Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2024 ▲▼ | Q1 2025 ▲▼ | Change ▲▼ | Q4 2024 ▲▼ | Q1 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| ASTRAZENECA PLC(AZN) | 0 | 32,534 | +32,534 | 0 | 4,726 | 4.23% | +4,726 |
| COGENT BIOSCIENCES INC(COGT) | 0 | 621,678 | +621,678 | 0 | 3,724 | 3.34% | +3,724 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 0 | 217,294 | +217,294 | 0 | 2,929 | 2.62% | +2,929 |
| REGENXBIO INC(RGNX) | 0 | 405,281 | +405,281 | 0 | 2,898 | 2.60% | +2,898 |
| DYNE THERAPEUTICS INC(DYN) | 0 | 258,391 | +258,391 | 0 | 2,703 | 2.42% | +2,703 |
| REPLIMUNE GROUP INC(REPL) | 54,738 | 294,846 | +240,108 | 663 | 2,875 | 2.57% | +2,212 |
| ANAPTYSBIO INC | 0 | 116,623 | +116,623 | 0 | 2,168 | 1.94% | +2,168 |
| TRAVERE THERAPEUTICS INC(TVTX) | 0 | 118,017 | +118,017 | 0 | 2,115 | 1.89% | +2,115 |
| GE HEALTHCARE TECHNOLOGIES I(GEHC) | 0 | 25,400 | +25,400 | 0 | 2,050 | 1.84% | +2,050 |
| IONIS PHARMACEUTICALS INC(IONS) | 61,367 | 135,616 | +74,249 | 2,145 | 4,092 | 3.66% | +1,946 |
| IMMUNOME INC(IMNM) | 0 | 263,841 | +263,841 | 0 | 1,776 | 1.59% | +1,776 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 0 | 51,295 | +51,295 | 0 | 1,720 | 1.54% | +1,720 |
| CORBUS PHARMACEUTICALS HLDGS(CRBP) | 0 | 289,690 | +289,690 | 0 | 1,538 | 1.38% | +1,538 |
| AKERO THERAPEUTICS INC | 68,608 | 76,379 | +7,771 | 1,909 | 3,092 | 2.77% | +1,183 |
| CYTOKINETICS INC(CYTK) | 65,883 | 103,483 | +37,600 | 3,099 | 4,159 | 3.73% | +1,060 |
| TREVI THERAPEUTICS INC(TRVI) | 0 | 163,738 | +163,738 | 0 | 1,030 | 0.92% | +1,030 |
| MBX BIOSCIENCES INC(MBX) | 0 | 133,113 | +133,113 | 0 | 982 | 0.88% | +982 |
| NEKTAR THERAPEUTICS(NKTR) | 618,174 | 2,232,453 | +1,614,279 | 575 | 1,518 | 1.36% | +943 |
| GUARDANT HEALTH INC(GH) | 147,800 | 127,182 | -20,618 | 4,515 | 5,418 | 4.85% | +903 |
| 89BIO INC | 225,323 | 353,882 | +128,559 | 1,762 | 2,573 | 2.30% | +811 |
| FULCRUM THERAPEUTICS INC(FULC) | 283,599 | 689,137 | +405,538 | 1,333 | 1,985 | 1.78% | +652 |
| BIOCRYST PHARMACEUTICALS INC(BCRX) | 0 | 60,600 | +60,600 | 0 | 455 | 0.41% | +455 |
| PENUMBRA INC(PEN) | 9,000 | 9,000 | 0 | 2,137 | 2,407 | 2.16% | +269 |
| GOSSAMER BIO INC(GOSS) | 1,097,999 | 1,097,999 | 0 | 993 | 1,208 | 1.08% | +215 |
| NUVATION BIO INC(NUVB) | 0 | 96,311 | +96,311 | 0 | 170 | 0.15% | +170 |
| SAVARA INC(SVRA) | 699,698 | 836,397 | +136,699 | 2,148 | 2,317 | 2.08% | +169 |
| AKEBIA THERAPEUTICS INC(AKBA) | 205,956 | 189,087 | -16,869 | 391 | 363 | 0.33% | -28 |
| KARYOPHARM THERAPEUTICS INC | 2,000,000 | 2,000,000 | 0 | 1,556 | 1,523 | 1.36% | -34 |
| ESTABLISHMENT LABS HLDGS INC(ESTA) | 13,100 | 13,100 | 0 | 604 | 535 | 0.48% | -69 |
| SYNDAX PHARMACEUTICALS INC(SNDX) | 318,900 | 337,198 | +18,298 | 4,216 | 4,142 | 3.71% | -73 |
| BEIGENE LTD(ONC) | 10,000 | 6,500 | -3,500 | 1,847 | 1,769 | 1.58% | -78 |
| ARBUTUS BIOPHARMA CORP(ABUS) | 28,300 | 0 | -28,300 | 93 | 0 | — | -93 |
| BIOHAVEN LTD(BHVN) | 28,159 | 39,900 | +11,741 | 1,052 | 959 | 0.86% | -93 |
| MERSANA THERAPEUTICS INC | 172,924 | 0 | -172,924 | 250 | 0 | — | -250 |
| CENTESSA PHARMACEUTICALS PLC | 137,716 | 142,744 | +5,028 | 2,307 | 2,053 | 1.84% | -254 |
| LEAP THERAPEUTICS INC(CYPH) | 102,631 | 0 | -102,631 | 295 | 0 | — | -295 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 987 | 0 | -987 | 305 | 0 | — | -305 |
| DR REDDYS LABS LTD(RDY) | 117,500 | 117,500 | 0 | 1,855 | 1,550 | 1.39% | -305 |
| ALVOTECH(ALVO) | 90,100 | 90,100 | 0 | 1,192 | 871 | 0.78% | -321 |
| APREA THERAPEUTICS INC(APRE) | 127,960 | 28,972 | -98,988 | 420 | 59 | 0.05% | -361 |
| SOLENO THERAPEUTICS INC | 77,285 | 43,441 | -33,844 | 3,474 | 3,104 | 2.78% | -370 |
| VYNE THERAPEUTICS INC(YARW) | 353,434 | 462,801 | +109,367 | 1,184 | 731 | 0.65% | -453 |
| GERON CORP(GERN) | 1,561,152 | 3,215,457 | +1,654,305 | 5,623 | 5,113 | 4.58% | -510 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 81,473 | 71,438 | -10,035 | 2,175 | 1,572 | 1.41% | -604 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 77,439 | 84,339 | +6,900 | 3,347 | 2,711 | 2.43% | -635 |
| ELEDON PHARMACEUTICALS INC(ELDN) | 256,373 | 114,145 | -142,228 | 1,056 | 387 | 0.35% | -669 |
| INTUITIVE SURGICAL INC | 7,427 | 6,358 | -1,069 | 3,877 | 3,149 | 2.82% | -728 |
| ACELYRIN INC | 234,435 | 0 | -234,435 | 736 | 0 | — | -736 |
| VERU INC(VERU) | 1,117,600 | 0 | -1,117,600 | 740 | 0 | — | -740 |
| ANNEXON INC(ANNX) | 144,830 | 0 | -144,830 | 743 | 0 | — | -743 |
| NATERA INC(NTRA) | 22,450 | 18,650 | -3,800 | 3,554 | 2,637 | 2.36% | -917 |
| ACLARIS THERAPEUTICS INC(ACRS) | 389,333 | 0 | -389,333 | 966 | 0 | — | -966 |
| BRIDGEBIO PHARMA INC(BBIO) | 246,700 | 165,496 | -81,204 | 6,769 | 5,721 | 5.12% | -1,048 |
| TECTONIC THERAPEUTIC INC(TECX) | 26,081 | 0 | -26,081 | 1,204 | 0 | — | -1,204 |
| LEGEND BIOTECH CORP(LEGN) | 37,600 | 0 | -37,600 | 1,224 | 0 | — | -1,224 |
| STOKE THERAPEUTICS INC(STOK) | 113,096 | 0 | -113,096 | 1,247 | 0 | — | -1,247 |
| DISC MEDICINE INC(IRON) | 69,072 | 61,656 | -7,416 | 4,379 | 3,061 | 2.74% | -1,319 |
| PLIANT THERAPEUTICS INC(PLRX) | 103,504 | 0 | -103,504 | 1,363 | 0 | — | -1,363 |
| TARSUS PHARMACEUTICALS INC(TARS) | 28,178 | 0 | -28,178 | 1,560 | 0 | — | -1,560 |
| ROCKET PHARMACEUTICALS INC(RCKT) | 159,552 | 0 | -159,552 | 2,006 | 0 | — | -2,006 |
| JANUX THERAPEUTICS INC(JANX) | 40,123 | 0 | -40,123 | 2,148 | 0 | — | -2,148 |
| SUMMIT THERAPEUTICS INC(SMMT) | 130,412 | 0 | -130,412 | 2,327 | 0 | — | -2,327 |
| STRUCTURE THERAPEUTICS INC | 151,965 | 102,944 | -49,021 | 4,121 | 1,782 | 1.60% | -2,339 |
| ELI LILLY & CO(LLY) | 8,247 | 4,673 | -3,574 | 6,367 | 3,859 | 3.46% | -2,507 |
| GILEAD SCIENCES INC(GILD) | 29,700 | 0 | -29,700 | 2,743 | 0 | — | -2,743 |
| BLUEPRINT MEDICINES CORP | 31,800 | 0 | -31,800 | 2,774 | 0 | — | -2,774 |
| ARVINAS INC(ARVN) | 218,700 | 195,295 | -23,405 | 4,192 | 1,371 | 1.23% | -2,822 |
| NUVALENT INC | 40,580 | 0 | -40,580 | 3,186 | 0 | — | -3,186 |
| BOSTON SCIENTIFIC CORP(BSX) | 40,500 | 0 | -40,500 | 3,617 | 0 | — | -3,617 |
| BRISTOL-MYERS SQUIBB CO(BMY) | 65,200 | 0 | -65,200 | 3,688 | 0 | — | -3,688 |
| APELLIS PHARMACEUTICALS INC COM | 119,467 | 0 | -119,467 | 3,812 | 0 | — | -3,812 |
| RELAY THERAPEUTICS INC(RLAY) | 1,083,487 | 0 | -1,083,487 | 4,464 | 0 | — | -4,464 |
| HUMANA INC(HUM) | 18,066 | 0 | -18,066 | 4,584 | 0 | — | -4,584 |