Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2024 ▲▼ | Q1 2025 ▲▼ | Change ▲▼ | Q4 2024 ▲▼ | Q1 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| REGENERON PHARMACEUTICALS(REGN) | 0 | 29,828 | +29,828 | 0 | 18,918 | 15.12% | +18,918 |
| ELI LILLY & CO(LLY) | 0 | 19,302 | +19,302 | 0 | 15,942 | 12.74% | +15,942 |
| JAZZ PHARMACEUTICALS PLC(JAZZ) | 14,719 | 87,189 | +72,470 | 1,813 | 10,825 | 8.65% | +9,012 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 0 | 62,247 | +62,247 | 0 | 6,885 | 5.50% | +6,885 |
| TG THERAPEUTICS INC(TGTX) | 47,805 | 207,883 | +160,078 | 1,439 | 8,197 | 6.55% | +6,758 |
| ARGENX SE(ARGX) | 679 | 12,279 | +11,600 | 422 | 7,179 | 5.74% | +6,757 |
| BIOMARIN PHARMACEUTICAL INC(BMRN) | 0 | 52,877 | +52,877 | 0 | 3,738 | 2.99% | +3,738 |
| ALNYLAM PHARMACEUTICALS INC(ALNY) | 0 | 13,115 | +13,115 | 0 | 3,541 | 2.83% | +3,541 |
| SOLENO THERAPEUTICS INC | 71,988 | 93,002 | +21,014 | 3,236 | 6,645 | 5.31% | +3,409 |
| IMMUNOCORE HLDGS PLC(IMCR) | 0 | 96,984 | +96,984 | 0 | 2,878 | 2.30% | +2,878 |
| VAXCYTE INC(PCVX) | 10,000 | 92,385 | +82,385 | 819 | 3,488 | 2.79% | +2,670 |
| SPRINGWORKS THERAPEUTICS INC | 0 | 60,000 | +60,000 | 0 | 2,648 | 2.12% | +2,648 |
| VIKING THERAPEUTICS INC(VKTX) | 0 | 104,121 | +104,121 | 0 | 2,515 | 2.01% | +2,515 |
| 89BIO INC | 0 | 231,436 | +231,436 | 0 | 1,683 | 1.34% | +1,683 |
| NOVO-NORDISK A S(NVO) | 0 | 24,618 | +24,618 | 0 | 1,676 | 1.34% | +1,676 |
| COGENT BIOSCIENCES INC(COGT) | 90,000 | 392,213 | +302,213 | 702 | 2,349 | 1.88% | +1,647 |
| KALVISTA PHARMACEUTICALS INC | 0 | 135,509 | +135,509 | 0 | 1,564 | 1.25% | +1,564 |
| SAGE THERAPEUTICS INC | 0 | 183,466 | +183,466 | 0 | 1,459 | 1.17% | +1,459 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 49,478 | 162,063 | +112,585 | 948 | 2,185 | 1.75% | +1,236 |
| TREVI THERAPEUTICS INC(TRVI) | 0 | 180,000 | +180,000 | 0 | 1,132 | 0.90% | +1,132 |
| PACIRA BIOSCIENCES INC(PCRX) | 0 | 38,926 | +38,926 | 0 | 967 | 0.77% | +967 |
| CYTOKINETICS INC(CYTK) | 0 | 20,000 | +20,000 | 0 | 804 | 0.64% | +804 |
| REVIVA PHARMACEUTCLS HLDGS I | 0 | 650,723 | +650,723 | 0 | 621 | 0.50% | +621 |
| UNIQURE NV(QURE) | 0 | 36,500 | +36,500 | 0 | 387 | 0.31% | +387 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 0 | 100,000 | +100,000 | 0 | 376 | 0.30% | +376 |
| UROGEN PHARMA LTD(URGN) | 50,000 | 76,220 | +26,220 | 533 | 843 | 0.67% | +310 |
| MEREO BIOPHARMA GROUP PLC(MREO) | 0 | 492,215 | +492,215 | 0 | 169 | 0.13% | +169 |
| CENTESSA PHARMACEUTICALS PLC | 131,862 | 164,048 | +32,186 | 2,209 | 2,359 | 1.88% | +150 |
| SAGIMET BIOSCIENCES INC(SGMT) | 0 | 46,019 | +46,019 | 0 | 150 | 0.12% | +150 |
| CLIMB BIO INC(CLYM) | 374,423 | 669,803 | +295,380 | 674 | 817 | 0.65% | +143 |
| ALECTOR INC | 239,019 | 456,546 | +217,527 | 452 | 562 | 0.45% | +110 |
| VISTAGEN THERAPEUTICS INC(VTGN) | 442,520 | 565,975 | +123,455 | 1,305 | 1,415 | 1.13% | +110 |
| GOSSAMER BIO INC(GOSS) | 217,987 | 269,589 | +51,602 | 197 | 297 | 0.24% | +99 |
| LARIMAR THERAPEUTICS INC(LRMR) | 3,800 | 0 | -3,800 | 15 | 0 | — | -15 |
| APTEVO THERAPEUTICS INC | 4,050 | 0 | -4,050 | 17 | 0 | — | -17 |
| LAVA THERAPEUTICS NV | 21,508 | 0 | -21,508 | 20 | 0 | — | -20 |
| CANDEL THERAPEUTICS INC(CADL) | 20,000 | 25,045 | +5,045 | 174 | 142 | 0.11% | -32 |
| MIND MEDICINE MINDMED INC | 4,710 | 0 | -4,710 | 33 | 0 | — | -33 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 1,359 | 0 | -1,359 | 36 | 0 | — | -36 |
| Q32 BIO INC(FIXX) | 19,700 | 0 | -19,700 | 68 | 0 | — | -68 |
| ELEDON PHARMACEUTICALS INC(ELDN) | 75,794 | 64,613 | -11,181 | 312 | 219 | 0.18% | -93 |
| CHIMERIX INC | 29,082 | 0 | -29,082 | 101 | 0 | — | -101 |
| SAB BIOTHERAPEUTICS INC(SABS) | 30,000 | 0 | -30,000 | 114 | 0 | — | -114 |
| TERNS PHARMACEUTICALS INC | 50,370 | 56,098 | +5,728 | 279 | 155 | 0.12% | -124 |
| PROQR THRAPEUTICS N V SHS EURO | 158,023 | 207,694 | +49,671 | 419 | 276 | 0.22% | -143 |
| ALX ONCOLOGY HLDGS INC(ALXO) | 197,680 | 0 | -197,680 | 330 | 0 | — | -330 |
| ZEVRA THERAPEUTICS INC(ZVRA) | 42,081 | 0 | -42,081 | 351 | 0 | — | -351 |
| ERASCA INC(ERAS) | 156,973 | 0 | -156,973 | 394 | 0 | — | -394 |
| BEIGENE LTD(ONC) | 30,000 | 0 | -30,000 | 422 | 0 | — | -422 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 53,160 | 57,923 | +4,763 | 2,298 | 1,862 | 1.49% | -435 |
| NEKTAR THERAPEUTICS(NKTR) | 698,919 | 0 | -698,919 | 650 | 0 | — | -650 |
| REPLIMUNE GROUP INC(REPL) | 114,000 | 74,530 | -39,470 | 1,381 | 727 | 0.58% | -654 |
| GERON CORP(GERN) | 200,000 | 0 | -200,000 | 708 | 0 | — | -708 |
| GH RESEARCH PLC(GHRS) | 101,502 | 0 | -101,502 | 711 | 0 | — | -711 |
| ARCELLX INC COMMON STOCK | 10,100 | 0 | -10,100 | 775 | 0 | — | -775 |
| APOGEE THERAPEUTICS INC(APGE) | 50,620 | 40,000 | -10,620 | 2,293 | 1,494 | 1.19% | -799 |
| RELAY THERAPEUTICS INC(RLAY) | 505,778 | 426,346 | -79,432 | 2,084 | 1,117 | 0.89% | -967 |
| BIONTECH SE(BNTX) | 8,767 | 0 | -8,767 | 999 | 0 | — | -999 |
| KEROS THERAPEUTICS INC(KROS) | 63,547 | 0 | -63,547 | 1,006 | 0 | — | -1,006 |
| EVOLUS INC(EOLS) | 97,423 | 0 | -97,423 | 1,076 | 0 | — | -1,076 |
| NUVALENT INC | 14,701 | 0 | -14,701 | 1,151 | 0 | — | -1,151 |
| DENALI THERAPEUTICS INC(DNLI) | 60,000 | 0 | -60,000 | 1,223 | 0 | — | -1,223 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 25,900 | 0 | -25,900 | 1,324 | 0 | — | -1,324 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 75,000 | 50,000 | -25,000 | 4,199 | 2,649 | 2.12% | -1,550 |
| ORIC PHARMACEUTICALS INC(ORIC) | 214,291 | 0 | -214,291 | 1,729 | 0 | — | -1,729 |
| ASCENDIS PHARMA A/S(ASND) | 25,276 | 8,321 | -16,955 | 3,480 | 1,297 | 1.04% | -2,183 |
| ARCUS BIOSCIENCES INC(RCUS) | 165,965 | 0 | -165,965 | 2,471 | 0 | — | -2,471 |
| TARSUS PHARMACEUTICALS INC(TARS) | 60,000 | 0 | -60,000 | 3,322 | 0 | — | -3,322 |
| INSMED INC(INSM) | 56,337 | 0 | -56,337 | 3,890 | 0 | — | -3,890 |
| ASTRAZENECA PLC(AZN) | 30,000 | 0 | -30,000 | 3,932 | 0 | — | -3,932 |
| BLUEPRINT MEDICINES CORP | 64,193 | 0 | -64,193 | 5,599 | 0 | — | -5,599 |
| TEVA PHARMACEUTICAL INDS LTD(TEVA) | 300,000 | 0 | -300,000 | 6,677 | 0 | — | -6,677 |
| ABBVIE INC(ABBV) | 50,000 | 0 | -50,000 | 8,885 | 0 | — | -8,885 |
| BRISTOL-MYERS SQUIBB CO(BMY) | 160,000 | 0 | -160,000 | 9,050 | 0 | — | -9,050 |