Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| PRAXIS PRECISION MEDICINES I(PRAX) | 101,996 | 58,122 | -43,874 | 5,406 | 17,131 | 8.46% | +11,725 |
| WAVE LIFE SCIENCES LTD(WVE) | 0 | 421,488 | +421,488 | 0 | 7,165 | 3.54% | +7,165 |
| ELEVANCE HEALTH INC FORMERLY(ELV) | 0 | 17,191 | +17,191 | 0 | 6,026 | 2.98% | +6,026 |
| JAZZ PHARMACEUTICALS PLC(JAZZ) | 0 | 26,494 | +26,494 | 0 | 4,504 | 2.22% | +4,504 |
| COGENT BIOSCIENCES INC(COGT) | 443,547 | 305,568 | -137,979 | 6,369 | 10,854 | 5.36% | +4,484 |
| GUARDANT HEALTH INC(GH) | 98,182 | 98,182 | 0 | 6,134 | 10,028 | 4.95% | +3,894 |
| AGIOS PHARMACEUTICALS INC(AGIO) | 0 | 136,942 | +136,942 | 0 | 3,728 | 1.84% | +3,728 |
| ENLIVEN THERAPEUTICS INC | 0 | 222,308 | +222,308 | 0 | 3,424 | 1.69% | +3,424 |
| CELCUITY INC(CELC) | 0 | 34,289 | +34,289 | 0 | 3,420 | 1.69% | +3,420 |
| APELLIS PHARMACEUTICALS INC COM | 0 | 135,849 | +135,849 | 0 | 3,413 | 1.69% | +3,413 |
| DEXCOM INC(DXCM) | 0 | 50,147 | +50,147 | 0 | 3,328 | 1.64% | +3,328 |
| VERASTEM INC(VSTM) | 0 | 401,743 | +401,743 | 0 | 3,101 | 1.53% | +3,101 |
| IMMUNOCORE HLDGS PLC(IMCR) | 0 | 76,750 | +76,750 | 0 | 2,664 | 1.32% | +2,664 |
| ELI LILLY & CO(LLY) | 7,852 | 7,852 | 0 | 5,991 | 8,438 | 4.17% | +2,447 |
| NEXTCURE INC | 0 | 165,000 | +165,000 | 0 | 2,341 | 1.16% | +2,341 |
| BELITE BIO INC(BLTE) | 0 | 14,328 | +14,328 | 0 | 2,292 | 1.13% | +2,292 |
| UNIVERSAL HLTH SVCS INC(UHS) | 7,955 | 17,628 | +9,673 | 1,626 | 3,843 | 1.90% | +2,217 |
| IRONWOOD PHARMACEUTICALS INC(IRWD) | 0 | 648,532 | +648,532 | 0 | 2,186 | 1.08% | +2,186 |
| KARYOPHARM THERAPEUTICS INC(KPTI) | 0 | 295,541 | +295,541 | 0 | 2,175 | 1.07% | +2,175 |
| ADAGENE INC | 0 | 1,060,221 | +1,060,221 | 0 | 2,004 | 0.99% | +2,004 |
| UNITEDHEALTH GROUP INC(UNH) | 0 | 5,835 | +5,835 | 0 | 1,926 | 0.95% | +1,926 |
| PALISADE BIO INC(PALI) | 0 | 758,203 | +758,203 | 0 | 1,782 | 0.88% | +1,782 |
| VERA THERAPEUTICS INC(VERA) | 156,072 | 124,391 | -31,681 | 4,535 | 6,299 | 3.11% | +1,764 |
| ALUMIS INC | 292,770 | 292,250 | -520 | 1,168 | 2,852 | 1.41% | +1,684 |
| IMMUNOVANT INC(IMVT) | 158,622 | 158,622 | 0 | 2,557 | 4,032 | 1.99% | +1,475 |
| GLAUKOS CORP(GKOS) | 27,143 | 31,471 | +4,328 | 2,214 | 3,553 | 1.76% | +1,340 |
| NATERA INC(NTRA) | 18,650 | 18,650 | 0 | 3,002 | 4,273 | 2.11% | +1,270 |
| INHIBIKASE THERAPEUTICS INC(IKT) | 0 | 600,000 | +600,000 | 0 | 1,230 | 0.61% | +1,230 |
| IQVIA HLDGS INC(IQV) | 0 | 5,378 | +5,378 | 0 | 1,212 | 0.60% | +1,212 |
| LIQUIDIA CORPORATION(LQDA) | 94,235 | 91,148 | -3,087 | 2,143 | 3,144 | 1.55% | +1,001 |
| ASTRAZENECA PLC(AZN) | 28,362 | 28,362 | 0 | 4,270 | 5,261 | 2.60% | +991 |
| UNITED THERAPEUTICS CORP DEL(UTHR) | 6,645 | 7,685 | +1,040 | 2,786 | 3,745 | 1.85% | +959 |
| CYTOMX THERAPEUTICS INC(CTMX) | 745,305 | 745,305 | 0 | 2,378 | 3,175 | 1.57% | +797 |
| UPSTREAM BIO INC(UPB) | 51,960 | 64,845 | +12,885 | 977 | 1,761 | 0.87% | +783 |
| INTUITIVE SURGICAL INC | 6,358 | 6,358 | 0 | 2,843 | 3,601 | 1.78% | +757 |
| 10X GENOMICS INC(TXG) | 163,658 | 163,658 | 0 | 1,913 | 2,669 | 1.32% | +756 |
| IONIS PHARMACEUTICALS INC(IONS) | 131,016 | 116,515 | -14,501 | 8,571 | 9,218 | 4.55% | +646 |
| PENUMBRA INC(PEN) | 9,000 | 9,000 | 0 | 2,280 | 2,798 | 1.38% | +518 |
| RAPT THERAPEUTICS INC | 0 | 14,194 | +14,194 | 0 | 481 | 0.24% | +481 |
| WAYSTAR HLDG CORP(WAY) | 46,900 | 68,969 | +22,069 | 1,778 | 2,259 | 1.12% | +480 |
| ESTABLISHMENT LABS HLDGS INC(ESTA) | 13,100 | 13,100 | 0 | 537 | 955 | 0.47% | +418 |
| GOSSAMER BIO INC(GOSS) | 451,699 | 451,699 | 0 | 1,188 | 1,400 | 0.69% | +212 |
| FULCRUM THERAPEUTICS INC(FULC) | 98,799 | 92,055 | -6,744 | 909 | 1,041 | 0.51% | +132 |
| CYTOKINETICS INC(CYTK) | 142,417 | 124,749 | -17,668 | 7,827 | 7,927 | 3.92% | +99 |
| ARBUTUS BIOPHARMA CORP(ABUS) | 75,484 | 75,484 | 0 | 343 | 363 | 0.18% | +20 |
| IMMUNIC INC(IMUX) | 173,900 | 0 | -173,900 | 153 | 0 | — | -153 |
| VENTYX BIOSCIENCES INC | 60,600 | 0 | -60,600 | 188 | 0 | — | -188 |
| ARROWHEAD PHARMACEUTICALS IN(ARWR) | 104,507 | 49,758 | -54,749 | 3,604 | 3,303 | 1.63% | -301 |
| REPLIMUNE GROUP INC(REPL) | 73,614 | 0 | -73,614 | 308 | 0 | — | -308 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 173,439 | 100,046 | -73,393 | 2,813 | 2,483 | 1.23% | -331 |
| DISC MEDICINE INC(IRON) | 61,356 | 46,743 | -14,613 | 4,054 | 3,712 | 1.83% | -343 |
| TRAVERE THERAPEUTICS INC(TVTX) | 156,917 | 89,052 | -67,865 | 3,750 | 3,403 | 1.68% | -348 |
| BRIDGEBIO PHARMA INC(BBIO) | 133,087 | 80,723 | -52,364 | 6,913 | 6,175 | 3.05% | -738 |
| MBX BIOSCIENCES INC(MBX) | 52,402 | 0 | -52,402 | 917 | 0 | — | -917 |
| AVALO THERAPEUTICS INC(AVTX) | 100,036 | 0 | -100,036 | 1,271 | 0 | — | -1,271 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX) | 178,084 | 0 | -178,084 | 1,277 | 0 | — | -1,277 |
| UNIQURE NV(QURE) | 22,090 | 0 | -22,090 | 1,289 | 0 | — | -1,289 |
| INSPIRE MED SYS INC(INSP) | 18,600 | 0 | -18,600 | 1,380 | 0 | — | -1,380 |
| PROCEPT BIOROBOTICS CORP(PRCT) | 39,900 | 0 | -39,900 | 1,424 | 0 | — | -1,424 |
| ORIC PHARMACEUTICALS INC(ORIC) | 120,644 | 0 | -120,644 | 1,448 | 0 | — | -1,448 |
| KARYOPHARM THERAPEUTICS INC | 2,000,000 | 0 | -2,000,000 | 1,634 | 0 | — | -1,634 |
| SAREPTA THERAPEUTICS INC(SRPT) | 2,000,000 | 0 | -2,000,000 | 1,764 | 0 | — | -1,764 |
| CORBUS PHARMACEUTICALS HLDGS(CRBP) | 229,962 | 139,543 | -90,419 | 2,909 | 1,136 | 0.56% | -1,773 |
| SYNDAX PHARMACEUTICALS INC(SNDX) | 117,783 | 0 | -117,783 | 1,812 | 0 | — | -1,812 |
| CENCORA INC | 6,000 | 0 | -6,000 | 1,875 | 0 | — | -1,875 |
| CENTESSA PHARMACEUTICALS PLC | 88,024 | 0 | -88,024 | 2,135 | 0 | — | -2,135 |
| TENET HEALTHCARE CORP(THC) | 18,100 | 6,084 | -12,016 | 3,675 | 1,209 | 0.60% | -2,466 |
| GERON CORP(GERN) | 1,858,354 | 0 | -1,858,354 | 2,546 | 0 | — | -2,546 |
| AKERO THERAPEUTICS INC | 58,579 | 0 | -58,579 | 2,781 | 0 | — | -2,781 |
| SOLENO THERAPEUTICS INC | 48,445 | 0 | -48,445 | 3,275 | 0 | — | -3,275 |
| CVS HEALTH CORP(CVS) | 43,600 | 0 | -43,600 | 3,287 | 0 | — | -3,287 |
| NOVABRIDGE BIOSCIENCES(NBP) | 1,439,604 | 499,587 | -940,017 | 5,442 | 1,988 | 0.98% | -3,453 |
| APOGEE THERAPEUTICS INC(APGE) | 94,400 | 0 | -94,400 | 3,751 | 0 | — | -3,751 |
| 89BIO INC | 273,661 | 0 | -273,661 | 4,023 | 0 | — | -4,023 |