Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2024 ▲▼ | Q1 2025 ▲▼ | Change ▲▼ | Q4 2024 ▲▼ | Q1 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| AMGEN INC(AMGN)(Call) | 0 | 103,300 | +103,300 | 0 | 32,183 | — | +32,183 |
| PFIZER INC(PFE)(Call) | 0 | 900,000 | +900,000 | 0 | 22,806 | — | +22,806 |
| REGENERON PHARMACEUTICALS(REGN) | 0 | 29,828 | +29,828 | 0 | 18,918 | 15.12% | +18,918 |
| CORCEPT THERAPEUTICS INC(CORT)(Put) | 0 | 150,200 | +150,200 | 0 | 17,156 | — | +17,156 |
| ELI LILLY & CO(LLY)(Put) | 0 | 20,700 | +20,700 | 0 | 17,096 | — | +17,096 |
| AMGEN INC(AMGN)(Put) | 0 | 52,100 | +52,100 | 0 | 16,232 | — | +16,232 |
| ELI LILLY & CO(LLY) | 0 | 19,302 | +19,302 | 0 | 15,942 | 12.74% | +15,942 |
| REGENERON PHARMACEUTICALS(REGN)(Put) | 0 | 20,000 | +20,000 | 0 | 12,685 | — | +12,685 |
| SOLENO THERAPEUTICS INC(Call) | 94,600 | 219,400 | +124,800 | 4,252 | 15,676 | — | +11,424 |
| JAZZ PHARMACEUTICALS PLC(JAZZ) | 14,719 | 87,189 | +72,470 | 1,813 | 10,825 | 8.65% | +9,012 |
| JAZZ PHARMACEUTICALS PLC(JAZZ)(Call) | 0 | 70,800 | +70,800 | 0 | 8,790 | — | +8,790 |
| NOVO-NORDISK A S(NVO)(Put) | 0 | 124,600 | +124,600 | 0 | 8,652 | — | +8,652 |
| ELI LILLY & CO(LLY)(Call) | 0 | 10,000 | +10,000 | 0 | 8,259 | — | +8,259 |
| SOLENO THERAPEUTICS INC(Put) | 175,400 | 217,000 | +41,600 | 7,884 | 15,505 | — | +7,620 |
| NOVO-NORDISK A S(NVO)(Call) | 0 | 108,700 | +108,700 | 0 | 7,548 | — | +7,548 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 0 | 62,247 | +62,247 | 0 | 6,885 | 5.50% | +6,885 |
| TG THERAPEUTICS INC(TGTX) | 47,805 | 207,883 | +160,078 | 1,439 | 8,197 | 6.55% | +6,758 |
| ARGENX SE(ARGX) | 679 | 12,279 | +11,600 | 422 | 7,179 | 5.74% | +6,757 |
| ALNYLAM PHARMACEUTICALS INC(ALNY)(Put) | 0 | 20,000 | +20,000 | 0 | 5,400 | — | +5,400 |
| APOGEE THERAPEUTICS INC(APGE)(Call) | 0 | 126,300 | +126,300 | 0 | 4,719 | — | +4,719 |
| CORCEPT THERAPEUTICS INC(CORT)(Call) | 0 | 40,000 | +40,000 | 0 | 4,569 | — | +4,569 |
| BIOMARIN PHARMACEUTICAL INC(BMRN) | 0 | 52,877 | +52,877 | 0 | 3,738 | 2.99% | +3,738 |
| ALNYLAM PHARMACEUTICALS INC(ALNY) | 0 | 13,115 | +13,115 | 0 | 3,541 | 2.83% | +3,541 |
| SOLENO THERAPEUTICS INC | 71,988 | 93,002 | +21,014 | 3,236 | 6,645 | 5.31% | +3,409 |
| IMMUNOCORE HLDGS PLC(IMCR) | 0 | 96,984 | +96,984 | 0 | 2,878 | 2.30% | +2,878 |
| MODERNA INC(MRNA)(Put) | 0 | 100,000 | +100,000 | 0 | 2,835 | — | +2,835 |
| VAXCYTE INC(PCVX) | 10,000 | 92,385 | +82,385 | 819 | 3,488 | 2.79% | +2,670 |
| SPRINGWORKS THERAPEUTICS INC | 0 | 60,000 | +60,000 | 0 | 2,648 | 2.12% | +2,648 |
| MANNKIND CORP(MNKD)(Call) | 0 | 519,900 | +519,900 | 0 | 2,615 | — | +2,615 |
| VIKING THERAPEUTICS INC(VKTX) | 0 | 104,121 | +104,121 | 0 | 2,515 | 2.01% | +2,515 |
| EDGEWISE THERAPEUTICS INC(EWTX)(Call) | 0 | 98,200 | +98,200 | 0 | 2,160 | — | +2,160 |
| ZYMEWORKS INC(ZYME)(Call) | 0 | 179,300 | +179,300 | 0 | 2,135 | — | +2,135 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE)(Call) | 52,300 | 117,000 | +64,700 | 2,200 | 4,237 | — | +2,036 |
| VAXCYTE INC(PCVX)(Put) | 0 | 51,600 | +51,600 | 0 | 1,948 | — | +1,948 |
| BRIDGEBIO PHARMA INC(BBIO)(Call) | 100,000 | 131,400 | +31,400 | 2,744 | 4,542 | — | +1,798 |
| 89BIO INC | 0 | 231,436 | +231,436 | 0 | 1,683 | 1.34% | +1,683 |
| NOVO-NORDISK A S(NVO) | 0 | 24,618 | +24,618 | 0 | 1,676 | 1.34% | +1,676 |
| RECURSION PHARMACEUTICALS IN(RXRX)(Call) | 300,000 | 698,400 | +398,400 | 2,028 | 3,695 | — | +1,667 |
| COGENT BIOSCIENCES INC(COGT) | 90,000 | 392,213 | +302,213 | 702 | 2,349 | 1.88% | +1,647 |
| KALVISTA PHARMACEUTICALS INC | 0 | 135,509 | +135,509 | 0 | 1,564 | 1.25% | +1,564 |
| MODERNA INC(MRNA)(Call) | 0 | 52,100 | +52,100 | 0 | 1,477 | — | +1,477 |
| SAGE THERAPEUTICS INC | 0 | 183,466 | +183,466 | 0 | 1,459 | 1.17% | +1,459 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 49,478 | 162,063 | +112,585 | 948 | 2,185 | 1.75% | +1,236 |
| VIKING THERAPEUTICS INC(VKTX)(Call) | 0 | 50,000 | +50,000 | 0 | 1,208 | — | +1,208 |
| COGENT BIOSCIENCES INC(COGT)(Put) | 0 | 201,400 | +201,400 | 0 | 1,206 | — | +1,206 |
| KALVISTA PHARMACEUTICALS INC(Call) | 0 | 103,300 | +103,300 | 0 | 1,192 | — | +1,192 |
| MEREO BIOPHARMA GROUP PLC(Call) | 0 | 515,200 | +515,200 | 0 | 1,159 | — | +1,159 |
| TREVI THERAPEUTICS INC(TRVI) | 0 | 180,000 | +180,000 | 0 | 1,132 | 0.90% | +1,132 |
| PACIRA BIOSCIENCES INC(PCRX) | 0 | 38,926 | +38,926 | 0 | 967 | 0.77% | +967 |
| ANAPTYSBIO INC(Put) | 100,000 | 117,300 | +17,300 | 1,324 | 2,181 | — | +857 |
| CYTOKINETICS INC(CYTK) | 0 | 20,000 | +20,000 | 0 | 804 | 0.64% | +804 |
| GOSSAMER BIO INC(Call) | 256,900 | 824,800 | +567,900 | 232 | 907 | — | +675 |
| CARDIFF ONCOLOGY INC(Call) | 0 | 208,100 | +208,100 | 0 | 653 | — | +653 |
| ALTIMMUNE INC(Call) | 200,000 | 418,800 | +218,800 | 1,442 | 2,094 | — | +652 |
| REVIVA PHARMACEUTCLS HLDGS I | 0 | 650,723 | +650,723 | 0 | 621 | 0.50% | +621 |
| EVOLUS INC(Put) | 0 | 50,000 | +50,000 | 0 | 602 | — | +602 |
| VERVE THERAPEUTICS INC(Call) | 0 | 116,900 | +116,900 | 0 | 534 | — | +534 |
| NEKTAR THERAPEUTICS(NKTR)(Call) | 0 | 678,200 | +678,200 | 0 | 461 | — | +461 |
| CASSAVA SCIENCES INC(Call) | 0 | 300,000 | +300,000 | 0 | 450 | — | +450 |
| UNIQURE NV(QURE) | 0 | 36,500 | +36,500 | 0 | 387 | 0.31% | +387 |
| COMPASS THERAPEUTICS INC(Call) | 0 | 200,000 | +200,000 | 0 | 380 | — | +380 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 0 | 100,000 | +100,000 | 0 | 376 | 0.30% | +376 |
| UNITY BIOTECHNOLOGY INC(Call) | 0 | 346,900 | +346,900 | 0 | 361 | — | +361 |
| IMMUNIC INC(Call) | 0 | 317,800 | +317,800 | 0 | 346 | — | +346 |
| UROGEN PHARMA LTD(URGN) | 50,000 | 76,220 | +26,220 | 533 | 843 | 0.67% | +310 |
| UNITY BIOTECHNOLOGY INC(Put) | 0 | 215,200 | +215,200 | 0 | 224 | — | +224 |
| MEREO BIOPHARMA GROUP PLC | 0 | 492,215 | +492,215 | 0 | 169 | 0.13% | +169 |
| ATYR PHARMA INC(Call) | 0 | 54,700 | +54,700 | 0 | 165 | — | +165 |
| AGIOS PHARMACEUTICALS INC(AGIO)(Call) | 102,000 | 119,700 | +17,700 | 3,352 | 3,507 | — | +155 |
| CENTESSA PHARMACEUTICALS PLC | 131,862 | 164,048 | +32,186 | 2,209 | 2,359 | 1.88% | +150 |
| SAGIMET BIOSCIENCES INC | 0 | 46,019 | +46,019 | 0 | 150 | 0.12% | +150 |
| CLIMB BIO INC | 374,423 | 669,803 | +295,380 | 674 | 817 | 0.65% | +143 |
| AMICUS THERAPEUTICS INC(Call) COM | 100,000 | 131,400 | +31,400 | 942 | 1,072 | — | +130 |
| SUMMIT THERAPEUTICS INC(SMMT)(Call) | 20,000 | 24,700 | +4,700 | 357 | 476 | — | +120 |
| OCULAR THERAPEUTIX INC(OCUL)(Call) | 104,000 | 136,700 | +32,700 | 888 | 1,002 | — | +114 |
| ALECTOR INC | 239,019 | 456,546 | +217,527 | 452 | 562 | 0.45% | +110 |
| VISTAGEN THERAPEUTICS INC | 442,520 | 565,975 | +123,455 | 1,305 | 1,415 | 1.13% | +110 |
| GOSSAMER BIO INC | 217,987 | 269,589 | +51,602 | 197 | 297 | 0.24% | +99 |
| MEREO BIOPHARMA GROUP PLC(Put) | 0 | 39,400 | +39,400 | 0 | 89 | — | +89 |
| BIOMEA FUSION INC(Put) | 71,400 | 170,100 | +98,700 | 277 | 362 | — | +85 |
| ATYR PHARMA INC(Put) | 0 | 11,800 | +11,800 | 0 | 36 | — | +36 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE)(Put) | 105,500 | 123,300 | +17,800 | 4,438 | 4,465 | — | +26 |
| JAZZ PHARMACEUTICALS PLC(JAZZ)(Put) | 0 | 100 | +100 | 0 | 12 | — | +12 |
| VISTAGEN THERAPEUTICS INC(Call) | 0 | 200 | +200 | 0 | 1 | — | +1 |
| LEXICON PHARMACEUTICALS INC(LXRX)(Call) | 0 | 0 | 0 | 0 | 0 | — | 0 |
| LARIMAR THERAPEUTICS INC | 0 | 0 | 0 | 0 | 0 | — | 0 |
| APTEVO THERAPEUTICS INC | 0 | 0 | 0 | 0 | 0 | — | 0 |
| Q32 BIO INC(Call) | 0 | 0 | 0 | 0 | 0 | — | 0 |
| LAVA THERAPEUTICS NV | 0 | 0 | 0 | 0 | 0 | — | 0 |
| CANDEL THERAPEUTICS INC | 20,000 | 25,045 | +5,045 | 174 | 142 | 0.11% | -32 |
| MIND MEDICINE MINDMED INC | 0 | 0 | 0 | 0 | 0 | — | 0 |
| ARS PHARMACEUTICALS INC(Call) | 3,200 | 0 | -3,200 | 34 | 0 | — | -34 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 1,359 | 0 | -1,359 | 36 | 0 | — | -36 |
| ARVINAS INC(Put) | 2,300 | 0 | -2,300 | 44 | 0 | — | -44 |
| ALX ONCOLOGY HLDGS INC(Call) | 38,900 | 0 | -38,900 | 65 | 0 | — | -65 |
| LARIMAR THERAPEUTICS INC(Put) | 16,900 | 0 | -16,900 | 65 | 0 | — | -65 |
| RELAY THERAPEUTICS INC(RLAY)(Call) | 100,000 | 131,400 | +31,400 | 412 | 344 | — | -68 |
| Q32 BIO INC | 19,700 | 0 | -19,700 | 68 | 0 | — | -68 |
| KODIAK SCIENCES INC(KOD)(Call) | 7,300 | 0 | -7,300 | 73 | 0 | — | -73 |
| ELEDON PHARMACEUTICALS INC | 75,794 | 64,613 | -11,181 | 312 | 219 | 0.18% | -93 |