc.(IRON) | 913,401 | 988,401 | +75,000 | $60.36M | $78.49M | 2.34% | +$18.13M |
| Structure Therapeutics IncADS | 1,026,811 | 1,078,698 | +51,887 | $28.75M | $75.02M | 2.24% | +$46.27M |
| Tango Therapeutics, Inc.(TNGX) | 5,883,188 | 8,165,374 | +2,282,186 | $49.42M | $72.35M | 2.16% | +$22.93M |
| Arcus Biosciences, Inc.(RCUS) | 2,912,077 | 3,007,077 | +95,000 | $39.60M | $71.66M | 2.14% | +$32.05M |
| Stoke Therapeutics, Inc.(STOK) | 2,247,347 | 2,247,347 | 0 | $52.81M | $71.33M | 2.13% | +$18.52M |
| Crinetics Pharmaceuticals Inc | 1,688,611 | 1,507,636 | -180,975 | $70.33M | $70.18M | 2.09% | -$150.2K |
| Dyne Therapeutics, Inc.(DYN) | 4,729,174 | 3,502,941 | -1,226,233 | $59.82M | $68.52M | 2.04% | +$8.69M |
| Apellis Pharmaceuticals Inc COM | 2,578,396 | 2,578,396 | 0 | $58.35M | $64.77M | 1.93% | +$6.42M |
| Cogent Biosciences, Inc.(COGT) | 1,724,279 | 1,629,279 | -95,000 | $24.76M | $57.87M | 1.73% | +$33.11M |
| Septerna, Inc.(SEPN) | 2,202,514 | 2,000,000 | -202,514 | $41.43M | $55.76M | 1.66% | +$14.33M |
| Taysha Gene Therapies, Inc.(TSHA) | 11,014,737 | 10,129,913 | -884,824 | $36.02M | $55.71M | 1.66% | +$19.70M |
| Rhythm Pharmaceuticals, Inc.(RYTM) | 499,975 | 499,975 | 0 | $50.49M | $53.52M | 1.60% | +$3.02M |
| Ascendis Pharma A/SADR(ASND) | 235,862 | 235,862 | 0 | $46.89M | $50.30M | 1.50% | +$3.40M |
| RAPT Therapeutics Inc | 580,466 | 1,375,000 | +794,534 | $14.97M | $46.57M | 1.39% | +$31.60M |
| Taboola.com Ltd.(TBLA) | 9,969,495 | 9,969,495 | 0 | $34.00M | $45.96M | 1.37% | +$11.96M |
| Lexicon Pharmaceuticals, Inc.(LXRX) | 38,918,903 | 38,918,903 | 0 | $52.54M | $44.76M | 1.34% | -$7.78M |
| Zymeworks Inc.(ZYME) | 0 | 1,680,121 | +1,680,121 | $0 | $44.24M | 1.32% | +$44.24M |
| Solid Biosciences Inc | 7,415,905 | 7,690,405 | +274,500 | $45.76M | $43.37M | 1.29% | -$2.38M |
| Wave Life Sciences, Inc.SHS(WVE) | 3,696,322 | 2,450,000 | -1,246,322 | $27.06M | $41.65M | 1.24% | +$14.59M |
| Xenon Pharmaceuticals Inc.(XENE) | 812,761 | 812,761 | 0 | $32.63M | $36.43M | 1.09% | +$3.80M |
| DBV Technologies S.A.ADS(DBVT) | 0 | 1,857,362 | +1,857,362 | $0 | $35.61M | 1.06% | +$35.61M |
| Erasca, Inc.(ERAS) | 8,757,249 | 8,757,249 | 0 | $19.09M | $32.58M | 0.97% | +$13.49M |
| enGene Holdings Inc COM | 0 | 3,336,264 | +3,336,264 | $0 | $30.13M | 0.90% | +$30.13M |
| Trevi Therapeutics, Inc.(TRVI) | 2,536,867 | 2,286,867 | -250,000 | $23.21M | $28.63M | 0.85% | +$5.42M |
| Spyre Therapeutics, Inc.(SYRE) | 368,598 | 818,598 | +450,000 | $6.18M | $26.82M | 0.80% | +$20.64M |
| Mineralys Therapeutics, Inc.(MLYS) | 0 | 699,999 | +699,999 | $0 | $25.40M | 0.76% | +$25.40M |
| Denali Therapeutics Inc.(DNLI) | 821,513 | 1,396,513 | +575,000 | $11.93M | $23.06M | 0.69% | +$11.13M |
| Remitly Global, Inc.(RELY) | 1,618,271 | 1,618,271 | 0 | $26.38M | $22.33M | 0.67% | -$4.05M |
| Fulcrum Therapeutics, Inc.(FULC) | 0 | 1,950,000 | +1,950,000 | $0 | $22.05M | 0.66% | +$22.05M |
| Rapport Therapeutics, Inc.(RAPP) | 1,053,469 | 708,469 | -345,000 | $31.29M | $21.49M | 0.64% | -$9.79M |
| Silence Therapeutics plcADS(SLN) | 2,911,438 | 2,911,438 | 0 | $15.11M | $17.70M | 0.53% | +$2.59M |
| IHS Holding Limited ORD SHS | 2,357,520 | 2,357,520 | 0 | $16.08M | $17.59M | 0.52% | +$1.51M |
| Gossamer Bio, Inc.(GOSS) | 5,208,968 | 5,208,968 | 0 | $13.70M | $16.15M | 0.48% | +$2.45M |
| Upstream Bio, Inc.(UPB) | 788,450 | 588,450 | -200,000 | $14.83M | $15.98M | 0.48% | +$1.15M |
| Bicycle Therapeutics PLCADS | 2,012,752 | 2,012,752 | 0 | $15.58M | $14.25M | 0.43% | -$1.33M |
| Monopar Therapeutics Inc.(MNPR) | 0 | 212,298 | +212,298 | $0 | $13.86M | 0.41% | +$13.86M |
| Cullinan Therapeutics, Inc.(CGEM) | 1,193,410 | 1,193,410 | 0 | $7.08M | $12.35M | 0.37% | +$5.27M |
| Sionna Therapeutics, Inc.(SION) | 325,000 | 300,000 | -25,000 | $9.56M | $12.34M | 0.37% | +$2.78M |
| Inhibikase Therapeutics, Inc.(IKT) | 0 | 5,850,000 | +5,850,000 | $0 | $11.99M | 0.36% | +$11.99M |
| NovaBridge BiosciencesADS(NBP) | 1,165,957 | 3,000,000 | +1,834,043 | $4.41M | $11.94M | 0.36% | +$7.53M |
| Amazon.com, Inc.(AMZN) | 58,500 | 51,500 | -7,000 | $12.84M | $11.89M | 0.35% | -$957.6K |
| Neumora Therapeutics, Inc.(NMRA) | 4,358,283 | 6,288,783 | +1,930,500 | $7.93M | $11.26M | 0.34% | +$3.32M |
| Mind Medicine (MindMed) Inc | 0 | 800,000 | +800,000 | $0 | $10.71M | 0.32% | +$10.71M |
| Benitec Biopharma Inc.(BNTC) | 0 | 775,000 | +775,000 | $0 | $10.44M | 0.31% | +$10.44M |
| Invivyd, Inc.(IVVD) | 0 | 4,000,000 | +4,000,000 | $0 | $9.88M | 0.29% | +$9.88M |
| Taiwan Semiconductor Manufacturing Company LimitedADS(TSM) | 28,200 | 27,700 | -500 | $7.88M | $8.42M | 0.25% | +$541.8K |
| ORIC Pharmaceuticals, Inc.(ORIC) | 1,007,575 | 1,007,575 | 0 | $12.09M | $8.24M | 0.25% | -$3.85M |
| MapLight Therapeutics, Inc.(MPLT) | 0 | 450,000 | +450,000 | $0 | $7.90M | 0.24% | +$7.90M |
| Palvella Therapeutics, Inc.(PVLA) | 0 | 75,000 | +75,000 | $0 | $7.85M | 0.23% | +$7.85M |
| CrowdStrike Holdings, Inc.CL A(CRWD) | 18,500 | 16,500 | -2,000 | $9.07M | $7.73M | 0.23% | -$1.34M |
| IonQ, Inc.(IONQ) | 170,000 | 170,000 | 0 | $10.46M | $7.63M | 0.23% | -$2.83M |
| Seer, Inc.CL A(SEER) | 4,000,000 | 4,000,000 | 0 | $8.68M | $7.32M | 0.22% | -$1.36M |
| Microsoft Corporation(MSFT) | 17,150 | 15,000 | -2,150 | $8.88M | $7.25M | 0.22% | -$1.63M |
| PDD Holdings Inc.ADS(PDD) | 43,401 | 63,401 | +20,000 | $5.74M | $7.19M | 0.21% | +$1.45M |
| Lexeo Therapeutics, Inc.(LXEO) | 603,435 | 720,622 | +117,187 | $4.01M | $7.16M | 0.21% | +$3.15M |
| NVIDIA Corporation(NVDA) | 37,485 | 37,485 | 0 | $6.99M | $6.99M | 0.21% | -$2.8K |
| Salesforce, Inc.(CRM) | 30,100 | 26,100 | -4,000 | $7.13M | $6.91M | 0.21% | -$219.5K |
| COMPASS Pathways plcADS(CMPS) | 0 | 1,000,000 | +1,000,000 | $0 | $6.90M | 0.21% | +$6.90M |
| BillionToOne IncCL A | 0 | 83,833 | +83,833 | $0 | $6.86M | 0.20% | +$6.86M |
| Workiva Inc.CL A(WK) | 30,000 | 79,123 | +49,123 | $2.58M | $6.82M | 0.20% | +$4.24M |
| Zura Bio LimitedCL A(ZURA) | 0 | 1,300,000 | +1,300,000 | $0 | $6.81M | 0.20% | +$6.81M |
| vTv Therapeutics Inc.CL A(VTVT) | 163,000 | 163,000 | 0 | $3.81M | $6.52M | 0.19% | +$2.71M |
| Alphabet Inc.CL A(GOOG) | 21,203 | 20,703 | -500 | $5.15M | $6.48M | 0.19% | +$1.33M |
| Nebius Group N.V.CL A(NBIS) | 72,600 | 76,218 | +3,618 | $8.15M | $6.38M | 0.19% | -$1.77M |
| Savara Inc.(SVRA) | 0 | 1,000,000 | +1,000,000 | $0 | $6.03M | 0.18% | +$6.03M |
| X4 Pharmaceuticals, Inc.(XFOR) | 0 | 1,500,000 | +1,500,000 | $0 | $6.00M | 0.18% | +$6.00M |
| JFrog Ltd.(FROG) | 107,116 | 93,616 | -13,500 | $5.07M | $5.85M | 0.17% | +$777.5K |
| ServiceNow, Inc.(NOW) | 7,126 | 35,630 | +28,504 | $6.56M | $5.46M | 0.16% | -$1.10M |
| Tenax Therapeutics, Inc.(TENX) | 352,441 | 427,141 | +74,700 | $2.68M | $5.21M | 0.16% | +$2.52M |
| Whitehawk Therapeutics, Inc.(WHWK) | 2,082,000 | 2,082,000 | 0 | $3.96M | $5.04M | 0.15% | +$1.08M |
| Dynatrace, Inc.(DT) | 100,229 | 115,229 | +15,000 | $4.86M | $4.99M | 0.15% | +$137.9K |
| Datadog, Inc.CL A(DDOG) | 32,925 | 36,425 | +3,500 | $4.69M | $4.95M | 0.15% | +$264.9K |
| Alumis Inc | 0 | 500,000 | +500,000 | $0 | $4.88M | 0.15% | +$4.88M |
| Meta Platforms, Inc.CL A(META) | 0 | 7,169 | +7,169 | $0 | $4.73M | 0.14% | +$4.73M |
| PepGen Inc.(PEPG) | 700,000 | 700,000 | 0 | $3.23M | $4.56M | 0.14% | +$1.32M |
| Sagimet Biosciences Inc.COM SER A(SGMT) | 724,771 | 724,771 | 0 | $4.97M | $4.29M | 0.13% | -$681.3K |
| Adobe Inc.(ADBE) | 15,051 | 12,051 | -3,000 | $5.31M | $4.22M | 0.13% | -$1.09M |
| Foghorn Therapeutics Inc.(FHTX) | 720,720 | 720,720 | 0 | $3.52M | $3.89M | 0.12% | +$367.6K |
| GitLab Inc.CL A(GTLB) | 64,000 | 99,000 | +35,000 | $2.89M | $3.72M | 0.11% | +$830.4K |
| Kalaris Therapeutics, Inc.(KLRS) | 318,264 | 435,798 | +117,534 | $1.84M | $3.68M | 0.11% | +$1.84M |
| New Oriental Education & Technology Group Inc.ADR(EDU) | 62,000 | 62,000 | 0 | $3.29M | $3.41M | 0.10% | +$121.5K |
| Agenus Inc.(AGEN) | 1,064,250 | 1,064,250 | 0 | $4.10M | $3.34M | 0.10% | -$755.6K |
| Medline Inc.CL A(MDLN) | 0 | 75,000 | +75,000 | $0 | $3.15M | 0.09% | +$3.15M |
| Korro Bio, Inc.(KRRO) | 418,833 | 347,718 | -71,115 | $20.06M | $2.79M | 0.08% | -$17.27M |
| Cellebrite DI Ltd.(CLBT) | 90,000 | 150,000 | +60,000 | $1.67M | $2.71M | 0.08% | +$1.04M |
| Rani Therapeutics Holdings, Inc.CL A(RANI) | 0 | 2,000,000 | +2,000,000 | $0 | $2.70M | 0.08% | +$2.70M |
| Zscaler, Inc.(ZS) | 0 | 12,000 | +12,000 | $0 | $2.70M | 0.08% | +$2.70M |
| Black Diamond Therapeutics Inc | 1,046,517 | 1,046,517 | 0 | $3.97M | $2.54M | 0.08% | -$1.42M |
| monday.com LtdSHS SHS | 7,000 | 17,000 | +10,000 | $1.36M | $2.51M | 0.07% | +$1.15M |
| Broadcom Inc.(AVGO) | 0 | 7,000 | +7,000 | $0 | $2.42M | 0.07% | +$2.42M |
| QUALCOMM Incorporated(QCOM) | 14,000 | 14,000 | 0 | $2.33M | $2.39M | 0.07% | +$65.7K |